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Genetic analysis of seven patients with inherited ichthyosis and Nagashima‑type palmoplantar keratoderma

  • Authors:
    • Jing Zhang
    • Yue Yao
    • Ya Tan
    • Hua-Ying Hu
    • Lin-Xi Zeng
    • Guo-Qiang Zhang
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    Affiliations: Department of Gynecology and Obstetrics, Beijing Jishuitan Hospital, Capital Medical University, Beijing 102208, P.R. China, Department of Dermatology, The First Hospital of Hebei Medical University, Candidate Branch of National Clinical Research Center for Skin Diseases, Hebei Provincial Innovation Center of Dermatology and Medical Cosmetology Technology, Shijiazhuang, Hebei 050030, P.R. China, Department of Obstetrics and Gynecology, Peking University International Hospital, Beijing 102206, P.R. China, Jiaen Genetics Laboratory, Beijing Jiaen Hospital, Beijing 100191, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 111
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    Published online on: May 1, 2024
       https://doi.org/10.3892/mmr.2024.13235
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Abstract

Inherited ichthyosis comprises a series of heterogeneous dermal conditions; it mainly manifests as widespread hyperkeratosis, xerosis and scaling of the skin. At times, overlapping symptoms require differential diagnosis between ichthyosis and several other similar disorders. The present study reports seven patients with confirmed or suspected to be associated with ichthyosis by conducting a thorough clinical and genetic investigation. Genetic testing was conducted using whole‑exome sequencing, with Sanger sequencing as the validation method. The MEGA7 program was used to analyze the conservation of amino acid residues affected by the detected missense variants. The enrolled patients exhibited ichthyosis‑like but distinct clinical manifestations. Genetic analysis identified diagnostic variations in the FLG, STS, KRT10 and SERPINB7 genes and clarified the carrying status of each variant in the respective family members. The two residues affected by the detected missense variants remained conserved across multiple species. Of note, the two variants, namely STS: c.452C>T(p.P151L) and c.647_650del(p.L216fs) are novel. In conclusion, a clear genetic differential diagnosis was made for the enrolled ichthyosis‑associated patients; the study findings also extended the mutation spectrum of ichthyosis and provided solid evidence for the counseling of the affected families.
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1 

Vahlquist A and Torma H: Ichthyosis: A road model for skin research. Acta Derm Venereol. 100:adv000972020. View Article : Google Scholar : PubMed/NCBI

2 

Fischer J and Bourrat E: Genetics of inherited ichthyoses and related diseases. Acta Derm Venereol. 100:adv000962020. View Article : Google Scholar : PubMed/NCBI

3 

Uitto J, Youssefian L, Saeidian AH and Vahidnezhad H: Molecular genetics of keratinization disorders-what's new about ichthyosis. Acta Derm Venereol. 100:adv000952020. View Article : Google Scholar : PubMed/NCBI

4 

Hotz A, Kopp J, Bourrat E, Oji V, Komlosi K, Giehl K, Bouadjar B, Bygum A, Tantcheva-Poor I, Hellstrom Pigg M, et al: Meta-Analysis of Mutations in ALOX12B or ALOXE3 Identified in a Large Cohort of 224 Patients. Genes (Basel). 12:802021. View Article : Google Scholar : PubMed/NCBI

5 

Ballin N, Hotz A, Bourrat E, Küsel J, Oji V, Bouadjar B, Brognoli D, Hickman G, Heinz L, Vabres P, et al: Genetical, clinical, and functional analysis of a large international cohort of patients with autosomal recessive congenital ichthyosis due to mutations in NIPAL4. Hum Mutat. 40:2318–2333. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Abdel-Hamid MS, Issa MY, Elbendary HM, Abdel-Ghafar SF, Rafaat K, Hosny H, Girgis M, Abdel-Salam GMH and Zaki MS: Phenotypic and mutational spectrum of thirty-five patients with Sjogren-Larsson syndrome: Identification of eleven novel ALDH3A2 mutations and founder effects. J Hum Genet. 64:859–865. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Youssefian L, Touati A, Saeidian AH, Zargari O, Zeinali S, Vahidnezhad H and Uitto J: A novel mutation in ST14 at a functionally significant amino acid residue expands the spectrum of ichthyosis-hypotrichosis syndrome. Orphanet J Rare Dis. 12:1762017. View Article : Google Scholar : PubMed/NCBI

8 

Smith FJ, Irvine AD, Terron-Kwiatkowski A, Sandilands A, Campbell LE, Zhao Y, Liao H, Evans AT, Goudie DR, Lewis-Jones S, et al: Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat Genet. 38:337–342. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Chen S, Kong X, Wei X, Sun Y, Yin D, Zhang Q, Du L, Man J, Mao L, Li H, et al: Targeted next-generation sequencing identifies nine novel filaggrin gene variants in Chinese Han patients with ichthyosis vulgaris. Br J Dermatol. 177:e202–e203. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Oji V, Seller N, Sandilands A, Gruber R, Gerss J, Huffmeier U, Hamm H, Emmert S, Aufenvenne K, Metze D, et al: Ichthyosis vulgaris: Novel FLG mutations in the German population and high presence of CD1a+ cells in the epidermis of the atopic subgroup. Br J Dermatol. 160:771–781. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Webster D, France JT, Shapiro LJ and Weiss R: X-linked ichthyosis due to steroid-sulphatase deficiency. Lancet. 1:70–72. 1978.PubMed/NCBI

12 

Kent L, Emerton J, Bhadravathi V, Weisblatt E, Pasco G, Willatt LR, McMahon R and Yates JR: X-linked ichthyosis (steroid sulfatase deficiency) is associated with increased risk of attention deficit hyperactivity disorder, autism and social communication deficits. J Med Genet. 45:519–524. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Diociaiuti A, Angioni A, Pisaneschi E, Alesi V, Zambruno G, Novelli A and El Hachem M: X-linked ichthyosis: Clinical and molecular findings in 35 Italian patients. Exp Dermatol. 28:1156–1163. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Richard G: Autosomal Recessive Congenital Ichthyosis. GeneReviews®. Adam MP, Everman DB, Mirzaa GM, et al: University of Washington; Seattle, WA: pp. 1993–2022

15 

Vahlquist A, Fischer J and Torma H: Inherited nonsyndromic ichthyoses: An Update on pathophysiology, diagnosis and treatment. Am J Clin Dermatol. 19:51–66. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Yao Y, Yang K, Qi KY, Zeng LX and Zhang GQ: Diverse clinical and genetic characteristics of six cases of inherited epidermolysis bullosa. Exp Ther Med. 24:7272022. View Article : Google Scholar : PubMed/NCBI

17 

Arslan S, Garcia FJ, Guo M, Kellinger MW, Kruglyak S, LeVieux JA, Mah AH, Wang H, Zhao J, Zhou C, et al: Sequencing by avidity enables high accuracy with low reagent consumption. Nat Biotechnol. 42:132–138. 2024. View Article : Google Scholar : PubMed/NCBI

18 

Wang K, Li M and Hakonarson H: ANNOVAR: Functional annotation of genetic variants from next-generation sequencing data. Nucleic Acids Res. 38:e1642010. View Article : Google Scholar : PubMed/NCBI

19 

Richards S, Aziz N, Bale S, Bick D, Das S, Gastier-Foster J, Grody WW, Hegde M, Lyon E, Spector E, et al: Standards and guidelines for the interpretation of sequence variants: A joint consensus recommendation of the American college of medical genetics and genomics and the association for molecular pathology. Genet Med. 17:405–424. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Ioannidis NM, Rothstein JH, Pejaver V, Middha S, McDonnell SK, Baheti S, Musolf A, Li Q, Holzinger E, Karyadi D, et al: REVEL: An ensemble method for predicting the pathogenicity of rare missense variants. Am J Hum Genet. 99:877–885. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Chen H, Ho JCC, Sandilands A, Chan YC, Giam YC, Evans AT, Lane EB and McLean WHI: Unique and Recurrent mutations in the filaggrin gene in singaporean Chinese patients with ichthyosis vulgaris. J Invest Dermatol. 128:1669–1675. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Zhang H, Guo Y, Wang W, Shi M, Chen X and Yao Z: Mutations in the filaggrin gene in Han Chinese patients with atopic dermatitis. Allergy. 66:420–427. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Nomura T, Sandilands A, Akiyama M, Liao H, Evans AT, Sakai K, Ota M, Sugiura H, Yamamoto K, Sato H, et al: Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis. J Allergy Clin Immunol. 119:434–440. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Valdes-Flores M, Kofman-Alfaro SH, Vaca AL and Cuevas-Covarrubias SA: Mutation report: A novel partial deletion of exons 2–10 of the STS gene in recessive X-linked ichthyosis. J Invest Dermatol. 114:591–593. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Matsukura H, Fuchizawa T, Ohtsuki A, Higashiyama H, Higuchi O, Higuchi A and Miyawaki T: End-stage renal failure in a child with X-linked ichthyosis. Pediatr Nephrol. 18:297–300. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Paller AS, Syder AJ, Chan YM, Yu QC, Hutton E, Tadini G and Fuchs E: Genetic and clinical mosaicism in a type of epidermal nevus. N Engl J Med. 331:1408–1415. 1994. View Article : Google Scholar : PubMed/NCBI

27 

Dahlqvist J, Klar J, Hausser I, Anton-Lamprecht I, Pigg MH, Gedde-Dahl T Jr, Gånemo A, Vahlquist A and Dahl N: Congenital ichthyosis: Mutations in ichthyin are associated with specific structural abnormalities in the granular layer of epidermis. J Med Genet. 44:615–620. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Diociaiuti A, Fortugno P, El Hachem M, Angelo C, Proto V, De Luca N, Martinelli D, Boldrini R, Castiglia D and Zambruno G: Early immunopathological diagnosis of ichthyosis with confetti in two sporadic cases with new mutations in keratin 10. Acta Derm Venereol. 94:579–582. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Gubb SJA, Brcic L, Underwood JFG, Kendall KM, Caseras X, Kirov G and Davies W: Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank. Hum Mol Genet. 29:2872–2881. 2020. View Article : Google Scholar : PubMed/NCBI

30 

Yang K, Xu YC, Hu HY, Li YZ, Li Q, Luan YY, Liu Y, Sun YQ, Feng ZK, Yan YS and Yin CH: Investigation of a Novel NTRK1 variation causing congenital insensitivity to pain with anhidrosis. Front Genet. 12:7634672021. View Article : Google Scholar : PubMed/NCBI

31 

Kubo A, Shiohama A, Sasaki T, Nakabayashi K, Kawasaki H, Atsugi T, Sato S, Shimizu A, Mikami S, Tanizaki H, et al: Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis. Am J Hum Genet. 93:945–956. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Yin J, Xu G, Wang H, Zhao J, Duo L, Cao X, Tang Z, Lin Z and Yang Y: New and recurrent SERPINB7 mutations in seven Chinese patients with Nagashima-type palmoplantar keratosis. J Invest Dermatol. 134:2269–2272. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Zhao J, Yang Z, Xiang X and Ma L: SERPINB7 novel mutation in Chinese patients with Nagashima-type palmoplantar keratosis and cases associated with atopic dermatitis. Int J Dermatol. 59:e320–e322. 2020. View Article : Google Scholar : PubMed/NCBI

34 

Li Q, Zhu X, Wang C, Meng J, Chen D and Kong X: Identification of a rare case with nagashima-type palmoplantar keratoderma and 18q deletion syndrome via exome sequencing and low-coverage whole-genome sequencing. Front Genet. 12:7074112021. View Article : Google Scholar : PubMed/NCBI

35 

Xiao T, Liu Y, Wang T, Ren J, Xia Y and Wang X: Two novel mutations of SERPINB7 in eight cases of Nagashima-type palmoplantar keratosis in the Chinese population. J Dermatol. 49:539–544. 2022. View Article : Google Scholar : PubMed/NCBI

36 

Liu J, Chen Z, Hu L, Song Z, Mo R, Tsang LS, Liu Y, Huang X, Gong Z, Lin Z and Yang Y: Investigation of Nagashima-type palmoplantar keratoderma in China: A cross-sectional study of 234 patients. J Dermatol. 50:375–382. 2023. View Article : Google Scholar : PubMed/NCBI

37 

van der Meulen MA, van der Meulen MJ and te Meerman GJ: Recurrence risk for germinal mosaics revisited. J Med Genet. 32:102–104. 1995. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Yao Y, Tan Y, Hu H, Zeng L and Zhang G: Genetic analysis of seven patients with inherited ichthyosis and Nagashima‑type palmoplantar keratoderma. Mol Med Rep 30: 111, 2024.
APA
Zhang, J., Yao, Y., Tan, Y., Hu, H., Zeng, L., & Zhang, G. (2024). Genetic analysis of seven patients with inherited ichthyosis and Nagashima‑type palmoplantar keratoderma. Molecular Medicine Reports, 30, 111. https://doi.org/10.3892/mmr.2024.13235
MLA
Zhang, J., Yao, Y., Tan, Y., Hu, H., Zeng, L., Zhang, G."Genetic analysis of seven patients with inherited ichthyosis and Nagashima‑type palmoplantar keratoderma". Molecular Medicine Reports 30.1 (2024): 111.
Chicago
Zhang, J., Yao, Y., Tan, Y., Hu, H., Zeng, L., Zhang, G."Genetic analysis of seven patients with inherited ichthyosis and Nagashima‑type palmoplantar keratoderma". Molecular Medicine Reports 30, no. 1 (2024): 111. https://doi.org/10.3892/mmr.2024.13235
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Yao Y, Tan Y, Hu H, Zeng L and Zhang G: Genetic analysis of seven patients with inherited ichthyosis and Nagashima‑type palmoplantar keratoderma. Mol Med Rep 30: 111, 2024.
APA
Zhang, J., Yao, Y., Tan, Y., Hu, H., Zeng, L., & Zhang, G. (2024). Genetic analysis of seven patients with inherited ichthyosis and Nagashima‑type palmoplantar keratoderma. Molecular Medicine Reports, 30, 111. https://doi.org/10.3892/mmr.2024.13235
MLA
Zhang, J., Yao, Y., Tan, Y., Hu, H., Zeng, L., Zhang, G."Genetic analysis of seven patients with inherited ichthyosis and Nagashima‑type palmoplantar keratoderma". Molecular Medicine Reports 30.1 (2024): 111.
Chicago
Zhang, J., Yao, Y., Tan, Y., Hu, H., Zeng, L., Zhang, G."Genetic analysis of seven patients with inherited ichthyosis and Nagashima‑type palmoplantar keratoderma". Molecular Medicine Reports 30, no. 1 (2024): 111. https://doi.org/10.3892/mmr.2024.13235
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