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Tenascin C activates the toll‑like receptor 4/NF‑κB signaling pathway to promote the development of polycystic ovary syndrome

  • Authors:
    • Han Wu
    • Mo Yang
    • Cuiping Yan
    • Mengchen Liu
    • Haoran Wang
    • Wenjuan Zhang
  • View Affiliations / Copyright

    Affiliations: Center for Reproductive Medicine, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong 271000, P.R. China, Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong 271000, P.R. China, Department of Women's Health Care, Taian Daiyue District Maternal and Child Health Care, Taian, Shandong 271021, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 106
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    Published online on: April 25, 2024
       https://doi.org/10.3892/mmr.2024.13230
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Abstract

Polycystic ovary syndrome (PCOS) is a globally prevalent gynecological disorder among women of childbearing age. The present study aimed to investigate the role of tenascin C (TNC) in PCOS and its potential mechanisms. Fasting blood glucose and serum insulin, the homeostasis model assessment of insulin resistance and the serum hormone levels were determined in PCOS rats. In addition, H&E staining was used for assessing pathology. In addition, the effects of TNC on oxidative stress and inflammation response in PCOS rat and cell models was assessed. Furthermore, the roles of TNC on KGN cell proliferation and apoptosis were determined employing EdU assay and flow cytometry. TLR4/NF‑κB pathway‑related proteins were measured using western blotting, immunofluorescence and immunohistochemistry. It was found that the mRNA and protein expression was upregulated in PCOS rats and in KGN cells induced by dihydrotestosterone (DHT). Knockdown of TNC relieved the pathological characteristics and the endocrine abnormalities of PCOS rats. Knockdown of TNC inhibited ovarian cell apoptosis, oxidative stress and inflammation in PCOS rats. Knockdown of TNC reversed the DHT‑induced reduction in cell proliferation and increase in apoptosis in KGN cells. Furthermore, knockdown of TNC alleviated oxidative stress and inflammatory responses induced by DHT in KGN cells. Additionally, knockdown of TNC inhibited the toll‑like receptor 4 (TLR4)/NF‑κB signaling pathway in PCOS rats and DHT‑treated KGN cells. In conclusion, knockdown of TNC could ameliorate PCOS in both rats and a cell model by inhibiting cell apoptosis, oxidative stress and inflammation via the suppression of the TLR4/NF‑κB signaling pathway.
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View References

1 

Kumariya S, Ubba V, Jha RK and Gayen JR: Autophagy in ovary and polycystic ovary syndrome: Role, dispute and future perspective. Autophagy. 17:2706–2733. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Azziz R, Carmina E, Chen Z, Dunaif A, Laven JS, Legro RS, Lizneva D, Natterson-Horowtiz B, Teede HJ and Yildiz BO: Polycystic ovary syndrome. Nat Rev Dis Primers. 2:160572016. View Article : Google Scholar : PubMed/NCBI

3 

Siddiqui S, Mateen S, Ahmad R and Moin S: A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS). J Assist Reprod Genet. 39:2439–2473. 2022. View Article : Google Scholar : PubMed/NCBI

4 

Moghetti P and Tosi F: Insulin resistance and PCOS: Chicken or egg? J Endocrinol Invest. 44:233–244. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Murri M, Luque-Ramírez M, Insenser M, Ojeda-Ojeda M and Escobar-Morreale HF: Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): A systematic review and meta-analysis. Hum Reprod Update. 19:268–288. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Jiang XL, Tai H, Xiao XS, Zhang SY, Cui SC, Qi SB, Hu DD, Zhang LN, Kuang JS, Meng XS and Li SM: Cangfudaotan decoction inhibits mitochondria-dependent apoptosis of granulosa cells in rats with polycystic ovarian syndrome. Front Endocrinol (Lausanne). 13:9621542022. View Article : Google Scholar : PubMed/NCBI

7 

Norman RJ, Dewailly D, Legro RS and Hickey TE: Polycystic ovary syndrome. Lancet. 370:685–697. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Lu Z, Chen C, Gao Y, Li Y, Zhao X, Zhang H, Wei Q, Zeng X, Li Y and Wan M: Screening target genes for the treatment of PCOS via analysis of single-cell sequencing data. Ann Med. 54:2975–2989. 2022. View Article : Google Scholar : PubMed/NCBI

9 

Liu X, Sun C, Zou K, Li C, Chen X, Gu H, Zhou Z, Yang Z, Tu Y, Qin N, et al: Novel PGK1 determines SKP2-dependent AR stability and reprograms granular cell glucose metabolism facilitating ovulation dysfunction. EBioMedicine. 61:1030582020. View Article : Google Scholar : PubMed/NCBI

10 

Wang Z, Dong H, Yang L, Yi P, Wang Q and Huang D: The role of FDX1 in granulosa cell of polycystic ovary syndrome (PCOS). BMC Endocr Disord. 21:1192021. View Article : Google Scholar : PubMed/NCBI

11 

Imanaka-Yoshida K and Aoki H: Tenascin-C and mechanotransduction in the development and diseases of cardiovascular system. Front Physiol. 5:2832014. View Article : Google Scholar : PubMed/NCBI

12 

Faissner A, Roll L and Theocharidis U: Tenascin-C in the matrisome of neural stem and progenitor cells. Mol Cell Neurosci. 81:22–31. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Chen S, Fu H, Wu S, Zhu W, Liao J, Hong X, Miao J, Luo C, Wang Y, Hou FF, et al: Tenascin-C protects against acute kidney injury by recruiting Wnt ligands. Kidney Int. 95:62–74. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Song W and Qiu N: MiR-495-3p depletion contributes to myocardial ischemia/reperfusion injury in cardiomyocytes by targeting TNC. Regen Ther. 21:380–388. 2022. View Article : Google Scholar : PubMed/NCBI

15 

Ishizaki J, Takemori A, Suemori K, Matsumoto T, Akita Y, Sada KE, Yuzawa Y, Amano K, Takasaki Y, Harigai M, et al: Targeted proteomics reveals promising biomarkers of disease activity and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Res Ther. 19:2182017. View Article : Google Scholar : PubMed/NCBI

16 

Cheng H, Li L, Xue J, Ma J and Ge J: TNC accelerates hypoxia-induced cardiac injury in a METTL3-dependent manner. Genes (Basel). 14:5912023. View Article : Google Scholar : PubMed/NCBI

17 

Li Z, Chen S, Cui H, Li X, Chen D, Hao W, Wang J, Li Z, Zheng Z, Zhang Z and Liu H: Tenascin-C-mediated suppression of extracellular matrix adhesion force promotes entheseal new bone formation through activation of Hippo signalling in ankylosing spondylitis. Ann Rheum Dis. 80:891–902. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Imanaka-Yoshida K, Tawara I and Yoshida T: Tenascin-C in cardiac disease: A sophisticated controller of inflammation, repair, and fibrosis. Am J Physiol Cell Physiol. 319:C781–C796. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Dumesic DA, Phan JD, Leung KL, Grogan TR, Ding X, Li X, Hoyos LR, Abbott DH and Chazenbalk GD: Adipose insulin resistance in normal-weight women with polycystic ovary syndrome. J Clin Endocrinol Metab. 104:2171–2183. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Xu A, Fan Y, Liu S, Sheng L, Sun Y and Yang H: GIMAP7 induces oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome by inhibiting sonic hedgehog signalling pathway. J Ovarian Res. 15:1412022. View Article : Google Scholar : PubMed/NCBI

21 

Zhang Y, Hu M, Jia W, Liu G, Zhang J, Wang B, Li J, Cui P, Li X, Lager S, et al: Hyperandrogenism and insulin resistance modulate gravid uterine and placental ferroptosis in PCOS-like rats. J Endocrinol. 246:247–263. 2020. View Article : Google Scholar : PubMed/NCBI

22 

Dăneasă A, Cucolaş C, Lenghel LM, Olteanu D, Orăsan R and Filip GA: Letrozole vs estradiol valerate induced PCOS in rats: Glycemic, oxidative and inflammatory status assessment. Reproduction. 151:401–409. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Feldmann RE Jr, Maurer MH, Hunzinger C, Lewicka S, Buergers HF, Kalenka A, Hinkelbein J, Broemme JO, Seidler GH, Martin E and Plaschke K: Reduction in rat phosphatidylethanolamine binding protein-1 (PEBP1) after chronic corticosterone treatment may be paralleled by cognitive impairment: A first study. Stress. 11:134–147. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Van Way CW, Dhar A, Reddy R, Evans L, Wogahn B and Helling TS: Changes in adenine nucleotides during hemorrhagic shock and reperfusion. J Surg Res. 66:159–166. 1996. View Article : Google Scholar : PubMed/NCBI

25 

Weksler B, Schneider A, Ng B and Burt M: Isolated single lung perfusion in the rat: An experimental model. J Appl Physiol (1985). 74:2736–2739. 1993. View Article : Google Scholar : PubMed/NCBI

26 

Edge D, Shortt CM, Johns EJ, Gobbo OL, Markos F, Abdulla MH and Barry EF: Assessment of renal function in the anaesthetised rat following injection of superparamagnetic iron oxide nanoparticles. Can J Physiol Pharmacol. 95:443–446. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Strohmaier CA, Motloch K, Runge C, Trost A, Bogner B, Kaser-Eichberger A, Schrödl F, Lenzhofer M and Reitsamer HA: Retinal vessel diameter responses to central electrical stimulation in the rat: Effect of nitric oxide synthase inhibition. Invest Ophthalmol Vis Sci. 57:4553–4557. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Clifford PS, Ferguson BS, Jasperse JL and Hill MA: Arteriolar vasodilation involves actin depolymerization. Am J Physiol Heart Circ Physiol. 315:H423–H428. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Huang Y and Zhang X: Luteolin alleviates polycystic ovary syndrome in rats by resolving insulin resistance and oxidative stress. Am J Physiol Endocrinol Metab. 320:E1085–E1092. 2021. View Article : Google Scholar : PubMed/NCBI

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Corbould A, Kim YB, Youngren JF, Pender C, Kahn BB, Lee A and Dunaif A: Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling. Am J Physiol Endocrinol Metab. 288:E1047–E1054. 2005. View Article : Google Scholar : PubMed/NCBI

32 

de Medeiros SF, de Medeiros MAS, Santos NS, Barbosa BB and Yamamoto MMW: Combined oral contraceptive effects on low-grade chronic inflammatory mediators in women with polycystic ovary syndrome: A systematic review and meta-analysis. Int J Inflam. 2018:95915092018.PubMed/NCBI

33 

Zheng X, Guo W, Zeng L, Zheng D, Yang S, Wang L, Wang R, Mol BW, Li R and Qiao J: Live birth after in vitro maturation versus standard in vitro fertilisation for women with polycystic ovary syndrome: Protocol for a non-inferiority randomised clinical trial. BMJ Open. 10:e0353342020. View Article : Google Scholar : PubMed/NCBI

34 

Wang T, Sha L, Li Y, Zhu L, Wang Z, Li K, Lu H, Bao T, Guo L, Zhang X and Wang H: Dietary α-linolenic acid-rich flaxseed oil exerts beneficial effects on polycystic ovary syndrome through sex steroid hormones-microbiota-inflammation axis in rats. Front Endocrinol (Lausanne). 11:2842020. View Article : Google Scholar : PubMed/NCBI

35 

Diamanti-Kandarakis E and Dunaif A: Insulin resistance and the polycystic ovary syndrome revisited: An update on mechanisms and implications. Endocr Rev. 33:981–1030. 2012. View Article : Google Scholar : PubMed/NCBI

36 

González F, Considine RV, Abdelhadi OA and Acton AJ: Oxidative stress in response to saturated fat ingestion is linked to insulin resistance and hyperandrogenism in polycystic ovary syndrome. J Clin Endocrinol Metab. 104:5360–5371. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Wang D, Wang T, Wang R, Zhang X, Wang L, Xiang Z, Zhuang L, Shen S, Wang H, Gao Q and Wang Y: Suppression of p66Shc prevents hyperandrogenism-induced ovarian oxidative stress and fibrosis. J Transl Med. 18:842020. View Article : Google Scholar : PubMed/NCBI

38 

Shorakae S, Ranasinha S, Abell S, Lambert G, Lambert E, de Courten B and Teede H: Inter-related effects of insulin resistance, hyperandrogenism, sympathetic dysfunction and chronic inflammation in PCOS. Clin Endocrinol (Oxf). 89:628–633. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Liu M, Gao J, Zhang Y, Li P, Wang H, Ren X and Li C: Serum levels of TSP-1, NF-κB and TGF-β1 in polycystic ovarian syndrome (PCOS) patients in northern China suggest PCOS is associated with chronic inflammation. Clin Endocrinol (Oxf). 83:913–922. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Chen H, Yang J and Tan Z: Upregulation of microRNA-9-5p inhibits apoptosis of chondrocytes through downregulating Tnc in mice with osteoarthritis following tibial plateau fracture. J Cell Physiol. 234:23326–23336. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Shiba M, Fujimoto M, Imanaka-Yoshida K, Yoshida T, Taki W and Suzuki H: Tenascin-C causes neuronal apoptosis after subarachnoid hemorrhage in rats. Transl Stroke Res. 5:238–247. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Zhou Y, Ma XY, Han JY, Yang M, Lv C, Shao Y, Wang YL, Kang JY and Wang QY: Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop. World J Diabetes. 12:19–46. 2021. View Article : Google Scholar : PubMed/NCBI

43 

Karataş Z, Baysal T, Sap F, Altın H and Çiçekler H: The role of tenascin-C and oxidative stress in rheumatic and congenital heart valve diseases: An observational study. Anadolu Kardiyol Derg. 13:350–356. 2013.PubMed/NCBI

44 

Tong X, Zhang J and Shen M: Silencing of tenascin-C inhibited inflammation and apoptosis via PI3K/Akt/NF-κB signaling pathway in subarachnoid hemorrhage cell model. J Stroke Cerebrovasc Dis. 29:1044852020. View Article : Google Scholar : PubMed/NCBI

45 

Imanaka-Yoshida K: Tenascin-C in heart diseases-the role of inflammation. Int J Mol Sci. 22:58282021. View Article : Google Scholar : PubMed/NCBI

46 

Yonebayashi S, Tajiri K, Hara M, Saito H, Suzuki N, Sakai S, Kimura T, Sato A, Sekimoto A, Fujita S, et al: Generation of transgenic mice that conditionally overexpress tenascin-C. Front Immunol. 12:6205412021. View Article : Google Scholar : PubMed/NCBI

47 

Patel L, Sun W, Glasson SS, Morris EA, Flannery CR and Chockalingam PS: Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage. BMC Musculoskelet Disord. 12:1642011. View Article : Google Scholar : PubMed/NCBI

48 

Chiovaro F, Chiquet-Ehrismann R and Chiquet M: Transcriptional regulation of tenascin genes. Cell Adh Migr. 9:34–47. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Midwood KS, Chiquet M, Tucker RP and Orend G: Tenascin-C at a glance. J Cell Sci. 129:4321–4327. 2016.PubMed/NCBI

50 

Wang Y, He J and Yang J: Eicosapentaenoic acid improves polycystic ovary syndrome in rats via sterol regulatory element-binding protein 1 (SREBP-1)/toll-like receptor 4 (TLR4) pathway. Med Sci Monit. 24:2091–2097. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Shen HR, Xu X and Li XL: Berberine exerts a protective effect on rats with polycystic ovary syndrome by inhibiting the inflammatory response and cell apoptosis. Reprod Biol Endocrinol. 19:32021. View Article : Google Scholar : PubMed/NCBI

52 

Turner NA: Inflammatory and fibrotic responses of cardiac fibroblasts to myocardial damage associated molecular patterns (DAMPs). J Mol Cell Cardiol. 94:189–200. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Marzeda AM and Midwood KS: Internal affairs: Tenascin-C as a clinically relevant, endogenous driver of innate immunity. J Histochem Cytochem. 66:289–304. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Liu L, Li YH, Niu YB, Sun Y, Guo ZJ, Li Q, Li C, Feng J, Cao SS and Mei QB: An apple oligogalactan prevents against inflammation and carcinogenesis by targeting LPS/TLR4/NF-κB pathway in a mouse model of colitis-associated colon cancer. Carcinogenesis. 31:1822–1832. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Wang Z, Zhai D, Zhang D, Bai L, Yao R, Yu J, Cheng W and Yu C: Quercetin decreases insulin resistance in a polycystic ovary syndrome rat model by improving inflammatory microenvironment. Reprod Sci. 24:682–690. 2017. View Article : Google Scholar : PubMed/NCBI

56 

Bhaskar S, Shalini V and Helen A: Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-κB signaling pathway. Immunobiology. 216:367–373. 2011. View Article : Google Scholar : PubMed/NCBI

57 

Hu M, Zhang Y, Li X, Cui P, Sferruzzi-Perri AN, Brännström M, Shao LR and Billig H: TLR4-associated IRF-7 and NFκB signaling act as a molecular link between androgen and metformin activities and cytokine synthesis in the PCOS endometrium. J Clin Endocrinol Metab. 106:1022–1040. 2021. View Article : Google Scholar : PubMed/NCBI

58 

Jin W, Wang C, Cui M, Wang M, Fu B, Sun L and Chen X: Inhibitory effect of bushen huoxue formula against dehydroepiandrosterone-induced inflammation in granulosa cells through TLR4/NF-κB signaling pathway. Pak J Pharm Sci. 35:701–710. 2022.PubMed/NCBI

59 

Yang Y, Yang L, Qi C, Hu G, Wang L, Sun Z and Ni X: Cryptotanshinone alleviates polycystic ovary syndrome in rats by regulating the HMGB1/TLR4/NF-κB signaling pathway. Mol Med Rep. 22:3851–3861. 2020.PubMed/NCBI

60 

Ren Y, Ye Y, Xuan F, Chen A, Jin R, Zhou W and Lu J: The effect of sitagliptin combined with rosiglitazone on autophagy and inflammation in polycystic ovary syndrome by regulating PI3K/AKT/mTOR and TLR4/NF-κB pathway. Reprod Biol. 23:1007632023. View Article : Google Scholar : PubMed/NCBI

61 

Midwood K, Sacre S, Piccinini AM, Inglis J, Trebaul A, Chan E, Drexler S, Sofat N, Kashiwagi M, Orend G, et al: Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Nat Med. 15:774–780. 2009. View Article : Google Scholar : PubMed/NCBI

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Wu H, Yang M, Yan C, Liu M, Wang H and Zhang W: Tenascin C activates the toll‑like receptor 4/NF‑κB signaling pathway to promote the development of polycystic ovary syndrome. Mol Med Rep 29: 106, 2024.
APA
Wu, H., Yang, M., Yan, C., Liu, M., Wang, H., & Zhang, W. (2024). Tenascin C activates the toll‑like receptor 4/NF‑κB signaling pathway to promote the development of polycystic ovary syndrome. Molecular Medicine Reports, 29, 106. https://doi.org/10.3892/mmr.2024.13230
MLA
Wu, H., Yang, M., Yan, C., Liu, M., Wang, H., Zhang, W."Tenascin C activates the toll‑like receptor 4/NF‑κB signaling pathway to promote the development of polycystic ovary syndrome". Molecular Medicine Reports 29.6 (2024): 106.
Chicago
Wu, H., Yang, M., Yan, C., Liu, M., Wang, H., Zhang, W."Tenascin C activates the toll‑like receptor 4/NF‑κB signaling pathway to promote the development of polycystic ovary syndrome". Molecular Medicine Reports 29, no. 6 (2024): 106. https://doi.org/10.3892/mmr.2024.13230
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Spandidos Publications style
Wu H, Yang M, Yan C, Liu M, Wang H and Zhang W: Tenascin C activates the toll‑like receptor 4/NF‑κB signaling pathway to promote the development of polycystic ovary syndrome. Mol Med Rep 29: 106, 2024.
APA
Wu, H., Yang, M., Yan, C., Liu, M., Wang, H., & Zhang, W. (2024). Tenascin C activates the toll‑like receptor 4/NF‑κB signaling pathway to promote the development of polycystic ovary syndrome. Molecular Medicine Reports, 29, 106. https://doi.org/10.3892/mmr.2024.13230
MLA
Wu, H., Yang, M., Yan, C., Liu, M., Wang, H., Zhang, W."Tenascin C activates the toll‑like receptor 4/NF‑κB signaling pathway to promote the development of polycystic ovary syndrome". Molecular Medicine Reports 29.6 (2024): 106.
Chicago
Wu, H., Yang, M., Yan, C., Liu, M., Wang, H., Zhang, W."Tenascin C activates the toll‑like receptor 4/NF‑κB signaling pathway to promote the development of polycystic ovary syndrome". Molecular Medicine Reports 29, no. 6 (2024): 106. https://doi.org/10.3892/mmr.2024.13230
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