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Mechanism of flavonoids in the treatment of gouty arthritis (Review)

  • Authors:
    • Feifan Liu
    • Yuanmei Bai
    • Yan Wan
    • Jinglin He
    • Qiongchao Li
    • Yuhuan Xie
    • Peixin Guo
  • View Affiliations / Copyright

    Affiliations: College of Ethnic Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, P.R. China, College of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 132
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    Published online on: May 28, 2024
       https://doi.org/10.3892/mmr.2024.13256
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Abstract

The present review expounds the advancements in the application and mechanisms of flavonoids in gouty arthritis, highlighting their significance in managing the disease. Gouty arthritis is among the most common and severe inflammatory diseases, caused by hyperuricemia and the deposition of sodium urate crystals in the joints and surrounding tissues, posing a serious threat to human life and health. Flavonoids, extracted from various herbs, have attracted significant attention due to their efficacy in improving gouty arthritis. The present study systematically reviews the in vivo studies and in vitro animal studies on flavonoids from herbal medicines for the treatment of gouty arthritis that have been previously published in the PubMed, ScienceDirect, Google Scholar and China National Knowledge Infrastructure databases between 2000 and 2023. The review of the literature indicated that flavonoids can improve gouty arthritis through multiple mechanisms. These include lowering xanthine oxidase activity, inhibiting uric acid (UA) synthesis, regulating UA transporters to promote UA excretion, reducing the inflammatory response and improving oxidative stress. These mechanisms predominantly involve regulating the NOD‑like receptor 3 inflammasome, the Toll‑like receptor 4/myeloid differentiation factor 88/nuclear factor‑κB signaling pathway, and the levels of UA transporter proteins, namely recombinant urate transporter 1, glucose transporter 9, organic anion transporter (OAT)1 and OAT3. Various flavonoids used in traditional Chinese medicine hold therapeutic promise for gouty arthritis and are anticipated to pave the way for novel pharmaceuticals and clinical applications.
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Copy and paste a formatted citation
Spandidos Publications style
Liu F, Bai Y, Wan Y, He J, Li Q, Xie Y and Guo P: Mechanism of flavonoids in the treatment of gouty arthritis (Review). Mol Med Rep 30: 132, 2024.
APA
Liu, F., Bai, Y., Wan, Y., He, J., Li, Q., Xie, Y., & Guo, P. (2024). Mechanism of flavonoids in the treatment of gouty arthritis (Review). Molecular Medicine Reports, 30, 132. https://doi.org/10.3892/mmr.2024.13256
MLA
Liu, F., Bai, Y., Wan, Y., He, J., Li, Q., Xie, Y., Guo, P."Mechanism of flavonoids in the treatment of gouty arthritis (Review)". Molecular Medicine Reports 30.2 (2024): 132.
Chicago
Liu, F., Bai, Y., Wan, Y., He, J., Li, Q., Xie, Y., Guo, P."Mechanism of flavonoids in the treatment of gouty arthritis (Review)". Molecular Medicine Reports 30, no. 2 (2024): 132. https://doi.org/10.3892/mmr.2024.13256
Copy and paste a formatted citation
x
Spandidos Publications style
Liu F, Bai Y, Wan Y, He J, Li Q, Xie Y and Guo P: Mechanism of flavonoids in the treatment of gouty arthritis (Review). Mol Med Rep 30: 132, 2024.
APA
Liu, F., Bai, Y., Wan, Y., He, J., Li, Q., Xie, Y., & Guo, P. (2024). Mechanism of flavonoids in the treatment of gouty arthritis (Review). Molecular Medicine Reports, 30, 132. https://doi.org/10.3892/mmr.2024.13256
MLA
Liu, F., Bai, Y., Wan, Y., He, J., Li, Q., Xie, Y., Guo, P."Mechanism of flavonoids in the treatment of gouty arthritis (Review)". Molecular Medicine Reports 30.2 (2024): 132.
Chicago
Liu, F., Bai, Y., Wan, Y., He, J., Li, Q., Xie, Y., Guo, P."Mechanism of flavonoids in the treatment of gouty arthritis (Review)". Molecular Medicine Reports 30, no. 2 (2024): 132. https://doi.org/10.3892/mmr.2024.13256
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