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TIFA contributes to periodontitis in diabetic mice via activating the NF‑κB signaling pathway

  • Authors:
    • Xiaoqian Guo
    • Guangwei Qiao
    • Jingjiao Wang
    • Changyi Yang
    • Min Zhao
    • Qian Zhang
    • Yingbiao Wan
  • View Affiliations / Copyright

    Affiliations: Department of Periodontology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China, Department of Oral and Maxillofacial Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China, Department of Prosthodontics and Oral Implantology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 23
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    Published online on: December 13, 2023
       https://doi.org/10.3892/mmr.2023.13146
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Abstract

Diabetic periodontitis (DP) refers to destruction of periodontal tissue and absorption of bone tissue in diabetic patients. Tumor necrosis factor receptor‑associated factor (TRAF)‑interacting protein with forkhead‑associated domain (TIFA) as a crucial regulator of inflammation activates the NF‑κB signaling pathway to regulate cell biological behavior. However, the function and mechanism of TIFA on DP suffer from a lack of research. In the present study, TIFA was upregulated in the periodontal tissue of a DP mouse model. In addition, the expression of TIFA in RAW264.7 cells was induced by high glucose (HG) culture and increased by lipopolysaccharide (LPS) from Porphyromonas gingivalis treatment in a time‑dependent manner. Knockdown of TIFA significantly reduced the levels of inflammatory cytokines, including TNF‑α, IL‑6, IL‑1β and monocyte chemoattractant protein‑1, in HG and LPS‑induced RAW264.7 cells. The nuclear translocation of NF‑κB p65 was induced by HG and LPS and was clearly suppressed by absence of TIFA. The expression of downstream factors Nod‑like receptor family pyrin domain‑containing 3 and apoptosis‑associated speck‑like protein was inhibited by silencing TIFA. Moreover, TIFA was increased by receptor activator of NF‑κB (RANK) ligand (RANKL) in a concentration dependent manner. The expression of cathepsin K, MMP9 and nuclear factor of activated T cells cytoplasmic 1 was downregulated by depletion of TIFA. RANKL‑induced osteoclast differentiation was inhibited by silencing of TIFA. Meanwhile, the decrease of TIFA blocked activation of the NF‑κB pathway in RANKL‑treated RAW264.7 cells. In conclusion, TIFA as a promoter regulates the inflammation and osteoclast differentiation via activating the NF‑κB signaling pathway.
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View References

1 

Pihlstrom BL, Michalowicz BS and Johnson NW: Periodontal diseases. Lancet. 366:1809–1820. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Eke PI, Dye BA, Wei L, Thornton-Evans GO and Genco RJ; CDC Periodontal Disease Surveillance workgroup, : James Beck (University of North Carolina, Chapel Hill, USA), Gordon Douglass (Past President, American Academy of Periodontology), Roy Page (University of Washin: Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res. 91:914–920. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Preshaw PM, Alba AL, Herrera D, Jepsen S, Konstantinidis A, Makrilakis K and Taylor R: Periodontitis and diabetes: A two-way relationship. Diabetologia. 55:21–31. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Sanz M, Ceriello A, Buysschaert M, Chapple I, Demmer RT, Graziani F, Herrera D, Jepsen S, Lione L, Madianos P, et al: Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology. J Clin Periodontol. 45:138–149. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Polak D and Shapira L: An update on the evidence for pathogenic mechanisms that may link periodontitis and diabetes. J Clin Periodontol. 45:150–166. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Hajishengallis G: Periodontitis: From microbial immune subversion to systemic inflammation. Nat Rev Immunol. 15:30–44. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Bohannon JK, Hernandez A, Enkhbaatar P, Adams WL and Sherwood ER: The immunobiology of toll-like receptor 4 agonists: From endotoxin tolerance to immunoadjuvants. Shock. 40:451–462. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Suda K, Udagawa N, Sato N, Takami M, Itoh K, Woo JT, Takahashi N and Nagai K: Suppression of osteoprotegerin expression by prostaglandin E2 is crucially involved in lipopolysaccharide-induced osteoclast formation. J Immunol. 172:2504–2510. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Takatsuna H, Kato H, Gohda J, Akiyama T, Moriya A, Okamoto Y, Yamagata Y, Otsuka M, Umezawa K, Semba K and Inoue J: Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. J Biol Chem. 278:12144–12150. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Shen W, Chang A, Wang J, Zhou W, Gao R, Li J, Xu Y, Luo X, Xiang R, Luo N and Stupack DG: TIFA, an inflammatory signaling adaptor, is tumor suppressive for liver cancer. Oncogenesis. 4:e1732015. View Article : Google Scholar : PubMed/NCBI

11 

Shen W, Du R, Li J, Luo X, Zhao S, Chang A, Zhou W, Gao R, Luo D, Wang J, et al: TIFA suppresses hepatocellular carcinoma progression via MALT1-dependent and -independent signaling pathways. Signal Transduct Target Ther. 1:160132016. View Article : Google Scholar : PubMed/NCBI

12 

Zimmermann S, Pfannkuch L, Al-Zeer MA, Bartfeld S, Koch M, Liu J, Rechner C, Soerensen M, Sokolova O, Zamyatina A, et al: ALPK1- and TIFA-Dependent Innate immune response triggered by the helicobacter pylori type IV secretion system. Cell Rep. 20:2384–2395. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Milivojevic M, Dangeard AS, Kasper CA, Tschon T, Emmenlauer M, Pique C, Schnupf P, Guignot J and Arrieumerlou C: ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria. PLoS Pathog. 13:e10062242017. View Article : Google Scholar : PubMed/NCBI

14 

Lin TY, Wei TW, Li S, Wang SC, He M, Martin M, Zhang J, Shentu TP, Xiao H, Kang J, et al: TIFA as a crucial mediator for NLRP3 inflammasome. Proc Natl Acad Sci USA. 113:15078–15083. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Jimi E and Ghosh S: Role of nuclear factor-kappaB in the immune system and bone. Immunol Rev. 208:80–87. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Hayden MS and Ghosh S: Regulation of NF-κB by TNF family cytokines. Semin Immunol. 26:253–266. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Guan X, He Y, Wei Z, Shi C, Li Y, Zhao R, Pan L, Han Y, Hou T and Yang J: Crosstalk between Wnt/β-catenin signaling and NF-κB signaling contributes to apical periodontitis. Int Immunopharmacol. 98:1078432021. View Article : Google Scholar : PubMed/NCBI

18 

Tian Y, Li Y, Liu J, Lin Y, Jiao J, Chen B, Wang W, Wu S and Li C: Photothermal therapy with regulated Nrf2/NF-κB signaling pathway for treating bacteria-induced periodontitis. Bioact Mater. 9:428–445. 2021.PubMed/NCBI

19 

Odes-Barth S, Khanin M, Linnewiel-Hermoni K, Miller Y, Abramov K, Levy J and Sharoni Y: Inhibition of osteoclast differentiation by carotenoid derivatives through inhibition of the NF-ƙB pathway. Antioxidants (Basel). 9:11672020. View Article : Google Scholar : PubMed/NCBI

20 

Lalla E, Lamster IB, Feit M, Huang L, Spessot A, Qu W, Kislinger T, Lu Y, Stern DM and Schmidt AM: Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice. J Clin Invest. 105:1117–1124. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Krongbaramee T, Zhu M, Qian Q, Zhang Z, Eliason S, Shu Y, Qian F, Akkouch A, Su D, Amendt BA, et al: Plasmid encoding microRNA-200c ameliorates periodontitis and systemic inflammation in obese mice. Mol Ther Nucleic Acids. 23:1204–1216. 2021. View Article : Google Scholar : PubMed/NCBI

22 

National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals: Guide for the Care and Use of Laboratory Animals. 8th edition. National Academies Press (US); Washington, DC: 2011

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Bauer M, Nascakova Z, Mihai AI, Cheng PF, Levesque MP, Lampart S, Hurwitz R, Pfannkuch L, Dobrovolna J, Jacobs M, et al: The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress. Nat Commun. 11:51172020. View Article : Google Scholar : PubMed/NCBI

25 

Fuller K, Lawrence KM, Ross JL, Grabowska UB, Shiroo M, Samuelsson B and Chambers TJ: Erratum to ‘Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts’. Bone. 145:1153542021. View Article : Google Scholar : PubMed/NCBI

26 

Sundaram K, Nishimura R, Senn J, Youssef RF, London SD and Reddy SV: RANK ligand signaling modulates the matrix metalloproteinase-9 gene expression during osteoclast differentiation. Exp Cell Res. 313:168–178. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Preshaw PM: Periodontal disease and diabetes. J Dent. 37:S575–S577. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Kinane DF: Causation and pathogenesis of periodontal disease. Periodontol 2000. 25:8–20. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Boyle WJ, Simonet WS and Lacey DL: Osteoclast differentiation and activation. Nature. 423:337–342. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Van Dyke TE and Serhan CN: Resolution of inflammation: A new paradigm for the pathogenesis of periodontal diseases. J Dent Res. 82:82–90. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Zhen L, Fan DS, Zhang Y, Cao XM and Wang LM: Resveratrol ameliorates experimental periodontitis in diabetic mice through negative regulation of TLR4 signaling. Acta Pharmacol Sin. 36:221–228. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Hayata M, Watanabe N, Kamio N, Tamura M, Nodomi K, Tanaka K, Iddamalgoda A, Tsuda H, Ogata Y, Sato S, et al: Cynaropicrin from Cynara scolymus L. suppresses Porphyromonas gingivalis LPS-induced production of inflammatory cytokines in human gingival fibroblasts and RANKL-induced osteoclast differentiation in RAW264.7 cells. J Nat Med. 73:114–123. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Fu J, Huang D, Yuan F, Xie N, Li Q, Sun X, Zhou X, Li G, Tong T and Zhang Y: TRAF-interacting protein with forkhead-associated domain (TIFA) transduces DNA damage-induced activation of NF-κB. J Biol Chem. 293:7268–7280. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Chang HC, Wei TW, Wu PY, Tsai MD, Yu WC, Chen CH and Sung SH: TIFA protein expression is associated with pulmonary arterial hypertension. Sci Rep. 11:141402021. View Article : Google Scholar : PubMed/NCBI

35 

Müller AK, Albrecht F, Rohrer C, Koeberle A, Werz O, Schlörmann W, Glei M, Lorkowski S and Wallert M: Olive Oil extracts and oleic acid attenuate the LPS-Induced inflammatory response in murine RAW264.7 macrophages but induce the release of prostaglandin E2. Nutrients. 13:44372021. View Article : Google Scholar : PubMed/NCBI

36 

Li JY, Zheng ZX, Liu L, Du O, Yu NW, Zou Y, Seong SY and Du JR: Neuroprotective effect of alpha-kinase 1 knockdown against cerebral ischemia through inhibition of the NF-κB pathway and neuroinflammation. Int Immunopharmacol. 113((Pt A)): 1093302022. View Article : Google Scholar : PubMed/NCBI

37 

Snelling T, Shpiro N, Gourlay R, Lamoliatte F and Cohen P: Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC. Biochem J. 479:2195–2216. 2022. View Article : Google Scholar : PubMed/NCBI

38 

Yu JW, Wu J, Zhang Z, Datta P, Ibrahimi I, Taniguchi S, Sagara J, Fernandes-Alnemri T and Alnemri ES: Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. Cell Death Differ. 13:236–249. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Fernandes-Alnemri T, Wu J, Yu JW, Datta P, Miller B, Jankowski W, Rosenberg S, Zhang J and Alnemri ES: The pyroptosome: A supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ. 14:1590–1604. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Roodman GD: Cell biology of the osteoclast. Exp Hematol. 27:1229–1241. 1999. View Article : Google Scholar : PubMed/NCBI

41 

Teitelbaum SL: Bone resorption by osteoclasts. Science. 289:1504–1508. 2000. View Article : Google Scholar : PubMed/NCBI

42 

He Y, Zhang Q, Shen Y, Chen X, Zhou F and Peng D: Schisantherin A suppresses osteoclast formation and wear particle-induced osteolysis via modulating RANKL signaling pathways. Biochem Biophys Res Commun. 449:344–350. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Song C, Yang X, Lei Y, Zhang Z, Smith W, Yan J and Kong L: Evaluation of efficacy on RANKL induced osteoclast from RAW264.7 cells. J Cell Physiol. 234:11969–11975. 2019. View Article : Google Scholar : PubMed/NCBI

44 

Kang MR, Jo SA, Yoon YD, Park KH, Oh SJ, Yun J, Lee CW, Nam KH, Kim Y, Han SB, et al: Agelasine D suppresses RANKL-induced osteoclastogenesis via down-regulation of c-Fos, NFATc1 and NF-κB. Mar Drugs. 12:5643–5656. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Li X, Jiang J, Yang Z, Jin S, Lu X and Qian Y: Galangin suppresses RANKL-induced osteoclastogenesis via inhibiting MAPK and NF-κB signalling pathways. J Cell Mol Med. 25:4988–5000. 2021. View Article : Google Scholar : PubMed/NCBI

46 

Wu L, Luo Z and Liu Y, Jia L, Jiang Y, Du J, Guo L, Bai Y and Liu Y: Aspirin inhibits RANKL-induced osteoclast differentiation in dendritic cells by suppressing NF-κB and NFATc1 activation. Stem Cell Res Ther. 10:3752019. View Article : Google Scholar : PubMed/NCBI

47 

Zenger S, Hollberg K, Ljusberg J, Norgård M, Ek-Rylander B, Kiviranta R and Andersson G: Proteolytic processing and polarized secretion of tartrate-resistant acid phosphatase is altered in a subpopulation of metaphyseal osteoclasts in cathepsin K-deficient mice. Bone. 41:820–832. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Takayanagi H: The role of NFAT in osteoclast formation. Ann N Y Acad Sci. 1116:227–237. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Guo X, Qiao G, Wang J, Yang C, Zhao M, Zhang Q and Wan Y: TIFA contributes to periodontitis in diabetic mice via activating the NF‑κB signaling pathway. Mol Med Rep 29: 23, 2024.
APA
Guo, X., Qiao, G., Wang, J., Yang, C., Zhao, M., Zhang, Q., & Wan, Y. (2024). TIFA contributes to periodontitis in diabetic mice via activating the NF‑κB signaling pathway. Molecular Medicine Reports, 29, 23. https://doi.org/10.3892/mmr.2023.13146
MLA
Guo, X., Qiao, G., Wang, J., Yang, C., Zhao, M., Zhang, Q., Wan, Y."TIFA contributes to periodontitis in diabetic mice via activating the NF‑κB signaling pathway". Molecular Medicine Reports 29.2 (2024): 23.
Chicago
Guo, X., Qiao, G., Wang, J., Yang, C., Zhao, M., Zhang, Q., Wan, Y."TIFA contributes to periodontitis in diabetic mice via activating the NF‑κB signaling pathway". Molecular Medicine Reports 29, no. 2 (2024): 23. https://doi.org/10.3892/mmr.2023.13146
Copy and paste a formatted citation
x
Spandidos Publications style
Guo X, Qiao G, Wang J, Yang C, Zhao M, Zhang Q and Wan Y: TIFA contributes to periodontitis in diabetic mice via activating the NF‑κB signaling pathway. Mol Med Rep 29: 23, 2024.
APA
Guo, X., Qiao, G., Wang, J., Yang, C., Zhao, M., Zhang, Q., & Wan, Y. (2024). TIFA contributes to periodontitis in diabetic mice via activating the NF‑κB signaling pathway. Molecular Medicine Reports, 29, 23. https://doi.org/10.3892/mmr.2023.13146
MLA
Guo, X., Qiao, G., Wang, J., Yang, C., Zhao, M., Zhang, Q., Wan, Y."TIFA contributes to periodontitis in diabetic mice via activating the NF‑κB signaling pathway". Molecular Medicine Reports 29.2 (2024): 23.
Chicago
Guo, X., Qiao, G., Wang, J., Yang, C., Zhao, M., Zhang, Q., Wan, Y."TIFA contributes to periodontitis in diabetic mice via activating the NF‑κB signaling pathway". Molecular Medicine Reports 29, no. 2 (2024): 23. https://doi.org/10.3892/mmr.2023.13146
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