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Targeted reversal of multidrug resistance in ovarian cancer cells using exosome‑encapsulated tetramethylpyrazine

  • Authors:
    • Chenge Zhao
    • Lulu Qiu
    • Di Wu
    • Ming Zhang
    • Wanying Xia
    • Huiyi Lv
    • Lichun Cheng
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 25
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    Published online on: December 14, 2023
       https://doi.org/10.3892/mmr.2023.13148
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Abstract

The objective of the present study was to develop exosomes (EXOs) encapsulating tetramethylpyrazine (TMP) for the reversal of drug resistance in ovarian cancer therapy. Human A2780 cells were incubated with TMP for 48 h. Purified TMP‑primed EXOs (EXOs‑TMP) were isolated through ultracentrifugation. The developed EXOs‑TMP were characterized using techniques such as transmission electron microscopy, nanoparticle tracking analysis, Fluorescence microscopy and western blotting. Subsequently, MTT, western blotting and flow cytometry assays were performed to evaluate the biological effects in drug‑resistant A2780T cells. The results demonstrated that the incorporation of TMP into EXOs exhibited an anti‑ovarian cancer effect and markedly enhanced the antitumor efficacy of paclitaxel (PTX). Furthermore, it was identified that the ability of EXO‑TMP to reverse cell resistance was associated with the downregulation of multidrug resistance protein 1, multidrug resistant‑associated protein 1 and glutathione S‑transferase Pi protein expression. Flow cytometry analysis revealed that EXO‑TMP induced apoptosis in drug‑resistant cells and enhanced the apoptotic effect when combined with PTX. EXOs are naturally sourced, exhibit excellent biocompatibility and enable precise drug delivery to target sites, thereby reducing toxic side effects. Overall, EXO‑TMP exhibited direct targeting capabilities towards A2780T cells and effectively reduced their drug resistance. EXOs‑TMP provide a novel and effective drug delivery pathway for reversing drug resistance in ovarian cancer.
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1 

Miller KD, Nogueira L, Mariotto AB, Rowland JH, Yabroff KR, Alfano CM, Jemal A, Kramer JL and Siegel RL: Cancer treatment and survivorship statistics, 2019. CA Cancer J Clin. 69:363–385. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Bodurka-Bevers D, Sun CC and Gershenson DM: Pharmacoeconomic considerations in treating ovarian cancer. Pharmacoeconomics. 17:133–150. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Yang ZJ, Zhao BB and Li L: The significance of the change pattern of serum CA125 level for judging prognosis and diagnosing recurrences of epithelial ovarian cancer. J Ovarian Res. 9:572016. View Article : Google Scholar : PubMed/NCBI

4 

Xiao R, You L, Zhang L, Guo X, Guo E, Zhao F, Yang B, Li X, Fu Y, Lu F, et al: Inhibiting the IRE1α axis of the unfolded protein response enhances the antitumor effect of AZD1775 in TP53 mutant ovarian cancer. Adv Sci (Weinh). 9:e21054692022. View Article : Google Scholar : PubMed/NCBI

5 

Miller EM, Samec TM and Alexander-Bryant AA: Nanoparticle delivery systems to combat drug resistance in ovarian cancer. Nanomedicine. 31:1023092021. View Article : Google Scholar : PubMed/NCBI

6 

Chiappa M, Guffanti F, Bertoni F, Colombo I and Damia G: Overcoming PARPi resistance: Preclinical and clinical evidence in ovarian cancer. Drug Resist Updat. 55:1007442021. View Article : Google Scholar : PubMed/NCBI

7 

Norouzi-Barough L, Sarookhani MR, Sharifi M, Moghbelinejad S, Jangjoo S and Salehi R: Molecular mechanisms of drug resistance in ovarian cancer. J Cell Physiol. 233:4546–4562. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Eisenhauer EA: Real-world evidence in the treatment of ovarian cancer. Ann Oncol. 28 (Suppl 8):viii61–viii65. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Huang MY, Zhang LL, Ding J and Lu JJ: Anticancer drug discovery from Chinese medicinal herbs. Chin Med. 13:352018. View Article : Google Scholar : PubMed/NCBI

10 

Wang X, Liu Z, Sui X, Wu Q, Wang J and Xu C: Elemene injection as adjunctive treatment to platinum-based chemotherapy in patients with stage III/IV non-small cell lung cancer: A meta-analysis following the PRISMA guidelines. Phytomedicine. 59:1527872019. View Article : Google Scholar : PubMed/NCBI

11 

Zhang E, Shi H, Yang L, Wu X and Wang Z: Ginsenoside Rd regulates the Akt/mTOR/p70S6K signaling cascade and suppresses angiogenesis and breast tumor growth. Oncol Rep. 38:359–367. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Malyutina A, Majumder MM, Wang W, Pessia A, Heckman CA and Tang J: Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer. PLoS Comput Biol. 15:e10067522019. View Article : Google Scholar : PubMed/NCBI

13 

Guo SK, Chen KJ, Qian ZH, Weng WL and Qian MY: Tetramethylpyrazine in the treatment of cardiovascular and cerebrovascular diseases. Planta Med. 47:891983. View Article : Google Scholar : PubMed/NCBI

14 

Chen Z, Zhang C, Gao F, Fu Q, Fu C, He Y and Zhang J: A systematic review on the rhizome of Ligusticum chuanxiong Hort. (Chuanxiong). Food Chem Toxicol. 119:309–325. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Zhao Y, Liu Y and Chen K: Mechanisms and clinical application of tetramethylpyrazine (an interesting natural compound isolated from Ligusticum Wallichii): Current status and perspective. Oxid Med Cell Longev. 2016:21246382016. View Article : Google Scholar : PubMed/NCBI

16 

Wang S, Lei T and Zhang M: The reversal effect and its mechanisms of tetramethylpyrazine on multidrug resistance in human bladder cancer. PLoS One. 11:e01577592016. View Article : Google Scholar : PubMed/NCBI

17 

Wang XB, Wang SS, Zhang QF, Liu M, Li HL, Liu Y, Wang JN, Zheng F, Guo LY and Xiang JZ: Inhibition of tetramethylpyrazine on P-gp, MRP2, MRP3 and MRP5 in multidrug resistant human hepatocellular carcinoma cells. Oncol Rep. 23:211–215. 2010.PubMed/NCBI

18 

Zhou X, Wang A, Wang L, Yin J, Wang L, Di L, Hoi MP, Shan L, Wu X and Wang Y: A danshensu-tetramethylpyrazine conjugate DT-010 overcomes multidrug resistance in human breast cancer. Front Pharmacol. 10:7222019. View Article : Google Scholar : PubMed/NCBI

19 

Huang HH, Liu FB, Ruan Z, Zheng J, Su YJ and Wang J: Tetramethylpyrazine (TMPZ) triggers S-phase arrest and mitochondria-dependent apoptosis in lung cancer cells. Neoplasma. 65:367–375. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Alotaibi BS, Buabeid M, Ibrahim NA, Kharaba ZJ, Ijaz M, Noreen S and Murtaza G: Potential of nanocarrier-based drug delivery systems for brain targeting: A current review of literature. Int J Nanomedicine. 16:7517–7533. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Kalluri R and LeBleu VS: The biology, function, and biomedical applications of exosomes. Science. 367:eaau69772020. View Article : Google Scholar : PubMed/NCBI

22 

Antimisiaris SG, Mourtas S and Marazioti A: Exosomes and exosome-inspired vesicles for targeted drug delivery. Pharmaceutics. 10:2182018. View Article : Google Scholar : PubMed/NCBI

23 

Kim MS, Haney MJ, Zhao Y, Mahajan V, Deygen I, Klyachko NL, Inskoe E, Piroyan A, Sokolsky M, Okolie O, et al: Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells. Nanomedicine. 12:655–664. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Elsharkasy OM, Nordin JZ, Hagey DW, de Jong OG, Schiffelers RM, Andaloussi SE and Vader P: Extracellular vesicles as drug delivery systems: Why and how? Adv Drug Deliv Rev. 159:332–343. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Chinnappan M, Srivastava A, Amreddy N, Razaq M, Pareek V, Ahmed R, Mehta M, Peterson JE, Munshi A and Ramesh R: Exosomes as drug delivery vehicle and contributor of resistance to anticancer drugs. Cancer Lett. 486:18–28. 2020. View Article : Google Scholar : PubMed/NCBI

26 

Ma J, Zhang Y, Tang K, Zhang H, Yin X, Li Y, Xu P, Sun Y, Ma R, Ji T, et al: Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles. Cell Res. 26:713–727. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Gao Y, Zhang H, Zhou N, Xu P, Wang J, Gao Y, Jin X, Liang X, Lv J, Zhang Y, et al: Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma. Nat Biomed Eng. 4:743–753. 2020. View Article : Google Scholar : PubMed/NCBI

28 

Rao Q, Zuo B, Lu Z, Gao X, You A, Wu C, Du Z and Yin H: Tumor-derived exosomes elicit tumor suppression in murine hepatocellular carcinoma models and humans in vitro. Hepatology. 64:456–472. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Yong T, Zhang X, Bie N, Zhang H, Zhang X, Li F, Hakeem A, Hu J, Gan L, Santos HA and Yang X: Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy. Nat Commun. 10:38382019. View Article : Google Scholar : PubMed/NCBI

30 

Yu Z, Tang H, Chen S, Xie Y, Shi L, Xia S, Jiang M, Li J and Chen D: Exosomal LOC85009 inhibits docetaxel resistance in lung adenocarcinoma through regulating ATG5-induced autophagy. Drug Resist Updat. 67:1009152023. View Article : Google Scholar : PubMed/NCBI

31 

Shieh MJ, Hsu CY, Huang LY, Chen HY, Huang FH and Lai PS: Reversal of doxorubicin-resistance by multifunctional nanoparticles in MCF-7/ADR cells. J Control Release. 152:418–425. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Bruckmueller H and Cascorbi I: ABCB1, ABCG2, ABCC1, ABCC2, and ABCC3 drug transporter polymorphisms and their impact on drug bioavailability: What is our current understanding? Expert Opin Drug Metab Toxicol. 17:369–396. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Cui J, Li G, Yin J, Li L, Tan Y, Wei H, Liu B, Deng L, Tang J, Chen Y and Yi L: GSTP1 and cancer: Expression, methylation, polymorphisms and signaling (review). Int J Oncol. 56:867–878. 2020.PubMed/NCBI

34 

Jiang L and Hou R: Tetrandrine reverses paclitaxel resistance in human ovarian cancer via inducing apoptosis, cell cycle arrest through β-catenin pathway. Onco Targets Ther. 13:3631–3639. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

36 

Jayson GC, Kohn EC, Kitchener HC and Ledermann JA: Ovarian cancer. Lancet. 384:1376–1388. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Yang Z, Zhang Q, Yu L, Zhu J, Cao Y and Gao X: The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer. J Ethnopharmacol. 264:1132492021. View Article : Google Scholar : PubMed/NCBI

38 

Meyer CT, Wooten DJ, Paudel BB, Bauer J, Hardeman KN, Westover D, Lovly CM, Harris LA, Tyson DR and Quaranta V: Quantifying drug combination synergy along potency and efficacy axes. Cell Syst. 8:97–108.e116. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Fu Z, Lin L, Liu S, Qin M, He S, Zhu L and Huang J: Ginkgo biloba extract inhibits metastasis and ERK/nuclear factor kappa B (NF-κB) signaling pathway in gastric cancer. Med Sci Monit. 25:6836–6845. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Liu Y, Gao S, Zhu J, Zheng Y, Zhang H and Sun H: Dihydroartemisinin induces apoptosis and inhibits proliferation, migration, and invasion in epithelial ovarian cancer via inhibition of the hedgehog signaling pathway. Cancer Med. 7:5704–5715. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Li CY, Wang Q, Wang X, Li G, Shen S and Wei X: Scutellarin inhibits the invasive potential of malignant melanoma cells through the suppression epithelial-mesenchymal transition and angiogenesis via the PI3K/Akt/mTOR signaling pathway. Eur J Pharmacol. 858:1724632019. View Article : Google Scholar : PubMed/NCBI

42 

Yi M, Jiao D, Qin S, Chu Q, Wu K and Li A: Synergistic effect of immune checkpoint blockade and anti-angiogenesis in cancer treatment. Mol Cancer. 18:602019. View Article : Google Scholar : PubMed/NCBI

43 

Cui H, Guo W, Zhang B, Li G, Li T, Yuan Y, Zhang N, Yang Y, Feng W, Chu F, et al: BA-12 inhibits angiogenesis via glutathione metabolism activation. Int J Mol Sci. 20:40622019. View Article : Google Scholar : PubMed/NCBI

44 

Zhang H, Ding S and Xia L: Ligustrazine inhibits the proliferation and migration of ovarian cancer cells via regulating miR-211. Biosci Rep. 41:BSR202001992021. View Article : Google Scholar : PubMed/NCBI

45 

Ma H, Deng C, Zong X, He Y, Cheng L, Fan Q, Shao M, Lin Y, Zhao C, Li G and Zhang C: Reversal of doxorubicin-resistance by delivering tetramethylprazine via folate-chitosan nanoparticles in MCF-7/ADM cells. Int J Clin Exp Med. 9:5439–5448. 2016.

46 

Li FS and Weng JK: Demystifying traditional herbal medicine with modern approach. Nat Plants. 3:171092017. View Article : Google Scholar : PubMed/NCBI

47 

Shi J, Kantoff PW, Wooster R and Farokhzad OC: Cancer nanomedicine: Progress, challenges and opportunities. Nat Rev Cancer. 17:20–37. 2017. View Article : Google Scholar : PubMed/NCBI

48 

He H, Liu L, Morin EE, Liu M and Schwendeman A: Survey of clinical translation of cancer nanomedicines-lessons learned from successes and failures. Acc Chem Res. 52:2445–2461. 2019. View Article : Google Scholar : PubMed/NCBI

49 

Namee NM and O'Driscoll L: Extracellular vesicles and anti-cancer drug resistance. Biochim Biophys Acta Rev Cancer. 1870:123–136. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Batrakova EV and Kim MS: Using exosomes, naturally-equipped nanocarriers, for drug delivery. J Control Release. 219:396–405. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Kalimuthu S, Gangadaran P, Rajendran RL, Zhu L, Oh JM, Lee HW, Gopal A, Baek SH, Jeong SY, Lee SW, et al: A new approach for loading anticancer drugs into mesenchymal stem cell-derived exosome mimetics for cancer therapy. Front Pharmacol. 9:11162018. View Article : Google Scholar : PubMed/NCBI

52 

Li YJ, Wu JY, Wang JM, Hu XB, Cai JX and Xiang DX: Gemcitabine loaded autologous exosomes for effective and safe chemotherapy of pancreatic cancer. Acta Biomater. 101:519–530. 2020. View Article : Google Scholar : PubMed/NCBI

53 

Qiao L, Hu S, Huang K, Su T, Li Z, Vandergriff A, Cores J, Dinh PU, Allen T, Shen D, et al: Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs. Theranostics. 10:3474–3487. 2020. View Article : Google Scholar : PubMed/NCBI

54 

Zou L, Liu X, Li J, Li W, Zhang L, Li J and Zhang J: Tetramethylpyrazine enhances the antitumor effect of paclitaxel by inhibiting angiogenesis and inducing apoptosis. Front Pharmacol. 10:7072019. View Article : Google Scholar : PubMed/NCBI

55 

Wang JQ, Yang Y, Cai CY, Teng QX, Cui Q, Lin J, Assaraf YG and Chen ZS: Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance. Drug Resist Updat. 54:1007432021. View Article : Google Scholar : PubMed/NCBI

56 

Lei X, Du L, Yu W, Wang Y, Ma N and Qu B: GSTP1 as a novel target in radiation induced lung injury. J Transl Med. 19:2972021. View Article : Google Scholar : PubMed/NCBI

57 

Sawers L, Ferguson MJ, Ihrig BR, Young HC, Chakravarty P, Wolf CR and Smith G: Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines. Br J Cancer. 111:1150–1158. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Ding Q, Zhang W, Cheng C, Mo F, Chen L, Peng G, Cai X, Wang J, Yang S and Liu X: Dioscin inhibits the growth of human osteosarcoma by inducing G2/M-phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo. J Cell Physiol. 235:2911–2924. 2020. View Article : Google Scholar : PubMed/NCBI

59 

Mohammad RM, Muqbil I, Lowe L, Yedjou C, Hsu HY, Lin LT, Siegelin MD, Fimognari C, Kumar NB, Dou QP, et al: Broad targeting of resistance to apoptosis in cancer. Semin Cancer Biol. 35 (Suppl):S78–S103. 2015. View Article : Google Scholar : PubMed/NCBI

60 

Wu X, Wang Z, Wu G, Xu X, Zhang J, Li Y, Zhang H and Guo S: Tetramethylpyrazine induces apoptosis and inhibits proliferation of hypertrophic scar-derived fibroblasts via inhibiting the phosphorylation of AKT. Front Pharmacol. 11:6022020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao C, Qiu L, Wu D, Zhang M, Xia W, Lv H and Cheng L: Targeted reversal of multidrug resistance in ovarian cancer cells using exosome‑encapsulated tetramethylpyrazine. Mol Med Rep 29: 25, 2024.
APA
Zhao, C., Qiu, L., Wu, D., Zhang, M., Xia, W., Lv, H., & Cheng, L. (2024). Targeted reversal of multidrug resistance in ovarian cancer cells using exosome‑encapsulated tetramethylpyrazine. Molecular Medicine Reports, 29, 25. https://doi.org/10.3892/mmr.2023.13148
MLA
Zhao, C., Qiu, L., Wu, D., Zhang, M., Xia, W., Lv, H., Cheng, L."Targeted reversal of multidrug resistance in ovarian cancer cells using exosome‑encapsulated tetramethylpyrazine". Molecular Medicine Reports 29.2 (2024): 25.
Chicago
Zhao, C., Qiu, L., Wu, D., Zhang, M., Xia, W., Lv, H., Cheng, L."Targeted reversal of multidrug resistance in ovarian cancer cells using exosome‑encapsulated tetramethylpyrazine". Molecular Medicine Reports 29, no. 2 (2024): 25. https://doi.org/10.3892/mmr.2023.13148
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao C, Qiu L, Wu D, Zhang M, Xia W, Lv H and Cheng L: Targeted reversal of multidrug resistance in ovarian cancer cells using exosome‑encapsulated tetramethylpyrazine. Mol Med Rep 29: 25, 2024.
APA
Zhao, C., Qiu, L., Wu, D., Zhang, M., Xia, W., Lv, H., & Cheng, L. (2024). Targeted reversal of multidrug resistance in ovarian cancer cells using exosome‑encapsulated tetramethylpyrazine. Molecular Medicine Reports, 29, 25. https://doi.org/10.3892/mmr.2023.13148
MLA
Zhao, C., Qiu, L., Wu, D., Zhang, M., Xia, W., Lv, H., Cheng, L."Targeted reversal of multidrug resistance in ovarian cancer cells using exosome‑encapsulated tetramethylpyrazine". Molecular Medicine Reports 29.2 (2024): 25.
Chicago
Zhao, C., Qiu, L., Wu, D., Zhang, M., Xia, W., Lv, H., Cheng, L."Targeted reversal of multidrug resistance in ovarian cancer cells using exosome‑encapsulated tetramethylpyrazine". Molecular Medicine Reports 29, no. 2 (2024): 25. https://doi.org/10.3892/mmr.2023.13148
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