Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March-2024 Volume 29 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2024 Volume 29 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Liver sinusoidal endothelial cells as potential drivers of liver fibrosis (Review)

  • Authors:
    • Jiaqin Gao
    • Bin Zuo
    • Yang He
  • View Affiliations / Copyright

    Affiliations: National Health Commission Key Laboratory of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 40
    |
    Published online on: January 16, 2024
       https://doi.org/10.3892/mmr.2024.13164
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global health. It is a critical pre‑stage condition of severe hepatopathy, characterized by excessive accumulation of extracellular matrix components and ongoing chronic inflammation. To date, early prevention of liver fibrosis remains challenging. As the most abundant non‑parenchymal hepatic cell population, liver sinusoidal endothelial cells (LSECs) are stabilizers that maintain the intrahepatic environment. Notably, LSECs dysfunction appears to be implicated in the progression of liver fibrosis via numerous mechanisms. Following sustained liver injury, they lose their fenestrae (cytoplasmic pores) and change their crosstalk with other cellular interactions in the hepatic blood environment. LSEC‑targeted therapy has shown promising effects on fibrosis resolution, opening up new opportunities for anti‑fibrotic therapy. In light of this, the present study summarized changes in LSECs during liver fibrosis and their interactions with hepatic milieu, as well as possible therapeutic approaches that specially target LSECs.
View Figures

Figure 1

View References

1 

Parola M and Pinzani M: Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues. Mol Aspects Med. 65:37–55. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Mallat A and Lotersztajn S: Cellular mechanisms of tissue fibrosis. 5. Novel insights into liver fibrosis. Am J Physiol Cell Physiol. 305:C789–C799. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Gofton C, Upendran Y, Zheng MH and George J: MAFLD: How is it different from NAFLD? Clin Mol Hepatol. 29 (Suppl):S17–S31. 2023. View Article : Google Scholar : PubMed/NCBI

4 

Asrani SK, Devarbhavi H, Eaton J and Kamath PS: Burden of liver diseases in the world. J Hepatol. 70:151–171. 2019. View Article : Google Scholar : PubMed/NCBI

5 

D'Amico G, Morabito A, D'Amico M, Pasta L, Malizia G, Rebora P and Valsecchi MG: New concepts on the clinical course and stratification of compensated and decompensated cirrhosis. Hepatol Int. 12 (Suppl 1):S34–S43. 2018. View Article : Google Scholar

6 

Dewidar B, Meyer C, Dooley S and Meindl-Beinker AN: TGF-β in hepatic stellate cell activation and liver fibrogenesis-updated 2019. Cells. 8:14192019. View Article : Google Scholar : PubMed/NCBI

7 

Rockey DC and Friedman SL: Fibrosis regression after eradication of hepatitis C virus: From bench to bedside. Gastroenterology. 160:1502–1520.e1. 2021. View Article : Google Scholar : PubMed/NCBI

8 

Friedman SL and Pinzani M: Hepatic fibrosis 2022: Unmet needs and a blueprint for the future. Hepatology. 75:473–488. 2022. View Article : Google Scholar : PubMed/NCBI

9 

Xu M, Wang X, Zou Y and Zhong Y: Key role of liver sinusoidal endothelial cells in liver fibrosis. Biosci Trends. 11:163–168. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Brozat JF, Brandt EF, Stark M, Fischer P, Wirtz TH, Flaßhove A, Rodenhausen AN, Vajen T, Heinzmann ACA, Schmitz SM, et al: JAM-A is a multifaceted regulator in hepatic fibrogenesis, supporting LSEC integrity and stellate cell quiescence. Liver Int. 42:1185–1203. 2022. View Article : Google Scholar : PubMed/NCBI

11 

Lafoz E, Ruart M, Anton A, Oncins A and Hernández-Gea V: The endothelium as a driver of liver fibrosis and regeneration. Cells. 9:9292020. View Article : Google Scholar : PubMed/NCBI

12 

Poisson J, Lemoinne S, Boulanger C, Durand F, Moreau R, Valla D and Rautou PE: Liver sinusoidal endothelial cells: Physiology and role in liver diseases. J Hepatol. 66:212–227. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Xie G, Wang L, Wang X, Wang L and DeLeve LD: Isolation of periportal, midlobular, and centrilobular rat liver sinusoidal endothelial cells enables study of zonated drug toxicity. Am J Physiol Gastrointest Liver Physiol. 299:G1204–G1210. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Mönkemöller V, Øie C, Hübner W, Huser T and McCourt P: Multimodal super-resolution optical microscopy visualizes the close connection between membrane and the cytoskeleton in liver sinusoidal endothelial cell fenestrations. Sci Rep. 5:162792015. View Article : Google Scholar : PubMed/NCBI

15 

Wack KE, Ross MA, Zegarra V, Sysko LR, Watkins SC and Stolz DB: Sinusoidal ultrastructure evaluated during the revascularization of regenerating rat liver. Hepatology. 33:363–378. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Scoazec JY, Racine L, Couvelard A, Flejou JF and Feldmann G: Endothelial cell heterogeneity in the normal human liver acinus: In situ immunohistochemical demonstration. Liver. 14:113–123. 1994. View Article : Google Scholar : PubMed/NCBI

17 

Barberá-Guillem E, Rocha M, Alvarez A and Vidal-Vanaclocha F: Differences in the lectin-binding patterns of the periportal and perivenous endothelial domains in the liver sinusoids. Hepatology. 14:131–139. 1991. View Article : Google Scholar : PubMed/NCBI

18 

Di Martino J, Mascalchi P, Legros P, Lacomme S, Gontier E, Bioulac-Sage P, Balabaud C, Moreau V and Saltel F: Actin depolymerization in dedifferentiated liver sinusoidal endothelial cells promotes fenestrae re-formation. Hepatol Commun. 3:213–219. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Herrnberger L, Hennig R, Kremer W, Hellerbrand C, Goepferich A, Kalbitzer HR and Tamm ER: Formation of fenestrae in murine liver sinusoids depends on plasmalemma vesicle-associated protein and is required for lipoprotein passage. PLoS One. 9:e1150052014. View Article : Google Scholar : PubMed/NCBI

20 

DeLeve LD: Liver sinusoidal endothelial cells in hepatic fibrosis. Hepatology. 61:1740–1746. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Malovic I, Sørensen KK, Elvevold KH, Nedredal GI, Paulsen S, Erofeev AV, Smedsrød BH and McCourt PA: The mannose receptor on murine liver sinusoidal endothelial cells is the main denatured collagen clearance receptor. Hepatology. 45:1454–1461. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Verwilligen RAF, Mulder L, Rodenburg FJ, Van Dijke A, Hoekstra M, Bussmann J and Van Eck M: Stabilin 1 and 2 are important regulators for cellular uptake of apolipoprotein B-containing lipoproteins in zebrafish. Atherosclerosis. 346:18–25. 2022. View Article : Google Scholar : PubMed/NCBI

23 

Sørensen KK, McCourt P, Berg T, Crossley C, Le Couteur D, Wake K and Smedsrød B: The scavenger endothelial cell: A new player in homeostasis and immunity. Am J Physiol Regul Integr Comp Physiol. 303:R1217–R1230. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Su T, Yang Y, Lai S, Jeong J, Jung Y, McConnell M, Utsumi T and Iwakiri Y: Single-cell transcriptomics reveals zone-specific alterations of liver sinusoidal endothelial cells in cirrhosis. Cell Mol Gastroenterol Hepatol. 11:1139–1161. 2021. View Article : Google Scholar : PubMed/NCBI

25 

Deleve LD, Wang X and Guo Y: Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence. Hepatology. 48:920–930. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Horn T, Christoffersen P and Henriksen JH: Alcoholic liver injury: Defenestration in noncirrhotic livers-a scanning electron microscopic study. Hepatology. 7:77–82. 1987. View Article : Google Scholar : PubMed/NCBI

27 

Jin Y, Guo YH, Li JC, Li Q, Ye D, Zhang XX and Li JT: Vascular endothelial growth factor protein and gene delivery by novel nanomaterials for promoting liver regeneration after partial hepatectomy. World J Gastroenterol. 29:3748–3757. 2023. View Article : Google Scholar : PubMed/NCBI

28 

Xie G, Wang X, Wang L, Wang L, Atkinson RD, Kanel GC, Gaarde WA and Deleve LD: Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats. Gastroenterology. 142:918–927.e6. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Carpenter B, Lin Y, Stoll S, Raffai RL, McCuskey R and Wang R: VEGF is crucial for the hepatic vascular development required for lipoprotein uptake. Development. 132:3293–3303. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Chen L, Gu T, Li B, Li F, Ma Z, Zhang Q, Cai X and Lu L: Delta-like ligand 4/DLL4 regulates the capillarization of liver sinusoidal endothelial cell and liver fibrogenesis. Biochim Biophys Acta Mol Cell Res. 1866:1663–1675. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Duan JL, Ruan B, Yan XC, Liang L, Song P, Yang ZY, Liu Y, Dou KF, Han H and Wang L: Endothelial Notch activation reshapes the angiocrine of sinusoidal endothelia to aggravate liver fibrosis and blunt regeneration in mice. Hepatology. 68:677–690. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Francis H, Bohanan J and Alpini G: Hedgehog signalling and LSEC capillarisation: Stopping this one in its tracks. Gut. 61:1243–1244. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Yang L, Xu X, Chen Z, Zhang Y, Chen H and Wang X: miR-511-3p promotes hepatic sinusoidal obstruction syndrome by activating hedgehog pathway via targeting Ptch1. Am J Physiol Gastrointest Liver Physiol. 321:G344–G354. 2021. View Article : Google Scholar : PubMed/NCBI

34 

Chen T, Shi Z, Zhao Y, Meng X, Zhao S, Zheng L, Han X, Hu Z, Yao Q, Lin H, et al: LncRNA Airn maintains LSEC differentiation to alleviate liver fibrosis via the KLF2-eNOS-sGC pathway. BMC Med. 20:3352022. View Article : Google Scholar : PubMed/NCBI

35 

Winkler M, Staniczek T, Kürschner SW, Schmid CD, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, et al: Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling. J Hepatol. 74:380–393. 2021. View Article : Google Scholar : PubMed/NCBI

36 

Marrone G, Maeso-Díaz R, García-Cardena G, Abraldes JG, García-Pagán JC, Bosch J and Gracia-Sancho J: KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: Behind the molecular mechanisms of statins. Gut. 64:1434–1443. 2015. View Article : Google Scholar : PubMed/NCBI

37 

de Haan W, Dheedene W, Apelt K, Décombas-Deschamps S, Vinckier S, Verhulst S, Conidi A, Deffieux T, Staring MW, Vandervoort P, et al: Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis. Cardiovasc Res. 118:1262–1275. 2022. View Article : Google Scholar : PubMed/NCBI

38 

Maretti-Mira AC, Wang X, Wang L and DeLeve LD: Incomplete differentiation of engrafted bone marrow endothelial progenitor cells initiates hepatic fibrosis in the rat. Hepatology. 69:1259–1272. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Desroches-Castan A, Tillet E, Ricard N, Ouarné M, Mallet C, Belmudes L, Couté Y, Boillot O, Scoazec JY, Bailly S and Feige JJ: Bone morphogenetic protein 9 is a paracrine factor controlling liver sinusoidal endothelial cell fenestration and protecting against hepatic fibrosis. Hepatology. 70:1392–1408. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Gaitantzi H, Karch J, Germann L, Cai C, Rausch V, Birgin E, Rahbari N, Seitz T, Hellerbrand C, König C, et al: BMP-9 modulates the hepatic responses to LPS. Cells. 9:6172020. View Article : Google Scholar : PubMed/NCBI

41 

Desroches-Castan A, Tillet E, Ricard N, Ouarné M, Mallet C, Feige JJ and Bailly S: Differential Consequences of Bmp9 deletion on sinusoidal endothelial cell differentiation and liver fibrosis in 129/Ola and C57BL/6 Mice. Cells. 8:10792019. View Article : Google Scholar : PubMed/NCBI

42 

Kawai H, Osawa Y, Matsuda M, Tsunoda T, Yanagida K, Hishikawa D, Okawara M, Sakamoto Y, Shimagaki T, Tsutsui Y, et al: Sphingosine-1-phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy. Hepatology. 76:112–125. 2022. View Article : Google Scholar : PubMed/NCBI

43 

Kantari-Mimoun C, Krzywinska E, Castells M, Milien C, Klose R, Meinecke AK, Lemberger U, Mathivet T, Gojkovic M, Schrödter K, et al: Boosting the hypoxic response in myeloid cells accelerates resolution of fibrosis and regeneration of the liver in mice. Oncotarget. 8:15085–15100. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Kwok W, Lee SH, Culberson C, Korneszczuk K and Clemens MG: Caveolin-1 mediates endotoxin inhibition of endothelin-1-induced endothelial nitric oxide synthase activity in liver sinusoidal endothelial cells. Am J Physiol Gastrointest Liver Physiol. 297:G930–G939. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Li H: Intercellular crosstalk of liver sinusoidal endothelial cells in liver fibrosis, cirrhosis and hepatocellular carcinoma. Dig Liver Dis. 54:598–613. 2022. View Article : Google Scholar : PubMed/NCBI

46 

Trautwein C, Friedman SL, Schuppan D and Pinzani M: Hepatic fibrosis: Concept to treatment. J Hepatol. 62 (1 Suppl):S15–S24. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Venkatraman L and Tucker-Kellogg L: The CD47-binding peptide of thrombospondin-1 induces defenestration of liver sinusoidal endothelial cells. Liver Int. 33:1386–1397. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Liepelt A and Tacke F: Stromal cell-derived factor-1 (SDF-1) as a target in liver diseases. Am J Physiol Gastrointest Liver Physiol. 311:G203–G209. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Wu X, Shu L, Zhang Z, Li J, Zong J, Cheong LY, Ye D, Lam KSL, Song E, Wang C, Xu A and Hoo RLC: Adipocyte fatty acid binding protein promotes the onset and progression of liver fibrosis via mediating the crosstalk between liver sinusoidal endothelial cells and hepatic stellate cells. Adv Sci (Weinh). 8:e20037212021. View Article : Google Scholar : PubMed/NCBI

50 

Wang R, Ding Q, Yaqoob U, de Assuncao TM, Verma VK, Hirsova P, Cao S, Mukhopadhyay D, Huebert RC and Shah VH: Exosome adherence and internalization by hepatic stellate cells triggers Sphingosine 1-Phosphate-dependent Migration. J Biol Chem. 290:30684–30696. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Zapotoczny B, Szafranska K, Kus E, Braet F, Wisse E, Chlopicki S and Szymonski M: Tracking fenestrae dynamics in live murine liver sinusoidal endothelial cells. Hepatology. 69:876–888. 2019. View Article : Google Scholar : PubMed/NCBI

52 

Du W and Wang L: The crosstalk between liver sinusoidal endothelial cells and hepatic microenvironment in NASH related liver fibrosis. Front Immunol. 13:9361962022. View Article : Google Scholar : PubMed/NCBI

53 

Lao Y, Li Y, Zhang P, Shao Q, Lin W, Qiu B, Lv Y, Tang L, Su S, Zhang H, et al: Targeting Endothelial Erk1/2-Akt axis as a regeneration strategy to bypass fibrosis during chronic liver injury in mice. Mol Ther. 26:2779–2797. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Colucci S, Altamura S, Marques O, Dropmann A, Horvat NK, Müdder K, Hammad S, Dooley S and Muckenthaler MU: Liver sinusoidal endothelial cells suppress bone morphogenetic protein 2 production in response to TGFβ pathway activation. Hepatology. 74:2186–2200. 2021. View Article : Google Scholar : PubMed/NCBI

55 

Ding BS, Cao Z, Lis R, Nolan DJ, Guo P, Simons M, Penfold ME, Shido K, Rabbany SY and Rafii S: Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Nature. 505:97–102. 2014. View Article : Google Scholar : PubMed/NCBI

56 

Yan Z, Qu K, Zhang J, Huang Q, Qu P, Xu X, Yuan P, Huang X, Shao Y, Liu C, et al: CD147 promotes liver fibrosis progression via VEGF-A/VEGFR2 signalling-mediated cross-talk between hepatocytes and sinusoidal endothelial cells. Clin Sci (Lond). 129:699–710. 2015. View Article : Google Scholar : PubMed/NCBI

57 

Su T and Iwakiri Y: Endothelial Leukocyte Cell-Derived Chemotaxin 2/Tyrosine Kinase with immunoglobulin-like and epidermal growth factor-like domains 1 signaling in liver fibrosis. Hepatology. 72:347–349. 2020. View Article : Google Scholar : PubMed/NCBI

58 

Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, et al: Macrophage activation and polarization: Nomenclature and experimental guidelines. Immunity. 41:14–20. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Arrese M, Cabrera D, Kalergis AM and Feldstein AE: Innate Immunity and Inflammation in NAFLD/NASH. Dig Dis Sci. 61:1294–1303. 2016. View Article : Google Scholar : PubMed/NCBI

60 

Shetty S, Lalor PF and Adams DH: Liver sinusoidal endothelial cells-gatekeepers of hepatic immunity. Nat Rev Gastroenterol Hepatol. 15:555–567. 2018. View Article : Google Scholar : PubMed/NCBI

61 

You Q, Holt M, Yin H, Li G, Hu CJ and Ju C: Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem Pharmacol. 86:836–843. 2013. View Article : Google Scholar : PubMed/NCBI

62 

Miyao M, Kotani H, Ishida T, Kawai C, Manabe S, Abiru H and Tamaki K: Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression. Lab Invest. 95:1130–1144. 2015. View Article : Google Scholar : PubMed/NCBI

63 

Ford AJ, Jain G and Rajagopalan P: Designing a fibrotic microenvironment to investigate changes in human liver sinusoidal endothelial cell function. Acta Biomater. 24:220–227. 2015. View Article : Google Scholar : PubMed/NCBI

64 

Kamada Y, Sato M, Kida S, Akita M, Mizutani K, Fujii H, Sobajima T, Yoshida Y, Shinzaki S, Takamatsu S, et al: N-acetylglucosaminyltransferase V exacerbates concanavalin A-induced hepatitis in mice. Mol Med Rep. 11:3573–3584. 2015. View Article : Google Scholar : PubMed/NCBI

65 

Ni Y, Li JM, Liu MK, Zhang TT, Wang DP, Zhou WH, Hu LZ and Lv WL: Pathological process of liver sinusoidal endothelial cells in liver diseases. World J Gastroenterol. 23:7666–7677. 2017. View Article : Google Scholar : PubMed/NCBI

66 

Connolly MK, Bedrosian AS, Malhotra A, Henning JR, Ibrahim J, Vera V, Cieza-Rubio NE, Hassan BU, Pachter HL, Cohen S, et al: In hepatic fibrosis, liver sinusoidal endothelial cells acquire enhanced immunogenicity. J Immunol. 185:2200–2208. 2010. View Article : Google Scholar : PubMed/NCBI

67 

Bonder CS, Norman MU, Swain MG, Zbytnuik LD, Yamanouchi J, Santamaria P, Ajuebor M, Salmi M, Jalkanen S and Kubes P: Rules of recruitment for Th1 and Th2 lymphocytes in inflamed liver: A role for alpha-4 integrin and vascular adhesion protein-1. Immunity. 23:153–163. 2005. View Article : Google Scholar : PubMed/NCBI

68 

Barrow F, Khan S, Wang H and Revelo XS: The Emerging Role of B Cells in the Pathogenesis of NAFLD. Hepatology. 74:2277–2286. 2021. View Article : Google Scholar : PubMed/NCBI

69 

Wehr A, Baeck C, Heymann F, Niemietz PM, Hammerich L, Martin C, Zimmermann HW, Pack O, Gassler N, Hittatiya K, et al: Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis. J Immunol. 190:5226–5236. 2013. View Article : Google Scholar : PubMed/NCBI

70 

Neumann K, Rudolph C, Neumann C, Janke M, Amsen D and Scheffold A: Liver sinusoidal endothelial cells induce immunosuppressive IL-10-producing Th1 cells via the Notch pathway. Eur J Immunol. 45:2008–2016. 2015. View Article : Google Scholar : PubMed/NCBI

71 

Dauphinee SM and Karsan A: Lipopolysaccharide signaling in endothelial cells. Lab Invest. 86:9–22. 2006. View Article : Google Scholar : PubMed/NCBI

72 

Gola A, Dorrington MG, Speranza E, Sala C, Shih RM, Radtke AJ, Wong HS, Baptista AP, Hernandez JM, Castellani G, et al: Commensal-driven immune zonation of the liver promotes host defence. Nature. 589:131–136. 2021. View Article : Google Scholar : PubMed/NCBI

73 

Greuter T, Yaqoob U, Gan C, Jalan-Sakrikar N, Kostallari E, Lu J, Gao J, Sun L, Liu M, Sehrawat TS, et al: Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivo. J Hepatol. 77:723–734. 2022. View Article : Google Scholar : PubMed/NCBI

74 

Fujita K, Nozaki Y, Wada K, Yoneda M, Endo H, Takahashi H, Iwasaki T, Inamori M, Abe Y, Kobayashi N, et al: Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease. Gut. 57:1583–1591. 2008. View Article : Google Scholar : PubMed/NCBI

75 

Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, et al: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer. Nat Med. 25:641–655. 2019. View Article : Google Scholar : PubMed/NCBI

76 

Lalor PF, Herbert J, Bicknell R and Adams DH: Hepatic sinusoidal endothelium avidly binds platelets in an integrin-dependent manner, leading to platelet and endothelial activation and leukocyte recruitment. Am J Physiol Gastrointest Liver Physiol. 304:G469–G478. 2013. View Article : Google Scholar : PubMed/NCBI

77 

Joshi N, Kopec AK, Ray JL, Cline-Fedewa H, Groeneveld DJ, Lisman T and Luyendyk JP: Von Willebrand factor deficiency reduces liver fibrosis in mice. Toxicol Appl Pharmacol. 328:540592017. View Article : Google Scholar : PubMed/NCBI

78 

Weyrich AS: Platelets: More than a sack of glue. Hematology Am Soc Hematol Educ Program. 2014:400–403. 2014. View Article : Google Scholar : PubMed/NCBI

79 

Chauhan A, Adams DH, Watson SP and Lalor PF: Platelets: No longer bystanders in liver disease. Hepatology. 64:1774–1784. 2016. View Article : Google Scholar : PubMed/NCBI

80 

Ripoche J: Blood platelets and inflammation: Their relationship with liver and digestive diseases. Clin Res Hepatol Gastroenterol. 35:353–357. 2011. View Article : Google Scholar : PubMed/NCBI

81 

Lisman T and Luyendyk JP: Platelets as modulators of liver diseases. Semin Thromb Hemost. 44:114–125. 2018. View Article : Google Scholar : PubMed/NCBI

82 

Brougham-Cook A, Kimmel HRC, Monckton CP, Owen D, Khetani SR and Underhill GH: Engineered matrix microenvironments reveal the heterogeneity of liver sinusoidal endothelial cell phenotypic responses. APL Bioeng. 6:0461022022. View Article : Google Scholar : PubMed/NCBI

83 

Olsen AL, Sackey BK, Marcinkiewicz C, Boettiger D and Wells RG: Fibronectin extra domain-A promotes hepatic stellate cell motility but not differentiation into myofibroblasts. Gastroenterology. 142:928–937.e3. 2012. View Article : Google Scholar : PubMed/NCBI

84 

Liu L, You Z, Yu H, Zhou L, Zhao H, Yan X, Li D, Wang B, Zhu L, Xu Y, et al: Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis. Nat Mater. 16:1252–1261. 2017. View Article : Google Scholar : PubMed/NCBI

85 

Ruan B, Duan JL, Xu H, Tao KS, Han H, Dou GR and Wang L: Capillarized Liver sinusoidal endothelial cells undergo partial endothelial-mesenchymal transition to actively deposit sinusoidal ECM in liver fibrosis. Front Cell Dev Biol. 9:6710812021. View Article : Google Scholar : PubMed/NCBI

86 

Iwakiri Y and Trebicka J: Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy. JHEP Rep. 3:1003162021. View Article : Google Scholar : PubMed/NCBI

87 

Trebicka J, Reiberger T and Laleman W: Gut-Liver Axis Links Portal Hypertension to Acute-on-Chronic Liver Failure. Visc Med. 34:270–275. 2018. View Article : Google Scholar : PubMed/NCBI

88 

Bravo M, Raurell I, Hide D, Fernández-Iglesias A, Gil M, Barberá A, Salcedo MT, Augustin S, Genescà J and Martell M: Restoration of liver sinusoidal cell phenotypes by statins improves portal hypertension and histology in rats with NASH. Sci Rep. 9:201832019. View Article : Google Scholar : PubMed/NCBI

89 

Iwakiri Y: Endothelial dysfunction in the regulation of portal hypertension. Liver Int. 32:199–213. 2012. View Article : Google Scholar : PubMed/NCBI

90 

Rockey DC and Chung JJ: Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: Endothelial dysfunction in portal hypertension. Gastroenterology. 114:344–351. 1998. View Article : Google Scholar : PubMed/NCBI

91 

Gracia-Sancho J, Marrone G and Fernández-Iglesias A: Hepatic microcirculation and mechanisms of portal hypertension. Nat Rev Gastroenterol Hepatol. 16:221–234. 2019. View Article : Google Scholar : PubMed/NCBI

92 

Hammoutene A, Biquard L, Lasselin J, Kheloufi M, Tanguy M, Vion AC, Mérian J, Colnot N, Loyer X, Tedgui A, et al: A defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis. J Hepatol. 72:528–538. 2020. View Article : Google Scholar : PubMed/NCBI

93 

Maeso-Díaz R, Ortega-Ribera M, Lafoz E, Lozano JJ, Baiges A, Francés R, Albillos A, Peralta C, García-Pagán JC, Bosch J, et al: Aging influences hepatic microvascular biology and liver fibrosis in advanced chronic liver disease. Aging Dis. 10:684–698. 2019. View Article : Google Scholar : PubMed/NCBI

94 

Bosch J, Groszmann RJ and Shah VH: Evolution in the understanding of the pathophysiological basis of portal hypertension: How changes in paradigm are leading to successful new treatments. J Hepatol. 62 (1 Suppl):S121–S130. 2015. View Article : Google Scholar : PubMed/NCBI

95 

Medina J, Arroyo AG, Sánchez-Madrid F and Moreno-Otero R: Angiogenesis in chronic inflammatory liver disease. Hepatology. 39:1185–1195. 2004. View Article : Google Scholar : PubMed/NCBI

96 

Hilscher MB, Sehrawat T, Arab JP, Zeng Z, Gao J, Liu M, Kostallari E, Gao Y, Simonetto DA, Yaqoob U, et al: Mechanical stretch increases expression of CXCL1 in liver sinusoidal endothelial cells to recruit neutrophils, generate sinusoidal microthombi, and promote portal hypertension. Gastroenterology. 157:193–209.e9. 2019. View Article : Google Scholar : PubMed/NCBI

97 

Yu Z, Guo J, Liu Y, Wang M, Liu Z, Gao Y and Huang L: Nano delivery of simvastatin targets liver sinusoidal endothelial cells to remodel tumor microenvironment for hepatocellular carcinoma. J Nanobiotechnology. 20:92022. View Article : Google Scholar : PubMed/NCBI

98 

Boyer-Diaz Z, Aristu-Zabalza P, Andrés-Rozas M, Robert C, Ortega-Ribera M, Fernández-Iglesias A, Broqua P, Junien JL, Wettstein G, Bosch J and Gracia-Sancho J: Pan-PPAR agonist lanifibranor improves portal hypertension and hepatic fibrosis in experimental advanced chronic liver disease. J Hepatol. 74:1188–1199. 2021. View Article : Google Scholar : PubMed/NCBI

99 

Hide D, Gil M, Andrade F, Rafael D, Raurell I, Bravo M, Barberá A, Gracia-Sancho J, Vargas V, Augustin S, et al: Simvastatin-loaded polymeric micelles are more effective and less toxic than conventional statins in a pre-clinical model of advanced chronic liver disease. Nanomedicine. 29:1022672020. View Article : Google Scholar : PubMed/NCBI

100 

Zhang LF, Wang XH, Zhang CL, Lee J, Duan BW, Xing L, Li L, Oh YK and Jiang HL: Sequential nano-penetrators of capillarized liver sinusoids and extracellular matrix barriers for liver fibrosis therapy. ACS Nano. 16:14029–14042. 2022. View Article : Google Scholar : PubMed/NCBI

101 

Gu T, Shen B, Li B, Guo Y, Li F, Ma Z, Chen L, Zhang Q, Qu Y, Dong H, et al: miR-30c inhibits angiogenesis by targeting delta-like ligand 4 in liver sinusoidal endothelial cell to attenuate liver fibrosis. FASEB J. 35:e215712021. View Article : Google Scholar : PubMed/NCBI

102 

Mookerjee RP, Mehta G, Balasubramaniyan V, Mohamed Fel Z, Davies N, Sharma V, Iwakiri Y and Jalan R: Hepatic dimethylarginine-dimethylaminohydrolase1 is reduced in cirrhosis and is a target for therapy in portal hypertension. J Hepatol. 62:325–331. 2015. View Article : Google Scholar : PubMed/NCBI

103 

Kumar K, Dong Y, Kumar V, Almawash S and Mahato RI: The use of micelles to deliver potential hedgehog pathway inhibitor for the treatment of liver fibrosis. Theranostics. 9:7537–7555. 2019. View Article : Google Scholar : PubMed/NCBI

104 

Zhao S, Zhang Z, Qian L, Lin Q, Zhang C, Shao J, Zhang F and Zheng S: Tetramethylpyrazine attenuates carbon tetrachloride-caused liver injury and fibrogenesis and reduces hepatic angiogenesis in rats. Biomed Pharmacother. 86:521–530. 2017. View Article : Google Scholar : PubMed/NCBI

105 

Gao L, Yang X, Li Y, Wang Z, Wang S, Tan S, Chen A, Cao P, Shao J, Zhang Z, et al: Curcumol inhibits KLF5-dependent angiogenesis by blocking the ROS/ERK signaling in liver sinusoidal endothelial cells. Life Sci. 264:1186962021. View Article : Google Scholar : PubMed/NCBI

106 

Yang X, Wang Z, Kai J, Wang F, Jia Y, Wang S, Tan S, Shen X, Chen A, Shao J, et al: Curcumol attenuates liver sinusoidal endothelial cell angiogenesis via regulating Glis-PROX1-HIF-1α in liver fibrosis. Cell Prolif. 53:e127622020. View Article : Google Scholar : PubMed/NCBI

107 

Bae CR, Zhang H and Kwon YG: The endothelial dysfunction blocker CU06-1004 ameliorates choline-deficient L-amino acid diet-induced non-alcoholic steatohepatitis in mice. PLoS One. 15:e02434972020. View Article : Google Scholar : PubMed/NCBI

108 

Turaga RC, Satyanarayana G, Sharma M, Yang JJ, Wang S, Liu C, Li S, Yang H, Grossniklaus H, Farris AB, et al: Targeting integrin αvβ3 by a rationally designed protein for chronic liver disease treatment. Commun Biol. 4:10872021. View Article : Google Scholar : PubMed/NCBI

109 

Ye Q, Zhou Y, Zhao C, Xu L and Ping J: Salidroside Inhibits CCl4-Induced Liver fibrosis in mice by reducing activation and migration of HSC induced by liver sinusoidal endothelial cell-derived exosomal SphK1. Front Pharmacol. 12:6778102021. View Article : Google Scholar : PubMed/NCBI

110 

Guo Q, Furuta K, Islam S, Caporarello N, Kostallari E, Dielis K, Tschumperlin DJ, Hirsova P and Ibrahim SH: Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis. Front Immunol. 13:9832552022. View Article : Google Scholar : PubMed/NCBI

111 

Ruart M, Chavarria L, Campreciós G, Suárez-Herrera N, Montironi C, Guixé-Muntet S, Bosch J, Friedman SL, Garcia-Pagán JC and Hernández-Gea V: Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury. J Hepatol. 70:458–469. 2019. View Article : Google Scholar : PubMed/NCBI

112 

Lin Y, Dong MQ, Liu ZM, Xu M, Huang ZH, Liu HJ, Gao Y and Zhou WJ: A strategy of vascular-targeted therapy for liver fibrosis. Hepatology. 76:660–675. 2022. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gao J, Zuo B and He Y: Liver sinusoidal endothelial cells as potential drivers of liver fibrosis (Review). Mol Med Rep 29: 40, 2024.
APA
Gao, J., Zuo, B., & He, Y. (2024). Liver sinusoidal endothelial cells as potential drivers of liver fibrosis (Review). Molecular Medicine Reports, 29, 40. https://doi.org/10.3892/mmr.2024.13164
MLA
Gao, J., Zuo, B., He, Y."Liver sinusoidal endothelial cells as potential drivers of liver fibrosis (Review)". Molecular Medicine Reports 29.3 (2024): 40.
Chicago
Gao, J., Zuo, B., He, Y."Liver sinusoidal endothelial cells as potential drivers of liver fibrosis (Review)". Molecular Medicine Reports 29, no. 3 (2024): 40. https://doi.org/10.3892/mmr.2024.13164
Copy and paste a formatted citation
x
Spandidos Publications style
Gao J, Zuo B and He Y: Liver sinusoidal endothelial cells as potential drivers of liver fibrosis (Review). Mol Med Rep 29: 40, 2024.
APA
Gao, J., Zuo, B., & He, Y. (2024). Liver sinusoidal endothelial cells as potential drivers of liver fibrosis (Review). Molecular Medicine Reports, 29, 40. https://doi.org/10.3892/mmr.2024.13164
MLA
Gao, J., Zuo, B., He, Y."Liver sinusoidal endothelial cells as potential drivers of liver fibrosis (Review)". Molecular Medicine Reports 29.3 (2024): 40.
Chicago
Gao, J., Zuo, B., He, Y."Liver sinusoidal endothelial cells as potential drivers of liver fibrosis (Review)". Molecular Medicine Reports 29, no. 3 (2024): 40. https://doi.org/10.3892/mmr.2024.13164
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team