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Article Open Access

Infection‑associated bile acid disturbance contributes to macrophage activation in patients with cirrhosis

  • Authors:
    • Yong Su
    • Qiaoling Zhou
    • Qiong Wu
    • Yijie Ding
    • Meijie Jiang
    • Xiaoyu Zhang
    • Jia Wang
    • Xinming Wang
    • Chaoliang Ge
  • View Affiliations / Copyright

    Affiliations: School of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui 230032, P.R. China, School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui 230012, P.R. China, Health Management Center, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China, Department of Pharmacy, Hefei First People's Hospital, Hefei, Anhui 230032, P.R. China
    Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 150
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    Published online on: June 28, 2024
       https://doi.org/10.3892/mmr.2024.13274
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Abstract

Cirrhosis impairs macrophage function and disrupts bile acid homeostasis. Although bile acids affect macrophage function in patients with sepsis, whether and how the bile acid profile is changed by infection in patients with cirrhosis to modulate macrophage function remains unclear. The present study aimed to investigate the changes in the bile acid profile of patients with cirrhosis and infection and their effects on macrophage function. Serum was collected from 20 healthy subjects, 18 patients with cirrhosis and 39 patients with cirrhosis and infection. Bile acid profiles were detected using high‑performance liquid chromatography‑triple time‑of‑flight mass spectrometer. The association between bile acid changes and infection was analysed using receiver operating characteristic (ROC) curves. Infection‑altered bile acids were used in combination with lipopolysaccharides (LPS) to stimulate RAW264.7/THP‑1 cells in vitro. The migratory capacity was evaluated using wound healing and Transwell migration assays. The expression of Arg‑1, iNOS, IκBα, phosphorylated (p‑)IκBα and p65 was examined with western blotting and immunofluorescence, Tnfα, Il1b and Il6 mRNA was examined with RT‑qPCR, and CD86, CD163 and phagocytosis was measured with flow cytometry. The ROC curves showed that decreased hyodeoxycholic acid (HDCA) and deoxycholic acid (DCA) levels were associated with infection. HDCA or DCA combined with LPS enhanced the phagocytic and migratory ability of macrophages, accompanied by upregulation of iNOS and CD86 protein expression as well as Tnfα, Il1b, and Il6 mRNA expression. However, neither HDCA nor DCA alone showed an effect on these phenotypes. In addition, DCA and HDCA acted synergistically with LPS to increase the expression of p‑IκBα and the intranuclear migration of p65. Infection changed the bile acid profile in patients with cirrhosis, among which the reduction of DCA and HDCA associated most strongly with infection. HDCA and DCA enhanced the sensitivity of macrophage function loss to LPS stimulation. These findings suggested a potential role for monitoring the bile acid profile that could help manage patients with cirrhosis and infection.
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View References

1 

Wilde B and Katsounas A: Immune dysfunction and albumin-related immunity in liver cirrhosis. Mediators Inflamm. 2019:75376492019. View Article : Google Scholar : PubMed/NCBI

2 

Ginès P, Krag A, Abraldes JG, Solà E, Fabrellas N and Kamath PS: Liver cirrhosis. Lancet. 398:1359–1376. 2021. View Article : Google Scholar : PubMed/NCBI

3 

Irvine KM, Ratnasekera I, Powell EE and Hume DA: Causes and consequences of innate immune dysfunction in cirrhosis. Front Immunol. 10:2932019. View Article : Google Scholar : PubMed/NCBI

4 

Haidar G and Singh N: The evolving challenge of infections in cirrhosis. N Engl J Med. 385:1150–1151. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Fernández J, Piano S, Bartoletti M and Wey EQ: Management of bacterial and fungal infections in cirrhosis: The MDRO challenge. J Hepatol. 75 (Suppl 1):S101–S117. 2021. View Article : Google Scholar : PubMed/NCBI

6 

Albillos A, Lario M and Álvarez-Mon M: Cirrhosis-associated immune dysfunction: Distinctive features and clinical relevance. J Hepatol. 61:1385–1396. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Noor MT and Manoria P: Immune dysfunction in cirrhosis. J Clin Transl Hepatol. 5:50–58. 2017.PubMed/NCBI

8 

Yunna C, Mengru H, Lei W and Weidong C: Macrophage M1/M2 polarization. Eur J Pharmacol. 877:1730902020. View Article : Google Scholar : PubMed/NCBI

9 

Geiß C, Salas E, Guevara-Coto J, Régnier-Vigouroux A and Mora-Rodriguez RA: Multistability in macrophage activation pathways and metabolic implications. Cells. 11:4042022. View Article : Google Scholar

10 

Van der Merwe S, Chokshi S, Bernsmeier C and Albillos A: The multifactorial mechanisms of bacterial infection in decompensated cirrhosis. J Hepatol. 75 (Suppl 1):S82–S100. 2021. View Article : Google Scholar : PubMed/NCBI

11 

Jia W, Xie G and Jia W: Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis. Nat Rev Gastroenterol Hepatol. 15:111–128. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Balazs I, Horvath A, Leber B, Feldbacher N, Sattler W, Rainer F, Fauler G, Vermeren S and Stadlbauer V: Serum bile acids in liver cirrhosis promote neutrophil dysfunction. Clin Transl Med. 12:e7352022. View Article : Google Scholar : PubMed/NCBI

13 

Zhou J, Huang N, Guo Y, Cui S, Ge C, He Q, Pan X, Wang G, Wang H and Hao H: Combined obeticholic acid and apoptosis inhibitor treatment alleviates liver fibrosis. Acta Pharm Sin B. 9:526–536. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Cao S, Meng X, Li Y, Sun L, Jiang L, Xuan H and Chen X: Bile acids elevated in chronic periaortitis could activate farnesoid-X-receptor to suppress IL-6 production by macrophages. Front Immunol. 12:6328642021. View Article : Google Scholar : PubMed/NCBI

15 

Hao H, Cao L, Jiang C, Che Y, Zhang S, Takahashi S, Wang G and Gonzalez FJ: Farnesoid X receptor regulation of the NLRP3 inflammasome underlies cholestasis-associated sepsis. Cell Metab. 25:856–867.e5. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Yoshiji H, Nagoshi S, Akahane T, Asaoka Y, Ueno Y, Ogawa K, Kawaguchi T, Kurosaki M, Sakaida I, Shimizu M, et al: Evidence-based clinical practice guidelines for liver cirrhosis 2020. J Gastroenterol. 56:593–619. 2021. View Article : Google Scholar : PubMed/NCBI

17 

European Association for the Study of the Liver, . EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis. J Hepatol. 53:397–417. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Aithal GP, Palaniyappan N, China L, Härmälä S, Macken L, Ryan JM, Wilkes EA, Moore K, Leithead JA, Hayes PC, et al: Guidelines on the management of ascites in cirrhosis. Gut. 70:9–29. 2021. View Article : Google Scholar : PubMed/NCBI

19 

Chinese Society of Hepatology Chinese Medical Association, ; Xu X, Duan Z, Ding H, Li W, Jia J, Wei L, Linghu E and Zhuang H: Chinese guidelines on the management of ascites and its related complications in cirrhosis. Hepatol Int. 13:1–21. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Fuenzalida B, Yañez MJ, Mueller M, Mistry HD, Leiva A and Albrecht C: Evidence for hypoxia-induced dysregulated cholesterol homeostasis in preeclampsia: Insights into the mechanisms from human placental cells and tissues. FASEB J. 38:e234312024. View Article : Google Scholar : PubMed/NCBI

21 

Buzzetti E, Parikh PM, Gerussi A and Tsochatzis E: Gender differences in liver disease and the drug-dose gender gap. Pharmacol Res. 120:97–108. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Durand F and Valla D: Assessment of the prognosis of cirrhosis: Child-Pugh versus MELD. J Hepatol. 42 (Suppl):S100–S107. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Qamar AA, Grace ND, Groszmann RJ, Garcia-Tsao G, Bosch J, Burroughs AK, Ripoll C, Maurer R, Planas R, Escorsell A, et al: Incidence, prevalence, and clinical significance of abnormal hematologic indices in compensated cirrhosis. Clin Gastroenterol Hepatol. 7:689–695. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Deng W, Rao J, Chen X, Li D, Zhang Z, Liu D, Liu J, Wang Y and Huang O: Metabolomics study of serum and urine samples reveals metabolic pathways and biomarkers associated with pelvic organ prolapse. J Chromatogr B Analyt Technol Biomed Life Sci. 1136:1218822020. View Article : Google Scholar : PubMed/NCBI

25 

Xia L, Zhang C, Lv N, Liang Z, Ma T, Cheng H, Xia Y and Shi L: AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages. Theranostics. 12:2928–2947. 2022. View Article : Google Scholar : PubMed/NCBI

26 

Weber M, Lutz R, Olmos M, Glajzer J, Baran C, Nobis CP, Möst T, Eckstein M, Kesting M and Ries J: Beyond PD-L1-identification of further potential therapeutic targets in oral cancer. Cancers (Basel). 14:18122022. View Article : Google Scholar : PubMed/NCBI

27 

Bonnel AR, Bunchorntavakul C and Reddy KR: Immune dysfunction and infections in patients with cirrhosis. Clin Gastroenterol Hepatol. 9:727–738. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Garrido A, Kim E, Teijeiro A, Sánchez Sánchez P, Gallo R, Nair A, Matamala Montoya M, Perna C, Vicent GP, Muñoz J, et al: Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis. J Hepatol. 76:850–861. 2022. View Article : Google Scholar : PubMed/NCBI

29 

Rauchbach E, Zeigerman H, Abu-Halaka D and Tirosh O: Cholesterol induces oxidative stress, mitochondrial damage and death in hepatic stellate cells to mitigate liver fibrosis in mice model of NASH. Antioxidants (Basel). 11:5362022. View Article : Google Scholar : PubMed/NCBI

30 

Aliwa B, Horvath A, Traub J, Feldbacher N, Habisch H, Fauler G, Madl T and Stadlbauer V: Altered gut microbiome, bile acid composition and metabolome in sarcopenia in liver cirrhosis. J Cachexia Sarcopenia Muscle. 14:2676–2691. 2023. View Article : Google Scholar : PubMed/NCBI

31 

Bertolini A, Fiorotto R and Strazzabosco M: Bile acids and their receptors: Modulators and therapeutic targets in liver inflammation. Semin Immunopathol. 44:547–564. 2022. View Article : Google Scholar : PubMed/NCBI

32 

Režen T, Rozman D, Kovács T, Kovács P, Sipos A, Bai P and Mikó E: The role of bile acids in carcinogenesis. Cell Mol Life Sci. 79:2432022. View Article : Google Scholar : PubMed/NCBI

33 

Wang H, Ge C, Zhou J, Guo Y, Cui S, Huang N, Yan T, Cao L, Che Y, Zheng Q, et al: Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosis. EBioMedicine. 37:322–333. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Thomas JP, Modos D, Rushbrook SM, Powell N and Korcsmaros T: The emerging role of bile acids in the pathogenesis of inflammatory bowel disease. Front Immunol. 13:8295252022. View Article : Google Scholar : PubMed/NCBI

35 

Thibaut MM and Bindels LB: Crosstalk between bile acid-activated receptors and microbiome in entero-hepatic inflammation. Trends Mol Med. 28:223–236. 2022. View Article : Google Scholar : PubMed/NCBI

36 

Yan T, Yan N, Wang H, Yagai T, Luo Y, Takahashi S, Zhao M, Krausz KW, Wang G, Hao H and Gonzalez FJ: FXR-deoxycholic Acid-TNF-α axis modulates acetaminophen-induced hepatotoxicity. Toxicol Sci. 181:273–284. 2021. View Article : Google Scholar : PubMed/NCBI

37 

Sun R, Zhang Z, Bao R, Guo X, Gu Y, Yang W, Wei J, Chen X, Tong L, Meng J, et al: Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis. J Hepatol. 77:453–466. 2022. View Article : Google Scholar : PubMed/NCBI

38 

Romero-Ramirez L, Garcia-Rama C, Wu S and Mey J: Bile acids attenuate PKM2 pathway activation in proinflammatory microglia. Sci Rep. 12:14592022. View Article : Google Scholar : PubMed/NCBI

39 

Wang L, Gong Z, Zhang X, Zhu F, Liu Y, Jin C, Du X, Xu C, Chen Y, Cai W, et al: Gut microbial bile acid metabolite skews macrophage polarization and contributes to high-fat diet-induced colonic inflammation. Gut Microbes. 12:1–20. 2020. View Article : Google Scholar

40 

Pi Y, Wu Y, Zhang X, Lu D, Han D, Zhao J, Zheng X, Zhang S, Ye H, Lian S, et al: Gut microbiota-derived ursodeoxycholic acid alleviates low birth weight-induced colonic inflammation by enhancing M2 macrophage polarization. Microbiome. 11:192023. View Article : Google Scholar : PubMed/NCBI

41 

Mobraten K, Haugbro T, Karlstrom E, Kleiveland CR and Lea T: Activation of the bile acid receptor TGR5 enhances LPS-induced inflammatory responses in a human monocytic cell line. J Recept Signal Transduct Res. 35:402–409. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Zhu H, Bai Y, Wang G, Su Y, Tao Y, Wang L, Yang L, Wu H, Huang F, Shi H and Wu X: Hyodeoxycholic acid inhibits lipopolysaccharide-induced microglia inflammatory responses through regulating TGR5/AKT/NF-κB signaling pathway. J Psychopharmacol. 36:849–859. 2022. View Article : Google Scholar : PubMed/NCBI

43 

Li J, Chen Y, Li R, Zhang X, Chen T, Mei F, Liu R, Chen M, Ge Y, Hu H, et al: Gut microbial metabolite hyodeoxycholic acid targets the TLR4/MD2 complex to attenuate inflammation and protect against sepsis. Mol Ther. 31:1017–1032. 2023. View Article : Google Scholar : PubMed/NCBI

44 

Fiorucci S, Biagioli M, Zampella A and Distrutti E: Bile acids activated receptors regulate innate immunity. Front Immunol. 9:18532018. View Article : Google Scholar : PubMed/NCBI

45 

Cai J, Rimal B, Jiang C, Chiang JYL and Patterson AD: Bile acid metabolism and signaling, the microbiota, and metabolic disease. Pharmacol Ther. 237:1082382022. View Article : Google Scholar : PubMed/NCBI

46 

Che Y, Xu W, Ding C, He T, Xu X, Shuai Y, Huang H, Wu J, Wang Y, Wang C, et al: Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions. Cell Rep. 42:1120112023. View Article : Google Scholar : PubMed/NCBI

47 

Liu J, Wei Y, Jia W, Can C, Wang R, Yang X, Gu C, Liu F, Ji C and Ma D: Chenodeoxycholic acid suppresses AML progression through promoting lipid peroxidation via ROS/p38 MAPK/DGAT1 pathway and inhibiting M2 macrophage polarization. Redox Biol. 56:1024522022. View Article : Google Scholar : PubMed/NCBI

48 

Vogel DY, Glim JE, Stavenuiter AW, Breur M, Heijnen P, Amor S, Dijkstra CD and Beelen RH: Human macrophage polarization in vitro: Maturation and activation methods compared. Immunobiology. 219:695–703. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Li P, Hao Z, Wu J, Ma C, Xu Y, Li J, Lan R, Zhu B, Ren P, Fan D and Sun S: Comparative proteomic analysis of polarized human THP-1 and mouse RAW264.7 macrophages. Front Immunol. 12:7000092021. View Article : Google Scholar : PubMed/NCBI

50 

Bajaj JS and Khoruts A: Microbiota changes and intestinal microbiota transplantation in liver diseases and cirrhosis. J Hepatol. 72:1003–1027. 2020. View Article : Google Scholar : PubMed/NCBI

51 

Liu J, Yang D, Wang X, Asare PT, Zhang Q, Na L and Shao L: Gut microbiota targeted approach in the management of chronic liver diseases. Front Cell Infect Microbiol. 12:7743352022. View Article : Google Scholar : PubMed/NCBI

52 

Philips CA, Ahamed R, Abduljaleel JKP, Rajesh S and Augustine P: Identification and analysis of gut microbiota and functional metabolism in decompensated cirrhosis with infection. J Clin Transl Hepatol. 11:15–25. 2023.PubMed/NCBI

53 

Abrigo J, Olguin H, Tacchi F, Orozco-Aguilar J, Valero-Breton M, Soto J, Castro-Sepúlveda M, Elorza AA, Simon F and Cabello-Verrugio C: Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic flux in skeletal muscle cells. Biol Res. 56:302023. View Article : Google Scholar : PubMed/NCBI

54 

Zhao Q, Dai MY, Huang RY, Duan JY, Zhang T, Bao WM, Zhang JY, Gui SQ, Xia SM, Dai CT, et al: Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice. Nat Commun. 14:18292023. View Article : Google Scholar : PubMed/NCBI

55 

Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding P, Gerbec Z, Zimmermann MT, Zeighami A, et al: Mitochondrial metabolic reprogramming by CD36 signaling drives macrophage inflammatory responses. Circ Res. 125:1087–1102. 2019. View Article : Google Scholar : PubMed/NCBI

56 

Li Y, Zhu L, Cai MX, Wang ZL, Zhuang M, Tan CY, Xie TH, Yao Y and Wei TT: TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy. Cell Death Dis. 14:5832023. View Article : Google Scholar : PubMed/NCBI

57 

Zhang MY, Zhu L, Zheng X, Xie TH, Wang W, Zou J, Li Y, Li HY, Cai J, Gu S, et al: TGR5 activation ameliorates mitochondrial homeostasis via regulating the PKCδ/Drp1-HK2 signaling in diabetic retinopathy. Front Cell Dev Biol. 9:7594212022. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Su Y, Zhou Q, Wu Q, Ding Y, Jiang M, Zhang X, Wang J, Wang X and Ge C: Infection‑associated bile acid disturbance contributes to macrophage activation in patients with cirrhosis. Mol Med Rep 30: 150, 2024.
APA
Su, Y., Zhou, Q., Wu, Q., Ding, Y., Jiang, M., Zhang, X. ... Ge, C. (2024). Infection‑associated bile acid disturbance contributes to macrophage activation in patients with cirrhosis. Molecular Medicine Reports, 30, 150. https://doi.org/10.3892/mmr.2024.13274
MLA
Su, Y., Zhou, Q., Wu, Q., Ding, Y., Jiang, M., Zhang, X., Wang, J., Wang, X., Ge, C."Infection‑associated bile acid disturbance contributes to macrophage activation in patients with cirrhosis". Molecular Medicine Reports 30.3 (2024): 150.
Chicago
Su, Y., Zhou, Q., Wu, Q., Ding, Y., Jiang, M., Zhang, X., Wang, J., Wang, X., Ge, C."Infection‑associated bile acid disturbance contributes to macrophage activation in patients with cirrhosis". Molecular Medicine Reports 30, no. 3 (2024): 150. https://doi.org/10.3892/mmr.2024.13274
Copy and paste a formatted citation
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Spandidos Publications style
Su Y, Zhou Q, Wu Q, Ding Y, Jiang M, Zhang X, Wang J, Wang X and Ge C: Infection‑associated bile acid disturbance contributes to macrophage activation in patients with cirrhosis. Mol Med Rep 30: 150, 2024.
APA
Su, Y., Zhou, Q., Wu, Q., Ding, Y., Jiang, M., Zhang, X. ... Ge, C. (2024). Infection‑associated bile acid disturbance contributes to macrophage activation in patients with cirrhosis. Molecular Medicine Reports, 30, 150. https://doi.org/10.3892/mmr.2024.13274
MLA
Su, Y., Zhou, Q., Wu, Q., Ding, Y., Jiang, M., Zhang, X., Wang, J., Wang, X., Ge, C."Infection‑associated bile acid disturbance contributes to macrophage activation in patients with cirrhosis". Molecular Medicine Reports 30.3 (2024): 150.
Chicago
Su, Y., Zhou, Q., Wu, Q., Ding, Y., Jiang, M., Zhang, X., Wang, J., Wang, X., Ge, C."Infection‑associated bile acid disturbance contributes to macrophage activation in patients with cirrhosis". Molecular Medicine Reports 30, no. 3 (2024): 150. https://doi.org/10.3892/mmr.2024.13274
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