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Review Open Access

Research advances of MAL family members in tumorigenesis and tumor progression (Review)

  • Authors:
    • Mengyao Li
    • Yan Du
    • Xianzhuo Zhang
    • Wence Zhou
  • View Affiliations / Copyright

    Affiliations: The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu 730000, P.R. China, The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 57
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    Published online on: February 14, 2024
       https://doi.org/10.3892/mmr.2024.13181
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Abstract

The myelin and lymphocyte protein (MAL) family is a novel gene family first identified and characterized in 2002. This family is comprised of seven members, including MAL, MAL2, plasmolipin, MALL, myeloid differentiation‑associated marker (MYADM), MYADML2 and CMTM8, which are located on different chromosomes. In addition to exhibiting extensive activity during transcytosis, the MAL family plays a vital role in the neurological, digestive, respiratory, genitourinary and other physiological systems. Furthermore, the intimate association between MAL and the pathogenesis, progression and metastasis of malignancies, attributable to several mechanisms such as DNA methylation has also been elucidated. In the present review, an overview of the structural and functional properties of the MAL family and the latest research findings regarding the relationship between several MAL members and various cancers is provided. Furthermore, the potential clinical and scientific significance of MAL is discussed and directions for future research are summarized.
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Spandidos Publications style
Li M, Du Y, Zhang X and Zhou W: Research advances of MAL family members in tumorigenesis and tumor progression (Review). Mol Med Rep 29: 57, 2024.
APA
Li, M., Du, Y., Zhang, X., & Zhou, W. (2024). Research advances of MAL family members in tumorigenesis and tumor progression (Review). Molecular Medicine Reports, 29, 57. https://doi.org/10.3892/mmr.2024.13181
MLA
Li, M., Du, Y., Zhang, X., Zhou, W."Research advances of MAL family members in tumorigenesis and tumor progression (Review)". Molecular Medicine Reports 29.4 (2024): 57.
Chicago
Li, M., Du, Y., Zhang, X., Zhou, W."Research advances of MAL family members in tumorigenesis and tumor progression (Review)". Molecular Medicine Reports 29, no. 4 (2024): 57. https://doi.org/10.3892/mmr.2024.13181
Copy and paste a formatted citation
x
Spandidos Publications style
Li M, Du Y, Zhang X and Zhou W: Research advances of MAL family members in tumorigenesis and tumor progression (Review). Mol Med Rep 29: 57, 2024.
APA
Li, M., Du, Y., Zhang, X., & Zhou, W. (2024). Research advances of MAL family members in tumorigenesis and tumor progression (Review). Molecular Medicine Reports, 29, 57. https://doi.org/10.3892/mmr.2024.13181
MLA
Li, M., Du, Y., Zhang, X., Zhou, W."Research advances of MAL family members in tumorigenesis and tumor progression (Review)". Molecular Medicine Reports 29.4 (2024): 57.
Chicago
Li, M., Du, Y., Zhang, X., Zhou, W."Research advances of MAL family members in tumorigenesis and tumor progression (Review)". Molecular Medicine Reports 29, no. 4 (2024): 57. https://doi.org/10.3892/mmr.2024.13181
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