Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-2024 Volume 30 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2024 Volume 30 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.xlsx
    • Supplementary_Data2.xlsx
    • Supplementary_Data3.xlsx
    • Supplementary_Data4.xlsx
Article Open Access

Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan

  • Authors:
    • Jai-Sing Yang
    • Ting-Yuan Liu
    • Hsing-Fang Lu
    • Shih-Chang Tsai
    • Wen-Ling Liao
    • Yu-Jen Chiu
    • Yu-Wen Wang
    • Fuu-Jen Tsai
  • View Affiliations / Copyright

    Affiliations: Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan, R.O.C., Million‑Person Precision Medicine Initiative, Department of Medical Research, China Medical University Hospital, Taichung 404327, Taiwan, R.O.C., Department of Biological Science and Technology, China Medical University, Taichung 406040, Taiwan, R.O.C., Graduate Institute of Integrated Medicine, China Medical University, Taichung 404333, Taiwan, R.O.C., Department of Surgery, Division of Plastic and Reconstructive Surgery, Taipei Veterans General Hospital, Taipei 112201, Taiwan, R.O.C., 8School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404333, Taiwan, R.O.C.
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 115
    |
    Published online on: May 13, 2024
       https://doi.org/10.3892/mmr.2024.13239
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Psoriasis is a chronic inflammatory dermatological disease, and there is a lack of understanding of the genetic factors involved in psoriasis in Taiwan. To establish associations between genetic variations and psoriasis, a genome‑wide association study was performed in a cohort of 2,248 individuals with psoriasis and 67,440 individuals without psoriasis. Using the ingenuity pathway analysis software, biological networks were constructed. Human leukocyte antigen (HLA) diplotypes and haplotypes were analyzed using Attribute Bagging (HIBAG)‑R software and chi‑square analysis. The present study aimed to assess the potential risks associated with psoriasis using a polygenic risk score (PRS) analysis. The genetic association between single nucleotide polymorphisms (SNPs) in psoriasis and various human diseases was assessed by phenome‑wide association study. METAL software was used to analyze datasets from China Medical University Hospital (CMUH) and BioBank Japan (BBJ). The results of the present study revealed 8,585 SNPs with a significance threshold of P<5x10‑8, located within 153 genes strongly associated with the psoriasis phenotype, particularly on chromosomes 5 and 6. This specific genomic region has been identified by analyzing the biological networks associated with numerous pathways, including immune responses and inflammatory signaling. HLA genotype analysis indicated a strong association between HLA‑A*02:07 and HLA‑C*06:02 in a Taiwanese population. Based on our PRS analysis, the risk of psoriasis associated with the SNPs identified in the present study was quantified. These SNPs are associated with various dermatological, circulatory, endocrine, metabolic, musculoskeletal, hematopoietic and infectious diseases. The meta‑analysis results indicated successful replication of a study conducted on psoriasis in the BBJ. Several genetic loci are significantly associated with susceptibility to psoriasis in Taiwanese individuals. The present study contributes to our understanding of the genetic determinants that play a role in susceptibility to psoriasis. Furthermore, it provides valuable insights into the underlying etiology of psoriasis in the Taiwanese community.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Balda A, Wani I, Roohi TF, Suman, Krishna KL, Mehdi S, Nadiga AP, Makkapati M and Baig MAI: Psoriasis and skin cancer-Is there a link? Int Immunopharmacol. 121:1104642023. View Article : Google Scholar : PubMed/NCBI

2 

Chi CC, Wu YW, Chao TH, Chen CC, Chen YJ, Cheng HM, Chiu HY, Chiu YW, Chung WH, Hsieh TY, et al: 2022 Taiwanese Dermatological Association (TDA), Taiwanese Association for Psoriasis and Skin Immunology (TAPSI), and Taiwan Society of cardiology (TSOC) joint consensus recommendations for the management of psoriatic disease with attention to cardiovascular comorbidities. J Formos Med Assoc. 122:442–457. 2023. View Article : Google Scholar : PubMed/NCBI

3 

Michalek IM, Loring B and John SM: A systematic review of worldwide epidemiology of psoriasis. J Eur Acad Dermatol Venereol. 31:205–212. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Wang TS, Hsieh CF and Tsai TF: Epidemiology of psoriatic disease and current treatment patterns from 2003 to 2013: A nationwide, population-based observational study in Taiwan. J Dermatol Sci. 84:340–345. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Kubota K, Kamijima Y, Sato T, Ooba N, Koide D, Iizuka H and Nakagawa H: Epidemiology of psoriasis and palmoplantar pustulosis: A nationwide study using the Japanese national claims database. BMJ Open. 5:e0064502015. View Article : Google Scholar : PubMed/NCBI

6 

Lee JY, Kang S, Park JS and Jo SJ: Prevalence of psoriasis in Korea: A population-based epidemiological study using the Korean National Health Insurance Database. Ann Dermatol. 29:761–767. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Ding X, Wang T, Shen Y, Wang X, Zhou C, Tian S, Liu Y, Peng G, Zhou J, Xue S, et al: Prevalence of psoriasis in China: A population-based study in six cities. Eur J Dermatol. 22:663–667. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Yang SF, Lin MH, Chou PC, Hu SK, Shih SY, Yu HS and Yu S: Genetics of generalized pustular psoriasis: Current understanding and implications for future therapeutics. Genes (Basel). 14:12972023. View Article : Google Scholar : PubMed/NCBI

9 

Lee LL, Huo AP and Chen SL: Experiences and coping behaviors of patients with psoriasis: A qualitative study. J Dermatolog Treat. 34:21936612023. View Article : Google Scholar : PubMed/NCBI

10 

Wang CY, Wang CW, Chen CB, Chen WT, Chang YC, Hui RC and Chung WH: Pharmacogenomics on the treatment response in patients with psoriasis: An updated review. Int J Mol Sci. 24:73292023. View Article : Google Scholar : PubMed/NCBI

11 

Honma M and Hayashi K: Psoriasis: Recent progress in molecular-targeted therapies. J Dermatol. 48:761–777. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Furue M and Kadono T: Psoriasis: Behind the scenes. J Dermatol. 43:4–8. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Rendon A and Schakel K: Psoriasis pathogenesis and treatment. Int J Mol Sci. 20:14752019. View Article : Google Scholar : PubMed/NCBI

14 

Ohata C, Anezaki H, Kaneko S, Okazaki F, Ito K, Matsuzaka Y, Kikuchi S, Koike Y, Murota H, Miyagi T, et al: Clinical characteristics of patients with psoriasis with family history: A multicenter observational study. J Dermatol. 50:746–752. 2023. View Article : Google Scholar : PubMed/NCBI

15 

Bayaraa B and Imafuku S: Relationship between environmental factors, age of onset and familial history in Japanese patients with psoriasis. J Dermatol. 45:715–718. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Kaur I, Handa S and Kumar B: Natural history of psoriasis: A study from the Indian subcontinent. J Dermatol. 24:230–234. 1997. View Article : Google Scholar : PubMed/NCBI

17 

Kocaaga A and Kocaaga M: Psoriasis: An Immunogenetic perspective. Glob Med Genet. 9:82–89. 2022. View Article : Google Scholar : PubMed/NCBI

18 

Elyoussfi S, Rane SS, Eyre S and Warren RB: TYK2 as a novel therapeutic target in psoriasis. Expert Rev Clin Pharmacol. 16:549–558. 2023. View Article : Google Scholar : PubMed/NCBI

19 

Yarmolinsky J, Amos CI, Hung RJ, Moreno V, Burrows K, Smith-Byrne K, Atkins JR, Brennan P; Colon Cancer Family Registry (CCFR), Colorectal Cancer Transdisciplinary Study (CORECT), ; et al: Association of germline TYK2 variation with lung cancer and non-Hodgkin lymphoma risk. Int J Cancer. 151:2155–2160. 2022. View Article : Google Scholar : PubMed/NCBI

20 

Enerback C, Sandin C, Lambert S, Zawistowski M, Stuart PE, Verma D, Tsoi LC, Nair RP, Johnston A and Elder JT: The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells. Sci Rep. 8:70432018. View Article : Google Scholar : PubMed/NCBI

21 

Hao L, Kraft P, Berriz GF, Hynes ED, Koch C, Korategere V Kumar P, Parpattedar SS, Steeves M, Yu W, et al: Development of a clinical polygenic risk score assay and reporting workflow. Nat Med. 28:1006–1013. 2022. View Article : Google Scholar : PubMed/NCBI

22 

Liao WL, Huang YN, Chang YW, Liu TY, Lu HF, Tiao ZY, Su PH, Wang CH and Tsai FJ: Combining polygenic risk scores and human leukocyte antigen variants for personalized risk assessment of type 1 diabetes in the Taiwanese population. Diabetes Obes Metab. 25:2928–2936. 2023. View Article : Google Scholar : PubMed/NCBI

23 

Janssens ACJW: Validity of polygenic risk scores: Are we measuring what we think we are? Hum Mol Genet. 28:R143–R150. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Cross B, Turner R and Pirmohamed M: Polygenic risk scores: An overview from bench to bedside for personalised medicine. Front Genet. 13:10006672022. View Article : Google Scholar : PubMed/NCBI

25 

Dixon P, Keeney E, Taylor JC, Wordsworth S and Martin RM: Can polygenic risk scores contribute to cost-effective cancer screening? A systematic review. Genet Med. 24:1604–1617. 2022. View Article : Google Scholar : PubMed/NCBI

26 

Byrne L and Toland AE: Polygenic risk scores in prostate cancer risk assessment and screening. Urol Clin North Am. 48:387–399. 2021. View Article : Google Scholar : PubMed/NCBI

27 

Lambert SA, Abraham G and Inouye M: Towards clinical utility of polygenic risk scores. Hum Mol Genet. 28:R133–R142. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Johnson D, Wilke MAP, Lyle SM, Kowalec K, Jorgensen A, Wright GEB and Drögemöller BI: A systematic review and analysis of the use of polygenic scores in pharmacogenomics. Clin Pharmacol Ther. 111:919–930. 2022. View Article : Google Scholar : PubMed/NCBI

29 

Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, et al: A cross-population atlas of genetic associations for 220 human phenotypes. Nat Genet. 53:1415–1424. 2021. View Article : Google Scholar : PubMed/NCBI

30 

Chen TC, Wang TC, Yiu ZZN, Lee MS, Chen LC, Chan KA, Griffiths CEM and Ashcroft DM; Global Psoriasis Atlas (GPA), : Risk of serious infection and infection mortality in patients with psoriasis: A nationwide cohort study using the Taiwan National Health Insurance claims database. J Eur Acad Dermatol Venereol. 38:136–144. 2024. View Article : Google Scholar : PubMed/NCBI

31 

Hsu MC, Wang CC, Huang LY, Lin CY, Lin FJ and Toh S: Effect of ICD-9-CM to ICD-10-CM coding system transition on identification of common conditions: An interrupted time series analysis. Pharmacoepidemiol Drug Saf. 30:1653–1674. 2021. View Article : Google Scholar : PubMed/NCBI

32 

Huang YH, Tang CH, Goh CH, Chang CL, Qiu H, Yang YW, Saadoun C, Chang CL and Liu Y: Persistence and adherence to biologics in patients with psoriasis in Taiwan: A new biologics user cohort study. Front Pharmacol. 13:8809852022. View Article : Google Scholar : PubMed/NCBI

33 

Wei JC, Shi LH, Huang JY, Wu XF, Wu R and Chiou JY: Epidemiology and medication pattern change of psoriatic diseases in Taiwan from 2000 to 2013: A nationwide, population-based cohort study. J Rheumatol. 45:385–392. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Lee WC, Wang LY and Cheng KF: An easy-to-implement approach for analyzing case-control and case-only studies assuming gene-environment independence and Hardy-Weinberg equilibrium. Stat Med. 29:2557–2567. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Chiou JS, Cheng CF, Liang WM, Chou CH, Wang CH, Lin WD, Chiu ML, Cheng WC, Lin CW, Lin TH, et al: Your height affects your health: genetic determinants and health-related outcomes in Taiwan. BMC Med. 20:2502022. View Article : Google Scholar : PubMed/NCBI

36 

Genomes Project Consortium, . Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, Korbel JO, Marchini JL, McCarthy S, McVean GA and Abecasis GR: A global reference for human genetic variation. Nature. 526:68–74. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Lu HF, Chou CH, Lin YJ, Uchiyama S, Terao C, Wang YW, Yang JS, Liu TY, Wong HS, Chen SC and Tsai FJ: The genome-wide association study of serum IgE levels demonstrated a shared genetic background in allergic diseases. Clin Immunol. 260:1098972024. View Article : Google Scholar : PubMed/NCBI

38 

Liu TY, Lin CF, Wu HT, Wu YL, Chen YC, Liao CC, Chou YP, Chao D, Chang YS, Lu HF, et al: Comparison of multiple imputation algorithms and verification using whole-genome sequencing in the CMUH genetic biobank. Biomedicine (Taipei). 11:57–65. 2021. View Article : Google Scholar : PubMed/NCBI

39 

Yang JS, Liu TY, Chen YC, Tsai SC, Chiu YJ, Liao CC and Tsai FJ: Genome-Wide association study of alopecia areata in Taiwan: The conflict between individuals and hair follicles. Clin Cosmet Investig Dermatol. 16:2597–2612. 2023. View Article : Google Scholar : PubMed/NCBI

40 

Wu CY, Hu HY, Li CP, Chou YJ and Chang YT: Comorbidity profiles of psoriasis in Taiwan: A latent class analysis. PLoS One. 13:e01925372018. View Article : Google Scholar : PubMed/NCBI

41 

Cheng YD, Lu CC, Hsu YM, Tsai FJ, Bau DT, Tsai SC, Cheng CC, Lin JJ, Huang YY, Juan YN, et al: In Silico and In Vitro studies of Taiwan Chingguan Yihau (NRICM101) on TNF-α/IL-1β-induced human lung cells. Biomedicine (Taipei). 12:56–71. 2022. View Article : Google Scholar : PubMed/NCBI

42 

Yang JS, Kang CY, Su CH, Chen CJ, Chiu YJ and Hsu YM: Helicobacter pylori Targets in AGS Human gastric adenocarcinoma: In situ proteomic profiling and systematic analysis. Anticancer Res. 42:531–546. 2022. View Article : Google Scholar : PubMed/NCBI

43 

Liao WL, Liu TY, Cheng CF, Chou YP, Wang TY, Chang YW, Chen SY and Tsai FJ: Analysis of HLA variants and graves' disease and its comorbidities using a high resolution imputation system to examine electronic medical health records. Front Endocrinol (Lausanne). 13:8426732022. View Article : Google Scholar : PubMed/NCBI

44 

Liu TY, Liao WL, Wang TY, Chan CJ, Chang JG, Chen YC, Lu HF, Yang HH, Chen SY and Tsai FJ: Genome-wide association study of hyperthyroidism based on electronic medical record from Taiwan. Front Med (Lausanne). 9:8306212022. View Article : Google Scholar : PubMed/NCBI

45 

Willer CJ, Li Y and Abecasis GR: METAL: Fast and efficient meta-analysis of genomewide association scans. Bioinformatics. 26:2190–2191. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Chiu HY, Tsai SC, Tsai FJ, Lo YH, Cheng CC, Liu TY, Jhan SR, Yang JS and Chiu YJ: Liraglutide With Metformin Therapy Ameliorates Hepatic Steatosis and Liver Injury in a Mouse Model of Non-alcoholic Steatohepatitis. In Vivo. 37:1037–1046. 2023. View Article : Google Scholar : PubMed/NCBI

47 

Takenaka S, Itoh T and Fujiwara R: Expression pattern of human ATP-binding cassette transporters in skin. Pharmacol Res Perspect. 1:e000052013. View Article : Google Scholar : PubMed/NCBI

48 

Amagai R, Takahashi T, Terui H, Fujimura T, Yamasaki K, Aiba S and Asano Y: The antimicrobial peptide cathelicidin exerts immunomodulatory effects via scavenger receptors. Int J Mol Sci. 24:8752023. View Article : Google Scholar : PubMed/NCBI

49 

Orsmark C, Skoog T, Jeskanen L, Kere J and Saarialho-Kere U: Expression of allograft inflammatory factor-1 in inflammatory skin disorders. Acta Derm Venereol. 87:223–227. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Zhang F, Han L, Wang B, Huang Q, Yawalkar N, Zhang Z and Yan K: Annexin A6 polymorphism is associated with pro-atherogenic lipid profiles and with the downregulation of methotrexate on anti-atherogenic lipid profiles in psoriasis. J Clin Med. 11:70792022. View Article : Google Scholar

51 

Slivka PF, Hsieh CL, Lipovsky A, Pratt SD, Locklear J, Namovic MT, McDonald HA, Wetter J, Edelmayer R, Hu M, et al: Small molecule and pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a novel contributor to keratinocyte inflammatory responses. ACS Chem Biol. 14:857–872. 2019. View Article : Google Scholar : PubMed/NCBI

52 

Nakagawa H, Akazaki S, Asahina A, Tokunaga K, Matsuki K, Kuwata S, Ishibashi Y and Juji T: Study of HLA class I, class II and complement genes (C2, C4A, C4B and BF) in Japanese psoriatics and analysis of a newly-found high-risk haplotype by pulsed field gel electrophoresis. Arch Dermatol Res. 283:281–284. 1991. View Article : Google Scholar : PubMed/NCBI

53 

Abbas Zadeh S, Mlitz V, Lachner J, Golabi B, Mildner M, Pammer J, Tschachler E and Eckhart L: Phylogenetic profiling and gene expression studies implicate a primary role of PSORS1C2 in terminal differentiation of keratinocytes. Exp Dermatol. 26:352–358. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Sanchez F, Holm SJ, Mallbris L, O'Brien KP and Stahle M: STG does not associate with psoriasis in the Swedish population. Exp Dermatol. 13:413–418. 2004. View Article : Google Scholar : PubMed/NCBI

55 

Acevedo F and Hammar H: Complement C3 proteins in psoriasis. Br J Dermatol. 121:329–335. 1989. View Article : Google Scholar : PubMed/NCBI

56 

Fuentelsaz-Romero S, Cuervo A, Estrada-Capetillo L, Celis R, García-Campos R, Ramírez J, Sastre S, Samaniego R, Puig-Kröger A and Cañete JD: GM-CSF expression and macrophage polarization in joints of undifferentiated arthritis patients evolving to rheumatoid arthritis or psoriatic arthritis. Front Immunol. 11:6139752021. View Article : Google Scholar : PubMed/NCBI

57 

Nair RP, Stuart PE, Nistor I, Hiremagalore R, Chia NVC, Jenisch S, Weichenthal M, Abecasis GR, Lim HW, Christophers E, et al: Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet. 78:827–851. 2006. View Article : Google Scholar : PubMed/NCBI

58 

Knight J, Spain SL, Capon F, Hayday A, Nestle FO, Clop A; Wellcome Trust Case Control Consortium; Genetic Analysis of Psoriasis Consortium; I-chip for Psoriasis Consortium; Barker JN, ; et al: Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis. Hum Mol Genet. 21:5185–5192. 2012. View Article : Google Scholar : PubMed/NCBI

59 

Rajesh D, Nagraj S, Kumar KSP, Kutty AVM and Balakrishna S: Evaluation of HCP5 and Chemokine C Receptor type 5 gene polymorphisms in indian psoriatic patients. Indian J Dermatol. 64:182–186. 2019. View Article : Google Scholar : PubMed/NCBI

60 

Li XL, Yu H and Wu GS: Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population. Int J Immunogenet. 41:503–507. 2014. View Article : Google Scholar : PubMed/NCBI

61 

Massy E, Pedini P, Pollet E, Martin M, Roudier J, Picard C and Balandraud N: Association study between HLA-A, -B, -C, -DRB1 alleles and Psoriatic arthritis in southern France. Hum Immunol. 83:515–520. 2022. View Article : Google Scholar : PubMed/NCBI

62 

Cassia FF, Cardoso JF, Porto LC, Ramos-E-Silva M and Carneiro S: Association of HLA Alleles and HLA haplotypes with psoriasis, psoriatic arthritis and disease severity in a miscegenated population. Psoriasis (Auckl). 11:41–51. 2021.PubMed/NCBI

63 

Crivellato E and Zacchi T: The HLA system and psoriasis: A family study. G Ital Dermatol Venereol. 120:247–254. 1985.(In Italian). PubMed/NCBI

64 

Pyo CW, Hur SS, Kim YK, Kim TY and Kim TG: Association of TAP and HLA-DM genes with psoriasis in Koreans. J Invest Dermatol. 120:616–622. 2003. View Article : Google Scholar : PubMed/NCBI

65 

Zhou X, He Y, Kuang Y, Chen W and Zhu W: HLA-DQA1 and DQB1 alleles are associated with acitretin response in patients with psoriasis. Front Biosci (Landmark Ed). 27:2662022. View Article : Google Scholar : PubMed/NCBI

66 

Zhu KJ, Lv YM, Yin XY, Wang ZX, Sun LD, He SM, Cheng H, Hu DY, Zhang Z, Li Y, et al: Psoriasis regression analysis of MHC loci identifies shared genetic variants with vitiligo. PLoS One. 6:e230892011. View Article : Google Scholar : PubMed/NCBI

67 

Shawkatova I, Javor J, Parnicka Z, Kozub P, Zilínková M, Frey P, Ferenčík S and Buc M: HLA-C, DRB1 and DQB1 alleles involved in genetic predisposition to psoriasis vulgaris in the Slovak population. Folia Microbiol (Praha). 58:319–324. 2013. View Article : Google Scholar : PubMed/NCBI

68 

Patel F, Marusina AI, Duong C, Adamopoulos IE and Maverakis E: NKG2C, HLA-E and their association with psoriasis. Exp Dermatol. 22:797–799. 2013. View Article : Google Scholar : PubMed/NCBI

69 

Tamiya G, Shiina T, Oka A, Tomizawa M, Ota M, Katsuyama Y, Yoshitome M, Makino S, Kimura M and Inoko H: New polymorphic microsatellite markers in the human MHC class I region. Tissue Antigens. 54:221–228. 1999. View Article : Google Scholar : PubMed/NCBI

70 

Aractingi S, Briand N, Le Danff C, Viguier M, Bachelez H, Michel L, Dubertret L and Carosella ED: HLA-G and NK receptor are expressed in psoriatic skin: A possible pathway for regulating infiltrating T cells? Am J Pathol. 159:71–77. 2001. View Article : Google Scholar : PubMed/NCBI

71 

Lamore SD and Wondrak GT: Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermis. Biometals. 24:875–890. 2011. View Article : Google Scholar : PubMed/NCBI

72 

Vincken NLA, Welsing PMJ, Silva-Cardoso SC, Bekker CPJ, Lopes AP, Olde Nordkamp M, Leijten EFA, Radstake TRDJ and Angiolilli C: Suppression of IL-12/IL-23 p40 subunit in the skin and blood of psoriasis patients by Tofacitinib is dependent on active interferon-ү signaling in dendritic cells: Implications for the treatment of psoriasis and interferon-driven diseases. Exp Dermatol. 31:962–969. 2022. View Article : Google Scholar : PubMed/NCBI

73 

Bojko A, Ostasz R, Bialecka M, Klimowicz A, Malinowski D, Budawski R, Bojko P, Droździk M and Kurzawski M: IL12B, IL23A, IL23R and HLA-C*06 genetic variants in psoriasis susceptibility and response to treatment. Hum Immunol. 79:213–217. 2018. View Article : Google Scholar : PubMed/NCBI

74 

Woo J and Lee C: Identification of functional haplotypes in the promoter region of the LST1 gene. Biochem Genet. 52:365–371. 2014. View Article : Google Scholar : PubMed/NCBI

75 

Morelli M, Galluzzo M, Scarponi C, Madonna S, Scaglione GL, Girolomoni G, Talamonti M, Bianchi L and Albanesi C: Allelic Variants of HLA-C Upstream Region, PSORS1C3, MICA, TNFA and genes involved in epidermal homeostasis and barrier function influence the clinical response to Anti-IL-12/IL-23 treatment of patients with psoriasis. Vaccines (Basel). 10:19772022. View Article : Google Scholar : PubMed/NCBI

76 

Morelli M, Galluzzo M, Madonna S, Scarponi C, Scaglione GL, Galluccio T, Andreani M, Pallotta S, Girolomoni G, Bianchi L, et al: HLA-Cw6 and other HLA-C alleles, as well as MICB-DT, DDX58, and TYK2 genetic variants associate with optimal response to anti-IL-17A treatment in patients with psoriasis. Expert Opin Biol Ther. 21:259–270. 2021. View Article : Google Scholar : PubMed/NCBI

77 

Lommers E, Depierreux F, Hansen I, Dive D and Maquet P: NMOSD with anti-MOG antibodies following anti-TNFα therapy: A case report. Mult Scler Relat Disord. 26:37–39. 2018. View Article : Google Scholar : PubMed/NCBI

78 

Setsirichok D, Tienboon P, Jaroonruang N, Kittichaijaroen S, Wongseree W, Piroonratana T, Usavanarong T, Limwongse C, Aporntewan C, Phadoongsidhi M and Chaiyaratana N: An omnibus permutation test on ensembles of two-locus analyses can detect pure epistasis and genetic heterogeneity in genome-wide association studies. Springerplus. 2:2302013. View Article : Google Scholar : PubMed/NCBI

79 

Wu X, Dong H, Luo L, Zhu Y, Peng G, Reveille JD and Xiong M: A novel statistic for genome-wide interaction analysis. PLoS Genet. 6:e10011312010. View Article : Google Scholar : PubMed/NCBI

80 

Frew JW: The contradictory inefficacy of methotrexate in hidradenitis suppurativa: A need to revise pathogenesis or acknowledge disease heterogeneity? J Dermatolog Treat. 31:422–423. 2020. View Article : Google Scholar : PubMed/NCBI

81 

Cai M, Huang H, Hu Z, Yuan T, Li W, Liu Y, Zheng L, Zhang Y, Sheng Y and Zhang X: Two variants in the NOTCH4 and HLA-C genes contribute to familial clustering of psoriasis. Int J Genomics. 2020:69073782020. View Article : Google Scholar : PubMed/NCBI

82 

Michailidis C, Karpouzis A, Kourmouli N, Tripsianis G, Diplas A and Veletza S: Notch2, notch4 gene polymorphisms in psoriasis vulgaris. Eur J Dermatol. 23:146–153. 2013. View Article : Google Scholar : PubMed/NCBI

83 

Gao W, Sweeney C, Walsh C, Rooney P, McCormick J, Veale DJ and Fearon U: Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2. Ann Rheum Dis. 72:1080–1088. 2013. View Article : Google Scholar : PubMed/NCBI

84 

Mehta K, Jaiswal P, Briggs F, Faubion WA, Tabibian JH, Cominelli F and Dave M: In-patient outcomes of hematopoietic stem cell transplantation in patients with immune mediated inflammatory diseases: A nationwide study. Sci Rep. 8:68252018. View Article : Google Scholar : PubMed/NCBI

85 

Chang YT, Liu HN, Shiao YM, Lin MW, Lee DD, Liu MT, Wang WJ, Wu S, Lai CY and Tsai SF: A study of PSORS1C1 gene polymorphisms in Chinese patients with psoriasis. Br J Dermatol. 153:90–96. 2005. View Article : Google Scholar : PubMed/NCBI

86 

Skibola CF, Bracci PM, Halperin E, Conde L, Craig DW, Agana L, Iyadurai K, Becker N, Brooks-Wilson A, Curry JD, et al: Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma. Nat Genet. 41:873–875. 2009. View Article : Google Scholar : PubMed/NCBI

87 

Rahman P, Roslin NM, Pellett FJ, Lemire M, Greenwood CM, Beyene J, Pope A, Peddle L, Paterson AD, Uddin M and Gladman DD: High resolution mapping in the major histocompatibility complex region identifies multiple independent novel loci for psoriatic arthritis. Ann Rheum Dis. 70:690–694. 2011. View Article : Google Scholar : PubMed/NCBI

88 

Gregory AP, Dendrou CA, Attfield KE, Haghikia A, Xifara DK, Butter F, Poschmann G, Kaur G, Lambert L, Leach OA, et al: TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis. Nature. 488:508–511. 2012. View Article : Google Scholar : PubMed/NCBI

89 

Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng BJ, et al: Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet. 41:199–204. 2009. View Article : Google Scholar : PubMed/NCBI

90 

Witoelar A, Jansen IE, Wang Y, Desikan RS, Gibbs JR, Blauwendraat C, Thompson WK, Hernandez DG, Djurovic S, Schork AJ, et al: Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases. JAMA Neurol. 74:780–792. 2017. View Article : Google Scholar : PubMed/NCBI

91 

Roy M, Singh K, Shinde A, Singh J, Mane M, Bedekar S, Tailor Y, Gohel D, Vasiyani H, Currim F and Singh R: TNF-α-induced E3 ligase, TRIM15 inhibits TNF-alpha-regulated NF-κB pathway by promoting turnover of K63 linked ubiquitination of TAK1. Cell Signal. 91:1102102022. View Article : Google Scholar : PubMed/NCBI

92 

Miao X, Xiang Y, Mao W, Chen Y, Li Q and Fan B: TRIM27 promotes IL-6-induced proliferation and inflammation factor production by activating STAT3 signaling in HaCaT cells. Am J Physiol Cell Physiol. 318:C272–C281. 2020. View Article : Google Scholar : PubMed/NCBI

93 

He P, Cao RR, Deng FY and Lei SF: Identification of potential pleiotropic genes for immune and skeletal diseases using multivariate MetaCCA analysis. Curr Genomics. 22:596–606. 2021. View Article : Google Scholar : PubMed/NCBI

94 

Burkhart JG, Wu G, Song X, Raimondi F, McWeeney S, Wong MH and Deng Y: Biology-inspired graph neural network encodes reactome and reveals biochemical reactions of disease. Patterns (NY). 4:1007582023. View Article : Google Scholar : PubMed/NCBI

95 

Zhen Q, Yang Z, Wang W, Li B, Bai M, Wu J, Ge H, Dong Z, Shen J, Tang H, et al: Genetic study on small insertions and deletions in psoriasis reveals a role in complex human diseases. J Invest Dermatol. 139:2302–2312 e14. 2019. View Article : Google Scholar : PubMed/NCBI

96 

Gupta R, Debbaneh MG and Liao W: Genetic epidemiology of psoriasis. Curr Dermatol Rep. 3:61–78. 2014. View Article : Google Scholar : PubMed/NCBI

97 

Oh SM, Kim SK, Ahn HJ and Jeong KH: A pilot genome-wide association study identifies novel markers of metabolic syndrome in patients with psoriasis. Ann Dermatol. 35:285–292. 2023. View Article : Google Scholar : PubMed/NCBI

98 

Chen W, Wang W, Yong L, Zhen Q, Yu Y, Ge H, Mao Y, Cao L, Zhang R, Hu X, et al: Genome-wide meta-analysis identifies ten new psoriasis susceptibility loci in the Chinese population. J Genet Genomics. 49:177–180. 2022. View Article : Google Scholar : PubMed/NCBI

99 

Connell WT, Hong J and Liao W: Genome-Wide association study of ustekinumab response in psoriasis. Front Immunol. 12:8151212022. View Article : Google Scholar : PubMed/NCBI

100 

Ren Y, Wang L, Dai H, Qiu G, Liu J, Yu D, Liu J, Lyu CZ, Liu L and Zheng M: Genome-wide association analysis of anti-TNF-α treatment response in Chinese patients with psoriasis. Front Pharmacol. 13:9689352022. View Article : Google Scholar : PubMed/NCBI

101 

Kisielnicka A, Sobalska-Kwapis M, Purzycka-Bohdan D, Nedoszytko B, Zabłotna M, Seweryn M, Strapagiel D, Nowicki RJ, Reich A, Samotij D, et al: The analysis of a genome-wide association study (GWAS) of overweight and obesity in psoriasis. Int J Mol Sci. 23:73962022. View Article : Google Scholar : PubMed/NCBI

102 

Huang YH, See LC, Chang YC, Chung WH, Chang LC, Yang SF and Su SC: Impact of ABCG2 gene polymorphism on the predisposition to psoriasis. Genes (Basel). 12:16012021. View Article : Google Scholar : PubMed/NCBI

103 

Chang YC, Wu WM, Huang YH, Chung WH, Tsai HY and Hsu LA: The (CCTTT) n pentanucleotide repeat polymorphism in the inducible nitric oxide synthase gene promoter and the risk of psoriasis in Taiwanese. Arch Dermatol Res. 307:425–432. 2015. View Article : Google Scholar : PubMed/NCBI

104 

Chandran V and Raychaudhuri SP: Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis. J Autoimmun. 34:J314–J321. 2010. View Article : Google Scholar : PubMed/NCBI

105 

Elder JT, Bruce AT, Gudjonsson JE, Johnston A, Stuart PE, Tejasvi T, Voorhees JJ, Abecasis GR and Nair RP: Molecular dissection of psoriasis: Integrating genetics and biology. J Invest Dermatol. 130:1213–1226. 2010. View Article : Google Scholar : PubMed/NCBI

106 

Sanchez-Mazas A: A review of HLA allele and SNP associations with highly prevalent infectious diseases in human populations. Swiss Med Wkly. 150:W202142020.PubMed/NCBI

107 

Buhler S and Sanchez-Mazas A: HLA DNA sequence variation among human populations: Molecular signatures of demographic and selective events. PLoS One. 6:e146432011. View Article : Google Scholar : PubMed/NCBI

108 

Melief CJ and Kast WM: Cytotoxic T lymphocyte therapy of cancer and tumor escape mechanisms. Semin Cancer Biol. 2:347–354. 1991.PubMed/NCBI

109 

Neefjes J, Jongsma ML, Paul P and Bakke O: Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nat Rev Immunol. 11:823–836. 2011. View Article : Google Scholar : PubMed/NCBI

110 

Rock KL, Reits E and Neefjes J: Present Yourself! By MHC Class I and MHC Class II Molecules. Trends Immunol. 37:724–737. 2016. View Article : Google Scholar : PubMed/NCBI

111 

Gottlieb AB: Immunologic mechanisms in psoriasis. J Invest Dermatol. 95 (5 Suppl):18S–19S. 1990. View Article : Google Scholar : PubMed/NCBI

112 

Harden JL, Krueger JG and Bowcock AM: The immunogenetics of psoriasis: A comprehensive review. J Autoimmun. 64:66–73. 2015. View Article : Google Scholar : PubMed/NCBI

113 

Bartosinska J, Michalak-Stoma A, Kowal M, Raczkiewicz D, Krasowska D, Chodorowska G and Giannopoulos K: Analysis of circulating soluble programmed death 1 (PD-1), neuropilin 1 (NRP-1) and human leukocyte antigen-G (HLA-G) in psoriatic patients. Postepy Dermatol Alergol. 36:167–172. 2019. View Article : Google Scholar : PubMed/NCBI

114 

Lee YH, Choi SJ, Ji JD and Song GG: Genome-wide pathway analysis of a genome-wide association study on psoriasis and Behcet's disease. Mol Biol Rep. 39:5953–5959. 2012. View Article : Google Scholar : PubMed/NCBI

115 

Sokolik R, Gebura K, Iwaszko M, Świerkot J, Korman L, Wiland P and Bogunia-Kubik K: Significance of association of HLA-C and HLA-E with psoriatic arthritis. Hum Immunol. 75:1188–1191. 2014. View Article : Google Scholar : PubMed/NCBI

116 

Dand N, Duckworth M, Baudry D, Russell A, Curtis CJ, Lee SH, Evans I, Mason KJ, Alsharqi A, Becher G, et al: HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis. J Allergy Clin Immunol. 143:2120–2130. 2019. View Article : Google Scholar : PubMed/NCBI

117 

Talamonti M, Galluzzo M, Zangrilli A, Papoutsaki M, Egan CG, Bavetta M, Tambone S, Fargnoli MC and Bianchi L: HLA-C*06:02 does not predispose to clinical response following long-term adalimumab treatment in psoriatic patients: A retrospective cohort study. Mol Diagn Ther. 21:295–301. 2017. View Article : Google Scholar : PubMed/NCBI

118 

Stuart PE, Tejasvi T, Shaiq PA, Kullavanijaya P, Qamar R, Raja GK, Li Y, Voorhees JJ, Abecasis GR, Elder JT and Nair RP: A single SNP surrogate for genotyping HLA-C*06:02 in diverse populations. J Invest Dermatol. 135:1177–1180. 2015. View Article : Google Scholar : PubMed/NCBI

119 

Nikamo P and Stahle M: Cost-effective HLA-Cw06:02 typing in a Caucasian population. Exp Dermatol. 21:221–223. 2012. View Article : Google Scholar : PubMed/NCBI

120 

Chiu HY, Huang PY, Jee SH, Hu CY, Chou CT, Chang YT, Hwang CY and Tsai TF: HLA polymorphism among Chinese patients with chronic plaque psoriasis: subgroup analysis. Br J Dermatol. 166:288–297. 2012. View Article : Google Scholar : PubMed/NCBI

121 

Shen M, Lim SWD, Tan ES, Oon HH and Ren EC: HLA correlations with clinical phenotypes and risk of metabolic comorbidities in Singapore Chinese psoriasis patients. Mol Diagn Ther. 23:751–760. 2019. View Article : Google Scholar : PubMed/NCBI

122 

Cai M, Huang H, Ran D, Zheng X, Wen L, Zhu Z, Liu L, Zhang C, Hong X, Hong J, et al: HLA-C*01:02 and HLA-A*02:07 confer risk specific for psoriatic patients in Southern China. J Invest Dermatol. 139:2045–2048. e42019. View Article : Google Scholar : PubMed/NCBI

123 

Hirata J, Hirota T, Ozeki T, Kanai M, Sudo T, Tanaka T, Hizawa N, Nakagawa H, Sato S, Mushiroda T, et al: Variants at HLA-A, HLA-C, and HLA-DQB1 Confer Risk of Psoriasis Vulgaris in Japanese. J Invest Dermatol. 138:542–548. 2018. View Article : Google Scholar : PubMed/NCBI

124 

van Vugt LJ, van den Reek JMPA, Hannink G, Coenen MJH and de Jong EMGJ: Association of HLA-C*06:02 Status With Differential Response to Ustekinumab in Patients With Psoriasis: A systematic review and meta-analysis. JAMA Dermatol. 155:708–715. 2019. View Article : Google Scholar : PubMed/NCBI

125 

Wei P, Yang Y, Liu Z, Luo Z, Tu W, Han J, Deng Y and Yin L: Characterization of autoantigen presentation by HLA-C*06:02 in psoriasis. J Invest Dermatol. 137:2238–2241. 2017. View Article : Google Scholar : PubMed/NCBI

126 

Huang YW and Tsai TF: HLA-Cw1 and psoriasis. Am J Clin Dermatol. 22:339–347. 2021. View Article : Google Scholar : PubMed/NCBI

127 

Teng MW, Bowman EP, McElwee JJ, Smyth MJ, Casanova JL, Cooper AM and Cua DJ: IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nat Med. 21:719–729. 2015. View Article : Google Scholar : PubMed/NCBI

128 

Mirlekar B and Pylayeva-Gupta Y: IL-12 family cytokines in cancer and immunotherapy. Cancers (Basel). 13:1672021. View Article : Google Scholar : PubMed/NCBI

129 

Gee K, Guzzo C, Che Mat NF, Ma W and Kumar A: The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. Inflamm Allergy Drug Targets. 8:40–52. 2009. View Article : Google Scholar : PubMed/NCBI

130 

Ek WE, Karlsson T, Hoglund J, Rask-Andersen M and Johansson A: Causal effects of inflammatory protein biomarkers on inflammatory diseases. Sci Adv. 7:eabl43592021. View Article : Google Scholar : PubMed/NCBI

131 

Lowes MA, Russell CB, Martin DA, Towne JE and Krueger JG: The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses. Trends Immunol. 34:174–181. 2013. View Article : Google Scholar : PubMed/NCBI

132 

Magyari L, Varszegi D, Sarlos P, Jaromi L, Melegh BI, Duga B, Kisfali P, Kovesdi E, Matyas P, Szabo A, et al: Marked differences of haplotype tagging SNP distribution, linkage, and haplotype profile of IL23 receptor gene in Roma and Hungarian population samples. Cytokine. 65:148–152. 2014. View Article : Google Scholar : PubMed/NCBI

133 

Ogbodo E, Michelangeli F and Williams JHH: Exogenous heat shock proteins HSPA1A and HSPB1 regulate TNF-α, IL-1β and IL-10 secretion from monocytic cells. FEBS Open Bio. 13:1922–1940. 2023. View Article : Google Scholar : PubMed/NCBI

134 

Generali E, Ceribelli A, Stazi MA and Selmi C: Lessons learned from twins in autoimmune and chronic inflammatory diseases. J Autoimmun. 83:51–61. 2017. View Article : Google Scholar : PubMed/NCBI

135 

Valdimarsson H: The genetic basis of psoriasis. Clin Dermatol. 25:563–567. 2007. View Article : Google Scholar : PubMed/NCBI

136 

Kere J: Mapping and identifying genes for asthma and psoriasis. Philos Trans R Soc Lond B Biol Sci. 360:1551–1561. 2005. View Article : Google Scholar : PubMed/NCBI

137 

Feng BJ, Sun LD, Soltani-Arabshahi R, Bowcock AM, Nair RP, Stuart P, Elder JT, Schrodi SJ, Begovich AB, Abecasis GR, et al: Multiple Loci within the major histocompatibility complex confer risk of psoriasis. PLoS Genet. 5:e10006062009. View Article : Google Scholar : PubMed/NCBI

138 

Fan X, Yang S, Huang W, Wang ZM, Sun LD, Liang YH, Gao M, Ren YQ, Zhang KY, Du WH, et al: Fine mapping of the psoriasis susceptibility locus PSORS1 supports HLA-C as the susceptibility gene in the Han Chinese population. PLoS Genet. 4:e10000382008. View Article : Google Scholar : PubMed/NCBI

139 

Velastegui E, Vera E, Vanden Berghe W, Munoz MS and Orellana-Manzano A: ‘HLA-C: Evolution, epigenetics, and pathological implications in the major histocompatibility complex’. Front Genet. 14:12060342023. View Article : Google Scholar : PubMed/NCBI

140 

Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL and Spies T: Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 285:727–729. 1999. View Article : Google Scholar : PubMed/NCBI

141 

Kowalczyk AP and Green KJ: Structure, function, and regulation of desmosomes. Prog Mol Biol Transl Sci. 116:95–118. 2013. View Article : Google Scholar : PubMed/NCBI

142 

Linh NTT, Giang NH, Lien NTK, Trang BK, Trang DT, Ngoc NT, Nghia VX, My LT, Mao CV, Hoang NH and Xuan NT: Association of PSORS1C3, CARD14 and TLR4 genotypes and haplotypes with psoriasis susceptibility. Genet Mol Biol. 45:e202200992022. View Article : Google Scholar : PubMed/NCBI

143 

Allen MH, Ameen H, Veal C, Evans J, Ramrakha-Jones VS, Marsland AM, Burden AD, Griffiths CE, Trembath RC and Barker JN: The major psoriasis susceptibility locus PSORS1 is not a risk factor for late-onset psoriasis. J Invest Dermatol. 124:103–106. 2005. View Article : Google Scholar : PubMed/NCBI

144 

Tawfik NZ, Abdallah HY, Hassan R, Hosny A, Ghanem DE, Adel A and Atwa MA: PSORS1 locus genotyping profile in psoriasis: A pilot case-control study. Diagnostics (Basel). 12:10352022. View Article : Google Scholar : PubMed/NCBI

145 

Clop A, Bertoni A, Spain SL, Simpson MA, Pullabhatla V, Tonda R, Hundhausen C, Di Meglio P, De Jong P, Hayday AC, et al: An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element. PLoS One. 8:e716902013. View Article : Google Scholar : PubMed/NCBI

146 

Wisniewski A, Matusiak L, Szczerkowska-Dobosz A, Nowak I and Kusnierczyk P: HLA-C*06:02-independent, gender-related association of PSORS1C3 and PSORS1C1/CDSN single-nucleotide polymorphisms with risk and severity of psoriasis. Mol Genet Genomics. 293:957–966. 2018. View Article : Google Scholar : PubMed/NCBI

147 

Ameen M, Allen MH, Fisher SA, Lewis CM, Cuthbert A, Kondeatis E, Vaughan RW, Murakami H, Nakagawa H and Barker JN: Corneodesmosin (CDSN) gene association with psoriasis vulgaris in Caucasian but not in Japanese populations. Clin Exp Dermatol. 30:414–418. 2005. View Article : Google Scholar : PubMed/NCBI

148 

Allen M, Ishida-Yamamoto A, McGrath J, Davison S, Iizuka H, Simon M, Guerrin M, Hayday A, Vaughan R, Serre G, et al: Corneodesmosin expression in psoriasis vulgaris differs from normal skin and other inflammatory skin disorders. Lab Invest. 81:969–976. 2001. View Article : Google Scholar : PubMed/NCBI

149 

Tazi Ahnini R, Camp NJ, Cork MJ, Mee JB, Keohane SG, Duff GW and di Giovine FS: Novel genetic association between the corneodesmosin (MHC S) gene and susceptibility to psoriasis. Hum Mol Genet. 8:1135–1140. 1999. View Article : Google Scholar : PubMed/NCBI

150 

Zwirner NW, Dole K and Stastny P: Differential surface expression of MICA by endothelial cells, fibroblasts, keratinocytes, and monocytes. Hum Immunol. 60:323–330. 1999. View Article : Google Scholar : PubMed/NCBI

151 

Carlen L, Sakuraba K, Stahle M and Sanchez F: HLA-C expression pattern is spatially different between psoriasis and eczema skin lesions. J Invest Dermatol. 127:342–348. 2007. View Article : Google Scholar : PubMed/NCBI

152 

Schon MP, Boehncke WH and Brocker EB: Psoriasis: Clinical manifestations, pathogenesis and therapeutic perspectives. Discov Med. 5:253–258. 2005.PubMed/NCBI

153 

Telem DF, Israeli S, Sarig O and Sprecher E: Inflammatory peeling skin syndrome caused a novel mutation in CDSN. Arch Dermatol Res. 304:251–255. 2012. View Article : Google Scholar : PubMed/NCBI

154 

Maekawa K, Nishikawa J, Kaniwa N, Sugiyama E, Koizumi T, Kurose K, Tohkin M and Saito Y: Development of a rapid and inexpensive assay for detecting a surrogate genetic polymorphism of HLA-B*58:01: A partially predictive but useful biomarker for allopurinol-related Stevens-Johnson syndrome/toxic epidermal necrolysis in Japanese. Drug Metab Pharmacokinet. 27:447–450. 2012. View Article : Google Scholar : PubMed/NCBI

155 

Lu HF, Liu TY, Chou YP, Chang SS, Hsieh YW, Chang JG and Tsai FJ: Comprehensive characterization of pharmacogenes in a Taiwanese Han population. Front Genet. 13:9486162022. View Article : Google Scholar : PubMed/NCBI

156 

Patrick MT, Stuart PE, Zhang H, Zhao Q, Yin X, He K, Zhou XJ, Mehta NN, Voorhees JJ, Boehnke M, et al: Causal relationship and shared genetic loci between psoriasis and type 2 diabetes through trans-disease meta-analysis. J Invest Dermatol. 141:1493–1502. 2021. View Article : Google Scholar : PubMed/NCBI

157 

Abramczyk R, Queller JN, Rachfal AW and Schwartz SS: Diabetes and psoriasis: Different sides of the same prism. Diabetes Metab Syndr Obes. 13:3571–3577. 2020. View Article : Google Scholar : PubMed/NCBI

158 

Eiris N, Gonzalez-Lara L, Santos-Juanes J, Queiro R, Coto E and Coto-Segura P: Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus. J Dermatol Sci. 75:167–172. 2014. View Article : Google Scholar : PubMed/NCBI

159 

Patrick MT, Nair RP, He K, Stuart PE, Billi AC, Zhou X, Gudjonsson JE, Oksenberg JR, Elder JT and Tsoi LC: Shared genetic risk factors for multiple sclerosis/psoriasis suggest involvement of interleukin-17 and janus kinase-signal transducers and activators of transcription signaling. Ann Neurol. 94:384–397. 2023. View Article : Google Scholar : PubMed/NCBI

160 

Tang Y, Liu W, Kong W, Zhang S and Zhu T: Multisite chronic pain and the risk of autoimmune diseases: A Mendelian randomization study. Front Immunol. 14:10770882023. View Article : Google Scholar : PubMed/NCBI

161 

Huang J, Su B, Karhunen V, Gill D, Zuber V, Ahola-Olli A, Palaniswamy S, Auvinen J, Herzig KH, Keinänen-Kiukaanniemi S, et al: Inflammatory diseases, inflammatory biomarkers, and Alzheimer disease: An observational analysis and mendelian randomization. Neurology. 100:e568–e581. 2023. View Article : Google Scholar : PubMed/NCBI

162 

Li C, Li X, Lin J, Cui Y and Shang H: Psoriasis and progression of Parkinson's disease: a Mendelian randomization study. J Eur Acad Dermatol Venereol. 36:2401–2405. 2022. View Article : Google Scholar : PubMed/NCBI

163 

Ellinghaus D, Jostins L, Spain SL, Cortes A, Bethune J, Han B, Park YR, Raychaudhuri S, Pouget JG, Hübenthal M, et al: Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nat Genet. 48:510–518. 2016. View Article : Google Scholar : PubMed/NCBI

164 

Yin X, Low HQ, Wang L, Li Y, Ellinghaus E, Han J, Estivill X, Sun L, Zuo X, Shen C, et al: Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility. Nat Commun. 6:69162015. View Article : Google Scholar : PubMed/NCBI

165 

Gandhi G, Buttar BS, Albert L, Hasan Q and Aggarwal RK: Psoriasis-associated genetic polymorphism in North Indian population in the CCHCR1 gene and in a genomic segment flanking the HLA-C region. Dis Markers. 31:361–370. 2011. View Article : Google Scholar : PubMed/NCBI

166 

Chang YT, Hsu CY, Chou CT, Lin MW, Shiao YM, Tsai CY, Yu CW, Shiue JJ, Lee YF, Huang CH, et al: The genetic polymorphisms of POU5F1 gene are associated with psoriasis vulgaris in Chinese. J Dermatol Sci. 46:153–156. 2007. View Article : Google Scholar : PubMed/NCBI

167 

Chang YT, Tsai SF, Lee DD, Shiao YM, Huang CY, Liu HN, Wang WJ and Wong CK: A study of candidate genes for psoriasis near HLA-C in Chinese patients with psoriasis. Br J Dermatol. 148:418–423. 2003. View Article : Google Scholar : PubMed/NCBI

168 

Xia X, Yu H, Li Y, Liang Y, Li G and Huang F: transcriptome analysis identifies biomarkers for the diagnosis and management of psoriasis complicated with depression. Clin Cosmet Investig Dermatol. 16:1287–1301. 2023. View Article : Google Scholar : PubMed/NCBI

169 

Chantarangsu S, Mushiroda T, Mahasirimongkol S, Kiertiburanakul S, Sungkanuparph S, Manosuthi W, Tantisiriwat W, Charoenyingwattana A, Sura T, Takahashi A, et al: Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash. Clin Infect Dis. 53:341–348. 2011. View Article : Google Scholar : PubMed/NCBI

170 

Sanchez FO, Linga Reddy MV, Mallbris L, Sakuraba K, Stahle M and Alarcon-Riquelme ME: IFN-regulatory factor 5 gene variants interact with the class I MHC locus in the Swedish psoriasis population. J Invest Dermatol. 128:1704–1709. 2008. View Article : Google Scholar : PubMed/NCBI

171 

Tervaniemi MH, Siitonen HA, Soderhall C, Minhas G, Vuola J, Tiala I, Sormunen R, Samuelsson L, Suomela S, Kere J and Elomaa O: Centrosomal localization of the psoriasis candidate gene product, CCHCR1, supports a role in cytoskeletal organization. PLoS One. 7:e499202012. View Article : Google Scholar : PubMed/NCBI

172 

Ishida-Yamamoto A, Furio L, Igawa S, Honma M, Tron E, Malan V, Murakami M and Hovnanian A: Inflammatory peeling skin syndrome caused by homozygous genomic deletion in the PSORS1 region encompassing the CDSN gene. Exp Dermatol. 23:60–63. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang J, Liu T, Lu H, Tsai S, Liao W, Chiu Y, Wang Y and Tsai F: Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan. Mol Med Rep 30: 115, 2024.
APA
Yang, J., Liu, T., Lu, H., Tsai, S., Liao, W., Chiu, Y. ... Tsai, F. (2024). Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan. Molecular Medicine Reports, 30, 115. https://doi.org/10.3892/mmr.2024.13239
MLA
Yang, J., Liu, T., Lu, H., Tsai, S., Liao, W., Chiu, Y., Wang, Y., Tsai, F."Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan". Molecular Medicine Reports 30.1 (2024): 115.
Chicago
Yang, J., Liu, T., Lu, H., Tsai, S., Liao, W., Chiu, Y., Wang, Y., Tsai, F."Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan". Molecular Medicine Reports 30, no. 1 (2024): 115. https://doi.org/10.3892/mmr.2024.13239
Copy and paste a formatted citation
x
Spandidos Publications style
Yang J, Liu T, Lu H, Tsai S, Liao W, Chiu Y, Wang Y and Tsai F: Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan. Mol Med Rep 30: 115, 2024.
APA
Yang, J., Liu, T., Lu, H., Tsai, S., Liao, W., Chiu, Y. ... Tsai, F. (2024). Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan. Molecular Medicine Reports, 30, 115. https://doi.org/10.3892/mmr.2024.13239
MLA
Yang, J., Liu, T., Lu, H., Tsai, S., Liao, W., Chiu, Y., Wang, Y., Tsai, F."Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan". Molecular Medicine Reports 30.1 (2024): 115.
Chicago
Yang, J., Liu, T., Lu, H., Tsai, S., Liao, W., Chiu, Y., Wang, Y., Tsai, F."Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan". Molecular Medicine Reports 30, no. 1 (2024): 115. https://doi.org/10.3892/mmr.2024.13239
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team