|
1
|
Njoroge JN and Teerlink JR:
Pathophysiology and therapeutic approaches to acute decompensated
heart failure. Circ Res. 128:1468–1486. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Nakamura M and Sadoshima J: Mechanisms of
physiological and pathological cardiac hypertrophy. Nat Rev
Cardiol. 15:387–407. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Guo J, Mihic A, Wu J, Zhang Y, Singh K,
Dhingra S, Weisel RD and Li RK: Canopy 2 attenuates the transition
from compensatory hypertrophy to dilated heart failure in
hypertrophic cardiomyopathy. Eur Heart J. 36:2530–2540. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Gao M, Cai Q, Si H, Shi S, Wei H, Lv M,
Wang X and Dong T: Isoliquiritigenin attenuates pathological
cardiac hypertrophy via regulating AMPKα in vivo and in vitro. J
Mol Histol. 53:679–689. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Kou T, Luo H, Shen Y, Su Y and Yin L:
Effects of berberine hydrochloride on left ventricular structure
and function in rats with myocardial hypertrophy. Acta Cardiol.
78:433–441. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Dickhout JG, Carlisle RE and Austin RC:
Interrelationship between cardiac hypertrophy, heart failure, and
chronic kidney disease: Endoplasmic reticulum stress as a mediator
of pathogenesis. Circ Res. 108:629–642. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Ziaeian B and Fonarow GC: Epidemiology and
aetiology of heart failure. Nat Rev Cardiol. 13:368–378. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Tham YK, Bernardo BC, Ooi JY, Weeks KL and
McMullen JR: Pathophysiology of cardiac hypertrophy and heart
failure: Signaling pathways and novel therapeutic targets. Arch
Toxicol. 89:1401–1438. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Sherrid MV: Drug therapy for hypertrophic
cardiomypathy: Physiology and practice. Curr Cardiol Rev. 12:52–65.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Hetz C, Zhang K and Kaufman RJ:
Mechanisms, regulation and functions of the unfolded protein
response. Nat Rev Mol Cell Biol. 21:421–438. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Wang S, Binder P, Fang Q, Wang Z, Xiao W,
Liu W and Wang X: Endoplasmic reticulum stress in the heart:
insights into mechanisms and drug targets. Br J Pharmacol.
175:1293–1304. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Ren J, Bi Y, Sowers JR, Hetz C and Zhang
Y: Endoplasmic reticulum stress and unfolded protein response in
cardiovascular diseases. Nat Rev Cardiol. 18:499–521. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Kim I, Xu W and Reed JC: Cell death and
endoplasmic reticulum stress: Disease relevance and therapeutic
opportunities. Nat Rev Drug Discov. 7:1013–1030. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Yao Y, Lu Q, Hu Z, Yu Y, Chen Q and Wang
QK: A non-canonical pathway regulates ER stress signaling and
blocks ER stress-induced apoptosis and heart failure. Nat Commun.
8:1332017. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Wang J, Hu X and Jiang H: ER
stress-induced apoptosis: A novel therapeutic target in heart
failure. Int J Cardiol. 177:564–565. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Gatica D, Chiong M, Lavandero S and
Klionsky DJ: Molecular mechanisms of autophagy in the
cardiovascular system. Circ Res. 116:456–467. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Tagashira H, Bhuiyan MS, Shinoda Y,
Kawahata I, Numata T and Fukunaga K: Sigma-1 receptor is involved
in modification of ER-mitochondria proximity and Ca(2+) homeostasis
in cardiomyocytes. J Pharmacol Sci. 151:128–133. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Sun X, Zhou L, Han Y, Yang Q, Li X, Xin B,
Chi M, Wang Y and Guo C: Scutellarin attenuates doxorubicin-induced
cardiotoxicity by inhibiting myocardial fibrosis, apoptosis and
autophagy in rats. Chem Biodivers. 20:e2022004502023. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Lindqvist LM, Tandoc K, Topisirovic I and
Furic L: Cross-talk between protein synthesis, energy metabolism
and autophagy in cancer. Curr Opin Genet Dev. 48:104–111. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Shirakabe A, Zhai P, Ikeda Y, Saito T,
Maejima Y, Hsu CP, Nomura M, Egashira K, Levine B and Sadoshima J:
Drp1-dependent mitochondrial autophagy plays a protective role
against pressure overload-induced mitochondrial dysfunction and
heart failure. Circulation. 133:1249–1263. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Yang Z, Su W, Zhang Y, Zhou L, Xia ZY and
Lei S: Selective inhibition of PKCβ2 improves Caveolin-3/eNOS
signaling and attenuates lipopolysaccharide-induced injury by
inhibiting autophagy in H9C2 cardiomyocytes. J Mol Histol.
52:705–715. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Guo X, Zhang Y, Lu C, Qu F and Jiang X:
Protective effect of hyperoside on heart failure rats via
attenuating myocardial apoptosis and inducing autophagy. Biosci
Biotechnol Biochem. 84:714–724. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Gao G, Chen W, Yan M, Liu J, Luo H, Wang C
and Yang P: Rapamycin regulates the balance between cardiomyocyte
apoptosis and autophagy in chronic heart failure by inhibiting mTOR
signaling. Int J Mol Med. 45:195–209. 2020.PubMed/NCBI
|
|
24
|
Buss SJ, Muenz S, Riffel JH, Malekar P,
Hagenmueller M, Weiss CS, Bea F, Bekeredjian R, Schinke-Braun M,
Izumo S, et al: Beneficial effects of Mammalian target of rapamycin
inhibition on left ventricular remodeling after myocardial
infarction. J Am Coll Cardiol. 54:2435–2446. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Pires Da Silva J, Monceaux K, Guilbert A,
Gressette M, Piquereau J, Novotova M, Ventura-Clapier R, Garnier A
and Lemaire C: SIRT1 protects the heart from ER stress-induced
injury by promoting eEF2K/eEF2-dependent autophagy. Cells.
9:4262020. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Martín-Bórnez M, Galeano-Otero I, Del Toro
R and Smani T: TRPC and TRPV channels' role in vascular remodeling
and disease. Int J Mol Sci. 21:61252020. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Eder P and Molkentin JD: TRPC channels as
effectors of cardiac hypertrophy. Circ Res. 108:265–272. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Kinoshita H, Kuwahara K, Nishida M, Jian
Z, Rong X, Kiyonaka S, Kuwabara Y, Kurose H, Inoue R, Mori Y, et
al: Inhibition of TRPC6 channel activity contributes to the
antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A
signaling in the heart. Circ Res. 106:1849–1860. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Tang N, Tian W, Ma GY, Xiao X, Zhou L, Li
ZZ, Liu XX, Li CY, Wu KH, Liu W, et al: TRPC channels blockade
abolishes endotoxemic cardiac dysfunction by hampering
intracellular inflammation and Ca(2+) leakage. Nat Commun.
13:74552022. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Urban N, Wang L, Kwiek S, Rademann J,
Kuebler WM and Schaefer M: Identification and validation of Larixyl
acetate as a potent TRPC6 inhibitor. Mol Pharmacol. 89:197–213.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Chen X, Taylor-Nguyen NN, Riley AM,
Herring BP, White FA and Obukhov AG: The TRPC6 inhibitor, larixyl
acetate, is effective in protecting against traumatic brain
injury-induced systemic endothelial dysfunction. J
Neuroinflammation. 16:212019. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Chen QZ, Zhou YB, Zhou LF, Fu ZD, Wu YS,
Chen Y, Li SN, Huang JR and Li JH: TRPC6 modulates adhesion of
neutrophils to airway epithelial cells via NF-kappaB activation and
ICAM-1 expression with ozone exposure. Exp Cell Res. 377:56–66.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Wang M, Zhang X, Guo J, Yang S, Yang F and
Chen X: TRPC6 deletion enhances eNOS expression and reduces
LPS-induced acute lung injury. Int J Mol Sci. 24:167562023.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Wang J, Zhao M, Jia P, Liu FF, Chen K,
Meng FY, Hong JH, Zhang T, Jin XH and Shi J: The analgesic action
of larixyl acetate, a potent TRPC6 inhibitor, in rat neuropathic
pain model induced by spared nerve injury. J Neuroinflammation.
17:1182020. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Kuwahara K, Wang Y, McAnally J, Richardson
JA, Bassel-Duby R, Hill JA and Olson EN: TRPC6 fulfills a
calcineurin signaling circuit during pathologic cardiac remodeling.
J Clin Invest. 116:3114–3126. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Sciarretta S, Forte M, Frati G and
Sadoshima J: New insights into the role of mTOR signaling in the
cardiovascular system. Circ Res. 122:489–505. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Jain PP, Lai N, Xiong M, Chen J, Babicheva
A, Zhao T, Parmisano S, Zhao M, Paquin C, Matti M, et al: TRPC6, a
therapeutic target for pulmonary hypertension. Am J Physiol Lung
Cell Mol Physiol. 321:L1161–L1182. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
National Research Council (US) Committee
for the Update of the Guide for the Care and Use of Laboratory
Animals, . Guide for the Care and Use of Laboratory Animals. 8th
edition. National Academies Press (US); Washington, DC: 2011
|
|
39
|
Wilkins BJ, Dai YS, Bueno OF, Parsons SA,
Xu J, Plank DM, Jones F, Kimball TR and Molkentin JD:
Calcineurin/NFAT coupling participates in pathological, but not
physiological, cardiac hypertrophy. Circ Res. 94:110–118. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Vanhoutte D, Schips TG, Vo A, Grimes KM,
Baldwin TA, Brody MJ, Accornero F, Sargent MA and Molkentin JD:
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated
autophagy. Nat Commun. 12:39282021. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Ye T, Yan Z, Chen C, Wang D, Wang A, Li T,
Yang B, Ding X and Shen C: Lactoferrin attenuates cardiac fibrosis
and cardiac remodeling after myocardial infarction via inhibiting
mTORC1/S6K signaling pathway. Theranostics. 13:3419–3433. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Okada K, Minamino T, Tsukamoto Y, Liao Y,
Tsukamoto O, Takashima S, Hirata A, Fujita M, Nagamachi Y, Nakatani
T, et al: Prolonged endoplasmic reticulum stress in hypertrophic
and failing heart after aortic constriction: Possible contribution
of endoplasmic reticulum stress to cardiac myocyte apoptosis.
Circulation. 110:705–712. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Klaiber M, Kruse M, Völker K, Schröter J,
Feil R, Freichel M, Gerling A, Feil S, Dietrich A, Londoño JE, et
al: Novel insights into the mechanisms mediating the local
antihypertrophic effects of cardiac atrial natriuretic peptide:
Role of cGMP-dependent protein kinase and RGS2. Basic Res Cardiol.
105:583–595. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Sadoshima J and Izumo S: Rapamycin
selectively inhibits angiotensin II-induced increase in protein
synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6
kinase in angiotensin II-induced cardiac hypertrophy. Circ Res.
77:1040–1052. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Scheuble J, Rössler OG, Ulrich M and Thiel
G: Pharmacological and genetic inhibition of TRPC6-induced gene
transcription. Eur J Pharmacol. 886:1733572020. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Gao L, Lv G, Li R, Liu WT, Zong C, Ye F,
Li XY, Yang X, Jiang JH, Hou XJ, et al: Glycochenodeoxycholate
promotes hepatocellular carcinoma invasion and migration by
AMPK/mTOR dependent autophagy activation. Cancer Lett. 454:215–223.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Nagalingam RS, Chattopadhyaya S, Al-Hattab
DS, Cheung DYC, Schwartz LY, Jana S, Aroutiounova N, Ledingham DA,
Moffatt TL, Landry NM, et al: Scleraxis and fibrosis in the
pressure-overloaded heart. Eur Heart J. 43:4739–4750. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Travers KJ, Patil CK, Wodicka L, Lockhart
DJ, Weissman JS and Walter P: Functional and genomic analyses
reveal an essential coordination between the unfolded protein
response and ER-associated degradation. Cell. 101:249–258. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Minamino T, Komuro I and Kitakaze M:
Endoplasmic reticulum stress as a therapeutic target in
cardiovascular disease. Circ Res. 107:1071–1082. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Ghosh R and Pattison JS: Macroautophagy
and chaperone-mediated autophagy in heart failure: The known and
the unknown. Oxid Med Cell Longev. 2018:86020412018. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Nemchenko A, Chiong M, Turer A, Lavandero
S and Hill JA: Autophagy as a therapeutic target in cardiovascular
disease. J Mol Cell Cardiol. 51:584–593. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Wang ZV, Ferdous A and Hill JA:
Cardiomyocyte autophagy: Metabolic profit and loss. Heart Fail Rev.
18:585–594. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Chen J, Li L, Bai X, Xiao L, Shangguan J,
Zhang W, Zhang X, Wang S and Liu G: Inhibition of autophagy
prevents panax notoginseng saponins (PNS) protection on cardiac
myocytes against endoplasmic reticulum (ER) stress-induced
mitochondrial injury, Ca(2+) homeostasis and associated apoptosis.
Front Pharmacol. 12:6208122021. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Hariharan N, Ikeda Y, Hong C, Alcendor RR,
Usui S, Gao S, Maejima Y and Sadoshima J: Autophagy plays an
essential role in mediating regression of hypertrophy during
unloading of the heart. PLoS One. 8:e516322013. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Shi S and Jiang P: Therapeutic potentials
of modulating autophagy in pathological cardiac hypertrophy. Biomed
Pharmacother. 156:1139672022. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Onohara N, Nishida M, Inoue R, Kobayashi
H, Sumimoto H, Sato Y, Mori Y, Nagao T and Kurose H: TRPC3 and
TRPC6 are essential for angiotensin II-induced cardiac hypertrophy.
EMBO J. 25:5305–5316. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Selvaraj S, Sun Y, Watt JA, Wang S, Lei S,
Birnbaumer L and Singh BB: Neurotoxin-induced ER stress in mouse
dopaminergic neurons involves downregulation of TRPC1 and
inhibition of AKT/mTOR signaling. J Clin Invest. 122:1354–1367.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
González A, Schelbert EB, Díez J and
Butler J: Myocardial interstitial fibrosis in heart failure:
Biological and translational perspectives. J Am Coll Cardiol.
71:1696–1706. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Wu YL, Xie J, An SW, Oliver N, Barrezueta
NX, Lin MH, Birnbaumer L and Huang CL: Inhibition of TRPC6 channels
ameliorates renal fibrosis and contributes to renal protection by
soluble klotho. Kidney Int. 91:830–841. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Hofmann K, Fiedler S, Vierkotten S, Weber
J, Klee S, Jia J, Zwickenpflug W, Flockerzi V, Storch U, Yildirim
AÖ, et al: Classical transient receptor potential 6 (TRPC6)
channels support myofibroblast differentiation and development of
experimental pulmonary fibrosis. Biochim Biophys Acta Mol Basis
Dis. 1863:560–568. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Davis J, Burr AR, Davis GF, Birnbaumer L
and Molkentin JD: A TRPC6-dependent pathway for myofibroblast
transdifferentiation and wound healing in vivo. Dev Cell.
23:705–715. 2012. View Article : Google Scholar : PubMed/NCBI
|
