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Deciphering microglial activation and neuronal apoptosis post‑traumatic brain injury: The role of TYROBP in inflammation regulation networks

  • Authors:
    • Xudong Zhou
    • Huiping Song
    • Jingjing He
    • Wei Han
    • Qin Li
  • View Affiliations / Copyright

    Affiliations: The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, P.R. China, Emergency Department, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong 518060, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 104
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    Published online on: April 18, 2024
       https://doi.org/10.3892/mmr.2024.13228
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Abstract

Traumatic Brain Injury (TBI) represents a significant public health challenge. Recovery from brain injury necessitates the collaborative efforts of various resident neural cells, predominantly microglia. The present study analyzed rat and mouse RNA expression micro‑arrays, high‑throughput RNA sequencing and single‑cell sequencing data sourced from public databases. To construct an inflammation regulation network around TYRO protein tyrosine kinase‑binding protein (TYROBP), to evaluate the role of TYROBP in cell death after TBI. These findings indicate that following TBI, neurons predominantly communicate with one another through the CXC chemokine ligand (CXCL) and CC chemokine ligand (CCL) signaling pathways, employing a paracrine mechanism to activate microglia. These activated microglia intensify the pathological progression of brain injury by releasing factors such as tumor necrosis factor α (TNF‑α), vascular endothelial growth factor and transforming growth factor β via the NF‑κB pathway. Cells co‑culture experiments demonstrated that neurons, impaired by mechanical injury, interact with microglia through non‑contact mechanisms. Activated microglia secrete cytokines, including TNF‑α, CXCL‑8 and CCL2, which trigger an inflammatory response and facilitate neuronal apoptosis. TYROBP gene knockout in microglia was demonstrated to reduce this interaction and reduce neuronal cell apoptosis rates.
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1 

GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators, . Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 18:56–87. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Howlett JR, Nelson LD and Stein MB: Mental health consequences of traumatic brain injury. Biol Psychiatry. 91:413–420. 2022. View Article : Google Scholar : PubMed/NCBI

3 

Sharp DJ, Scott G and Leech R: Network dysfunction after traumatic brain injury. Nat Rev Neurol. 10:156–166. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Kenney K, Amyot F, Haber M, Pronger A, Bogoslovsky T, Moore C and Diaz-Arrastia R: Cerebral vascular injury in traumatic brain injury. Exp Neurol. 275:353–366. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Corps KN, Roth TL and McGavern DB: Inflammation and neuroprotection in traumatic brain injury. JAMA Neurol. 72:355–362. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Maas AIR, Menon DK, Manley GT, Abrams M, Åkerlund C, Andelic N, Aries M, Bashford T, Bell MJ, Bodien YG, et al: Traumatic brain injury: Integrated approaches to improve prevention, clinical care, and research. Lancet Neurol. 16:987–1048. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Devanney NA, Stewart AN and Gensel JC: Microglia and macrophage metabolism in CNS injury and disease: The role of immunometabolism in neurodegeneration and neurotrauma. Exp Neurol. 329:1133102020. View Article : Google Scholar : PubMed/NCBI

8 

Zhang ZW, Liang J, Yan JX, Ye YC, Wang JJ, Chen C, Sun HT, Chen F, Tu Y and Li XH: TBHQ improved neurological recovery after traumatic brain injury by inhibiting the overactivation of astrocytes. Brain Res. 1739:1468182020. View Article : Google Scholar : PubMed/NCBI

9 

Tang B, Song M, Xie X, Le D, Tu Q, Wu X and Chen M: Tumor necrosis factor-stimulated gene-6 (TSG-6) Secreted by BMSCs regulates activated astrocytes by inhibiting NF-κB signaling pathway to ameliorate blood brain barrier damage after intracerebral hemorrhage. Neurochem Res. 46:2387–2402. 2021. View Article : Google Scholar : PubMed/NCBI

10 

Dinet V, Petry KG and Badaut J: Brain-Immune Interactions and Neuroinflammation After Traumatic Brain Injury. Front Neurosci. 13:11782019. View Article : Google Scholar : PubMed/NCBI

11 

Takahashi H, Klein ZA, Bhagat SM, Kaufman AC, Kostylev MA, Ikezu T and Strittmatter SM: Alzheimer's Disease Neuroimaging Initiative: Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network. Acta Neuropathol. 133:785–807. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Castranio EL, Mounier A, Wolfe CM, Nam KN, Fitz NF, Letronne F, Schug J, Koldamova R and Lefterov I: Gene co-expression networks identify Trem2 and TYROBP as major hubs in human APOE expressing mice following traumatic brain injury. Neurobiol Dis. 105:1–14. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Haure-Mirande JV, Audrain M, Ehrlich ME and Gandy S: Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological and pathological signals across TREM2. Mol Neurodegener. 17:552022. View Article : Google Scholar : PubMed/NCBI

14 

Haure-Mirande JV, Wang M, Audrain M, Fanutza T, Kim SH, Heja S, Readhead B, Dudley JT, Blitzer RD, Schadt EE, et al: Integrative approach to sporadic Alzheimer's disease: Deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden. Mol Psychiatry. 24:431–446. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Darwent L, Carmona S, Lohmann E, Guven G, Kun-Rodrigues C, Bilgic B, Hanagasi H, Gurvit H, Erginel-Unaltuna N, Pak M, et al: Mutations in TYROBP are not a common cause of dementia in a Turkish cohort. Neurobiol Aging. 58:240.e1–240.e3. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Siebold L, Obenaus A and Goyal R: Criteria to define mild, moderate, and severe traumatic brain injury in the mouse controlled cortical impact model. Exp Neurol. 310:48–57. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Leek JT, Johnson WE, Parker HS, Jaffe AE and Storey JD: The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics. 28:882–883. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

19 

Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C and Chanda SK: Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 10:15232019. View Article : Google Scholar : PubMed/NCBI

20 

Langfelder P and Horvath S: WGCNA: An R package for weighted correlation network analysis. BMC Bioinformatics. 9:5592008. View Article : Google Scholar : PubMed/NCBI

21 

Wilkerson MD and Hayes DN: ConsensusClusterPlus: A class discovery tool with confidence assessments and item tracking. Bioinformatics. 26:1572–1573. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Qiu X, Mao Q, Tang Y, Wang L, Chawla R, Pliner HA and Trapnell C: Reversed graph embedding resolves complex single-cell trajectories. Nat Methods. 14:979–982. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Hao Y, Hao S, Andersen-Nissen E, Mauck WM III, Zheng S, Butler A, Lee MJ, Wilk AJ, Darby C, Zager M, et al: Integrated analysis of multimodal single-cell data. Cell. 184:3573–3587.e29. 2021. View Article : Google Scholar : PubMed/NCBI

24 

Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, Kuan CH, Myung P, Plikus MV and Nie Q: Inference and analysis of cell-cell communication using CellChat. Nat Commun. 12:10882021. View Article : Google Scholar : PubMed/NCBI

25 

Liu N, Li Y, Jiang Y, Shi S, Niamnud A, Vodovoz SJ, Katakam PVG, Vidoudez C, Dumont AS and Wang X: Establishment and application of a novel in vitro model of microglial activation in traumatic brain injury. J Neurosci. 43:319–332. 2023. View Article : Google Scholar : PubMed/NCBI

26 

Sachse F, Becker K, Basel TJ, Weiss D and Rudack C: IKK-2 inhibitor TPCA-1 represses nasal epithelial inflammation in vitro. Rhinology. 49:168–173. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Willis EF, MacDonald KPA, Nguyen QH, Garrido AL, Gillespie ER, Harley SBR, Bartlett PF, Schroder WA, Yates AG, Anthony DC, et al: Repopulating microglia promote brain repair in an IL-6-Dependent manner. Cell. 180:833–846.e16. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Wu H, Zheng J, Xu S, Fang Y, Wu Y, Zeng J, Shao A, Shi L, Lu J, Mei S, et al: Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury. J Neuroinflammation. 18:22021. View Article : Google Scholar : PubMed/NCBI

30 

Krukowski K, Nolan A, Becker M, Picard K, Vernoux N, Frias ES, Feng X, Tremblay ME and Rosi S: Novel microglia-mediated mechanisms underlying synaptic loss and cognitive impairment after traumatic brain injury. Brain Behav Immun. 98:122–135. 2021. View Article : Google Scholar : PubMed/NCBI

31 

Kennedy A, Waters E, Rowshanravan B, Hinze C, Williams C, Janman D, Fox TA, Booth C, Pesenacker AM, Halliday N, et al: Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation. Nat Immunol. 23:1365–1378. 2022. View Article : Google Scholar : PubMed/NCBI

32 

Necula D, Riviere-Cazaux C, Shen Y and Zhou M: Insight into the roles of CCR5 in learning and memory in normal and disordered states. Brain Behav Immun. 92:1–9. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Al Barashdi MA, Ali A, McMullin MF and Mills K: Protein tyrosine phosphatase receptor type C (PTPRC or CD45). J Clin Pathol. 74:548–552. 2021. View Article : Google Scholar : PubMed/NCBI

34 

Xu H, Zhang A, Han X, Li Y, Zhang Z, Song L, Wang W and Lou M: ITGB2 as a prognostic indicator and a predictive marker for immunotherapy in gliomas. Cancer Immunol Immunother. 71:645–660. 2022. View Article : Google Scholar : PubMed/NCBI

35 

Verbeek JS, Hirose S and Nishimura H: The Complex association of FcγRIIb with autoimmune susceptibility. Front Immunol. 10:20612019. View Article : Google Scholar : PubMed/NCBI

36 

Konishi H and Kiyama H: Microglial TREM2/DAP12 Signaling: A Double-Edged sword in neural diseases. Front Cell Neurosci. 12:2062018. View Article : Google Scholar : PubMed/NCBI

37 

Audrain M, Haure-Mirande JV, Mleczko J, Wang M, Griffin JK, St George-Hyslop PH, Fraser P, Zhang B, Gandy S and Ehrlich ME: Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice. Alzheimers Dement. 17:149–163. 2021. View Article : Google Scholar : PubMed/NCBI

38 

Zhou Y, Tada M, Cai Z, Andhey PS, Swain A, Miller KR, Gilfillan S, Artyomov MN, Takao M, Kakita A, et al: Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia. Nat Immunol. 24:545–557. 2023. View Article : Google Scholar : PubMed/NCBI

39 

Zhao N, Ren Y, Yamazaki Y, Qiao W, Li F, Felton LM, Mahmoudiandehkordi S, Kueider-Paisley A, Sonoustoun B, Arnold M, et al: Alzheimer's risk factors age, APOE genotype, and sex drive distinct molecular pathways. Neuron. 106:727–742. 2020. View Article : Google Scholar : PubMed/NCBI

40 

Paradowska-Gorycka A and Jurkowska M: Structure, expression pattern and biological activity of molecular complex TREM-2/DAP12. Hum Immunol. 74:730–737. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Haure-Mirande JV, Audrain M, Ehrlich ME and Gandy S: Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological and pathological signals across TREM2. Mol Neurodegener. 17:552022. View Article : Google Scholar : PubMed/NCBI

42 

Lanier LL and Bakker AB: The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function. Immunol Today. 21:611–614. 2000. View Article : Google Scholar : PubMed/NCBI

43 

Peng Q, Malhotra S, Torchia JA, Kerr WG, Coggeshall KM and Humphrey MB: TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1. Sci Signal. 3:ra382010. View Article : Google Scholar : PubMed/NCBI

44 

Zhang L, Wei X, Wang Z, Liu P, Hou Y, Xu Y, Su H, Koci MD, Yin H and Zhang C: NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking. Cell Rep. 42:1121852023. View Article : Google Scholar : PubMed/NCBI

45 

Mecca C, Giambanco I, Donato R and Arcuri C: Microglia and aging: The role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes. Int J Mol Sci. 19:3182018. View Article : Google Scholar : PubMed/NCBI

46 

Gyoneva S and Ransohoff RM: Inflammation after traumatic brain injury: therapeutic potential of targeting cell-cell communication by chemokines. Trends Pharmacol Sci. 36:471–480. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Joy MT, Ben Assayag E, Shabashov-Stone D, Liraz-Zaltsman S, Mazzitelli J, Arenas M, Abduljawad N, Kliper E, Korczyn AD, Thareja NS, et al: CCR5 Is a therapeutic target for recovery after stroke and traumatic brain injury. Cell. 176:1143–1157.e13. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Morris AB, Farley CR, Pinelli DF, Adams LE, Cragg MS, Boss JM, Scharer CD, Fribourg M, Cravedi P, Heeger PS and Ford ML: Signaling through the Inhibitory Fc Receptor FcγRIIB Induces CD8+ T Cell Apoptosis to Limit T Cell Immunity. Immunity. 52:136–150. 2020. View Article : Google Scholar : PubMed/NCBI

49 

Pawelec P, Ziemka-Nalecz M, Sypecka J and Zalewska T: The impact of the CX3CL1/CX3CR1 axis in neurological disorders. Cells. 9:22772020. View Article : Google Scholar : PubMed/NCBI

50 

Younger D, Murugan M, Rama Rao KV, Wu LJ and Chandra N: Microglia receptors in animal models of traumatic brain injury. Mol Neurobiol. 56:5202–5228. 2019. View Article : Google Scholar : PubMed/NCBI

51 

Blaser H, Dostert C, Mak TW and Brenner D: TNF and ROS Crosstalk in Inflammation. Trends Cell Biol. 26:249–261. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Meyers EA and Kessler JA: TGF-β family signaling in neural and neuronal differentiation, development, and function. Cold Spring Harb Perspect Biol. 9:a0222442017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou X, Song H, He J, Han W and Li Q: Deciphering microglial activation and neuronal apoptosis post‑traumatic brain injury: The role of TYROBP in inflammation regulation networks. Mol Med Rep 29: 104, 2024.
APA
Zhou, X., Song, H., He, J., Han, W., & Li, Q. (2024). Deciphering microglial activation and neuronal apoptosis post‑traumatic brain injury: The role of TYROBP in inflammation regulation networks. Molecular Medicine Reports, 29, 104. https://doi.org/10.3892/mmr.2024.13228
MLA
Zhou, X., Song, H., He, J., Han, W., Li, Q."Deciphering microglial activation and neuronal apoptosis post‑traumatic brain injury: The role of TYROBP in inflammation regulation networks". Molecular Medicine Reports 29.6 (2024): 104.
Chicago
Zhou, X., Song, H., He, J., Han, W., Li, Q."Deciphering microglial activation and neuronal apoptosis post‑traumatic brain injury: The role of TYROBP in inflammation regulation networks". Molecular Medicine Reports 29, no. 6 (2024): 104. https://doi.org/10.3892/mmr.2024.13228
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou X, Song H, He J, Han W and Li Q: Deciphering microglial activation and neuronal apoptosis post‑traumatic brain injury: The role of TYROBP in inflammation regulation networks. Mol Med Rep 29: 104, 2024.
APA
Zhou, X., Song, H., He, J., Han, W., & Li, Q. (2024). Deciphering microglial activation and neuronal apoptosis post‑traumatic brain injury: The role of TYROBP in inflammation regulation networks. Molecular Medicine Reports, 29, 104. https://doi.org/10.3892/mmr.2024.13228
MLA
Zhou, X., Song, H., He, J., Han, W., Li, Q."Deciphering microglial activation and neuronal apoptosis post‑traumatic brain injury: The role of TYROBP in inflammation regulation networks". Molecular Medicine Reports 29.6 (2024): 104.
Chicago
Zhou, X., Song, H., He, J., Han, W., Li, Q."Deciphering microglial activation and neuronal apoptosis post‑traumatic brain injury: The role of TYROBP in inflammation regulation networks". Molecular Medicine Reports 29, no. 6 (2024): 104. https://doi.org/10.3892/mmr.2024.13228
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