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Review Open Access

Sepsis‑induced cardiac dysfunction and pathogenetic mechanisms (Review)

  • Authors:
    • Jiayu Song
    • Xiaolei Fang
    • Kaixuan Zhou
    • Huiwei Bao
    • Lijing Li
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Changchun University of Chinese Medicine, Changchun, Jilin 130117, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 227
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    Published online on: October 17, 2023
       https://doi.org/10.3892/mmr.2023.13114
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Abstract

Sepsis is a manifestation of the immune and inflammatory response to infection, which may lead to multi‑organ failure. Health care advances have improved outcomes in critical illness, but it still remains the leading cause of death. Septic cardiomyopathy is heart dysfunction brought on by sepsis. Septic cardiomyopathy is a common consequence of sepsis and has a mortality rate of up to 70%. There is a lack of understanding of septic cardiomyopathy pathogenesis; knowledge of its pathogenesis and the identification of potential therapeutic targets may reduce the mortality rate of patients with sepsis and lead to clinical improvements. The present review aimed to summarize advances in the pathogenesis of cardiac dysfunction in sepsis, with a focus on mitochondrial dysfunction, metabolic changes and cell death modalities and pathways. The present review summarized diagnostic criteria and outlook for sepsis treatment, with the goal of identifying appropriate treatment methods for this disease.
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Spandidos Publications style
Song J, Fang X, Zhou K, Bao H and Li L: Sepsis‑induced cardiac dysfunction and pathogenetic mechanisms (Review). Mol Med Rep 28: 227, 2023.
APA
Song, J., Fang, X., Zhou, K., Bao, H., & Li, L. (2023). Sepsis‑induced cardiac dysfunction and pathogenetic mechanisms (Review). Molecular Medicine Reports, 28, 227. https://doi.org/10.3892/mmr.2023.13114
MLA
Song, J., Fang, X., Zhou, K., Bao, H., Li, L."Sepsis‑induced cardiac dysfunction and pathogenetic mechanisms (Review)". Molecular Medicine Reports 28.6 (2023): 227.
Chicago
Song, J., Fang, X., Zhou, K., Bao, H., Li, L."Sepsis‑induced cardiac dysfunction and pathogenetic mechanisms (Review)". Molecular Medicine Reports 28, no. 6 (2023): 227. https://doi.org/10.3892/mmr.2023.13114
Copy and paste a formatted citation
x
Spandidos Publications style
Song J, Fang X, Zhou K, Bao H and Li L: Sepsis‑induced cardiac dysfunction and pathogenetic mechanisms (Review). Mol Med Rep 28: 227, 2023.
APA
Song, J., Fang, X., Zhou, K., Bao, H., & Li, L. (2023). Sepsis‑induced cardiac dysfunction and pathogenetic mechanisms (Review). Molecular Medicine Reports, 28, 227. https://doi.org/10.3892/mmr.2023.13114
MLA
Song, J., Fang, X., Zhou, K., Bao, H., Li, L."Sepsis‑induced cardiac dysfunction and pathogenetic mechanisms (Review)". Molecular Medicine Reports 28.6 (2023): 227.
Chicago
Song, J., Fang, X., Zhou, K., Bao, H., Li, L."Sepsis‑induced cardiac dysfunction and pathogenetic mechanisms (Review)". Molecular Medicine Reports 28, no. 6 (2023): 227. https://doi.org/10.3892/mmr.2023.13114
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