Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
February-2024 Volume 29 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2024 Volume 29 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

Mitochondrial abnormality in ovarian granulosa cells of patients with polycystic ovary syndrome

  • Authors:
    • Congcong Xie
    • Hui Lu
    • Xiujia Zhang
    • Zhuo An
    • Tong Chen
    • Wenbo Yu
    • Shusong Wang
    • Dandan Shang
    • Xueying Wang
  • View Affiliations / Copyright

    Affiliations: Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Hebei Institute of Reproductive Health Science and Technology, Shijiazhuang, Hebei 050071, P.R. China, Department of Biochemistry and Molecule Biology, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 27
    |
    Published online on: December 18, 2023
       https://doi.org/10.3892/mmr.2023.13150
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The quality of oocytes in patients with polycystic ovary syndrome (PCOS) decreases, which is closely related to the function of oocytes' mitochondria. If mitochondrial dysfunction is involved in PCOS, it is likely to affect the function of cumulus cells. However, the mechanism of mitochondrial dysfunction remains unclear. In the present study, granulosa cells were collected from women attending the Hebei Reproductive Health Hospital and were divided into the normal ovarian reserve group (CON group) and the PCOS group. The mitochondrial ultrastructure was observed by transmission electron microscope, and the mitochondrial function was determined by detecting the ATP content, reactive oxygen species levels, the number of mitochondria and the mitochondrial membrane potential. Additionally, western blotting was used to compare the expression levels of mitochondrial kinetic protein, the related channel protein, between the two groups. In the present study, it was found that patients with PCOS had abnormal granulosa cell morphology, increased mitochondrial abnormalities, decreased mitochondrial function and disturbed mitochondrial dynamics. In addition, the silent information regulator 1/phosphorylated‑AMP‑activated protein kinase/peroxisome proliferator‑activated receptor‑γ coactivator 1α pathway expression was decreased, and it was hypothesized that the decreased mitochondrial mass in the PCOS group was associated with it.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Aversa A, La Vignera S, Rago R, Gambineri A, Nappi RE, Calogero AE and Ferlin A: Fundamental concepts and novel aspects of polycystic ovarian syndrome: Expert consensus resolutions. Front Endocrinol (Lausanne). 11:5162020. View Article : Google Scholar : PubMed/NCBI

2 

Gleicher N, Darmon S, Patrizio P and Barad DH: Reconsidering the polycystic ovary syndrome (PCOS). Biomedicines. 10:15052022. View Article : Google Scholar : PubMed/NCBI

3 

Liu X, Wang L, Zuo X, Li C and Teng Y: Women with PCOS with a history of early pregnancy loss show a higher risk of gestational diabetes mellitus. Int J Gen Med. 14:6409–6416. 2021. View Article : Google Scholar : PubMed/NCBI

4 

Sayutti N, Abu MA and Ahmad MF: PCOS and role of cumulus gene expression in assessing oocytes quality. Front Endocrinol (Lausanne). 13:8438672022. View Article : Google Scholar : PubMed/NCBI

5 

Richani D, Dunning KR, Thompson JG and Gilchrist RB: Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence. Hum Reprod Update. 27:27–47. 2021. View Article : Google Scholar : PubMed/NCBI

6 

Kirillova A, Smitz JEJ, Sukhikh GT and Mazunin I: The role of mitochondria in oocyte maturation. Cells. 10:24842021. View Article : Google Scholar : PubMed/NCBI

7 

Li W, Cao J, Wang X, Zhang Y, Sun Q, Jiang Y, Yao J, Li C, Wang Y and Wang W: Ferruginol restores SIRT1-PGC-1α-mediated mitochondrial biogenesis and fatty acid oxidation for the treatment of DOX-induced cardiotoxicity. Front Pharmacol. 12:7738342021. View Article : Google Scholar : PubMed/NCBI

8 

Tian F, Li Q, Shi L, Li J, Shi M, Zhu Y, Li H and Ge RS: In utero bisphenol AF exposure causes fetal Leydig cell dysfunction and induces multinucleated gonocytes by generating oxidative stress and reducing the SIRT1/PGC1α signals. Toxicol Appl Pharmacol. 447:1160692022. View Article : Google Scholar : PubMed/NCBI

9 

Zhao Y, Zhang J, Zheng Y, Zhang Y, Zhang XJ, Wang H, Du Y, Guan J, Wang X and Fu J: NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway. J Neuroinflammation. 18:2072021. View Article : Google Scholar : PubMed/NCBI

10 

Tian L, Cao W, Yue R, Yuan Y, Guo X, Qin D, Xing J and Wang X: Pretreatment with Tilianin improves mitochondrial energy metabolism and oxidative stress in rats with myocardial ischemia/reperfusion injury via AMPK/SIRT1/PGC-1 alpha signaling pathway. J Pharmacol Sci. 139:352–360. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Chandrasekaran K, Anjaneyulu M, Choi J, Kumar P, Salimian M, Ho CY and Russell JW: Role of mitochondria in diabetic peripheral neuropathy: Influencing the NAD+-dependent SIRT1-PGC-1α-TFAM pathway. Int Rev Neurobiol. 145:177–209. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Kalliora C, Kyriazis ID, Oka SI, Lieu MJ, Yue Y, Area-Gomez E, Pol CJ, Tian Y, Mizushima W, Chin A, et al: Dual peroxisome-proliferator-activated-receptor-α/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction. JCI Insight. 5:e1295562019. View Article : Google Scholar : PubMed/NCBI

13 

Emidio GD, Placidi M, Rea F, Rossi G, Falone S, Cristiano L, Nottola S, D'Alessandro AM, Amicarelli F, Palmerini MG and Tatone C: Methylglyoxal-dependent glycative stress and deregulation of SIRT1 functional network in the ovary of PCOS mice. Cells. 9:2092020. View Article : Google Scholar : PubMed/NCBI

14 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

15 

He Y, Lu Y, Zhu Q, Wang Y, Lindheim SR, Qi J, Li X, Ding Y, Shi Y, Wei D, et al: Influence of metabolic syndrome on female fertility and in vitro fertilization outcomes in PCOS women. Am J Obstet Gynecol. 221:138.e1–138.e12. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Gong Y, Luo S, Fan P, Zhu H, Li Y and Huang W: Growth hormone activates PI3K/Akt signaling and inhibits ROS accumulation and apoptosis in granulosa cells of patients with polycystic ovary syndrome. Reprod Biol Endocrinol. 18:1212020. View Article : Google Scholar : PubMed/NCBI

17 

Guijarro LG, Sanmartin-Salinas P, Pérez-Cuevas E, Toledo-Lobo MV, Monserrat J, Zoullas S, Sáez MA, Álvarez-Mon MA, Bujan J, Noguerales-Fraguas F, et al: Actinomycin D arrests cell cycle of hepatocellular carcinoma cell lines and induces p53-dependent cell death: A study of the molecular mechanism involved in the protective effect of IRS-4. Pharmaceuticals (Basel). 14:8452021. View Article : Google Scholar : PubMed/NCBI

18 

Patil K, Shinde G, Hinduja I and Mukherjee S: Compromised cumulus-oocyte complex matrix organization and expansion in women with PCOS. Reprod Sci. 29:836–848. 2022. View Article : Google Scholar : PubMed/NCBI

19 

Yefimova MG, Lefevre C, Bashamboo A, Eozenou C, Burel A, Lavault MT, Meunier AC, Pimentel C, Veau S, Neyroud AS, et al: Granulosa cells provide elimination of apoptotic oocytes through unconventional autophagy-assisted phagocytosis. Hum Reprod. 35:1346–1362. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Lai Q, Xiang W, Li Q, Zhang H, Li Y, Zhu G, Xiong C and Jin L: Oxidative stress in granulosa cells contributes to poor oocyte quality and IVF-ET outcomes in women with polycystic ovary syndrome. Front Med. 12:518–524. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Zhang Q, Ren J, Wang F, Pan M, Cui L, Li M and Qu F: Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3. Free Radic Biol Med. 187:1–16. 2022. View Article : Google Scholar : PubMed/NCBI

22 

Chiang JL, Shukla P, Pagidas K, Ahmed NS, Karri S, Gunn DD, Hurd WW and Singh KK: Mitochondria in ovarian aging and reproductive longevity. Ageing Res Rev. 63:1011682020. View Article : Google Scholar : PubMed/NCBI

23 

Guijarro LG, Cano-Martínez D, Toledo-Lobo MV, Ruiz-Llorente L, Chaparro M, Guerra I, Iborra M, Cabriada JL, Bujanda L, Taxonera C, et al: Evaluation of AIF-1 (allograft inflammatory factor-1) as a biomarker of Crohn's disease severity. Biomedicines. 10:7272022. View Article : Google Scholar : PubMed/NCBI

24 

Adhikari D, Lee IW, Yuen WS and Carroll J: Oocyte mitochondria-key regulators of oocyte function and potential therapeutic targets for improving fertility. Biol Reprod. 106:366–377. 2022. View Article : Google Scholar : PubMed/NCBI

25 

Zhao S, Heng N, Wang H, Wang H, Zhang H, Gong J, Hu Z and Zhu H: Mitofusins: From mitochondria to fertility. Cell Mol Life Sci. 79:3702022. View Article : Google Scholar : PubMed/NCBI

26 

Liu Y, Han M, Li X, Wang H, Ma M, Zhang S, Guo Y, Wang S, Wang Y, Duan N, et al: Age-related changes in the mitochondria of human mural granulosa cells. Hum Reprod. 32:2465–2473. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Maremanda KP, Sundar IK and Rahman I: Role of inner mitochondrial protein OPA1 in mitochondrial dysfunction by tobacco smoking and in the pathogenesis of COPD. Redox Biol. 45:1020552021. View Article : Google Scholar : PubMed/NCBI

28 

Chen L, Liu B, Qin Y, Li A, Gao M, Liu H and Gong G: Mitochondrial fusion protein Mfn2 and its role in heart failure. Front Mol Biosci. 8:6812372021. View Article : Google Scholar : PubMed/NCBI

29 

Yapa NMB, Lisnyak V, Reljic B and Ryan MT: Mitochondrial dynamics in health and disease. FEBS Lett. 595:1184–1204. 2021. View Article : Google Scholar : PubMed/NCBI

30 

Kalia R, Wang RY, Yusuf A, Thomas PV, Agard DA, Shaw JM and Frost A: Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature. 558:401–405. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Kim HK, Jeon J, Song IS, Heo HJ, Jeong SH, Long LT, Thu VT, Ko TH, Kim M, Kim N, et al: Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac contractility via stimulation of PGC1α signaling. Biochim Biophys Acta Mol Basis Dis. 1865:1655242019. View Article : Google Scholar : PubMed/NCBI

32 

Hao L, Zhong W, Dong H, Guo W, Sun X, Zhang W, Yue R, Li T, Griffiths A, Ahmadi AR, et al: ATF4 activation promotes hepatic mitochondrial dysfunction by repressing NRF1-TFAM signalling in alcoholic steatohepatitis. Gut. 70:1933–1945. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Sun L, Tian H, Xue S, Ye H, Xue X, Wang R, Liu Y, Zhang C, Chen Q and Gao S: Circadian clock genes REV-ERBs inhibits granulosa cells apoptosis by regulating mitochondrial biogenesis and autophagy in polycystic ovary syndrome. Front Cell Dev Biol. 9:6581122021. View Article : Google Scholar : PubMed/NCBI

34 

Safaei Z, Bakhshalizadeh S, Nasr-Esfahani MH, Akbari Sene A, Najafzadeh V, Soleimani M and Shirazi R: Vitamin D3 affects mitochondrial biogenesis through mitogen-activated protein kinase in polycystic ovary syndrome mouse model. J Cell Physiol. 235:6113–6126. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Wang C, Liu T, Tong Y, Cui R, Qu K, Liu C and Zhang J: Ulinastatin protects against acetaminophen-induced liver injury by alleviating ferroptosis via the SIRT1/NRF2/HO-1 pathway. Am J Transl Res. 13:6031–6042. 2021.PubMed/NCBI

36 

Jalgaonkar MP, Parmar UM, Kulkarni YA and Oza MJ: SIRT1-FOXOs activity regulates diabetic complications. Pharmacol Res. 175:1060142022. View Article : Google Scholar : PubMed/NCBI

37 

Guo A, Li K and Xiao Q: Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle. Biochem Biophys Res Commun. 526:1069–1076. 2020. View Article : Google Scholar : PubMed/NCBI

38 

Ortega MA, De Leon-Oliva D, Garcia-Montero C, Fraile-Martinez O, Boaru DL, Del Val Toledo Lobo M, García-Tuñón I, Royuela M, García-Honduvilla N, Bujan J, et al: Understanding HAT1: A comprehensive review of noncanonical roles and connection with disease. Genes (Basel). 14:9152023. View Article : Google Scholar : PubMed/NCBI

39 

Wang ZH, Bao XG, Hu JJ, Shen SB, Xu GH and Wu YL: Nicotinamide riboside enhances endothelial precursor cell function to promote refractory wound healing through mediating the Sirt1/AMPK pathway. Front Pharmacol. 12:6715632021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xie C, Lu H, Zhang X, An Z, Chen T, Yu W, Wang S, Shang D and Wang X: Mitochondrial abnormality in ovarian granulosa cells of patients with polycystic ovary syndrome. Mol Med Rep 29: 27, 2024.
APA
Xie, C., Lu, H., Zhang, X., An, Z., Chen, T., Yu, W. ... Wang, X. (2024). Mitochondrial abnormality in ovarian granulosa cells of patients with polycystic ovary syndrome. Molecular Medicine Reports, 29, 27. https://doi.org/10.3892/mmr.2023.13150
MLA
Xie, C., Lu, H., Zhang, X., An, Z., Chen, T., Yu, W., Wang, S., Shang, D., Wang, X."Mitochondrial abnormality in ovarian granulosa cells of patients with polycystic ovary syndrome". Molecular Medicine Reports 29.2 (2024): 27.
Chicago
Xie, C., Lu, H., Zhang, X., An, Z., Chen, T., Yu, W., Wang, S., Shang, D., Wang, X."Mitochondrial abnormality in ovarian granulosa cells of patients with polycystic ovary syndrome". Molecular Medicine Reports 29, no. 2 (2024): 27. https://doi.org/10.3892/mmr.2023.13150
Copy and paste a formatted citation
x
Spandidos Publications style
Xie C, Lu H, Zhang X, An Z, Chen T, Yu W, Wang S, Shang D and Wang X: Mitochondrial abnormality in ovarian granulosa cells of patients with polycystic ovary syndrome. Mol Med Rep 29: 27, 2024.
APA
Xie, C., Lu, H., Zhang, X., An, Z., Chen, T., Yu, W. ... Wang, X. (2024). Mitochondrial abnormality in ovarian granulosa cells of patients with polycystic ovary syndrome. Molecular Medicine Reports, 29, 27. https://doi.org/10.3892/mmr.2023.13150
MLA
Xie, C., Lu, H., Zhang, X., An, Z., Chen, T., Yu, W., Wang, S., Shang, D., Wang, X."Mitochondrial abnormality in ovarian granulosa cells of patients with polycystic ovary syndrome". Molecular Medicine Reports 29.2 (2024): 27.
Chicago
Xie, C., Lu, H., Zhang, X., An, Z., Chen, T., Yu, W., Wang, S., Shang, D., Wang, X."Mitochondrial abnormality in ovarian granulosa cells of patients with polycystic ovary syndrome". Molecular Medicine Reports 29, no. 2 (2024): 27. https://doi.org/10.3892/mmr.2023.13150
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team