Open Access

Mincle as a potential intervention target for the prevention of inflammation and fibrosis (Review)

  • Authors:
    • Yuanxia Zou
    • Jianchun Li
    • Hongwei Su
    • Nathupakorn Dechsupa
    • Jian Liu
    • Li Wang
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  • Published online on: April 18, 2024     https://doi.org/10.3892/mmr.2024.13227
  • Article Number: 103
  • Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Macrophage‑inducible C‑type lectin receptor (Mincle) is predominantly found on antigen‑presenting cells. It can recognize specific ligands when stimulated by certain pathogens such as fungi and Mycobacterium tuberculosis. This recognition triggers the activation of the nuclear factor‑κB pathway, leading to the production of inflammatory factors and contributing to the innate immune response of the host. Moreover, Mincle identifies lipid damage‑related molecules discharged by injured cells, such as Sin3‑associated protein 130, which triggers aseptic inflammation and ultimately hastens the advancement of renal damage, autoimmune disorders and malignancies by fostering tissue inflammation. Presently, research on the functioning of the Mincle receptor in different inflammatory and fibrosis‑associated conditions has emerged as a popular topic. Nevertheless, there remains a lack of research on the impact of Mincle in promoting long‑lasting inflammatory reactions and fibrosis. Additional investigation is required into the function of Mincle receptors in chronological inflammatory reactions and fibrosis of organ systems, including the progression from inflammation to fibrosis. Hence, the present study showed an overview of the primary roles and potential mechanism of Mincle in inflammation, fibrosis, as well as the progression of inflammation to fibrosis. The aim of the present study was to clarify the potential mechanism of Mincle in inflammation and fibrosis and to offer perspectives for the development of drugs that target Mincle.
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June-2024
Volume 29 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zou Y, Li J, Su H, Dechsupa N, Liu J and Wang L: Mincle as a potential intervention target for the prevention of inflammation and fibrosis (Review). Mol Med Rep 29: 103, 2024
APA
Zou, Y., Li, J., Su, H., Dechsupa, N., Liu, J., & Wang, L. (2024). Mincle as a potential intervention target for the prevention of inflammation and fibrosis (Review). Molecular Medicine Reports, 29, 103. https://doi.org/10.3892/mmr.2024.13227
MLA
Zou, Y., Li, J., Su, H., Dechsupa, N., Liu, J., Wang, L."Mincle as a potential intervention target for the prevention of inflammation and fibrosis (Review)". Molecular Medicine Reports 29.6 (2024): 103.
Chicago
Zou, Y., Li, J., Su, H., Dechsupa, N., Liu, J., Wang, L."Mincle as a potential intervention target for the prevention of inflammation and fibrosis (Review)". Molecular Medicine Reports 29, no. 6 (2024): 103. https://doi.org/10.3892/mmr.2024.13227