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Drynaria rhizome water extract alleviates high‑fat diet‑induced obesity in mice

  • Authors:
    • Tae-Young Gil
    • Junkyu Park
    • Yea-Jin Park
    • Hyo-Jung Kim
    • Divina C. Cominguez
    • Hyo-Jin An
  • View Affiliations / Copyright

    Affiliations: Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea, Department of Science in Korean Medicine, College of Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea, Department of Rehabilitative Medicine of Korean Medicine and Neuropsychiatry, College of Korean Medicine, Sangji University, Wonju, Gangwon 26339, Republic of Korea
    Copyright: © Gil et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 30
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    Published online on: December 20, 2023
       https://doi.org/10.3892/mmr.2023.13153
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Abstract

Drynaria rhizome is a herbal medicine used for strengthening bones and treating bone diseases in East Asia. Although obesity is considered to benefit bone formation, it has been revealed that visceral fat accumulation can promote osteoporosis. Given the complex relationship between bone metabolism and obesity, bone‑strengthening medicines should be evaluated while considering the effects of obesity. The present study investigated the effects of Drynaria rhizome extract (DRE) on high‑fat diet (HFD)‑induced obese mice. DRE was supplemented with the HFD. Body weight, food intake, the expression levels of lipogenesis transcription factors, including sterol regulatory element binding protein (SREBP)‑1, peroxisome proliferator‑activated receptor (PPAR)‑γ and adenosine monophosphate‑activated protein kinase (AMPK)‑α, and AMPK activation were evaluated. Mice fed DRE and a HFD exhibited reduced body weight without differences in food intake compared with those in the HFD group. Furthermore, DRE; upregulated AMPK‑α of epididymal one; down‑regulated SREBP‑1 and PPAR‑γ, as determined using western blotting and quantitative polymerase chain reaction, respectively. Decreased lipid accumulation were observed in both fat pad and liver of HFD‑fed mice, which were suppressed by DRE treatment. These results demonstrated the potential of DRE as a dietary natural product for strengthening bones and managing obesity.
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Copy and paste a formatted citation
Spandidos Publications style
Gil T, Park J, Park Y, Kim H, Cominguez DC and An H: Drynaria rhizome water extract alleviates high‑fat diet‑induced obesity in mice. Mol Med Rep 29: 30, 2024.
APA
Gil, T., Park, J., Park, Y., Kim, H., Cominguez, D.C., & An, H. (2024). Drynaria rhizome water extract alleviates high‑fat diet‑induced obesity in mice. Molecular Medicine Reports, 29, 30. https://doi.org/10.3892/mmr.2023.13153
MLA
Gil, T., Park, J., Park, Y., Kim, H., Cominguez, D. C., An, H."Drynaria rhizome water extract alleviates high‑fat diet‑induced obesity in mice". Molecular Medicine Reports 29.2 (2024): 30.
Chicago
Gil, T., Park, J., Park, Y., Kim, H., Cominguez, D. C., An, H."Drynaria rhizome water extract alleviates high‑fat diet‑induced obesity in mice". Molecular Medicine Reports 29, no. 2 (2024): 30. https://doi.org/10.3892/mmr.2023.13153
Copy and paste a formatted citation
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Spandidos Publications style
Gil T, Park J, Park Y, Kim H, Cominguez DC and An H: Drynaria rhizome water extract alleviates high‑fat diet‑induced obesity in mice. Mol Med Rep 29: 30, 2024.
APA
Gil, T., Park, J., Park, Y., Kim, H., Cominguez, D.C., & An, H. (2024). Drynaria rhizome water extract alleviates high‑fat diet‑induced obesity in mice. Molecular Medicine Reports, 29, 30. https://doi.org/10.3892/mmr.2023.13153
MLA
Gil, T., Park, J., Park, Y., Kim, H., Cominguez, D. C., An, H."Drynaria rhizome water extract alleviates high‑fat diet‑induced obesity in mice". Molecular Medicine Reports 29.2 (2024): 30.
Chicago
Gil, T., Park, J., Park, Y., Kim, H., Cominguez, D. C., An, H."Drynaria rhizome water extract alleviates high‑fat diet‑induced obesity in mice". Molecular Medicine Reports 29, no. 2 (2024): 30. https://doi.org/10.3892/mmr.2023.13153
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