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Article Open Access

FGFR2 genetic variants in women with breast cancer

  • Authors:
    • Thérèse Dix-Peek
    • Caroline Dickens
    • Tanya N. Augustine
    • Boitumelo P. Phakathi
    • Eunice J. Van Den Berg
    • Maureen Joffe
    • Oluwatosin A. Ayeni
    • Herbert Cubasch
    • Sarah Nietz
    • Christopher G. Mathew
    • Mahtaab Hayat
    • Alfred I. Neugut
    • Judith S. Jacobson
    • Paul Ruff
    • Raquel A.B. Duarte
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg 2193, South Africa, School of Anatomical Sciences, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg 2193, South Africa, Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of Kwa-Zulu Natal, Durban 4001, South Africa, Department of Histopathology, National Health Laboratory Services, Chris Hani Baragwanath Hospital, Johannesburg 1864, South Africa, Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg 2193, South Africa, South African Medical Research Council Common Epithelial Cancer Research Centre, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg 2193, South Africa, Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg 2193, South Africa, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, New York 10032, United States of America
    Copyright: © Dix-Peek et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 226
    |
    Published online on: October 10, 2023
       https://doi.org/10.3892/mmr.2023.13113
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Abstract

Black African populations are more genetically diverse than others, but genetic variants have been studied primarily in European populations. The present study examined the association of four single nucleotide polymorphisms (SNPs) of the fibroblast growth factor receptor 2, associated with breast cancer in non‑African populations, with breast cancer in Black, southern African women. Genomic DNA was extracted from whole blood samples of 1,001 patients with breast cancer and 1,006 controls (without breast cancer), and the rs2981582, rs35054928, rs2981578, and rs11200014 polymorphisms were analyzed using allele‑specific Kompetitive allele‑specific PCR™, and the χ2 or Fisher's exact tests were used to compare the genotype frequencies. There was no association between those SNPs and breast cancer in the studied cohort, although an association was identified between the C/C homozygote genotype for rs2981578 and invasive lobular carcinoma. These results show that genetic biomarkers of breast cancer risk in European populations are not necessarily associated with risk in sub‑Saharan African populations. African populations are more heterogenous than other populations, and the information from this population can help focus genetic risks of cancer in this understudied population.
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Copy and paste a formatted citation
Spandidos Publications style
Dix-Peek T, Dickens C, Augustine TN, Phakathi BP, Van Den Berg EJ, Joffe M, Ayeni OA, Cubasch H, Nietz S, Mathew CG, Mathew CG, et al: FGFR2 genetic variants in women with breast cancer. Mol Med Rep 28: 226, 2023.
APA
Dix-Peek, T., Dickens, C., Augustine, T.N., Phakathi, B.P., Van Den Berg, E.J., Joffe, M. ... Duarte, R.A. (2023). FGFR2 genetic variants in women with breast cancer. Molecular Medicine Reports, 28, 226. https://doi.org/10.3892/mmr.2023.13113
MLA
Dix-Peek, T., Dickens, C., Augustine, T. N., Phakathi, B. P., Van Den Berg, E. J., Joffe, M., Ayeni, O. A., Cubasch, H., Nietz, S., Mathew, C. G., Hayat, M., Neugut, A. I., Jacobson, J. S., Ruff, P., Duarte, R. A."FGFR2 genetic variants in women with breast cancer". Molecular Medicine Reports 28.6 (2023): 226.
Chicago
Dix-Peek, T., Dickens, C., Augustine, T. N., Phakathi, B. P., Van Den Berg, E. J., Joffe, M., Ayeni, O. A., Cubasch, H., Nietz, S., Mathew, C. G., Hayat, M., Neugut, A. I., Jacobson, J. S., Ruff, P., Duarte, R. A."FGFR2 genetic variants in women with breast cancer". Molecular Medicine Reports 28, no. 6 (2023): 226. https://doi.org/10.3892/mmr.2023.13113
Copy and paste a formatted citation
x
Spandidos Publications style
Dix-Peek T, Dickens C, Augustine TN, Phakathi BP, Van Den Berg EJ, Joffe M, Ayeni OA, Cubasch H, Nietz S, Mathew CG, Mathew CG, et al: FGFR2 genetic variants in women with breast cancer. Mol Med Rep 28: 226, 2023.
APA
Dix-Peek, T., Dickens, C., Augustine, T.N., Phakathi, B.P., Van Den Berg, E.J., Joffe, M. ... Duarte, R.A. (2023). FGFR2 genetic variants in women with breast cancer. Molecular Medicine Reports, 28, 226. https://doi.org/10.3892/mmr.2023.13113
MLA
Dix-Peek, T., Dickens, C., Augustine, T. N., Phakathi, B. P., Van Den Berg, E. J., Joffe, M., Ayeni, O. A., Cubasch, H., Nietz, S., Mathew, C. G., Hayat, M., Neugut, A. I., Jacobson, J. S., Ruff, P., Duarte, R. A."FGFR2 genetic variants in women with breast cancer". Molecular Medicine Reports 28.6 (2023): 226.
Chicago
Dix-Peek, T., Dickens, C., Augustine, T. N., Phakathi, B. P., Van Den Berg, E. J., Joffe, M., Ayeni, O. A., Cubasch, H., Nietz, S., Mathew, C. G., Hayat, M., Neugut, A. I., Jacobson, J. S., Ruff, P., Duarte, R. A."FGFR2 genetic variants in women with breast cancer". Molecular Medicine Reports 28, no. 6 (2023): 226. https://doi.org/10.3892/mmr.2023.13113
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