Open Access

Advances in the relationship between periodontopathogens and respiratory diseases (Review)

  • Authors:
    • Zhiyi Zhang
    • Siyi Wen
    • Jiaohong Liu
    • Yuanting Ouyang
    • Zhikang Su
    • Ding Chen
    • Zitian Liang
    • Yan Wang
    • Tao Luo
    • Qianzhou Jiang
    • Lvhua Guo
  • View Affiliations

  • Published online on: January 17, 2024     https://doi.org/10.3892/mmr.2024.13166
  • Article Number: 42
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Periodontitis is a common chronic inflammatory and destructive disease in the mouth and is considered to be associated with systemic diseases. Accumulating evidence has suggested that periodontitis is a risk factor for pulmonary diseases such as pneumonia, chronic obstructive pulmonary disease (COPD), asthma, coronavirus disease 2019 (COVID‑19) and lung cancer. The presence of common periodontal pathogens has been detected in samples from a variety of pulmonary diseases. Periodontal pathogens can be involved in lung diseases by promoting the adhesion and invasion of respiratory pathogens, regulating the apoptosis of respiratory epithelium and inducing overexpression of mucin and disrupting the balance of immune systemin respiratory epithelium cells. Additionally, measures to control plaque and maintain the health of periodontal tissue can decrease the incidence of respiratory adverse events. This evidence suggests a close association between periodontitis and pulmonary diseases. The present study aimed to review the clinical association between periodontitis and pneumonia, COPD, asthma, COVID‑19 and lung cancer, and propose a possible mechanism and potential role of periodontal pathogens in linking periodontal disease and lung disease. This could provide a direction for further research on the association between periodontitis and lung disease and provide novel ideas for the clinical diagnosis and treatment management of these two diseases.
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March-2024
Volume 29 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang Z, Wen S, Liu J, Ouyang Y, Su Z, Chen D, Liang Z, Wang Y, Luo T, Jiang Q, Jiang Q, et al: Advances in the relationship between periodontopathogens and respiratory diseases (Review). Mol Med Rep 29: 42, 2024
APA
Zhang, Z., Wen, S., Liu, J., Ouyang, Y., Su, Z., Chen, D. ... Guo, L. (2024). Advances in the relationship between periodontopathogens and respiratory diseases (Review). Molecular Medicine Reports, 29, 42. https://doi.org/10.3892/mmr.2024.13166
MLA
Zhang, Z., Wen, S., Liu, J., Ouyang, Y., Su, Z., Chen, D., Liang, Z., Wang, Y., Luo, T., Jiang, Q., Guo, L."Advances in the relationship between periodontopathogens and respiratory diseases (Review)". Molecular Medicine Reports 29.3 (2024): 42.
Chicago
Zhang, Z., Wen, S., Liu, J., Ouyang, Y., Su, Z., Chen, D., Liang, Z., Wang, Y., Luo, T., Jiang, Q., Guo, L."Advances in the relationship between periodontopathogens and respiratory diseases (Review)". Molecular Medicine Reports 29, no. 3 (2024): 42. https://doi.org/10.3892/mmr.2024.13166