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Kynurenic acid inhibits macrophage pyroptosis by suppressing ROS production via activation of the NRF2 pathway

  • Authors:
    • Yuwei Gao
    • Xiaohui Guo
    • Yunpeng Zhou
    • Jie Du
    • Chengbo Lu
    • Lei Zhang
    • Siyuan Sun
    • Shengfang Wang
    • Yang Li
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Dentistry, Jiamusi University Affiliated Stomatological Hospital, Jiamusi, Heilongjiang 154000, P.R. China, Department of Pathology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, Department of Urology, Tianjin Baodi Hospital, Baodi Clinical College of Tianjin Medical University, Tianjin 300203, P.R. China, Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Cardiology, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China, Department of Cardiology, People's Hospital of Taihe County, Taihe, Anhui 236600, P.R. China, Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 211
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    Published online on: September 22, 2023
       https://doi.org/10.3892/mmr.2023.13098
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Abstract

Macrophage pyroptosis and related inflammatory responses play an important role in periodontitis. Kynurenic acid (KA) is hypothesized to have anti‑inflammatory potential, but whether KA can inhibit macrophage pyroptosis and the underlying mechanisms remain unclear. Lipopolysaccharide (LPS) was used to induce pyroptosis in THP‑1‑derived macrophages. KA or ML385 was used to pretreat macrophages, after which, cell viability, NOD‑like receptor protein 3 (NLRP3) inflammasome‑related protein expression, oxidative stress levels and nuclear factor erythroid 2‑related factor 2 (NRF2) expression were measured. The results showed that KA improved the LPS‑induced decrease in macrophage viability and lactate dehydrogenase release. KA prevented THP‑1 macrophage pyroptosis induced by LPS by reducing the expression of NLRP3, Gasdermin‑D, and Caspase1, and decreased the expression of inflammatory factors. KA suppressed NLRP3 inflammasome activation by inhibiting ROS overproduction and increasing Heme Oxygenase 1 and glutathione levels. Moreover, KA promoted NRF2 translocation from the cytoplasm to the nucleus. In addition, the anti‑pyroptotic and antioxidant effects of KA were reversed by ML385 inhibition of NRF2. In the present study, it was found that KA significantly suppressed macrophage pyroptosis induced by LPS. It was further demonstrated that the anti‑pyroptotic effects of KA were mediated by activation of the NRF2 pathway.
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1 

Slots J: Periodontitis: Facts, fallacies and the future. Periodontol. 75:7–23. 2017. View Article : Google Scholar

2 

Teles F, Collman RG, Mominkhan D and Wang Y: Viruses, periodontitis, and comorbidities. Periodontol. 89:190–206. 2022. View Article : Google Scholar

3 

Nagasawa Y, Misaki T, Ito S, Naka S, Wato K, Nomura R, Matsumoto-Nakano M and Nakano K: Title IgA nephropathy and oral bacterial species related to dental caries and periodontitis. Int J Mol Sci. 23:7252022. View Article : Google Scholar : PubMed/NCBI

4 

Suvan J, Leira Y, Sancho FM, Graziani F, Derks J and Tomasi C: Subgingival instrumentation for treatment of periodontitis. A systematic review. J Clin Periodontol. 22:155–175. 2020. View Article : Google Scholar

5 

Haas AN, Furlaneto F, Gaio EJ, Gomes SC, Palioto DB, Castilho RM, Sanz M and Messora MR: New tendencies in non-surgical periodontal therapy. Braz Oral Res. 35:e0952021. View Article : Google Scholar : PubMed/NCBI

6 

Krishna R and De Stefano JA: Ultrasonic vs. hand instrumentation in periodontal therapy: Clinical outcomes. Periodontol. 71:113–127. 2016. View Article : Google Scholar

7 

Li Y, Ling J and Jiang Q: Inflammasomes in alveolar bone loss. Front Immunol. 12:6910132021. View Article : Google Scholar : PubMed/NCBI

8 

Chen H, Wang Z, He Y, Peng L, Zhu J and Zhang X: Pyroptosis may play a crucial role in modifications of the immune microenvironment in periodontitis. J Periodontal Res. 57:977–990. 2022. View Article : Google Scholar : PubMed/NCBI

9 

Ning W, Acharya A, Li S, Schmalz G and Huang S: Identification of key pyroptosis-related genes and distinct pyroptosis-related clusters in periodontitis. Front Immunol. 13:8620492022. View Article : Google Scholar : PubMed/NCBI

10 

Sun X, Gao J, Meng X, Lu X, Zhang L and Chen R: Polarized macrophages in periodontitis: Characteristics, function, and molecular signaling. Front Immunol. 12:7633342021. View Article : Google Scholar : PubMed/NCBI

11 

Sharma BR and Kanneganti TD: NLRP3 inflammasome in cancer and metabolic diseases. Nat Immunol. 22:550–559. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Hooftman A, Angiari S, Hester S, Corcoran SE, Runtsch MC, Ling C, Ruzek MC, Slivka PF, McGettrick AF, Banahan K, et al: The immunomodulatory metabolite itaconate modifies NLRP3 and inhibits inflammasome activation. Cell Metab. 32:468–478.e7. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Zhao P, Yue Z, Nie L, Zhao Z and Wang Q, Chen J and Wang Q: Hyperglycaemia-associated macrophage pyroptosis accelerates periodontal inflamm-aging. J Clin Periodontol. 48:1379–1392. 2021. View Article : Google Scholar : PubMed/NCBI

14 

He Y, Wang Y, Jia X, Li Y, Yang Y, Pan L, Zhao R, Han Y, Wang F, Guan X and Hou T: Glycolytic reprogramming controls periodontitis-associated macrophage pyroptosis via AMPK/SIRT1/NF-κB signaling pathway. Int Immunopharmacol. 119:1101922023. View Article : Google Scholar : PubMed/NCBI

15 

Tóth F, Cseh EK and Vécsei L: Natural molecules and neuroprotection: Kynurenic acid, pantethine and α-lipoic acid. Int J Mol Sci. 22:4032021. View Article : Google Scholar : PubMed/NCBI

16 

Agudelo LZ, Ferreira DMS, Cervenka I, Bryzgalova G, Dadvar S, Jannig PR, Pettersson-Klein AT, Lakshmikanth T, Sustarsic EG, Porsmyr-Palmertz M, et al: Kynurenic acid and Gpr35 regulate adipose tissue energy homeostasis and inflammation. Cell Metab. 27:378–392.e5. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Ishida Y, Fujita H, Aratani S, Chijiiwa M, Taniguchi N, Yokota M, Ogihara Y, Uoshima N, Nagashima F, Uchino H and Nakajima T: The NRF2-PGC-1β pathway activates kynurenine aminotransferase 4 via attenuation of an E3 ubiquitin ligase, synoviolin, in a cecal ligation/perforation-induced septic mouse model. Mol Med Rep. 18:2467–2475. 2018.PubMed/NCBI

18 

An Y, Zhang H, Wang C, Jiao F, Xu H, Wang X, Luan W, Ma F, Ni L, Tang X, et al: Activation of ROS/MAPKs/NF-κB/NLRP3 and inhibition of efferocytosis in osteoclast-mediated diabetic osteoporosis. FASEB J. 33:12515–12527. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Lin Q, Li S, Jiang N, Shao X, Zhang M, Jin H, Zhang Z, Shen J, Zhou Y, Zhou W, et al: PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation. Redox Biol. 26:1012542019. View Article : Google Scholar : PubMed/NCBI

20 

He F, Ru X and Wen T: NRF2, a transcription factor for stress response and beyond. Int J Mol Sci. 21:47772020. View Article : Google Scholar : PubMed/NCBI

21 

Tonelli C, Chio IIC and Tuveson DA: Transcriptional regulation by Nrf2. Antioxid Redox Signal. 29:1727–1745. 2018. View Article : Google Scholar : PubMed/NCBI

22 

He F, Antonucci L and Karin M: NRF2 as a regulator of cell metabolism and inflammation in cancer. Carcinogenesis. 41:405–416. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Bellezza I, Giambanco I, Minelli A and Donato R: Nrf2-Keap1 signaling in oxidative and reductive stress. Biochim Biophys Acta Mol Cell Res. 1865:721–733. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Ulasov AV, Rosenkranz AA, Georgiev GP and Sobolev AS: Nrf2/Keap1/ARE signaling: Towards specific regulation. Life Sci. 291:1201112022. View Article : Google Scholar : PubMed/NCBI

25 

Luo X, Weng X, Bao X, Bai X, Lv Y, Zhang S, Chen Y, Zhao C, Zeng M, Huang J, et al: A novel anti-atherosclerotic mechanism of quercetin: Competitive binding to KEAP1 via Arg483 to inhibit macrophage pyroptosis. Redox Biol. 57:1025112022. View Article : Google Scholar : PubMed/NCBI

26 

Luo X, Bao X, Weng X, Bai X, Feng Y, Huang J, Liu S, Jia H and Yu B: The protective effect of quercetin on macrophage pyroptosis via TLR2/Myd88/NF-κB and ROS/AMPK pathway. Life Sci. 291:1200642022. View Article : Google Scholar : PubMed/NCBI

27 

Cai J, Yi M, Tan Y, Li X, Li G, Zeng Z, Xiong W and Xiang B: Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-II. J Exp Clin Cancer Res. 40:1902021. View Article : Google Scholar : PubMed/NCBI

28 

Kwon T, Lamster IB and Levin L: Current concepts in the management of periodontitis. Int Dent J. 71:462–476. 2021. View Article : Google Scholar : PubMed/NCBI

29 

Mombelli A: Microbial colonization of the periodontal pocket and its significance for periodontal therapy. Periodontol. 76:85–96. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Sztukowska MN, Roky M and Demuth DR: Peptide and non-peptide mimetics as potential therapeutics targeting oral bacteria and oral biofilms. Mol Oral Microbiol. 34:169–182. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Wang W, Zheng C, Yang J and Li B: Intersection between macrophages and periodontal pathogens in periodontitis. J Leukoc Biol. 110:577–583. 2021. View Article : Google Scholar : PubMed/NCBI

32 

Zhuang Z, Yoshizawa-Smith S, Glowacki A, Maltos K, Pacheco C, Shehabeldin M, Mulkeen M, Myers N, Chong R, Verdelis K, et al: Induction of M2 macrophages prevents bone loss in murine periodontitis models. J Dent Res. 98:200–208. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Zhang L, Li X, Yan H and Huang L: Salivary matrix metalloproteinase (MMP)-8 as a biomarker for periodontitis: A PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore). 97:e96422018. View Article : Google Scholar : PubMed/NCBI

34 

Luchian I, Goriuc A, Sandu D and Covasa M: The role of matrix metalloproteinases (MMP-8, MMP-9, MMP-13) in periodontal and peri-implant pathological processes. Int J Mol Sci. 23:18062022. View Article : Google Scholar : PubMed/NCBI

35 

Zhang B, Yang Y, Yi J, Zhao Z and Ye R: Hyperglycemia modulates M1/M2 macrophage polarization via reactive oxygen species overproduction in ligature-induced periodontitis. J Periodontal Res. 56:991–1005. 2021. View Article : Google Scholar : PubMed/NCBI

36 

Meng Q, Li Y, Ji T, Chao Y, Li J, Fu Y, Wang S, Chen Q, Chen W, Huang F, et al: Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor α-mediated autophagy. J Adv Res. 28:149–164. 2021. View Article : Google Scholar : PubMed/NCBI

37 

Almubarak A, Tanagala KKK, Papapanou PN, Lalla E and Momen-Heravi F: Disruption of monocyte and macrophage homeostasis in periodontitis. Front Immunol. 11:3302020. View Article : Google Scholar : PubMed/NCBI

38 

Xia Y, Zhou K, Sun M, Shu R, Qian J and Xie Y: The miR-223-3p regulates pyroptosis through NLRP3-caspase 1-GSDMD signal axis in periodontitis. Inflammation. 44:2531–2542. 2021. View Article : Google Scholar : PubMed/NCBI

39 

Sordi MB, Magini RS, Panahipour L and Gruber R: Pyroptosis-mediated periodontal disease. Int J Mol Sci. 23:3722021. View Article : Google Scholar : PubMed/NCBI

40 

Xu X, Zhang T, Xia X, Yin Y, Yang S, Ai D, Qin H, Zhou M and Song J: Pyroptosis in periodontitis: From the intricate interaction with apoptosis, NETosis, and necroptosis to the therapeutic prospects. Front Cell Infect Microbiol. 12:9532772022. View Article : Google Scholar : PubMed/NCBI

41 

Long JX, Tian MZ, Chen XY, Yu HH, Ding H, Liu F and Du K: The role of NLRP3 inflammasome-mediated pyroptosis in ischemic stroke and the intervention of traditional Chinese medicine. Front Pharmacol. 14:11511962023. View Article : Google Scholar : PubMed/NCBI

42 

Kelley N, Jeltema D, Duan Y and He Y: The NLRP3 inflammasome: An overview of mechanisms of activation and regulation. Int J Mol Sci. 20:33282019. View Article : Google Scholar : PubMed/NCBI

43 

Bai B, Yang Y, Wang Q, Li M, Tian C, Liu Y, Aung LHH, Li PF, Yu T and Chu XM: NLRP3 inflammasome in endothelial dysfunction. Cell Death Dis. 11:7762020. View Article : Google Scholar : PubMed/NCBI

44 

Wu X, Zhang H, Qi W, Zhang Y, Li J, Li Z, Lin Y, Bai X, Liu X, Chen X, et al: Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis. Cell Death Dis. 9:1712018. View Article : Google Scholar : PubMed/NCBI

45 

Qiu Y, Li L, Guo X, Liu J, Xu L and Li Y: Exogenous spermine inhibits high glucose/oxidized LDL-induced oxidative stress and macrophage pyroptosis by activating the Nrf2 pathway. Exp Ther Med. 23:3102022. View Article : Google Scholar : PubMed/NCBI

46 

Chiang SK, Chen SE and Chang LC: The role of HO-1 and its crosstalk with oxidative stress in cancer cell survival. Cells. 10:24012021. View Article : Google Scholar : PubMed/NCBI

47 

Huang C, Zhang C, Yang P, Chao R, Yue Z, Li C, Guo J and Li M: Eldecalcitol inhibits LPS-induced NLRP3 inflammasome-dependent pyroptosis in human gingival fibroblasts by activating the Nrf2/HO-1 signaling pathway. Drug Des Devel Ther. 14:4901–4913. 2020. View Article : Google Scholar : PubMed/NCBI

48 

Kang JY, Xu MM, Sun Y, Ding ZX, Wei YY, Zhang DW, Wang YG, Shen JL, Wu HM and Fei GH: Melatonin attenuates LPS-induced pyroptosis in acute lung injury by inhibiting NLRP3-GSDMD pathway via activating Nrf2/HO-1 signaling axis. Int Immunopharmacol. 109:1087822022. View Article : Google Scholar : PubMed/NCBI

49 

Zou Y, Luo X, Feng Y, Fang S, Tian J, Yu B and Li J: Luteolin prevents THP-1 macrophage pyroptosis by suppressing ROS production via Nrf2 activation. Chem Biol Interact. 345:1095732021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gao Y, Guo X, Zhou Y, Du J, Lu C, Zhang L, Sun S, Wang S and Li Y: Kynurenic acid inhibits macrophage pyroptosis by suppressing ROS production via activation of the NRF2 pathway. Mol Med Rep 28: 211, 2023.
APA
Gao, Y., Guo, X., Zhou, Y., Du, J., Lu, C., Zhang, L. ... Li, Y. (2023). Kynurenic acid inhibits macrophage pyroptosis by suppressing ROS production via activation of the NRF2 pathway. Molecular Medicine Reports, 28, 211. https://doi.org/10.3892/mmr.2023.13098
MLA
Gao, Y., Guo, X., Zhou, Y., Du, J., Lu, C., Zhang, L., Sun, S., Wang, S., Li, Y."Kynurenic acid inhibits macrophage pyroptosis by suppressing ROS production via activation of the NRF2 pathway". Molecular Medicine Reports 28.5 (2023): 211.
Chicago
Gao, Y., Guo, X., Zhou, Y., Du, J., Lu, C., Zhang, L., Sun, S., Wang, S., Li, Y."Kynurenic acid inhibits macrophage pyroptosis by suppressing ROS production via activation of the NRF2 pathway". Molecular Medicine Reports 28, no. 5 (2023): 211. https://doi.org/10.3892/mmr.2023.13098
Copy and paste a formatted citation
x
Spandidos Publications style
Gao Y, Guo X, Zhou Y, Du J, Lu C, Zhang L, Sun S, Wang S and Li Y: Kynurenic acid inhibits macrophage pyroptosis by suppressing ROS production via activation of the NRF2 pathway. Mol Med Rep 28: 211, 2023.
APA
Gao, Y., Guo, X., Zhou, Y., Du, J., Lu, C., Zhang, L. ... Li, Y. (2023). Kynurenic acid inhibits macrophage pyroptosis by suppressing ROS production via activation of the NRF2 pathway. Molecular Medicine Reports, 28, 211. https://doi.org/10.3892/mmr.2023.13098
MLA
Gao, Y., Guo, X., Zhou, Y., Du, J., Lu, C., Zhang, L., Sun, S., Wang, S., Li, Y."Kynurenic acid inhibits macrophage pyroptosis by suppressing ROS production via activation of the NRF2 pathway". Molecular Medicine Reports 28.5 (2023): 211.
Chicago
Gao, Y., Guo, X., Zhou, Y., Du, J., Lu, C., Zhang, L., Sun, S., Wang, S., Li, Y."Kynurenic acid inhibits macrophage pyroptosis by suppressing ROS production via activation of the NRF2 pathway". Molecular Medicine Reports 28, no. 5 (2023): 211. https://doi.org/10.3892/mmr.2023.13098
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