Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2024 Volume 30 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2024 Volume 30 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Research progress of DNA methylation in colorectal cancer (Review)

  • Authors:
    • Yuxin Wang
    • Chengcheng Wang
    • Ruiqi Zhong
    • Liang Wang
    • Lei Sun
  • View Affiliations / Copyright

    Affiliations: Emergency Department, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China, Comparative Medicine Department of Researching and Teaching, Dalian Medical University, Dalian, Liaoning 116044, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 154
    |
    Published online on: July 3, 2024
       https://doi.org/10.3892/mmr.2024.13278
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

DNA methylation is one of the earliest and most significant epigenetic mechanisms discovered. DNA methylation refers, in general, to the addition of a methyl group to a specific base in the DNA sequence under the catalysis of DNA methyltransferase, with S‑adenosine methionine as the methyl donor, via covalent bonding and chemical modifications. DNA methylation is an important factor in inducing cancer. There are different types of DNA methylation, and methylation at different sites plays different roles. It is well known that the progression of colorectal cancer (CRC) is affected by the methylation of key genes. The present review did not only discuss the potential relationship between DNA methylation and CRC but also discussed how DNA methylation affects the development of CRC by affecting key genes. Furthermore, the clinical significance of DNA methylation in CRC was highlighted, including that of the therapeutic targets and biomarkers of methylation; and the importance of DNA methylation inhibitors was discussed as a novel strategy for treatment of CRC. The present review did not only focus upon the latest research findings, but earlier reviews were also cited as references to older literature.
View Figures

Figure 1

Figure 2

View References

1 

Migliore L, Migheli F, Spisni R and Coppedè F: Genetics, cytogenetics, and epigenetics of colorectal cancer. J Biomed Biotechnol. 2011:7923622011.PubMed/NCBI

2 

Araghi M, Soerjomataram I, Bardot A, Ferlay J, Cabasag CJ, Morrison DS, De P, Tervonen H, Walsh PM, Bucher O, et al: Changes in colorectal cancer incidence in seven high-income countries: A population-based study. Lancet Gastroenterol Hepatol. 4:511–518. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Reilly NM, Novara L, Di Nicolantonio F and Bardelli A: Exploiting DNA repair defects in colorectal cancer. Mol Oncol. 13:681–700. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Liebl MC and Hofmann TG: The role of p53 signaling in colorectal cancer. Cancers (Basel). 13:21252021. View Article : Google Scholar : PubMed/NCBI

5 

Bose S, Saha S, Goswami H, Shanmugam G and Sarkar K: Involvement of CCCTC-binding factor in epigenetic regulation of cancer. Mol Biol Rep. 50:10383–10398. 2023. View Article : Google Scholar : PubMed/NCBI

6 

Jamai D, Gargouri R, Selmi B and Khabir A: ERCC1 and MGMT methylation as a predictive marker of relapse and FOLFOX response in colorectal cancer patients from South Tunisia. Genes (Basel). 14:14672023. View Article : Google Scholar : PubMed/NCBI

7 

Okada Y, Peng F, Perea J, Corchete L, Bujanda L, Li W and Goel A: Genome-wide methylation profiling identifies a novel gene signature for patients with synchronous colorectal cancer. Br J Cancer. 128:112–120. 2023. View Article : Google Scholar : PubMed/NCBI

8 

Okano M, Bell DW, Haber DA and Li E: DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 99:247–257. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Zhai P, Zhang H, Li Q, Yang M, Guo Y and Xing C: DNMT1-mediated NR3C1 DNA methylation enables transcription activation of connexin40 and augments angiogenesis during colorectal cancer progression. Gene. 892:1478872024. View Article : Google Scholar : PubMed/NCBI

10 

Christman JK, Sheikhnejad G, Dizik M, Abileah S and Wainfan E: Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency. Carcinogenesis. 14:551–557. 1993. View Article : Google Scholar : PubMed/NCBI

11 

Goll MG, Kirpekar F, Maggert KA, Yoder JA, Hsieh CL, Zhang X, Golic KG, Jacobsen SE and Bestor TH: Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science. 311:395–398. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Smith ZD and Meissner A: DNA methylation: Roles in mammalian development. Nat Rev Genet. 14:204–220. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Cho HY, Wang X, Campbell MR, Panduri V, Coviello S, Caballero MT, Bennett BD, Kleeberger SR, Polack FP, Ofman G and Bell DA: Prospective epigenome and transcriptome analyses of cord and peripheral blood from preterm infants at risk of bronchopulmonary dysplasia. Sci Rep. 13:122622023. View Article : Google Scholar : PubMed/NCBI

14 

Guinney J, Dienstmann R, Wang X, de Reyniès A, Schlicker A, Soneson C, Marisa L, Roepman P, Nyamundanda G, Angelino P, et al: The consensus molecular subtypes of colorectal cancer. Nat Med. 21:1350–1356. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, Vogelstein B and Kinzler KW: APC mutations occur early during colorectal tumorigenesis. Nature. 359:235–237. 1992. View Article : Google Scholar : PubMed/NCBI

16 

Cancer Genome Atlas Network, . Comprehensive molecular characterization of human colon and rectal cancer. Nature. 487:330–337. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Lin CY, Shen MY, Chen WTL and Yang CA: Evaluation of the prognostic value of low-frequency KRAS mutation detection in circulating tumor DNA of patients with metastatic colorectal cancer. J Pers Med. 13:10512023. View Article : Google Scholar : PubMed/NCBI

18 

Rajagopalan H, Bardelli A, Lengauer C, Kinzler KW, Vogelstein B and Velculescu VE: Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature. 418:9342002. View Article : Google Scholar : PubMed/NCBI

19 

Tsujii M, Kawano S and DuBois RN: Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci USA. 94:3336–3340. 1997. View Article : Google Scholar : PubMed/NCBI

20 

Hidalgo-Estévez AM, Stamatakis K, Jiménez-Martínez M, López-Pérez R and Fresno M: Cyclooxygenase 2-regulated genes an alternative avenue to the development of new therapeutic drugs for colorectal cancer. Front Pharmacol. 11:5332020. View Article : Google Scholar : PubMed/NCBI

21 

Samowitz WS, Slattery ML, Sweeney C, Herrick J, Wolff RK and Albertsen H: APC mutations and other genetic and epigenetic changes in colon cancer. Mol Cancer Res. 5:165–170. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Pruitt K and Der CJ: Ras and Rho regulation of the cell cycle and oncogenesis. Cancer Lett. 171:1–10. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Tozaki Y, Aoki H, Kato R, Toriuchi K, Arame S, Inoue Y, Hayashi H, Kubota E, Kataoka H and Aoyama M: The combination of ATM and Chk1 inhibitors induces synthetic lethality in colorectal cancer cells. Cancers (Basel). 15:7352023. View Article : Google Scholar : PubMed/NCBI

24 

Lai WL, Lee SC, Chang KF, Huang XF, Li CY, Lee CJ, Wu CY, Hsu HJ and Tsai NM: Juniperus communis extract induces cell cycle arrest and apoptosis of colorectal adenocarcinoma in vitro and in vivo. Braz J Med Biol Res. 54:e108912021. View Article : Google Scholar : PubMed/NCBI

25 

Zhou Y, Dai W, Wang H, Pan H and Wang Q: Long non-coding RNA CASP5 promotes the malignant phenotypes of human glioblastoma multiforme. Biochem Biophys Res Commun. 500:966–972. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Gönenc II, Wolff A, Schmidt J, Zibat A, Müller C, Cyganek L, Argyriou L, Räschle M, Yigit G and Wollnik B: Single-cell transcription profiles in Bloom syndrome patients link BLM deficiency with altered condensin complex expression signatures. Hum Mol Genet. 31:2185–2193. 2022. View Article : Google Scholar : PubMed/NCBI

27 

Bader S, Walker M, Hendrich B, Bird A, Bird C, Hooper M and Wyllie A: Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency. Oncogene. 18:8044–8047. 1999. View Article : Google Scholar : PubMed/NCBI

28 

De Palma FDE, D'Argenio V, Pol J, Kroemer G, Maiuri MC and Salvatore F: The molecular hallmarks of the serrated pathway in colorectal cancer. Cancers (Basel). 11:10172019. View Article : Google Scholar : PubMed/NCBI

29 

Rajamäki K, Taira A, Katainen R, Välimäki N, Kuosmanen A, Plaketti RM, Seppälä TT, Ahtiainen M, Wirta EV, Vartiainen E, et al: Genetic and epigenetic characteristics of inflammatory bowel disease-associated colorectal cancer. Gastroenterology. 161:592–607. 2021. View Article : Google Scholar : PubMed/NCBI

30 

Pajares MJ, Palanca-Ballester C, Urtasun R, Alemany-Cosme E, Lahoz A and Sandoval J: Methods for analysis of specific DNA methylation status. Methods. 187:3–12. 2021. View Article : Google Scholar : PubMed/NCBI

31 

Gaudet F, Hodgson JG, Eden A, Jackson-Grusby L, Dausman J, Gray JW, Leonhardt H and Jaenisch R: Induction of tumors in mice by genomic hypomethylation. Science. 300:489–492. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Takeuchi C, Yamashita S, Liu YY, Takeshima H, Sasaki A, Fukuda M, Hashimoto T, Naka T, Ishizu K, Sekine S, et al: Precancerous nature of intestinal metaplasia with increased chance of conversion and accelerated DNA methylation. Gut. 73:255–267. 2024. View Article : Google Scholar : PubMed/NCBI

33 

Oshima M, Murai N, Kargman S, Arguello M, Luk P, Kwong E, Taketo MM and Evans JF: Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. Cancer Res. 61:1733–1740. 2001.PubMed/NCBI

34 

Xu X, Nie J, Lu L, Du C, Meng F and Song D: LINC00337 promotes tumor angiogenesis in colorectal cancer by recruiting DNMT1, which suppresses the expression of CNN1. Cancer Gene Ther. 28:1285–1297. 2021. View Article : Google Scholar : PubMed/NCBI

35 

Hu YH, Ma S, Zhang XN, Zhang ZY, Zhu HF, Ji YH, Li J, Qian XL and Wang YX: Hypermethylation of ADHFE1 promotes the proliferation of colorectal cancer cell via modulating cell cycle progression. Onco Targets Ther. 12:8105–8115. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen WD, Pretlow TP, Yang B, Akiyama Y, Van Engeland M, et al: Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet. 36:417–422. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Jafarpour S, Yazdi M, Nedaeinia R, Vatandoost N, Ferns GA and Salehi R: Status of integrin subunit alpha 4 promoter DNA methylation in colorectal cancer and other malignant tumors: A systematic review and meta-analysis. Res Pharm Sci. 18:231–243. 2023. View Article : Google Scholar : PubMed/NCBI

38 

Wang Y, Zhou J, Zhang J, Cao H, Han F, Zhang H and Xu E: The expression of ADAMTS14 is regulated by promoter DNA methylation and is associated with poor prognosis in colorectal cancer. Exp Cell Res. 410:1129532022. View Article : Google Scholar : PubMed/NCBI

39 

Kim YI, Pogribny IP, Basnakian AG, Miller JW, Selhub J, James SJ and Mason JB: Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Am J Clin Nutr. 65:46–52. 1997. View Article : Google Scholar : PubMed/NCBI

40 

Kim YI, Christman JK, Fleet JC, Cravo ML, Salomon RN, Smith D, Ordovas J, Selhub J and Mason JB: Moderate folate deficiency does not cause global hypomethylation of hepatic and colonic DNA or c-myc-specific hypomethylation of colonic DNA in rats. Am J Clin Nutr. 61:1083–1090. 1995. View Article : Google Scholar : PubMed/NCBI

41 

Marugame T, Tsuji E, Kiyohara C, Eguchi H, Oda T, Shinchi K and Kono S: Relation of plasma folate and methylenetetrahydrofolate reductase C677T polymorphism to colorectal adenomas. Int J Epidemiol. 32:64–66. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Othman R, Mohtarrudin N, Ahmad Zubir NM, Seow HF, Ngan KW and Osman M: HER3 overexpression and hypomethylation in colorectal adenocarcinoma. Malays J Pathol. 44:67–74. 2022.PubMed/NCBI

43 

Timar J and Kashofer K: Molecular epidemiology and diagnostics of KRAS mutations in human cancer. Cancer Metastasis Rev. 39:1029–1038. 2020. View Article : Google Scholar : PubMed/NCBI

44 

Santini D, Loupakis F, Vincenzi B, Floriani I, Stasi I, Canestrari E, Rulli E, Maltese PE, Andreoni F, Masi G, et al: High concordance of KRAS status between primary colorectal tumors and related metastatic sites: Implications for clinical practice. Oncologist. 13:1270–1275. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Lièvre A, Bachet JB, Boige V, Cayre A, Le Corre D, Buc E, Ychou M, Bouché O, Landi B, Louvet C, et al: KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol. 26:374–379. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Wong CC, Xu J, Bian X, Wu JL, Kang W, Qian Y, Li W, Chen H, Gou H, Liu D, et al: In colorectal cancer cells with mutant KRAS, SLC25A22-mediated glutaminolysis reduces DNA demethylation to increase wnt signaling, stemness, and drug resistance. Gastroenterology. 159:2163–2180.e6. 2020. View Article : Google Scholar : PubMed/NCBI

47 

Mangelinck A and Mann C: DNA methylation and histone variants in aging and cancer. Int Rev Cell Mol Biol. 364:1–110. 2021. View Article : Google Scholar : PubMed/NCBI

48 

Sakai E, Nakajima A and Kaneda A: Accumulation of aberrant DNA methylation during colorectal cancer development. World J Gastroenterol. 20:978–987. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Kasprzak A: Prognostic biomarkers of cell proliferation in colorectal cancer (CRC): From immunohistochemistry to molecular biology techniques. Cancers (Basel). 15:45702023. View Article : Google Scholar : PubMed/NCBI

50 

Hinoue T, Weisenberger DJ, Lange CPE, Shen H, Byun HM, Van Den Berg D, Malik S, Pan F, Noushmehr H, van Dijk CM, et al: Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Res. 22:271–282. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Jensen SØ, Øgaard N, Ørntoft MW, Rasmussen MH, Bramsen JB, Kristensen H, Mouritzen P, Madsen MR, Madsen AH, Sunesen KG, et al: Novel DNA methylation biomarkers show high sensitivity and specificity for blood-based detection of colorectal cancer-a clinical biomarker discovery and validation study. Clin Epigenetics. 11:1582019. View Article : Google Scholar : PubMed/NCBI

52 

Li Y, Li B, Jiang R, Liao L, Zheng C, Yuan J, Zeng L, Hu K, Zhang Y, Mei W, et al: A novel screening method of DNA methylation biomarkers helps to improve the detection of colorectal cancer and precancerous lesions. Cancer Med. 12:20626–20638. 2023. View Article : Google Scholar : PubMed/NCBI

53 

Dai Y, Li H, Wu Q, Wang J, Wang K, Fei S, Pei B, Song L, Chen G, Ma Y, et al: A sensitive and robust plasma-based DNA methylation panel for early detection of target gastrointestinal cancers. Neoplasia. 46:1009412023. View Article : Google Scholar : PubMed/NCBI

54 

Benatti P, Gafà R, Barana D, Marino M, Scarselli A, Pedroni M, Maestri I, Guerzoni L, Roncucci L, Menigatti M, et al: Microsatellite instability and colorectal cancer prognosis. Clin Cancer Res. 11:8332–8340. 2005. View Article : Google Scholar : PubMed/NCBI

55 

Toh JWT, Phan K, Reza F, Chapuis P and Spring KJ: Rate of dissemination and prognosis in early and advanced stage colorectal cancer based on microsatellite instability status: Systematic review and meta-analysis. Int J Colorectal Dis. 36:1573–1596. 2021. View Article : Google Scholar : PubMed/NCBI

56 

Popat S, Hubner R and Houlston RS: Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol. 23:609–618. 2005. View Article : Google Scholar : PubMed/NCBI

57 

Klump B, Nehls O, Okech T, Hsieh CJ, Gaco V, Gittinger FS, Sarbia M, Borchard F, Greschniok A, Gruenagel HH, et al: Molecular lesions in colorectal cancer: Impact on prognosis? Original data and review of the literature. Int J Colorectal Dis. 19:23–42. 2004. View Article : Google Scholar : PubMed/NCBI

58 

Koyama M, Ito M, Nagai H, Emi M and Moriyama Y: Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: Identification of seven novel somatic mutations in tumors from Japanese patients. Mutat Res. 406:71–77. 1999.PubMed/NCBI

59 

Song JH, Oh TJ, An S, Lee KH, Kim JY and Kim JS: Comparative detection of syndecan-2 methylation in preoperative and postoperative stool DNA in patients with colorectal cancer. World J Gastrointest Surg. 15:2032–2041. 2023. View Article : Google Scholar : PubMed/NCBI

60 

Shima K, Nosho K, Baba Y, Cantor M, Meyerhardt JA, Giovannucci EL, Fuchs CS and Ogino S: Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review. Int J Cancer. 128:1080–1094. 2011. View Article : Google Scholar : PubMed/NCBI

61 

Carragher LAS, Snell KR, Giblett SM, Aldridge VS, Patel B, Cook SJ, Winton DJ, Marais R and Pritchard CA: V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a. EMBO Mol Med. 2:458–471. 2010. View Article : Google Scholar : PubMed/NCBI

62 

van der Weyden L, Arends MJ, Dovey OM, Harrison HL, Lefebvre G, Conte N, Gergely FV, Bradley A and Adams DJ: Loss of rassf1a cooperates with Apc(Min) to accelerate intestinal tumourigenesis. Oncogene. 27:4503–4508. 2008. View Article : Google Scholar : PubMed/NCBI

63 

Melling N, Muth J, Simon R, Bokemeyer C, Terracciano L, Sauter G, Izbicki JR and Marx AH: Cdc7 overexpression is an independent prognostic marker and a potential therapeutic target in colorectal cancer. Diagn Pathol. 10:1252015. View Article : Google Scholar : PubMed/NCBI

64 

el-Deiry WS, Nelkin BD, Celano P, Yen RW, Falco JP, Hamilton SR and Baylin SB: High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer. Proc Natl Acad Sci USA. 88:3470–3474. 1991. View Article : Google Scholar : PubMed/NCBI

65 

Lu ZH, Ding Y, Wang YJ, Chen C, Yao XR, Yuan XM, Bu F, Bao H, Dong YW, Zhou Q, et al: Early administration of Wumei Wan inhibit myeloid-derived suppressor cells via PI3K/Akt pathway and amino acids metabolism to prevent colitis-associated colorectal cancer. J Ethnopharmacol. 333:1182602024.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

66 

Chen J, Zheng X, Xu G, Wang B, Hu L, Mao J, Lu X, Cai Y, Chai K and Chen W: Sini decoction inhibits tumor progression and enhances the anti-tumor immune response in a murine model of colon cancer. Comb Chem High Throughput Screen. 26:2517–2526. 2023. View Article : Google Scholar : PubMed/NCBI

67 

Okuno K, Pratama MY, Li J, Tokunaga M, Wang X, Kinugasa Y and Goel A: Ginseng mediates its anticancer activity by inhibiting the expression of DNMTs and reactivating methylation-silenced genes in colorectal cancer. Carcinogenesis. 44:394–403. 2023. View Article : Google Scholar : PubMed/NCBI

68 

Boughanem H, Kompella P, Tinahones FJ and Macias-Gonzalez M: An overview of vitamins as epidrugs for colorectal cancer prevention. Nutr Rev. 81:455–479. 2023. View Article : Google Scholar : PubMed/NCBI

69 

Brockmueller A, Sajeev A, Koklesova L, Samuel SM, Kubatka P, Büsselberg D, Kunnumakkara AB and Shakibaei M: Resveratrol as sensitizer in colorectal cancer plasticity. Cancer Metastasis Rev. 43:55–85. 2024. View Article : Google Scholar : PubMed/NCBI

70 

Link A, Balaguer F, Shen Y, Lozano JJ, Leung HC, Boland CR and Goel A: Curcumin modulates DNA methylation in colorectal cancer cells. PLoS One. 8:e577092013. View Article : Google Scholar : PubMed/NCBI

71 

Lopez M, Gilbert J, Contreras J, Halby L and Arimondo PB: Inhibitors of DNA methylation. Adv Exp Med Biol. 1389:471–513. 2022. View Article : Google Scholar : PubMed/NCBI

72 

Fabianowska-Majewska K, Kaufman-Szymczyk A, Szymanska-Kolba A, Jakubik J, Majewski G and Lubecka K: Curcumin from turmeric rhizome: A potential modulator of DNA methylation machinery in breast cancer inhibition. Nutrients. 13:3322021. View Article : Google Scholar : PubMed/NCBI

73 

Sharma M and Tollefsbol TO: Combinatorial epigenetic mechanisms of sulforaphane, genistein and sodium butyrate in breast cancer inhibition. Exp Cell Res. 416:1131602022. View Article : Google Scholar : PubMed/NCBI

74 

Futterman B, Derr J, Beisler JA, Abbasi MM and Voytek P: Studies on the cytostatic action, phosphorylation and deamination of 5-azacytidine and 5,6-dihydro-5-azacytidine in HeLa cells. Biochem Pharmacol. 27:907–909. 1978. View Article : Google Scholar : PubMed/NCBI

75 

Ghanim V, Herrmann H, Heller G, Peter B, Hadzijusufovic E, Blatt K, Schuch K, Cerny-Reiterer S, Mirkina I, Karlic H, et al: 5-Azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of FAS-demethylation and FAS re-expression, and synergism with FAS-ligand. Blood. 119:4242–4252. 2012. View Article : Google Scholar : PubMed/NCBI

76 

Wang Y, Chen FR, Wei CC, Sun LL, Liu CY, Yang LB and Guo XY: Zinc finger protein 671 has a cancer-inhibiting function in colorectal carcinoma via the deactivation of Notch signaling. Toxicol Appl Pharmacol. 458:1163262023. View Article : Google Scholar : PubMed/NCBI

77 

Bhullar DS, Barriuso J, Mullamitha S, Saunders MP, O'Dwyer ST and Aziz O: Biomarker concordance between primary colorectal cancer and its metastases. EBioMedicine. 40:363–374. 2019. View Article : Google Scholar : PubMed/NCBI

78 

Guo H, Vuille JA, Wittner BS, Lachtara EM, Hou Y, Lin M, Zhao T, Raman AT, Russell HC, Reeves BA, et al: DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs. Cell. 186:2765–2782.e28. 2023. View Article : Google Scholar : PubMed/NCBI

79 

Gkountela S, Castro-Giner F, Szczerba BM, Vetter M, Landin J, Scherrer R, Krol I, Scheidmann MC, Beisel C, Stirnimann CU, et al: Circulating tumor cell clustering shapes DNA methylation to enable metastasis seeding. Cell. 176:98–112.e14. 2019. View Article : Google Scholar : PubMed/NCBI

80 

Padmanaban V, Krol I, Suhail Y, Szczerba BM, Aceto N, Bader JS and Ewald AJ: E-cadherin is required for metastasis in multiple models of breast cancer. Nature. 573:439–444. 2019. View Article : Google Scholar : PubMed/NCBI

81 

Warton K and Samimi G: Methylation of cell-free circulating DNA in the diagnosis of cancer. Front Mol Biosci. 2:132015. View Article : Google Scholar : PubMed/NCBI

82 

Zhou X, Yu L, Wang L, Xiao J, Sun J, Zhou Y, Xu X, Xu W, Spiliopoulou A, Timofeeva M, et al: Alcohol consumption, blood DNA methylation and breast cancer: A Mendelian randomisation study. Eur J Epidemiol. 37:701–712. 2022. View Article : Google Scholar : PubMed/NCBI

83 

Gaiani F, Marchesi F, Negri F, Greco L, Malesci A, de'Angelis GL and Laghi L: Heterogeneity of colorectal cancer progression: Molecular gas and brakes. Int J Mol Sci. 22:52462021. View Article : Google Scholar : PubMed/NCBI

84 

Bao Y, Zhai J, Chen H, Wong CC, Liang C, Ding Y, Huang D, Gou H, Chen D, Pan Y, et al: Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer. Gut. 72:1497–1509. 2023. View Article : Google Scholar : PubMed/NCBI

85 

Zhai J, Chen H, Wong CC, Peng Y, Gou H, Zhang J, Pan Y, Chen D, Lin Y, Wang S, et al: ALKBH5 drives immune suppression via targeting AXIN2 to promote colorectal cancer and is a target for boosting immunotherapy. Gastroenterology. 165:445–462. 2023. View Article : Google Scholar : PubMed/NCBI

86 

Liu Y, Jiang C, Xu C and Gu L: Systematic analysis of integrated bioinformatics to identify upregulated THBS2 expression in colorectal cancer cells inhibiting tumour immunity through the HIF1A/Lactic Acid/GPR132 pathway. Cancer Cell Int. 23:2532023. View Article : Google Scholar : PubMed/NCBI

87 

Yang L, Chen X, Lee C, Shi J, Lawrence EB, Zhang L, Li Y, Gao N, Jung SY, Creighton CJ, et al: Functional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer. J Exp Clin Cancer Res. 42:1132023. View Article : Google Scholar : PubMed/NCBI

88 

Sheikhnejad G, Brank A, Christman JK, Goddard A, Alvarez E, Ford H Jr, Marquez VE, Marasco CJ, Sufrin JR, O'Gara M and Cheng X: Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine. J Mol Biol. 285:2021–2034. 1999. View Article : Google Scholar : PubMed/NCBI

89 

Zheng Z, Zeng S, Liu C, Li W, Zhao L, Cai C, Nie G and He Y: The DNA methylation inhibitor RG108 protects against noise-induced hearing loss. Cell Biol Toxicol. 37:751–771. 2021. View Article : Google Scholar : PubMed/NCBI

90 

Ou Y, Zhang Q, Tang Y, Lu Z, Lu X, Zhou X and Liu C: DNA methylation enzyme inhibitor RG108 suppresses the radioresistance of esophageal cancer. Oncol Rep. 39:993–1002. 2018.PubMed/NCBI

91 

Tanaka S, Hosokawa M, Matsumura J, Matsubara E, Kobori A, Ueda K and Iwakawa S: Effects of zebularine on invasion activity and intracellular expression level of let-7b in colorectal cancer cells. Biol Pharm Bull. 40:1320–1325. 2017. View Article : Google Scholar : PubMed/NCBI

92 

Guo Y, Shu L, Zhang C, Su ZY and Kong ANT: Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1. Biochem Pharmacol. 94:69–78. 2015. View Article : Google Scholar : PubMed/NCBI

93 

Singh BN, Shankar S and Srivastava RK: Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications. Biochem Pharmacol. 82:1807–1821. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Wang C, Zhong R, Wang L and Sun L: Research progress of DNA methylation in colorectal cancer (Review). Mol Med Rep 30: 154, 2024.
APA
Wang, Y., Wang, C., Zhong, R., Wang, L., & Sun, L. (2024). Research progress of DNA methylation in colorectal cancer (Review). Molecular Medicine Reports, 30, 154. https://doi.org/10.3892/mmr.2024.13278
MLA
Wang, Y., Wang, C., Zhong, R., Wang, L., Sun, L."Research progress of DNA methylation in colorectal cancer (Review)". Molecular Medicine Reports 30.3 (2024): 154.
Chicago
Wang, Y., Wang, C., Zhong, R., Wang, L., Sun, L."Research progress of DNA methylation in colorectal cancer (Review)". Molecular Medicine Reports 30, no. 3 (2024): 154. https://doi.org/10.3892/mmr.2024.13278
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Wang C, Zhong R, Wang L and Sun L: Research progress of DNA methylation in colorectal cancer (Review). Mol Med Rep 30: 154, 2024.
APA
Wang, Y., Wang, C., Zhong, R., Wang, L., & Sun, L. (2024). Research progress of DNA methylation in colorectal cancer (Review). Molecular Medicine Reports, 30, 154. https://doi.org/10.3892/mmr.2024.13278
MLA
Wang, Y., Wang, C., Zhong, R., Wang, L., Sun, L."Research progress of DNA methylation in colorectal cancer (Review)". Molecular Medicine Reports 30.3 (2024): 154.
Chicago
Wang, Y., Wang, C., Zhong, R., Wang, L., Sun, L."Research progress of DNA methylation in colorectal cancer (Review)". Molecular Medicine Reports 30, no. 3 (2024): 154. https://doi.org/10.3892/mmr.2024.13278
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team