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Dicoumarol attenuates NLRP3 inflammasome activation to inhibit inflammation and fibrosis in knee osteoarthritis

  • Authors:
    • Wenjie Ge
    • Xian Zhang
    • Qing Wang
    • Jianjie Mao
    • Pengfei Jia
    • Jianping Cai
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics and Traumatology, Wuxi Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Wuxi, Jiangsu 214000, P.R. China
    Copyright: © Ge et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 100
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    Published online on: April 15, 2024
       https://doi.org/10.3892/mmr.2024.13224
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Abstract

Knee osteoarthritis (KOA) is a major cause of disability in elderly individuals. Dicoumarol is a coumarin‑like compound derived from sweet clover [Melilotus officinalis (L.) Pall]. It has been suggested that dicoumarol exhibits various types of pharmacological activities, including anticoagulant, antitumor and antibacterial effects. Due to its various biological activities, dicoumarol has a potential protective effect against OA. Therefore, the present study aimed to assess the effects of dicoumarol on knee osteoarthritis. In the present study, dicoumarol was found to protect rat synoviocytes from lipopolysaccharide (LPS)‑induced cell apoptosis. Western blot analysis showed that dicoumarol significantly reduced the protein expression levels of fibrosis‑related markers and inflammatory cytokines (Tgfb, Timp, Col1a, Il1b and Il18). The inhibitory rates of these proteins were all >50% (P<0.01) compared with those in the LPS and ATP‑induced group. Consistently, the mRNA expression levels of these markers and cytokines were decreased to normal levels by dicoumarol after the treatment of rat synovial fibroblasts with LPS and ATP. Mechanistic studies demonstrated that dicoumarol did not affect NF‑κB signaling, but it did directly interact with NOD‑like receptor protein 3 (NLRP3) to promote its protein degradation, which could be reversed by MG132, but not NH4Cl. The protein half‑life of NLRP3 was accelerated from 26.1 to 4.3 h by dicoumarol. Subsequently, dicoumarol could alleviate KOA in vivo; knee joint diameter was decreased from 11.03 to 9.93 mm. Furthermore, the inflammation and fibrosis of the knee joints were inhibited in rats. In conclusion, the present findings demonstrated that dicoumarol could impede the progression of KOA by inhibiting NLRP3 activation, providing a potential treatment strategy for KOA.
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1 

Lv Z, Yang YX, Li J, Fei Y, Guo H, Sun Z, Lu J, Xu X, Jiang Q, Ikegawa S and Shi D: Molecular classification of knee osteoarthritis. Front Cell Dev Biol. 9:7255682021. View Article : Google Scholar

2 

Mintarjo JA, Poerwanto E and Tedyanto EH: Current non-surgical management of knee osteoarthritis. Cureus. 15:e409662023.PubMed/NCBI

3 

Onuora S: Osteoarthritis: OA chondrocytes made senescent by genomic DNA damage. Nat Rev Rheumatol. 8:5022012. View Article : Google Scholar

4 

Dell'Isola A, Allan R, Smith SL, Marreiros SS and Steultjens M: Identification of clinical phenotypes in knee osteoarthritis: A systematic review of the literature. BMC Musculoskelet Disord. 17:4252016. View Article : Google Scholar

5 

Du X, Liu ZY, Tao XX, Mei YL, Zhou DQ, Cheng K, Gao SL, Shi HY, Song C and Zhang XM: Research progress on the pathogenesis of knee osteoarthritis. Orthop Surg. 15:2213–2224. 2023. View Article : Google Scholar : PubMed/NCBI

6 

Peloso P, Chen W, Lin HL, Gates D, Straus W and Moore R: (363) Pain improvement in osteoarthritis (OA) predicts improved functioning. J Pain. 15 (Suppl):S662014. View Article : Google Scholar

7 

Li R, Sun J, Hu H, Zhang Q, Sun R, Zhou S, Zhang H and Fang J: Research trends of acupuncture therapy on knee osteoarthritis from 2010 to 2019: A bibliometric analysis. J Pain Res. 13:1901–1913. 2020. View Article : Google Scholar : PubMed/NCBI

8 

Georgiev T and Angelov AK: Modifiable risk factors in knee osteoarthritis: Treatment implications. Rheumatol Int. 39:1145–1157. 2019. View Article : Google Scholar

9 

Zhang J, Fan F, Liu A, Zhang C, Li Q, Zhang C, He F and Shang M: Icariin: A potential molecule for treatment of knee osteoarthritis. Front Pharmacol. 13:8118082022. View Article : Google Scholar

10 

Yang X, Thudium CS, Bay-Jensen AC, Karsdal MA, van Santen J, Arden NK, Perry TA and Kluzek S: Association between markers of synovial inflammation, matrix turnover and symptoms in knee osteoarthritis: A cross-sectional study. Cells. 10:18262021. View Article : Google Scholar : PubMed/NCBI

11 

Li X, Mei W, Huang Z, Zhang L, Zhang L, Xu B, Shi X, Xiao Y, Ma Z, Liao T, et al: Casticin suppresses monoiodoacetic acid-induced knee osteoarthritis through inhibiting HIF-1α/NLRP3 inflammasome signaling. Int Immunopharmacol. 86:1067452020. View Article : Google Scholar

12 

Tan Q, Cai Z, Li J, Li J, Xiang H, Li B and Cai G: Imaging study on acupuncture inhibiting inflammation and bone destruction in knee osteoarthritis induced by monosodium iodoacetate in rat model. J Pain Res. 15:93–103. 2022. View Article : Google Scholar : PubMed/NCBI

13 

Jo EK, Kim JK, Shin DM and Sasakawa C: Molecular mechanisms regulating NLRP3 inflammasome activation. Cell Mol Immunol. 13:148–159. 2016. View Article : Google Scholar

14 

Zhang L, Li X, Zhang H, Huang Z, Zhang N, Zhang L, Xing R and Wang P: Agnuside alleviates synovitis and fibrosis in knee osteoarthritis through the inhibition of HIF-1α and NLRP3 inflammasome. Mediators Inflamm. 2021:55346142021. View Article : Google Scholar : PubMed/NCBI

15 

Sharma BR and Kanneganti TD: NLRP3 inflammasome in cancer and metabolic diseases. Nat Immunol. 22:550–559. 2021. View Article : Google Scholar

16 

Xu J and Núñez G: The NLRP3 inflammasome: Activation and regulation. Trends Biochem Sci. 48:331–344. 2023. View Article : Google Scholar

17 

Zhou R, Yazdi AS, Menu P and Tschopp J: A role for mitochondria in NLRP3 inflammasome activation. Nature. 469:221–225. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Kaufmann FN, Costa AP, Ghisleni G, Diaz AP, Rodrigues ALS, Peluffo H and Kaster MP: NLRP3 inflammasome-driven pathways in depression: Clinical and preclinical findings. Brain Behav Immun. 64:367–383. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Afonina IS, Zhong Z, Karin M and Beyaert R: Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome. Nat Immunol. 18:861–869. 2017. View Article : Google Scholar

20 

Conway R and McCarthy GM: Calcium-containing crystals and osteoarthritis: An unhealthy alliance. Curr Rheumatol Rep. 20:132018. View Article : Google Scholar : PubMed/NCBI

21 

Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP and Fahmi H: Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 7:33–42. 2011. View Article : Google Scholar

22 

Ding L, Liao T, Yang N, Wei Y, Xing R, Wu P, Li X, Mao J and Wang P: Chrysin ameliorates synovitis and fibrosis of osteoarthritic fibroblast-like synoviocytes in rats through PERK/TXNIP/NLRP3 signaling. Front Pharmacol. 14:11702432023. View Article : Google Scholar

23 

Zhao LR, Xing RL, Wang PM, Zhang NS, Yin SJ, Li XC and Zhang L: NLRP1 and NLRP3 inflammasomes mediate LPS/ATP-induced pyroptosis in knee osteoarthritis. Mol Med Rep. 17:5463–5469. 2018.PubMed/NCBI

24 

Ma Z, Huang Z, Zhang L, Li X, Xu B, Xiao Y, Shi X, Zhang H, Liao T and Wang P: Vanillic acid reduces pain-related behavior in knee osteoarthritis rats through the inhibition of NLRP3 inflammasome-related synovitis. Front Pharmacol. 11:5990222021. View Article : Google Scholar

25 

Sun C, Zhao W, Wang X, Sun Y and Chen X: A pharmacological review of dicoumarol: An old natural anticoagulant agent. Pharmacol Res. 160:1051932020. View Article : Google Scholar : PubMed/NCBI

26 

Chkhikvishvili I, Mamniashvili T, Gogia N, Enukidze M, Machavariani M and Sanikidze T: Antioxidant, anti-inflammatory activity of georgian leguminous crops cultures. Georgian Med News. 147–153. 2017.

27 

Timson DJ: Dicoumarol: A drug which hits at least two very different targets in vitamin K metabolism. Curr Drug Targets. 18:500–510. 2017. View Article : Google Scholar : PubMed/NCBI

28 

PERONNET, . Anticoagulants, heparin and dicoumarol. Fr Med. 11:3–8. 1948.(In French).

29 

Council NJP: Guide for the Care and Use of Laboratory Animals. 8th edition. National Academies Press; Washington, DC: pp. 963–965. 2010

30 

Liao T, Ding L, Wu P, Zhang L, Li X, Xu B, Zhang H, Ma Z, Xiao Y and Wang P: Chrysin attenuates the NLRP3 inflammasome cascade to reduce synovitis and pain in KOA rats. Drug Des Devel Ther. 14:3015–3027. 2020. View Article : Google Scholar : PubMed/NCBI

31 

Cheng ST, Hu JL, Ren JH, Yu HB, Zhong S, Wai Wong VK, Kwan Law BY, Chen WX, Xu HM, Zhang ZZ, et al: Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx. J Hepatol. 74:522–534. 2021. View Article : Google Scholar

32 

Shi J, Zhao W, Ying H, Zhang Y, Du J, Chen S, Li J and Shen B: Estradiol inhibits NLRP3 inflammasome in fibroblast-like synoviocytes activated by lipopolysaccharide and adenosine triphosphate. Int J Rheum Dis. 21:2002–2010. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Zhang L, Xu J, Zhou S, Yao F, Zhang R, You W, Dai J, Yu K, Zhang Y, Baheti T, et al: Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma. J Hepatol. 80:82–98. 2024. View Article : Google Scholar

34 

Nàger M, Sallán MC, Visa A, Pushparaj C, Santacana M, Macià A, Yeramian A, Cantí C and Herreros J: Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers. Autophagy. 14:619–636. 2018. View Article : Google Scholar

35 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Bhattaram P and Chandrasekharan U: The joint synovium: A critical determinant of articular cartilage fate in inflammatory joint diseases. Semin Cell Dev Biol. 62:86–93. 2017. View Article : Google Scholar

37 

Toldo S, Mezzaroma E, Buckley LF, Potere N, Di Nisio M, Biondi-Zoccai G, Van Tassell BW and Abbate A: Targeting the NLRP3 inflammasome in cardiovascular diseases. Pharmacol Ther. 236:1080532022. View Article : Google Scholar : PubMed/NCBI

38 

Shao BZ, Xu ZQ, Han BZ, Su DF and Liu C: NLRP3 inflammasome and its inhibitors: A review. Front Pharmacol. 6:2622015. View Article : Google Scholar

39 

He Y, Hara H and Núñez G: Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci. 41:1012–1021. 2016. View Article : Google Scholar

40 

Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitzgerald KA, Wu H and Egelman EH: Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell. 156:1193–1206. 2014. View Article : Google Scholar

41 

Elliott EI and Sutterwala FS: Initiation and perpetuation of NLRP3 inflammasome activation and assembly. Immunol Rev. 265:35–52. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Shimizu H, Shimoura K, Iijima H, Suzuki Y and Aoyama T: Functional manifestations of early knee osteoarthritis: A systematic review and meta-analysis. Clin Rheumatol. 41:2625–2634. 2022. View Article : Google Scholar

43 

Rannou F and Poiraudeau S: Non-pharmacological approaches for the treatment of osteoarthritis. Best Pract Res Clin Rheumatol. 24:93–106. 2010. View Article : Google Scholar

44 

Geng R, Li J, Yu C, Zhang C, Chen F, Chen J, Ni H, Wang J, Kang K, Wei Z, et al: Knee osteoarthritis: Current status and research progress in treatment (Review). Exp Ther Med. 26:4812023. View Article : Google Scholar : PubMed/NCBI

45 

Okada K, Yamaguchi S, Sato Y, Enomoto T, Ogawa Y, Ohtori S, Tahara M and Sasho T: Comparison of meniscal extrusion and osteophyte formation at the intercondylar notch as a predictive biomarker for incidence of knee osteoarthritis-data from the osteoarthritis initiative. J Orthop Sci. 24:121–127. 2019. View Article : Google Scholar

46 

Whittaker JL, Runhaar J, Bierma-Zeinstra S and Roos EM: A lifespan approach to osteoarthritis prevention. Osteoarthritis Cartilage. 29:1638–1653. 2021. View Article : Google Scholar : PubMed/NCBI

47 

Wang M, Liu L, Zhang CS, Liao Z, Jing X, Fishers M, Zhao L, Xu X and Li B: Mechanism of traditional Chinese medicine in treating knee osteoarthritis. J Pain Res. 13:1421–1429. 2020. View Article : Google Scholar : PubMed/NCBI

48 

Place DE and Kanneganti TD: Recent advances in inflammasome biology. Curr Opin Immunol. 50:32–38. 2018. View Article : Google Scholar

49 

Samadfam R, Chouinard L, Norton K and Smith S: Pain assessment in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) model. J Pharmacol Toxicol Methods. 68:e392013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ge W, Zhang X, Wang Q, Mao J, Jia P and Cai J: Dicoumarol attenuates NLRP3 inflammasome activation to inhibit inflammation and fibrosis in knee osteoarthritis. Mol Med Rep 29: 100, 2024.
APA
Ge, W., Zhang, X., Wang, Q., Mao, J., Jia, P., & Cai, J. (2024). Dicoumarol attenuates NLRP3 inflammasome activation to inhibit inflammation and fibrosis in knee osteoarthritis. Molecular Medicine Reports, 29, 100. https://doi.org/10.3892/mmr.2024.13224
MLA
Ge, W., Zhang, X., Wang, Q., Mao, J., Jia, P., Cai, J."Dicoumarol attenuates NLRP3 inflammasome activation to inhibit inflammation and fibrosis in knee osteoarthritis". Molecular Medicine Reports 29.6 (2024): 100.
Chicago
Ge, W., Zhang, X., Wang, Q., Mao, J., Jia, P., Cai, J."Dicoumarol attenuates NLRP3 inflammasome activation to inhibit inflammation and fibrosis in knee osteoarthritis". Molecular Medicine Reports 29, no. 6 (2024): 100. https://doi.org/10.3892/mmr.2024.13224
Copy and paste a formatted citation
x
Spandidos Publications style
Ge W, Zhang X, Wang Q, Mao J, Jia P and Cai J: Dicoumarol attenuates NLRP3 inflammasome activation to inhibit inflammation and fibrosis in knee osteoarthritis. Mol Med Rep 29: 100, 2024.
APA
Ge, W., Zhang, X., Wang, Q., Mao, J., Jia, P., & Cai, J. (2024). Dicoumarol attenuates NLRP3 inflammasome activation to inhibit inflammation and fibrosis in knee osteoarthritis. Molecular Medicine Reports, 29, 100. https://doi.org/10.3892/mmr.2024.13224
MLA
Ge, W., Zhang, X., Wang, Q., Mao, J., Jia, P., Cai, J."Dicoumarol attenuates NLRP3 inflammasome activation to inhibit inflammation and fibrosis in knee osteoarthritis". Molecular Medicine Reports 29.6 (2024): 100.
Chicago
Ge, W., Zhang, X., Wang, Q., Mao, J., Jia, P., Cai, J."Dicoumarol attenuates NLRP3 inflammasome activation to inhibit inflammation and fibrosis in knee osteoarthritis". Molecular Medicine Reports 29, no. 6 (2024): 100. https://doi.org/10.3892/mmr.2024.13224
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