Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-2024 Volume 30 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2024 Volume 30 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

LncRNA microarray profiling identifies novel circulating lncRNAs in hidradenitis suppurativa

  • Authors:
    • Bruna De Felice
    • Pasquale De Luca
    • Concetta Montanino
    • Marta Mallardo
    • Graziella Babino
    • Edi Mattera
    • Raffaele Sorbo
    • Giovanni Ragozzino
    • Giuseppe Argenziano
    • Aurora Daniele
    • Ersilia Nigro
  • View Affiliations / Copyright

    Affiliations: Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, I-81100 Caserta, Italy, Anton Dohrn Naples Zoological Station, I-80121 Naples, Italy, Dermatology Unit, University of Campania Luigi Vanvitelli, I-80131 Naples, Italy, Department of Internal and Experimental Medicine and Surgery Unit of Internal Medicine, University of Campania Luigi Vanvitelli, I-80131 Naples, Italy, CEINGE‑Franco Salvatore Advanced Biotechnology, I-80145 Naples, Italy
    Copyright: © De Felice et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 112
    |
    Published online on: May 2, 2024
       https://doi.org/10.3892/mmr.2024.13236
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Long noncoding RNAs (lncRNAs) have been demonstrated to be involved in biological processes, both physiological and pathological, including cancer, cardiovascular diseases, multiple sclerosis, autoimmune hepatitis and types I and II diabetes. LncRNAs are also known to have a critical role in the physiology of skin, and in the pathology of cutaneous diseases. LncRNAs are involved in a wide range of biological activities, including transcriptional post‑transcriptional processes, epigenetics, RNA splicing, gene activation and or silencing, modifications and/or editing; therefore, lncRNAs may be useful as potential targets for disease treatment. Hidradenitis suppurativa (HS), also termed acne inversa, is a major skin disease, being an inflammatory disorder that affects ~1% of global population in a chronic manner. Its pathogenesis, however, is only partly understood, although immune dysregulation is known to have an important role. To investigate the biological relevance of lncRNAs with HS, the most differentially expressed lncRNAs and mRNAs were first compared. Furthermore, the lncRNA‑microRNA regulatory network was also defined via reverse transcription‑quantitative PCR analysis, whereby a trio of lncRNA expression signatures, lncRNA‑TINCR, lncRNA‑RBM5‑ASI1 and lncRNA‑MRPL23‑AS1, were found to be significantly overexpressed in patients with HS compared with healthy controls. In conclusion, the three lncRNAs isolated in the present study may be useful for improving the prognostic prediction of HS, as well as contributing towards an improved understanding of the underlying pathogenic mechanisms, thereby potentially providing new therapeutic targets.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Mattick JS, Amaral PP, Carninci P, Carpenter S, Chang HY, Chen LL, Chen R, Dean C, Dinger ME, Fitzgerald KA, et al: Long non-coding RNAs: Definitions, functions, challenges and recommendations. Nat Rev Mol Cell Biol. 24:430–447. 2023. View Article : Google Scholar : PubMed/NCBI

2 

Schmitz SU, Grote P and Herrmann BG: Mechanisms of long noncoding RNA function in development and disease. Cell Mol Life Sci. 73:2491–2509. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Kazimierczyk M, Kasprowicz MK, Kasprzyk ME and Wrzesinski J: Human Long Noncoding RNA Interactome: Detection, characterization and function. Int J Mol Sci. 21:10272020. View Article : Google Scholar : PubMed/NCBI

4 

Herman AB, Tsitsipatis D and Gorospe M: Integrated lncRNA function upon genomic and epigenomic regulation. Mol Cell. 82:2252–2266. 2022. View Article : Google Scholar : PubMed/NCBI

5 

Devaux Y, Zangrando J, Schroen B, Creemers EE, Pedrazzini T, Chang CP, Dorn GW II, Thum T and Heymans S; Cardiolinc network, : Long noncoding RNAs in cardiac development and ageing. Nat Rev Cardiol. 12:415–425. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Liu Y, Zhang Y, Chen C and Li Y: lncRNA HIF1A-AS2: A potential oncogene in human cancers (Review). Biomed Rep. 15:852021. View Article : Google Scholar : PubMed/NCBI

7 

Chen M, Lei N, Tian W, Li Y and Chang L: Recent advances of non-coding RNAs in ovarian cancer prognosis and therapeutics. Ther Adv Med Oncol. 14:175883592211180102022. View Article : Google Scholar : PubMed/NCBI

8 

Jiang XY, Zhu QC, Zhang XJ, Duan T, Feng J, Sui XB, Sun XN and Mou YP: Roles of lncRNAs in pancreatic ductal adenocarcinoma: Diagnosis, treatment, and the development of drug resistance. Hepatobiliary Pancreat Dis Int. 22:128–139. 2023. View Article : Google Scholar : PubMed/NCBI

9 

Ashekyan O, Abdallah S, Shoukari AA, Chamandi G, Choubassy H, Itani ARS, Alwan N and Nasr R: Spotlight on Exosomal Non-Coding RNAs in breast cancer: An in silico analysis to identify potential lncRNA/circRNA-miRNA-Target Axis. Int J Mol Sci. 23:83512022. View Article : Google Scholar : PubMed/NCBI

10 

Hao Y, Xie B, Fu X, Xu R and Yang Y: New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer's Disease. Biomolecules. 12:18022022. View Article : Google Scholar : PubMed/NCBI

11 

Ghafouri-Fard S, Poulet C, Malaise M, Abak A, Mahmud Hussen B, Taheriazam A, Taheri M and Hallajnejad M: The emerging role of non-coding RNAs in osteoarthritis. Front Immunol. 12:7731712021. View Article : Google Scholar : PubMed/NCBI

12 

Sabaie H, Salkhordeh Z, Asadi MR, Ghafouri-Fard S, Amirinejad N, Askarinejad Behzadi M, Hussen BM, Taheri M and Rezazadeh M: Long Non-Coding RNA- Associated Competing Endogenous RNA Axes in T-Cells in multiple sclerosis. Front Immunol. 12:7706792021. View Article : Google Scholar : PubMed/NCBI

13 

De Benedittis G, Ciccacci C, Latini A, Novelli L, Novelli G and Borgiani P: Emerging Role of microRNAs and long non-coding RNAs in Sjögren's Syndrome. Genes (Basel). 12:9032021. View Article : Google Scholar : PubMed/NCBI

14 

Sirbe C, Simu G, Szabo I, Grama A and Pop TL: Pathogenesis of autoimmune hepatitis-cellular and molecular mechanisms. Int J Mol Sci. 22:135782021. View Article : Google Scholar : PubMed/NCBI

15 

Lv J, Liu Y, Cui J, Fang H, Wu Y, Zhu X, Guo M, Li C, Dou J, Chen Z and Du X: Profile screening of differentially expressed lncRNAs of circulating leukocytes in type 2 diabetes patients and differences from type 1 diabetes. Front Endocrinol (Lausanne). 12:6905552022. View Article : Google Scholar : PubMed/NCBI

16 

Wan DC and Wang KC: Long Noncoding RNA: Significance and potential in skin biology. Cold Spring Harb Perspect Med. 4:a0154042014. View Article : Google Scholar : PubMed/NCBI

17 

Chu CB, Yang CC and Tsai SJ: Hidradenitis suppurativa: Disease pathophysiology and sex hormones. Chin J Physiol. 64:257–265. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Fabbrocini G, Ruina G, Giovanardi G, Dini V, Raone B, Venturini M, Caposiena Caro RD, Veraldi S, Cannavò SP, Merlo G, et al: Hidradenitis suppurativa in a large cohort of Italian patients: Evaluation of the Burden of disease. Dermatology. 238:487–497. 2022. View Article : Google Scholar : PubMed/NCBI

19 

Scala E, Cacciapuoti S, Garzorz-Stark N, Megna M, Marasca C, Seiringer P, Volz T, Eyerich K and Fabbrocini G: Hidradenitis Suppurativa: Where we are and where we are going. Cells. 10:20942021. View Article : Google Scholar : PubMed/NCBI

20 

Nigro E, Polito R, Babino G, Mattera E, Fulgione E, Ragozzino G, D'Esposito V, Cabaro S, Signoriello G, Formisano P, et al: Adiponectin contributes to the inflammatory milieu in hidradenitis suppurativa. Dermatol Pract Concept. 12:e20221572022. View Article : Google Scholar : PubMed/NCBI

21 

Garg A, Naik HB, Alavi A, Hazen P, Hsiao JL, Shi VY, Weisman J, Tran T, Rudnik J, Jedrzejczyk A, et al: Real-World findings on the characteristics and treatment exposures of patients with hidradenitis suppurativa from US claims data. Dermatol Ther (Heidelb). 13:581–594. 2023. View Article : Google Scholar : PubMed/NCBI

22 

Rao X, Huang X, Zhou Z and Lin X: An improvement of the 2ˆ(−delta delta CT) method for quantitative real-time polymerase chain reaction data analysis. Biostat Bioinforma Biomath. 3:71–85. 2013.PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Yu G, Yao W, Wang J, Ma X, Xiao W, Li H, Xia D, Yang Y, Deng K, Xiao H, et al: LncRNAs expression signatures of renal clear cell carcinoma revealed by microarray. PLoS One. 7:e423772012. View Article : Google Scholar : PubMed/NCBI

25 

Kim J, Mooren OL, Onken MD and Cooper JA: Septin and actin contributions to endothelial cell-cell junctions and monolayer integrity. Cytoskeleton (Hoboken). 80:228–241. 2023. View Article : Google Scholar : PubMed/NCBI

26 

Nakahira M, Macedo JN, Seraphim TV, Cavalcante N, Souza TA, Damalio JC, Reyes LF, Assmann EM, Alborghetti MR, Garratt RC, et al: A draft of the human septin interactome. PLoS One. 5:e137992010. View Article : Google Scholar : PubMed/NCBI

27 

Neubauer K and Zieger B: The mammalian septin interactome. Front Cell Dev Biol. 5:32017. View Article : Google Scholar : PubMed/NCBI

28 

Gönczi M, Ráduly Z, Szabó L, Fodor J, Telek A, Dobrosi N, Balogh N, Szentesi P, Kis G, Antal M, et al: Septin7 is indispensable for proper skeletal muscle architecture and function. Elife. 11:e758632022. View Article : Google Scholar : PubMed/NCBI

29 

Dasgupta I and McCollum D: Control of cellular responses to mechanical cues through YAP/TAZ regulation. J Biol Chem. 294:17693–17706. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Kim K, Kim H and Sung GY: An Interleukin-4 and Interleukin-13 Induced Atopic Dermatitis Human Skin Equivalent Model by a Skin-On-A-Chip. Int J Mol Sci. 23:21162022. View Article : Google Scholar : PubMed/NCBI

31 

Napolitano M, di Vico F, Ruggiero A, Fabbrocini G and Patruno C: The hidden sentinel of the skin: An overview on the role of interleukin-13 in atopic dermatitis. Front Med (Lausanne). 10:11650982023. View Article : Google Scholar : PubMed/NCBI

32 

De Vuyst E, Salmon M, Evrard C, Lambert de Rouvroit C and Poumay Y: Atopic Dermatitis Studies through in vitro models. Front Med (Lausanne). 4:1192017. View Article : Google Scholar : PubMed/NCBI

33 

De Felice B, Montanino C, Mallardo M, Babino G, Mattera E, Ragozzino G, Argenziano G, Daniele A and Nigro E: Circulating microRNAs in Hidradenitis Suppurativa. Genes (Basel). 13:15442022. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
De Felice B, De Luca P, Montanino C, Mallardo M, Babino G, Mattera E, Sorbo R, Ragozzino G, Argenziano G, Daniele A, Daniele A, et al: LncRNA microarray profiling identifies novel circulating lncRNAs in hidradenitis suppurativa. Mol Med Rep 30: 112, 2024.
APA
De Felice, B., De Luca, P., Montanino, C., Mallardo, M., Babino, G., Mattera, E. ... Nigro, E. (2024). LncRNA microarray profiling identifies novel circulating lncRNAs in hidradenitis suppurativa. Molecular Medicine Reports, 30, 112. https://doi.org/10.3892/mmr.2024.13236
MLA
De Felice, B., De Luca, P., Montanino, C., Mallardo, M., Babino, G., Mattera, E., Sorbo, R., Ragozzino, G., Argenziano, G., Daniele, A., Nigro, E."LncRNA microarray profiling identifies novel circulating lncRNAs in hidradenitis suppurativa". Molecular Medicine Reports 30.1 (2024): 112.
Chicago
De Felice, B., De Luca, P., Montanino, C., Mallardo, M., Babino, G., Mattera, E., Sorbo, R., Ragozzino, G., Argenziano, G., Daniele, A., Nigro, E."LncRNA microarray profiling identifies novel circulating lncRNAs in hidradenitis suppurativa". Molecular Medicine Reports 30, no. 1 (2024): 112. https://doi.org/10.3892/mmr.2024.13236
Copy and paste a formatted citation
x
Spandidos Publications style
De Felice B, De Luca P, Montanino C, Mallardo M, Babino G, Mattera E, Sorbo R, Ragozzino G, Argenziano G, Daniele A, Daniele A, et al: LncRNA microarray profiling identifies novel circulating lncRNAs in hidradenitis suppurativa. Mol Med Rep 30: 112, 2024.
APA
De Felice, B., De Luca, P., Montanino, C., Mallardo, M., Babino, G., Mattera, E. ... Nigro, E. (2024). LncRNA microarray profiling identifies novel circulating lncRNAs in hidradenitis suppurativa. Molecular Medicine Reports, 30, 112. https://doi.org/10.3892/mmr.2024.13236
MLA
De Felice, B., De Luca, P., Montanino, C., Mallardo, M., Babino, G., Mattera, E., Sorbo, R., Ragozzino, G., Argenziano, G., Daniele, A., Nigro, E."LncRNA microarray profiling identifies novel circulating lncRNAs in hidradenitis suppurativa". Molecular Medicine Reports 30.1 (2024): 112.
Chicago
De Felice, B., De Luca, P., Montanino, C., Mallardo, M., Babino, G., Mattera, E., Sorbo, R., Ragozzino, G., Argenziano, G., Daniele, A., Nigro, E."LncRNA microarray profiling identifies novel circulating lncRNAs in hidradenitis suppurativa". Molecular Medicine Reports 30, no. 1 (2024): 112. https://doi.org/10.3892/mmr.2024.13236
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team