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M2 macrophage‑derived exosomes alleviate KCa3.1 channel expression in rapidly paced HL‑1 myocytes via the NF‑κB (p65)/STAT3 signaling pathway

  • Authors:
    • Huiyu Chen
    • Huafen Liu
    • Dishiwen Liu
    • Yuntao Fu
    • Yajun Yao
    • Zhen Cao
    • Zhibin Peng
    • Mei Yang
    • Qingyan Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Cardiology, Yidu People's Hospital, Yidu, Hubei 443000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 55
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    Published online on: February 8, 2024
       https://doi.org/10.3892/mmr.2024.13179
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Abstract

The present study was designed to explore the role of M2 macrophage‑derived exosomes (M2‑exos) on the KCa3.1 channel in a cellular atrial fibrillation (AF) model using rapidly paced HL‑1 myocytes. M2 macrophages and M2‑exos were isolated and identified. MicroRNA (miR)‑146a‑5p levels in M2 macrophages and M2‑exos were quantified using reverse transcription‑quantitative PCR (RT‑qPCR). HL‑1 myocytes were randomly divided into six groups: Control group, pacing group, pacing + coculture group (pacing HL‑1 cells cocultured with M2‑exos), pacing + mimic‑miR‑146a‑5p group, pacing + NC‑miR‑146a‑5p group and pacing + pyrrolidine dithiocarbamate (PDTC; a special blocker of the NF‑κB signaling pathway) group. Transmission electron microscopy, nanoparticle tracking analysis, western blotting, RT‑qPCR and immunohistochemistry were performed in the present study. A whole‑cell clamp was also applied to record the current density of KCa3.1 and action potential duration (APD) in each group. The results revealed that miR‑146a‑5p was highly expressed in both M2 macrophages and M2‑exos. Pacing HL‑1 cells led to a shorter APD, an increased KCa3.1 current density and higher protein levels of KCa3.1, phosphorylated (p‑)NF‑κB p65, p‑STAT3 and IL‑1β compared with the control group. M2‑exos, miR‑146a‑5p‑mimic and PDTC both reduced the protein expression of KCa3.1, p‑NF‑κB p65, p‑STAT3 and IL‑1β and the current density of KCa3.1, resulting in a longer APD in the pacing HL‑1 cells. In conclusion, M2‑exos and their cargo, which comprised miR‑146a‑5p, decreased KCa3.1 expression and IL‑1β secretion in pacing HL‑1 cells via the NF‑κB/STAT3 signaling pathway, limiting the shorter APD caused by rapid pacing.
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View References

1 

Hua T, Yang M, Song H, Kong E, Deng M, Li Y, Li J, Liu Z, Fu H, Wang Y and Yuan H: Huc-MSCs-derived exosomes attenuate inflammatory pain by regulating microglia pyroptosis and autophagy via the miR-146a-5p/TRAF6 axis. J Nanobiotechnology. 20:3242022. View Article : Google Scholar : PubMed/NCBI

2 

Yuan Y, Mei Z, Qu Z, Li G, Yu S, Liu Y, Liu K, Shen Z, Pu J, Wang Y, et al: Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure. Signal Transduct Target Ther. 8:1212023. View Article : Google Scholar : PubMed/NCBI

3 

Lin YN, Mesquita T, Sanchez L, Chen YH, Liu W, Li C, Rogers R, Wang Y, Li X, Wu D, et al: Extracellular vesicles from immortalized cardiosphere-derived cells attenuate arrhythmogenic cardiomyopathy in desmoglein-2 mutant mice. Eur Heart J. 42:3558–3571. 2021. View Article : Google Scholar : PubMed/NCBI

4 

Sagris M, Vardas EP, Theofilis P, Antonopoulos AS, Oikonomou E and Tousoulis D: Atrial fibrillation: Pathogenesis, predisposing factors, and genetics. Int J Mol Sci. 23:62021. View Article : Google Scholar : PubMed/NCBI

5 

Pegtel DM and Gould SJ: Exosomes. Annu Rev Biochem. 88:487–514. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Chen P, Wang L, Fan X, Ning X, Yu B, Ou C and Chen M: Targeted delivery of extracellular vesicles in heart injury. Theranostics. 11:2263–2277. 2021. View Article : Google Scholar : PubMed/NCBI

7 

Shaihov-Teper O, Ram E, Ballan N, Brzezinski RY, Naftali-Shani N, Masoud R, Ziv T, Lewis N, Schary Y, Levin-Kotler LP, et al: Extracellular vesicles from epicardial fat facilitate atrial fibrillation. Circulation. 143:2475–2493. 2021. View Article : Google Scholar : PubMed/NCBI

8 

Zhang Z, Xu Y, Cao C, Wang B, Guo J, Qin Z, Lu Y, Zhang J, Zhang L, Wang W, et al: Exosomes as a messager to regulate the crosstalk between macrophages and cardiomyocytes under hypoxia conditions. J Cell Mol Med. 26:1486–1500. 2022. View Article : Google Scholar : PubMed/NCBI

9 

Yao Y, He S, Wang Y, Cao Z, Liu D, Fu Y, Chen H, Wang X and Zhao Q: Blockade of exosome release suppresses atrial fibrillation by alleviating atrial fibrosis in canines with prolonged atrial pacing. Front Cardiovasc Med. 8:6991752021. View Article : Google Scholar : PubMed/NCBI

10 

He S, Wang Y, Yao Y, Cao Z, Yin J, Zi L, Chen H, Fu Y, Wang X and Zhao Q: Inhibition of KCa3.1 channels suppresses atrial fibrillation via the attenuation of macrophage pro-inflammatory polarization in a canine model with prolonged rapid atrial pacing. Front Cardiovasc Med. 8:6566312021. View Article : Google Scholar : PubMed/NCBI

11 

Sun Z, Ying X, Zhao W, He Y, Wang Z, Zheng L, Chen W and Xu H: M2c macrophages prevent atrial fibrillation in association with the inhibition of KCNQ1 in human embryonic stem cell-derived atrial-like cardiomyocytes. Hellenic J Cardiol. 62:457–459. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, et al: Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 7:15357502018. View Article : Google Scholar : PubMed/NCBI

13 

Liu D, Yang M, Yao Y, He S, Wang Y, Cao Z, Chen H, Fu Y, Liu H and Zhao Q: Cardiac fibroblasts promote ferroptosis in atrial fibrillation by secreting Exo-miR-23a-3p Targeting SLC7A11. Oxid Med Cell Longev. 2022:39614952022.PubMed/NCBI

14 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Odell ID and Cook D: Immunofluorescence techniques. J Invest Dermatol. 133:e42013. View Article : Google Scholar : PubMed/NCBI

16 

Al-Owais MM, Hettiarachchi NT, Dallas ML, Scragg JL, Lippiat JD, Holden AV, Steele DS and Peers C: Inhibition of the voltage-gated potassium channel Kv1.5 by hydrogen sulfide attenuates remodeling through S-nitrosylation-mediated signaling. Commun Biol. 6:6512023. View Article : Google Scholar : PubMed/NCBI

17 

Yang Z, Shen W, Rottman JN, Wikswo JP and Murray KT: Rapid stimulation causes electrical remodeling in cultured atrial myocytes. J Mol Cell Cardiol. 38:299–308. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Brundel BJ, Kampinga HH and Henning RH: Calpain inhibition prevents pacing-induced cellular remodeling in a HL-1 myocyte model for atrial fibrillation. Cardiovasc Res. 62:521–528. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Weisbrod D, Khun SH, Bueno H, Peretz A and Attali B: Mechanisms underlying the cardiac pacemaker: The role of SK4 calcium-activated potassium channels. Acta Pharmacologica Sinica. 37:82–97. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Liebau S, Tischendorf M, Ansorge D, Linta L, Stockmann M, Weidgang C, Iacovino M, Boeckers T, von Wichert G, Kyba M and Kleger A: An inducible expression system of the calcium-activated potassium channel 4 to study the differential impact on embryonic stem cells. Stem Cells Int. 2011:4568152011. View Article : Google Scholar : PubMed/NCBI

21 

Weisbrod D, Peretz A, Ziskind A, Menaker N, Oz S, Barad L, Eliyahu S, Itskovitz-Eldor J, Dascal N, Khananshvili D, et al: SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells. Proc Natl Acad Sci USA. 110:E1685–E1694. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Haron-Khun S, Weisbrod D, Bueno H, Yadin D, Behar J, Peretz A, Binah O, Hochhauser E, Eldar M, Yaniv Y, et al: SK4 K channels are therapeutic targets for the treatment of cardiac arrhythmias. EMBO Mol Med. 9:415–429. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Yang M, Wang Y, Zhao H, Yin J, Zi L, Wang X, Tang Y, Huang C and Zhao Q: Role of intermediate-conductance calcium-activated potassium channels in atrial fibrillation in canines with rapid atrial pacing. J Interv Card Electrophysiol. 60:247–253. 2021. View Article : Google Scholar : PubMed/NCBI

24 

Davidson SM, Boulanger CM, Aikawa E, Badimon L, Barile L, Binder CJ, Brisson A, Buzas E, Emanueli C, Jansen F, et al: Methods for the identification and characterization of extracellular vesicles in cardiovascular studies: From exosomes to microvesicles. Cardiovasc Res. 119:45–63. 2023. View Article : Google Scholar : PubMed/NCBI

25 

Hirai K, Ousaka D, Fukushima Y, Kondo M, Eitoku T, Shigemitsu Y, Hara M, Baba K, Iwasaki T, Kasahara S, et al: Cardiosphere-derived exosomal microRNAs for myocardial repair in pediatric dilated cardiomyopathy. Sci Transl Med. 12:eabb33362020. View Article : Google Scholar : PubMed/NCBI

26 

Dong M, Chen D, Zhu Y, Yang S, Kumar S, Zhang R, Zhou Y, Yang Z, Zheng N, Zhu T, et al: Impaired regulation of MMP2/16-MLCK3 by miR-146a-5p increased susceptibility to myocardial ischaemic injury in aging mice. Cardiovasc Res. 119:786–801. 2023. View Article : Google Scholar : PubMed/NCBI

27 

Rivera-Caravaca JM, Teruel-Montoya R, Roldán V, Cifuentes-Riquelme R, Crespo-Matas JA, de Los Reyes-García AM, Águila S, Fernández-Pérez MP, Reguilón-Gallego L, Zapata-Martínez L, et al: Pilot study on the role of circulating miRNAs for the improvement of the predictive ability of the 2MACE score in patients with atrial fibrillation. J Clin Med. 9:36452020. View Article : Google Scholar : PubMed/NCBI

28 

Zhang QB, Qing YF, Yin CC, Zhou L, Liu XS, Mi QS and Zhou JG: Mice with miR-146a deficiency develop severe gouty arthritis via dysregulation of TRAF 6, IRAK 1 and NALP3 inflammasome. Arthritis Res Ther. 20:452018. View Article : Google Scholar : PubMed/NCBI

29 

Pan J, Du M, Cao Z, Zhang C, Hao Y, Zhu J and He H: miR-146a-5p attenuates IL-1β-induced IL-6 and IL-1β expression in a cementoblast-derived cell line. Oral Dis. 26:1308–1317. 2020. View Article : Google Scholar : PubMed/NCBI

30 

Su YL, Wang X, Mann M, Adamus TP, Wang D, Moreira DF, Zhang Z, Ouyang C, He X, Zhang B, et al: Myeloid cell-targeted miR-146a mimic inhibits NF-κB-driven inflammation and leukemia progression in vivo. Blood. 135:167–180. 2020. View Article : Google Scholar : PubMed/NCBI

31 

Meng Q, Liang C, Hua J, Zhang B, Liu J, Zhang Y, Wei M, Yu X, Xu J and Shi S: A miR-146a-5p/TRAF6/NF-kB p65 axis regulates pancreatic cancer chemoresistance: Functional validation and clinical significance. Theranostics. 10:3967–3979. 2020. View Article : Google Scholar : PubMed/NCBI

32 

Sun W, Ma J, Zhao H, Xiao C, Zhong H, Ling H, Xie Z, Tian Q, Chen H, Zhang T, et al: Resolvin D1 suppresses pannus formation via decreasing connective tissue growth factor caused by upregulation of miRNA-146a-5p in rheumatoid arthritis. Arthritis Res Ther. 22:612020. View Article : Google Scholar : PubMed/NCBI

33 

Zhang L, Wei X, Wang Z, Liu P, Hou Y, Xu Y, Su H, Koci MD, Yin H and Zhang C: NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking. Cell Rep. 42:1121852023. View Article : Google Scholar : PubMed/NCBI

34 

Liu X, Zhang W, Luo J, Shi W, Zhang X, Li Z, Qin X, Liu B and Wei Y: TRIM21 deficiency protects against atrial inflammation and remodeling post myocardial infarction by attenuating oxidative stress. Redox Biol. 62:1026792023. View Article : Google Scholar : PubMed/NCBI

35 

Liu Y, Wu F, Wu Y, Elliott M, Zhou W, Deng Y, Ren D and Zhao H: Mechanism of IL-6-related spontaneous atrial fibrillation after coronary artery grafting surgery: IL-6 knockout mouse study and human observation. Transl Res. 233:16–31. 2021. View Article : Google Scholar : PubMed/NCBI

36 

Ye T, Zhang C, Wu G, Wan W, Liang J, Liu X, Liu D and Yang B: Pinocembrin attenuates autonomic dysfunction and atrial fibrillation susceptibility via inhibition of the NF-κB/TNF-α pathway in a rat model of myocardial infarction. Int Immunopharmacol. 77:1059262019. View Article : Google Scholar : PubMed/NCBI

37 

Xu H, Lai W, Zhang Y, Liu L, Luo X, Zeng Y, Wu H, Lan Q and Chu Z: Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner. BMC Cancer. 14:3302014. View Article : Google Scholar : PubMed/NCBI

38 

Zheng F, Tao Y, Liu J, Geng Z, Wang Y, Wang Y, Fu S, Wang W, Xie C, Zhang Y and Gong F: KCa3.1 inhibition of macrophages suppresses inflammatory response leading to endothelial damage in a cell model of kawasaki disease. J Inflamm Res. 14:719–735. 2021. View Article : Google Scholar : PubMed/NCBI

39 

Jiang XX, Bian W, Zhu YR, Wang Z, Ye P, Gu Y, Zhang H, Zuo G, Li X, Zhu L, et al: Targeting the KCa3.1 channel suppresses diabetes-associated atherosclerosis via the STAT3/CD36 axis. Diabetes Res Clin Pract. 185:1097762022. View Article : Google Scholar : PubMed/NCBI

40 

McFarland BC, Hong SW, Rajbhandari R, Twitty GB Jr, Gray GK, Yu H, Benveniste EN and Nozell SE: NF-κB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma. PLoS One. 8:e787282013. View Article : Google Scholar : PubMed/NCBI

41 

Cogswell JP, Godlevski MM, Wisely GB, Clay WC, Leesnitzer LM, Ways JP and Gray JG: NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site. J Immunol. 153:712–723. 1994. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen H, Liu H, Liu D, Fu Y, Yao Y, Cao Z, Peng Z, Yang M and Zhao Q: M2 macrophage‑derived exosomes alleviate KCa3.1 channel expression in rapidly paced HL‑1 myocytes via the NF‑κB (p65)/STAT3 signaling pathway. Mol Med Rep 29: 55, 2024.
APA
Chen, H., Liu, H., Liu, D., Fu, Y., Yao, Y., Cao, Z. ... Zhao, Q. (2024). M2 macrophage‑derived exosomes alleviate KCa3.1 channel expression in rapidly paced HL‑1 myocytes via the NF‑κB (p65)/STAT3 signaling pathway. Molecular Medicine Reports, 29, 55. https://doi.org/10.3892/mmr.2024.13179
MLA
Chen, H., Liu, H., Liu, D., Fu, Y., Yao, Y., Cao, Z., Peng, Z., Yang, M., Zhao, Q."M2 macrophage‑derived exosomes alleviate KCa3.1 channel expression in rapidly paced HL‑1 myocytes via the NF‑κB (p65)/STAT3 signaling pathway". Molecular Medicine Reports 29.4 (2024): 55.
Chicago
Chen, H., Liu, H., Liu, D., Fu, Y., Yao, Y., Cao, Z., Peng, Z., Yang, M., Zhao, Q."M2 macrophage‑derived exosomes alleviate KCa3.1 channel expression in rapidly paced HL‑1 myocytes via the NF‑κB (p65)/STAT3 signaling pathway". Molecular Medicine Reports 29, no. 4 (2024): 55. https://doi.org/10.3892/mmr.2024.13179
Copy and paste a formatted citation
x
Spandidos Publications style
Chen H, Liu H, Liu D, Fu Y, Yao Y, Cao Z, Peng Z, Yang M and Zhao Q: M2 macrophage‑derived exosomes alleviate KCa3.1 channel expression in rapidly paced HL‑1 myocytes via the NF‑κB (p65)/STAT3 signaling pathway. Mol Med Rep 29: 55, 2024.
APA
Chen, H., Liu, H., Liu, D., Fu, Y., Yao, Y., Cao, Z. ... Zhao, Q. (2024). M2 macrophage‑derived exosomes alleviate KCa3.1 channel expression in rapidly paced HL‑1 myocytes via the NF‑κB (p65)/STAT3 signaling pathway. Molecular Medicine Reports, 29, 55. https://doi.org/10.3892/mmr.2024.13179
MLA
Chen, H., Liu, H., Liu, D., Fu, Y., Yao, Y., Cao, Z., Peng, Z., Yang, M., Zhao, Q."M2 macrophage‑derived exosomes alleviate KCa3.1 channel expression in rapidly paced HL‑1 myocytes via the NF‑κB (p65)/STAT3 signaling pathway". Molecular Medicine Reports 29.4 (2024): 55.
Chicago
Chen, H., Liu, H., Liu, D., Fu, Y., Yao, Y., Cao, Z., Peng, Z., Yang, M., Zhao, Q."M2 macrophage‑derived exosomes alleviate KCa3.1 channel expression in rapidly paced HL‑1 myocytes via the NF‑κB (p65)/STAT3 signaling pathway". Molecular Medicine Reports 29, no. 4 (2024): 55. https://doi.org/10.3892/mmr.2024.13179
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