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Advances in the relationship between periodontopathogens and respiratory diseases (Review)

  • Authors:
    • Zhiyi Zhang
    • Siyi Wen
    • Jiaohong Liu
    • Yuanting Ouyang
    • Zhikang Su
    • Ding Chen
    • Zitian Liang
    • Yan Wang
    • Tao Luo
    • Qianzhou Jiang
    • Lvhua Guo
  • View Affiliations / Copyright

    Affiliations: Department of Prosthodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong 510182, P.R. China, Department of Endodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong 510182, P.R. China, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital, State Key Laboratory of Respiratory Diseases, Guangzhou, Guangdong 510182, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 42
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    Published online on: January 17, 2024
       https://doi.org/10.3892/mmr.2024.13166
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Abstract

Periodontitis is a common chronic inflammatory and destructive disease in the mouth and is considered to be associated with systemic diseases. Accumulating evidence has suggested that periodontitis is a risk factor for pulmonary diseases such as pneumonia, chronic obstructive pulmonary disease (COPD), asthma, coronavirus disease 2019 (COVID‑19) and lung cancer. The presence of common periodontal pathogens has been detected in samples from a variety of pulmonary diseases. Periodontal pathogens can be involved in lung diseases by promoting the adhesion and invasion of respiratory pathogens, regulating the apoptosis of respiratory epithelium and inducing overexpression of mucin and disrupting the balance of immune systemin respiratory epithelium cells. Additionally, measures to control plaque and maintain the health of periodontal tissue can decrease the incidence of respiratory adverse events. This evidence suggests a close association between periodontitis and pulmonary diseases. The present study aimed to review the clinical association between periodontitis and pneumonia, COPD, asthma, COVID‑19 and lung cancer, and propose a possible mechanism and potential role of periodontal pathogens in linking periodontal disease and lung disease. This could provide a direction for further research on the association between periodontitis and lung disease and provide novel ideas for the clinical diagnosis and treatment management of these two diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Wen S, Liu J, Ouyang Y, Su Z, Chen D, Liang Z, Wang Y, Luo T, Jiang Q, Jiang Q, et al: Advances in the relationship between periodontopathogens and respiratory diseases (Review). Mol Med Rep 29: 42, 2024.
APA
Zhang, Z., Wen, S., Liu, J., Ouyang, Y., Su, Z., Chen, D. ... Guo, L. (2024). Advances in the relationship between periodontopathogens and respiratory diseases (Review). Molecular Medicine Reports, 29, 42. https://doi.org/10.3892/mmr.2024.13166
MLA
Zhang, Z., Wen, S., Liu, J., Ouyang, Y., Su, Z., Chen, D., Liang, Z., Wang, Y., Luo, T., Jiang, Q., Guo, L."Advances in the relationship between periodontopathogens and respiratory diseases (Review)". Molecular Medicine Reports 29.3 (2024): 42.
Chicago
Zhang, Z., Wen, S., Liu, J., Ouyang, Y., Su, Z., Chen, D., Liang, Z., Wang, Y., Luo, T., Jiang, Q., Guo, L."Advances in the relationship between periodontopathogens and respiratory diseases (Review)". Molecular Medicine Reports 29, no. 3 (2024): 42. https://doi.org/10.3892/mmr.2024.13166
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Wen S, Liu J, Ouyang Y, Su Z, Chen D, Liang Z, Wang Y, Luo T, Jiang Q, Jiang Q, et al: Advances in the relationship between periodontopathogens and respiratory diseases (Review). Mol Med Rep 29: 42, 2024.
APA
Zhang, Z., Wen, S., Liu, J., Ouyang, Y., Su, Z., Chen, D. ... Guo, L. (2024). Advances in the relationship between periodontopathogens and respiratory diseases (Review). Molecular Medicine Reports, 29, 42. https://doi.org/10.3892/mmr.2024.13166
MLA
Zhang, Z., Wen, S., Liu, J., Ouyang, Y., Su, Z., Chen, D., Liang, Z., Wang, Y., Luo, T., Jiang, Q., Guo, L."Advances in the relationship between periodontopathogens and respiratory diseases (Review)". Molecular Medicine Reports 29.3 (2024): 42.
Chicago
Zhang, Z., Wen, S., Liu, J., Ouyang, Y., Su, Z., Chen, D., Liang, Z., Wang, Y., Luo, T., Jiang, Q., Guo, L."Advances in the relationship between periodontopathogens and respiratory diseases (Review)". Molecular Medicine Reports 29, no. 3 (2024): 42. https://doi.org/10.3892/mmr.2024.13166
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