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miR‑186‑5p regulates the inflammatory response of chronic obstructive pulmonary disorder by targeting HIF‑1α

  • Authors:
    • Yihui Fu
    • Jie Zhao
    • Jie Chen
    • Yamei Zheng
    • Rubing Mo
    • Lei Zhang
    • Bingli Zhang
    • Qi Lin
    • Chanyi He
    • Siguang Li
    • Lingsang Lin
    • Tian Xie
    • Yipeng Ding
  • View Affiliations / Copyright

    Affiliations: Department of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, P.R. China, Department of General Practice, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, P.R. China
    Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 34
    |
    Published online on: January 8, 2024
       https://doi.org/10.3892/mmr.2024.13158
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Abstract

Chronic obstructive pulmonary disorder (COPD) is a chronic respiratory disease that is a major cause of morbidity and mortality worldwide. Previous studies have shown that miR‑186‑5p expression is significantly increased in COPD and is involved in multiple physiological and pathological processes. However, the role of miRNA‑186‑5p in the inflammatory response of COPD remains unclear. In this study, an in vitro model of COPD was established using lipopolysaccharide (LPS)‑induced human bronchial epithelial cells (BEAS‑2B). CCK‑8 assays, flow cytometry, and a Muse cell analyzer were used to determine cell viability, cell cycle distribution, and apoptosis, respectively. The production of TNF‑α and IL‑6 were measured by ELISA. Reverse‑transcription‑quantitative PCR and western blotting were used to analyze mRNA and protein expression levels. The targeting relation between miR‑186‑5p and HIF‑1α was discovered using dual‑luciferase reporter assays. The results showed that transfection of miR‑186‑5p inhibitor inhibited cell proliferation and promoted cell apoptosis in the LPS‑induced BEAS‑2B cells. Inhibition of miR‑186‑5p markedly increased the levels of TNF‑α and IL‑6. miR‑186‑5p directly targeted and negatively regulated HIF‑1α expression. In addition, inhibition of miR‑186‑5p increased the expression of the NF‑κB pathway protein p‑p65. In conclusion, it was found that inhibiting miR‑186‑5p may improve inflammation of COPD through HIF‑1α in LPS‑induced BEAS‑2B cells, possibly by regulating NF‑κB signaling. These findings provide a novel potential avenue for the clinical management of COPD. Future research is required to determine the mechanism of the interaction between miR‑186‑5p and HIF‑1α in COPD.
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1 

Christenson SA, Smith BM, Bafadhel M and Putcha N: Chronic obstructive pulmonary disease. Lancet. 399:2227–2242. 2022. View Article : Google Scholar : PubMed/NCBI

2 

Celli B, Fabbri L, Criner G, Martinez FJ, Mannino D, Vogelmeier C, Montes de Oca M, Papi A, Sin DD, Han MK and Agusti A: Definition and nomenclature of chronic obstructive pulmonary disease: Time for its revision. Am J Respir Crit Care Med. 206:1317–1325. 2022. View Article : Google Scholar : PubMed/NCBI

3 

Safiri S, Carson-Chahhoud K, Noori M, Nejadghaderi SA, Sullman MJM, Ahmadian Heris J, Ansarin K, Mansournia MA, Collins GS, Kolahi AA and Kaufman JS: Burden of chronic obstructive pulmonary disease and its attributable risk factors in 204 countries and territories, 1990–2019: results from the Global Burden of Disease Study 2019. BMJ. 378:e0696792022. View Article : Google Scholar : PubMed/NCBI

4 

Silverman EK: Genetics of COPD. Annu Rev Physiol. 82:413–431. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Zhang PD, Zhang XR, Zhang A, Li ZH, Liu D, Zhang YJ and Mao C: Associations of genetic risk and smoking with incident COPD. Eur Respir J. 59:21013202022. View Article : Google Scholar : PubMed/NCBI

6 

Adeloye D, Song P, Zhu Y, Campbell H, Sheikh A and Rudan I: Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: A systematic review and modelling analysis. Lancet Respir Med. 10:447–458. 2022. View Article : Google Scholar : PubMed/NCBI

7 

Yin P, Wu J, Wang L, Luo C, Ouyang L, Tang X, Liu J, Liu Y, Qi J, Zhou M and Lai T: The Burden of COPD in China and Its Provinces: Findings From the Global Burden of Disease Study 2019. Front Public Health. 10:8594992022. View Article : Google Scholar : PubMed/NCBI

8 

Barnes PJ: Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 138:16–27. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Ghanbarian H, Yıldız MT and Tutar Y: MicroRNA Targeting. Methods Mol Biol. 2257:105–130. 2022. View Article : Google Scholar : PubMed/NCBI

10 

Vishnoi A and Rani S: miRNA Biogenesis and Regulation of Diseases: An Updated Overview. Methods Mol Biol. 2595:1–12. 2023. View Article : Google Scholar : PubMed/NCBI

11 

Specjalski K and Jassem E: MicroRNAs: Potential Biomarkers and Targets of Therapy in Allergic Diseases? Arch Immunol Ther Exp (Warsz). 67:213–223. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Liang Q, He J, Yang Q, Zhang Q and Xu Y: MicroRNA-335-5p alleviates inflammatory response, airway fibrosis, and autophagy in childhood asthma through targeted regulation of autophagy related 5. Bioengineered. 13:1791–1801. 2022. View Article : Google Scholar : PubMed/NCBI

13 

Li X, Gong Y, Lin X, Lin Q, Luo J, Yu T, Xu J, Chen L, Xu L and Hu Y: Down-regulation of microRNA-155 suppressed Candida albicans induced acute lung injury by activating SOCS1 and inhibiting inflammation response. J Microbiol. 60:402–410. 2022. View Article : Google Scholar : PubMed/NCBI

14 

Huang X, Zhu Z, Guo X and Kong X: The roles of microRNAs in the pathogenesis of chronic obstructive pulmonary disease. Int Immunopharmacol. 67:335–347. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Roffel MP, Bracke KR, Heijink IH and Maes T: miR-223: A key regulator in the innate immune response in asthma and COPD. Front Med (Lausanne). 7:1962020. View Article : Google Scholar : PubMed/NCBI

16 

Zhang J, Xu Z, Kong L, Gao H, Zhang Y, Zheng Y and Wan Y: miRNA-486-5p promotes COPD progression by targeting HAT1 to regulate the TLR4-Triggered inflammatory response of alveolar macrophages. Int J Chron Obstruct Pulmon Dis. 15:2991–3001. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Kim RY, Sunkara KP, Bracke KR, Jarnicki AG, Donovan C, Hsu AC, Ieni A, Beckett EL, Galvão I, Wijnant S, et al: A microRNA-21-mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis. Sci Transl Med. 13:eaav72232021. View Article : Google Scholar : PubMed/NCBI

18 

Ding Y, Tian Z, Yang H, Yao H, He P, Ouyang Y, Yao J, Li M and Jin T: MicroRNA expression profiles of whole blood in chronic obstructive pulmonary disease. Int J Clin Experiment Pathol. 10:4860–4865. 2017.

19 

Cai SC, Li XP, Li X, Tang GY, Yi LM and Hu XS: Oleanolic Acid Inhibits Neuronal Pyroptosis in Ischaemic Stroke by Inhibiting miR-186-5p Expression. Exp Neurobiol. 30:401–414. 2021. View Article : Google Scholar : PubMed/NCBI

20 

Yang P, Liang K, Wang W, Zhou D, Chen Y, Jiang X, Fu R, Zhu B and Lin X: LncRNA SOX2-OTinhibitionprotects against myocardialischemia/reperfusion-inducedinjury via themicroRNA-186-5p (miR-186-5p)/Yin Yang 1 (YY1) pathway. Bioengineered. 13:280–290. 2022. View Article : Google Scholar : PubMed/NCBI

21 

Nie Y and Wang F: Inhibiting miR-186-5p relieves traumatic brain injury by regulating insulin-like growth factor-I-NLRP3/ASC/caspase-1 signaling pathway. Neuroreport. 34:156–164. 2023. View Article : Google Scholar : PubMed/NCBI

22 

Li R, Xu F, Wu X, Ji S and Xia R: CUL1-Mediated organelle fission pathway inhibits the development of chronic obstructive pulmonary disease. Comput Math Methods Med. 2020:53901072020. View Article : Google Scholar : PubMed/NCBI

23 

Rong B, Liu Y, Li M, Fu T, Gao W and Liu H: Correlation of serum levels of HIF-1α and IL-19 with the disease progression of COPD: A retrospective study. Int J Chron Obstruct Pulmon Dis. 13:3791–3803. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Fu X and Zhang F: Role of the HIF-1 signaling pathway in chronic obstructive pulmonary disease. Exp Ther Med. 16:4553–4561. 2018.PubMed/NCBI

25 

Alharbi KS, Fuloria NK, Fuloria S, Rahman SB, Al-Malki WH, Javed Shaikh MA, Thangavelu L, Singh SK, Rama Raju Allam VS, Jha NK, et al: Nuclear factor-kappa B and its role in inflammatory lung disease. Chem Biol Interact. 345:1095682021. View Article : Google Scholar : PubMed/NCBI

26 

Tan H and Zhao L: lncRNA nuclear-enriched abundant transcript 1 promotes cell proliferation and invasion by targeting miR-186-5p/HIF-1α in osteosarcoma. J Cell Biochem. 120:6502–6514. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Wang Z, Sha HH and Li HJ: Functions and mechanisms of miR-186 in human cancer. Biomed Pharmacother. 119:1094282019. View Article : Google Scholar : PubMed/NCBI

29 

Becker V, Yuan X, Boewe AS, Ampofo E, Ebert E, Hohneck J, Bohle RM, Meese E, Zhao Y, Menger MD, et al: Hypoxia-induced downregulation of microRNA-186-5p in endothelial cells promotes non-small cell lung cancer angiogenesis by upregulating protein kinase C alpha. Molecular therapy. Mol Ther Nucleic Acids. 31:421–436. 2023. View Article : Google Scholar : PubMed/NCBI

30 

Lin L, Sun J, Wu D, Lin D, Sun D, Li Q, Chen J, Niu H, He P and Ding Y: MicroRNA-186 is associated with hypoxia-inducible factor-1α expression in chronic obstructive pulmonary disease. Mol Genet Genomic Med. 7:e5312019. View Article : Google Scholar : PubMed/NCBI

31 

De la Garza MM, Cumpian AM, Daliri S, Castro-Pando S, Umer M, Gong L, Khosravi N, Caetano MS, Ramos-Castañeda M, Flores AG, et al: COPD-Type lung inflammation promotes K-ras mutant lung cancer through epithelial HIF-1α mediated tumor angiogenesis and proliferation. Oncotarget. 9:32972–32983. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Zhang HX, Yang JJ, Zhang SA, Zhang SM, Wang JX, Xu ZY and Lin RY: HIF-1α promotes inflammatory response of chronic obstructive pulmonary disease by activating EGFR/PI3K/AKT pathway. Eur Rev Med Pharmacol Sci. 22:6077–6084. 2018.PubMed/NCBI

33 

Xu YR, Wang AL and Li YQ: Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer. Front Oncol. 12:9845252022. View Article : Google Scholar : PubMed/NCBI

34 

Jiang H, Zhu Y, Xu H, Sun Y and Li Q: Activation of hypoxia-inducible factor-1α via nuclear factor-κB in rats with chronic obstructive pulmonary disease. Acta Biochim Biophys Sin (Shanghai). 42:483–488. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Schuliga M: NF-kappaB signaling in chronic inflammatory airway disease. Biomolecules. 5:1266–1283. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fu Y, Zhao J, Chen J, Zheng Y, Mo R, Zhang L, Zhang B, Lin Q, He C, Li S, Li S, et al: miR‑186‑5p regulates the inflammatory response of chronic obstructive pulmonary disorder by targeting HIF‑1α. Mol Med Rep 29: 34, 2024.
APA
Fu, Y., Zhao, J., Chen, J., Zheng, Y., Mo, R., Zhang, L. ... Ding, Y. (2024). miR‑186‑5p regulates the inflammatory response of chronic obstructive pulmonary disorder by targeting HIF‑1α. Molecular Medicine Reports, 29, 34. https://doi.org/10.3892/mmr.2024.13158
MLA
Fu, Y., Zhao, J., Chen, J., Zheng, Y., Mo, R., Zhang, L., Zhang, B., Lin, Q., He, C., Li, S., Lin, L., Xie, T., Ding, Y."miR‑186‑5p regulates the inflammatory response of chronic obstructive pulmonary disorder by targeting HIF‑1α". Molecular Medicine Reports 29.2 (2024): 34.
Chicago
Fu, Y., Zhao, J., Chen, J., Zheng, Y., Mo, R., Zhang, L., Zhang, B., Lin, Q., He, C., Li, S., Lin, L., Xie, T., Ding, Y."miR‑186‑5p regulates the inflammatory response of chronic obstructive pulmonary disorder by targeting HIF‑1α". Molecular Medicine Reports 29, no. 2 (2024): 34. https://doi.org/10.3892/mmr.2024.13158
Copy and paste a formatted citation
x
Spandidos Publications style
Fu Y, Zhao J, Chen J, Zheng Y, Mo R, Zhang L, Zhang B, Lin Q, He C, Li S, Li S, et al: miR‑186‑5p regulates the inflammatory response of chronic obstructive pulmonary disorder by targeting HIF‑1α. Mol Med Rep 29: 34, 2024.
APA
Fu, Y., Zhao, J., Chen, J., Zheng, Y., Mo, R., Zhang, L. ... Ding, Y. (2024). miR‑186‑5p regulates the inflammatory response of chronic obstructive pulmonary disorder by targeting HIF‑1α. Molecular Medicine Reports, 29, 34. https://doi.org/10.3892/mmr.2024.13158
MLA
Fu, Y., Zhao, J., Chen, J., Zheng, Y., Mo, R., Zhang, L., Zhang, B., Lin, Q., He, C., Li, S., Lin, L., Xie, T., Ding, Y."miR‑186‑5p regulates the inflammatory response of chronic obstructive pulmonary disorder by targeting HIF‑1α". Molecular Medicine Reports 29.2 (2024): 34.
Chicago
Fu, Y., Zhao, J., Chen, J., Zheng, Y., Mo, R., Zhang, L., Zhang, B., Lin, Q., He, C., Li, S., Lin, L., Xie, T., Ding, Y."miR‑186‑5p regulates the inflammatory response of chronic obstructive pulmonary disorder by targeting HIF‑1α". Molecular Medicine Reports 29, no. 2 (2024): 34. https://doi.org/10.3892/mmr.2024.13158
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