Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2024 Volume 30 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2024 Volume 30 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review)

  • Authors:
    • Huonggiang Nguyen
    • Seon-Hwan Kim
    • Uijin Juang
    • Suhwan Gwon
    • Woohyeong Jung
    • Qingzhi Huang
    • Soohyeon Lee
    • Beomwoo Lee
    • So Hee Kwon
    • Jongsun Park
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea, Department of Neurosurgery, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea, College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Republic of Korea
    Copyright: © Nguyen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 158
    |
    Published online on: July 5, 2024
       https://doi.org/10.3892/mmr.2024.13282
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Acyl‑coenzyme A thioesterases (ACOTs) are crucial in mediating lipid metabolic functions, including energy expenditure, hepatic gluconeogenesis and neuronal function. The two distinct types are type I and II ACOTs, the latter of which are ‘hotdog’ fold superfamily members. Type II ACOTs include carboxyl‑terminal modulator protein 1 (CTMP1), also termed thioesterase superfamily member 4 (THEM4), and CTMP2, also termed THEM5. Due to their similar structural features and distinct sequence homology, CTMP1 and CTMP2 stand out from other type II ACOTs. CTMP1 was initially known as a protein kinase B (PKB) inhibitor that attenuates PKB phosphorylation. PKB is the central regulator of various cellular functions, including survival, proliferation, growth and metabolism. Therefore, by inhibiting PKB, CTMP1 can affect various cellular processes. Various other functions of CTMP1 have been revealed, including functions in cancer, brain injury, mitochondrial function and lipid metabolism. CTMP2 is a paralog of CTMP1 and was first identified as a cardiolipin remodeling factor involved in the development of fatty liver. As the functions of CTMP1 and CTMP2 were discovered separately, a review to summarize and connect these findings is essential. The current review delineates the intricate complexity of CTMP regulation across different metabolic pathways and encapsulates the principal discoveries concerning CTMP until the present day.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Maira SM, Galetic I, Brazil DP, Kaech S, Ingley E, Thelen M and Hemmings BA: Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. Science. 294:374–380. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Manning BD and Toker A: AKT/PKB signaling: Navigating the network. Cell. 169:381–405. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Glaviano A, Foo ASC, Lam HY, Yap KCH, Jacot W, Jones RH, Eng H, Nair MG, Makvandi P, Geoerger B, et al: PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer. Mol Cancer. 22:1382023. View Article : Google Scholar : PubMed/NCBI

4 

Wang Z: Regulation of cell cycle progression by growth factor-induced cell signaling. Cells. 10:33272021. View Article : Google Scholar : PubMed/NCBI

5 

Parcellier A, Tintignac LA, Zhuravleva E, Cron P, Schenk S, Bozulic L and Hemmings BA: Carboxy-terminal modulator protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis. Cell Signal. 21:639–650. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Piao L, Li Y, Yang KJ, Park KA, Byun HS, Won M, Hong J, Kim JL, Kweon GR, Hur GM, et al: Heat shock protein 70-mediated sensitization of cells to apoptosis by carboxyl-terminal modulator protein. BMC Cell Biol. 10:532009. View Article : Google Scholar : PubMed/NCBI

7 

Jin H, Xu CX, Lim HT, Park SJ, Shin JY, Chung YS, Park SC, Chang SH, Youn HJ, Lee KH, et al: High dietary inorganic phosphate increases lung tumorigenesis and alters Akt signaling. Am J Respir Crit Care Med. 179:59–68. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Hwang SK, Kwon JT, Park SJ, Chang SH, Lee ES, Chung YS, Beck GR Jr, Lee KH, Piao L, Park J and Cho MH: Lentivirus-mediated carboxyl-terminal modulator protein gene transfection via aerosol in lungs of K-ras null mice. Gene Ther. 14:1721–1730. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Niu F, Duan Y, Man Y, Liu W, Dai T, Zhang H, Li C and Wei D: Mitochondrial protein LETM1 and its-mediated CTMP are potential therapeutic targets for endometrial cancer. Anticancer Drugs. 33:632–641. 2022. View Article : Google Scholar : PubMed/NCBI

10 

Simon PO Jr, McDunn JE, Kashiwagi H, Chang K, Goedegebuure PS, Hotchkiss RS and Hawkins WG: Targeting AKT with the proapoptotic peptide, TAT-CTMP: A novel strategy for the treatment of human pancreatic adenocarcinoma. Int J Cancer. 125:942–951. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Knobbe CB, Reifenberger J, Blaschke B and Reifenberger G: Hypermethylation and transcriptional downregulation of the carboxyl-terminal modulator protein gene in glioblastomas. J Natl Cancer Inst. 96:483–486. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Chang JW, Jung SN, Kim JH, Shim GA, Park HS, Liu L, Kim JM, Park J and Koo BS: Carboxyl-terminal modulator protein positively acts as an oncogenic driver in head and neck squamous cell carcinoma via regulating Akt phosphorylation. Sci Rep. 6:285032016. View Article : Google Scholar : PubMed/NCBI

13 

Liu YP, Liao WC, Ger LP, Chen JC, Hsu TI, Lee YC, Chang HT, Chen YC, Jan YH, Lee KH, et al: Carboxyl-terminal modulator protein positively regulates Akt phosphorylation and acts as an oncogenic driver in breast cancer. Cancer Res. 73:6194–6205. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Lin CH, Lin WD, Huang YC, Chen YC, Loh ZJ, Ger LP, Lin FC, Li HY, Cheng HC, Lee KH, et al: Carboxyl-terminal modulator protein facilitates tumor metastasis in triple-negative breast cancer. Cancer Gene Ther. 30:404–413. 2023.PubMed/NCBI

15 

Bolze PA, Lopez J, Allias F, Hajri T, Patrier S, Devouassoux-Shisheboran M, Massardier J, You B, Golfier F and Mallet F: Transcriptomic and immunohistochemical approaches identify HLA-G as a predictive biomarker of gestational choriocarcinoma resistance to monochemotherapy. Gynecol Oncol. 158:785–793. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Ni FB, Lin Z, Fan XH, Shi KQ, Ao JY, Wang XD and Chen RC: A novel genomic-clinicopathologic nomogram to improve prognosis prediction of hepatocellular carcinoma. Clin Chim Acta. 504:88–97. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Zhang S, Li D, Zhao M, Yang F, Sang C, Yan C, Wang Z and Li Y: Exosomal miR-183-5p shuttled by M2 polarized tumor-associated macrophage promotes the development of colon cancer via targeting THEM4 mediated PI3K/AKT and NF-κB pathways. Front Oncol. 11:6726842021. View Article : Google Scholar : PubMed/NCBI

18 

Chen YC, Li HY, Liang JL, Ger LP, Chang HT, Hsiao M, Calkins MJ, Cheng HC, Chuang JH and Lu PJ: CTMP, a predictive biomarker for trastuzumab resistance in HER2-enriched breast cancer patient. Oncotarget. 8:29699–29710. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Block M, Grundker C, Fister S, Kubin J, Wilkens L, Mueller MD, Hemmerlein B, Emons G and Günthert AR: Inhibition of the AKT/mTOR and erbB pathways by gefitinib, perifosine and analogs of gonadotropin-releasing hormone I and II to overcome tamoxifen resistance in breast cancer cells. Int J Oncol. 41:1845–1854. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Li J, Shan W and Zuo Z: Age-related upregulation of carboxyl terminal modulator protein contributes to the decreased brain ischemic tolerance in older rats. Mol Neurobiol. 55:6145–6154. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Chen Y, Nie H, Tian L, Tong L, Deng J, Zhang Y, Dong H and Xiong L: Sevoflurane preconditioning-induced neuroprotection is associated with Akt activation via carboxy-terminal modulator protein inhibition. Br J Anaesth. 114:327–335. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Kao MH, Huang CY, Cheung WM, Yan YT, Chen JJ, Ho YS, Hsu CY and Lin TN: Activating transcription factor 3 diminishes ischemic cerebral infarct and behavioral deficit by downregulating carboxyl-terminal modulator protein. Int J Mol Sci. 24:23062023. View Article : Google Scholar : PubMed/NCBI

23 

Huang CY, Chen JJ, Wu JS, Tsai HD, Lin H, Yan YT, Hsu CY, Ho YS and Lin TN: Novel link of anti-apoptotic ATF3 with pro-apoptotic CTMP in the ischemic brain. Mol Neurobiol. 51:543–557. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Zhao S, Fu J, Liu F, Rastogi R, Zhang J and Zhao Y: Small interfering RNA directed against CTMP reduces acute traumatic brain injury in a mouse model by activating Akt. Neurol Res. 36:483–490. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Chen Y, Cai M, Deng J, Tian L, Wang S, Tong L, Dong H and Xiong L: Elevated expression of carboxy-terminal modulator protein (CTMP) aggravates brain ischemic injury in diabetic db/db Mice. Neurochem Res. 41:2179–2189. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Miyawaki T, Ofengeim D, Noh KM, Latuszek-Barrantes A, Hemmings BA, Follenzi A and Zukin RS: The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death. Nat Neurosci. 12:618–626. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Park J, Li Y, Kim SH, Yang KJ, Kong G, Shrestha R, Tran Q, Park KA, Jeon J, Hur GM, et al: New players in high fat diet-induced obesity: LETM1 and CTMP. Metabolism. 63:318–327. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Mondal AK, Sharma NK, Elbein SC and Das SK: Allelic expression imbalance screening of genes in chromosome 1q21-24 region to identify functional variants for Type 2 diabetes susceptibility. Physiol Genomics. 45:509–520. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Chen N, Hao J, Li L, Li F, Liu S and Duan H: Carboxy-terminal modulator protein attenuated extracellular matrix deposit by inhibiting phospho-Akt, TGF-β1 and α-SMA in kidneys of diabetic mice. Biochem Biophys Res Commun. 474:753–760. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Liu X, Yang Q, Zhu LH, Liu J, Deng KQ, Zhu XY, Liu Y, Gong J, Zhang P, Li S, et al: Carboxyl-terminal modulator protein ameliorates pathological cardiac hypertrophy by suppressing the protein kinase B signaling pathway. J Am Heart Assoc. 7:e0086542018. View Article : Google Scholar : PubMed/NCBI

31 

Zhuravleva E, Gut H, Hynx D, Marcellin D, Bleck CK, Genoud C, Cron P, Keusch JJ, Dummler B, Esposti MD and Hemmings BA: Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development. Mol Cell Biol. 32:2685–2697. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Swarbrick CMD, Nanson JD, Patterson EI and Forwood JKL: Structure, function, and regulation of thioesterases. Prog Lipid Res. 79:1010362020. View Article : Google Scholar : PubMed/NCBI

33 

Tillander V, Alexson SEH and Cohen DE: Deactivating fatty acids: Acyl-CoA thioesterase-mediated control of lipid metabolism. Trends Endocrinol Metab. 28:473–484. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Brocker C, Carpenter C, Nebert DW and Vasiliou V: Evolutionary divergence and functions of the human acyl-CoA thioesterase gene (ACOT) family. Hum Genomics. 4:411–420. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Zhao H, Martin BM, Bisoffi M and Dunaway-Mariano D: The Akt C-terminal modulator protein is an acyl-CoA thioesterase of the Hotdog-Fold family. Biochemistry. 48:5507–5509. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Zhao H, Lim K, Choudry A, Latham JA, Pathak MC, Dominguez D, Luo L, Herzberg O and Dunaway-Mariano D: Correlation of structure and function in the human hotdog-fold enzyme hTHEM4. Biochemistry. 51:6490–6492. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Jones PF, Jakubowicz T and Hemmings BA: Molecular cloning of a second form of rac protein kinase. Cell Regul. 2:1001–1009. 1991. View Article : Google Scholar : PubMed/NCBI

38 

Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, Franke TF, Hamilton TC, Tsichlis PN and Testa JR: AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc Natl Acad Sci USA. 89:9267–9271. 1992. View Article : Google Scholar : PubMed/NCBI

39 

Brodbeck D, Cron P and Hemmings BA: A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem. 274:9133–9136. 1999. View Article : Google Scholar : PubMed/NCBI

40 

Song G, Ouyang G and Bao S: The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med. 9:59–71. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Nicholson KM and Anderson NG: The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal. 14:381–395. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Ruan GX and Kazlauskas A: Focus on molecules: Akt (PKB). Exp Eye Res. 93:570–571. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Andjelkovic M, Alessi DR, Meier R, Fernandez A, Lamb NJ, Frech M, Cron P, Cohen P, Lucocq JM and Hemmings BA: Role of translocation in the activation and function of protein kinase B. J Biol Chem. 272:31515–31524. 1997. View Article : Google Scholar : PubMed/NCBI

44 

Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, Gaffney PR, Reese CB, McCormick F, Tempst P, et al: Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science. 279:710–714. 1998. View Article : Google Scholar : PubMed/NCBI

45 

Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Morrice N, Cohen P and Hemmings BA: Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15:6541–6551. 1996. View Article : Google Scholar : PubMed/NCBI

46 

Sarbassov DD, Guertin DA, Ali SM and Sabatini DM: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 307:1098–1101. 2005. View Article : Google Scholar : PubMed/NCBI

47 

Zhuravleva E: Structural and functional characterization of novel mitochondrial acyl-CoA thioesterase Them5/CTMP2 (Doctoral Thesis). University of Basel; 2013

48 

Brazil DP, Park J and Hemmings BA: PKB binding proteins. Getting in on the Akt. Cell. 111:293–303. 2002. View Article : Google Scholar : PubMed/NCBI

49 

Ono H, Sakoda H, Fujishiro M, Anai M, Kushiyama A, Fukushima Y, Katagiri H, Ogihara T, Oka Y, Kamata H, et al: Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways. Am J Physiol Cell Physiol. 293:C1576–C1585. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Zhou Q, Leeman SE and Amar S: Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses. Proc Natl Acad Sci USA. 106:10740–1075. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Shin JY, Chung YS, Kang B, Jiang HL, Yu DY, Han K, Chae C, Moon JH, Jang G and Cho MH: Co-delivery of LETM1 and CTMP synergistically inhibits tumor growth in H-ras12V liver cancer model mice. Cancer Gene Ther. 20:186–194. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Yu H, Deng J and Zuo Z: High-fat diet reduces neuroprotection of isoflurane post-treatment: Role of carboxyl-terminal modulator protein-Akt signaling. Obesity (Silver Spring). 22:2396–2405. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Zhao Y, Zhang Y, Khas E, Bai C, Cao Q and Ao C: Transcriptome analysis reveals candidate genes of the synthesis of branched-chain fatty acids related to mutton flavor in the lamb liver using Allium mongolicum Regel extract. J Anim Sci. 100:skac2562022. View Article : Google Scholar : PubMed/NCBI

54 

Yu B, Zheng Y, Alexander D, Morrison AC, Coresh J and Boerwinkle E: Genetic determinants influencing human serum metabolome among African Americans. PLoS Genet. 10:e10042122014. View Article : Google Scholar : PubMed/NCBI

55 

Hwang SK, Minai-Tehrani A, Yu KN, Chang SH, Kim JE, Lee KH, Park J, Beck GR Jr and Cho MH: Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells. Int J Oncol. 40:1515–1524. 2012.PubMed/NCBI

56 

Piao L, Li Y, Kim SJ, Sohn KC, Yang KJ, Park KA, Byun HS, Won M, Hong J, Hur GM, et al: Regulation of OPA1-mediated mitochondrial fusion by leucine zipper/EF-hand-containing transmembrane protein-1 plays a role in apoptosis. Cell Signal. 21:767–777. 2009. View Article : Google Scholar : PubMed/NCBI

57 

Parcellier A, Tintignac LA, Zhuravleva E, Dummler B, Brazil DP, Hynx D, Cron P, Schenk S, Olivieri V and Hemmings BA: The carboxy-terminal modulator protein (CTMP) regulates mitochondrial dynamics. PLoS One. 4:e54712009. View Article : Google Scholar : PubMed/NCBI

58 

Vo TT, Kong G, Kim C, Juang U, Gwon S, Jung W, Nguyen H, Kim SH and Park J: Exploring scavenger receptor class F member 2 and the importance of scavenger receptor family in prediagnostic diseases. Toxicol Res. 39:341–353. 2023. View Article : Google Scholar : PubMed/NCBI

59 

Wang B, Xu X, Liu X, Wang D, Zhuang H, He X, Han T and Hong J: Enolase-phosphatase 1 acts as an oncogenic driver in glioma. J Cell Physiol. 236:1184–1194. 2021. View Article : Google Scholar : PubMed/NCBI

60 

Tews B, Roerig P, Hartmann C, Hahn M, Felsberg J, Blaschke B, Sabel M, Kunitz A, Toedt G, Neben K, et al: Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q. Oncogene. 26:5010–5016. 2007. View Article : Google Scholar : PubMed/NCBI

61 

Knobbe CB, Trampe-Kieslich A and Reifenberger G: Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas. Neuropathol Appl Neurobiol. 31:486–490. 2005. View Article : Google Scholar : PubMed/NCBI

62 

Gao S, Gang J, Yu M, Xin G and Tan H: Computational analysis for identification of early diagnostic biomarkers and prognostic biomarkers of liver cancer based on GEO and TCGA databases and studies on pathways and biological functions affecting the survival time of liver cancer. BMC Cancer. 21:7912021. View Article : Google Scholar : PubMed/NCBI

63 

Yamasaki D, Kawabe N, Nakamura H, Tachibana K, Ishimoto K, Tanaka T, Aburatani H, Sakai J, Hamakubo T, Kodama T and Doi T: Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARalpha-independent mechanisms. Eur J Cell Biol. 90:657–664. 2011. View Article : Google Scholar : PubMed/NCBI

64 

Niu Q, Zhao W, Wang J, Li C, Yan T, Lv W, Wang G, Duan W, Zhang T, Wang K and Zhou D: LicA induces autophagy through ULK1/Atg13 and ROS pathway in human hepatocellular carcinoma cells. Int J Mol Med. 41:2601–2608. 2018.PubMed/NCBI

65 

Garrido-Castro AC, Lin NU and Polyak K: Insights into molecular classifications of triple-negative breast cancer: Improving patient selection for treatment. Cancer Discov. 9:176–198. 2019. View Article : Google Scholar : PubMed/NCBI

66 

Gutierrez-Barrera AM, Menter DG, Abbruzzese JL and Reddy SA: Establishment of three-dimensional cultures of human pancreatic duct epithelial cells. Biochem Biophys Res Commun. 358:698–703. 2007. View Article : Google Scholar : PubMed/NCBI

67 

Hwang SK, Lim HT, Minai-Tehrani A, Lee ES, Park J, Park SB, Beck GR Jr and Cho MH: Repeated aerosol delivery of carboxyl-terminal modulator protein suppresses tumor in the lungs of K-rasLA1 mice. Am J Respir Crit Care Med. 179:1131–1140. 2009. View Article : Google Scholar : PubMed/NCBI

68 

Wang B, Cai Y, Li X, Kong Y, Fu H and Zhou J: ETV4 mediated lncRNA C2CD4D-AS1 overexpression contributes to the malignant phenotype of lung adenocarcinoma cells via miR-3681-3p/NEK2 axis. Cell Cycle. 20:2607–2618. 2021. View Article : Google Scholar : PubMed/NCBI

69 

Gao S, Tan H and Li D: Oridonin suppresses gastric cancer SGC-7901 cell proliferation by targeting the TNF-alpha/androgen receptor/TGF-beta signalling pathway axis. J Cell Mol Med. 27:2661–2674. 2023. View Article : Google Scholar : PubMed/NCBI

70 

Strykowski R and Adegunsoye A: Idiopathic pulmonary fibrosis and progressive pulmonary fibrosis. Immunol Allergy Clin North Am. 43:209–228. 2023. View Article : Google Scholar : PubMed/NCBI

71 

Gul A, Yang F, Xie C, Du W, Mohammadtursun N, Wang B, Le J and Dong J: Pulmonary fibrosis model of mice induced by different administration methods of bleomycin. BMC Pulm Med. 23:912023. View Article : Google Scholar : PubMed/NCBI

72 

Shin N, Yi MH, Kim S, Baek H, Triantafillu UL, Park J and Kim DW: Astrocytic expression of CTMP following an excitotoxic lesion in the mouse hippocampus. Exp Neurobiol. 26:25–32. 2017. View Article : Google Scholar : PubMed/NCBI

73 

Chae KS, Martin-Caraballo M, Anderson M and Dryer SE: Akt activation is necessary for growth factor-induced trafficking of functional K(Ca) channels in developing parasympathetic neurons. J Neurophysiol. 93:1174–1182. 2005. View Article : Google Scholar : PubMed/NCBI

74 

Lampropoulos IC, Malli F, Sinani O, Gourgoulianis KI and Xiromerisiou G: Worldwide trends in mortality related to Parkinson's disease in the period of 1994–2019: Analysis of vital registration data from the WHO mortality database. Front Neurol. 13:9564402022. View Article : Google Scholar : PubMed/NCBI

75 

Dick F, Nido GS, Alves GW, Tysnes OB, Nilsen GH, Dolle C and Tzoulis C: Differential transcript usage in the Parkinson's disease brain. PLoS Genet. 16:e10091822020. View Article : Google Scholar : PubMed/NCBI

76 

Dolan ME, El Charif O, Wheeler HE, Gamazon ER, Ardeshir-Rouhani-Fard S, Monahan P, Feldman DR, Hamilton RJ, Vaughn DJ, Beard CJ, et al: Clinical and genome-wide analysis of cisplatin-induced peripheral neuropathy in survivors of adult-onset cancer. Clin Cancer Res. 23:5757–5768. 2017. View Article : Google Scholar : PubMed/NCBI

77 

Ren B, Wan S, Wu H, Qu M, Chen Y, Liu L, Jin M, Zhou Z and Shen H: Effect of different iodine levels on the DNA methylation of PRKAA2, ITGA6, THEM4 and PRL genes in PI3K-AKT signaling pathway and population-based validation from autoimmune thyroiditis patients. Eur J Nutr. 61:3571–3583. 2022. View Article : Google Scholar : PubMed/NCBI

78 

Wang Q, He Y, Shen Y, Zhang Q, Chen D, Zuo C, Qin J, Wang H, Wang J and Yu Y: Vitamin D inhibits COX-2 expression and inflammatory response by targeting thioesterase superfamily member 4. J Biol Chem. 289:11681–1194. 2014. View Article : Google Scholar : PubMed/NCBI

79 

Nambou K, Nie X, Tong Y and Anakpa M: Weighted gene co-expression network analysis and drug-gene interaction bioinformatics uncover key genes associated with various presentations of malaria infection in African children and major drug candidates. Infect Genet Evol. 89:1047232021. View Article : Google Scholar : PubMed/NCBI

80 

Wang J, Tierney L, Wilson C, Phillips V, Goldman L, Mumaw C, Muang E and Walker CL: Carboxyl-terminal modulator protein (CTMP) deficiency mitigates denervation-induced skeletal muscle atrophy. Biochem Biophys Res Commun. 644:155–161. 2023. View Article : Google Scholar : PubMed/NCBI

81 

Zhu M, Zheng R, Guo Y, Zhang Y and Zuo B: NDRG4 promotes myogenesis via Akt/CREB activation. Oncotarget. 8:101720–10134. 2017. View Article : Google Scholar : PubMed/NCBI

82 

Wang J, Fry CME and Walker CL: Carboxyl-terminal modulator protein regulates Akt signaling during skeletal muscle atrophy in vitro and a mouse model of amyotrophic lateral sclerosis. Sci Rep. 9:39202019. View Article : Google Scholar : PubMed/NCBI

83 

Sun X, Kellner M, Desai AA, Wang T, Lu Q, Kangath A, Qu N, Klinger C, Fratz S, Yuan JX, et al: Asymmetric dimethylarginine stimulates Akt1 phosphorylation via heat shock protein 70-facilitated carboxyl-terminal modulator protein degradation in pulmonary arterial endothelial cells. Am J Respir Cell Mol Biol. 55:275–287. 2016. View Article : Google Scholar : PubMed/NCBI

84 

Lu Z, Tang F, Li Z, Xie Z, Zheng H, Zhang J, Gao Y, Lu Z, Cai Y, Lai Y and He Z: Characteristic genes and immune infiltration analysis for acute rejection after kidney transplantation. Dis Markers. 2022:65750522022. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nguyen H, Kim S, Juang U, Gwon S, Jung W, Huang Q, Lee S, Lee B, Kwon S, Park J, Park J, et al: Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review). Mol Med Rep 30: 158, 2024.
APA
Nguyen, H., Kim, S., Juang, U., Gwon, S., Jung, W., Huang, Q. ... Park, J. (2024). Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review). Molecular Medicine Reports, 30, 158. https://doi.org/10.3892/mmr.2024.13282
MLA
Nguyen, H., Kim, S., Juang, U., Gwon, S., Jung, W., Huang, Q., Lee, S., Lee, B., Kwon, S., Park, J."Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review)". Molecular Medicine Reports 30.3 (2024): 158.
Chicago
Nguyen, H., Kim, S., Juang, U., Gwon, S., Jung, W., Huang, Q., Lee, S., Lee, B., Kwon, S., Park, J."Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review)". Molecular Medicine Reports 30, no. 3 (2024): 158. https://doi.org/10.3892/mmr.2024.13282
Copy and paste a formatted citation
x
Spandidos Publications style
Nguyen H, Kim S, Juang U, Gwon S, Jung W, Huang Q, Lee S, Lee B, Kwon S, Park J, Park J, et al: Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review). Mol Med Rep 30: 158, 2024.
APA
Nguyen, H., Kim, S., Juang, U., Gwon, S., Jung, W., Huang, Q. ... Park, J. (2024). Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review). Molecular Medicine Reports, 30, 158. https://doi.org/10.3892/mmr.2024.13282
MLA
Nguyen, H., Kim, S., Juang, U., Gwon, S., Jung, W., Huang, Q., Lee, S., Lee, B., Kwon, S., Park, J."Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review)". Molecular Medicine Reports 30.3 (2024): 158.
Chicago
Nguyen, H., Kim, S., Juang, U., Gwon, S., Jung, W., Huang, Q., Lee, S., Lee, B., Kwon, S., Park, J."Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review)". Molecular Medicine Reports 30, no. 3 (2024): 158. https://doi.org/10.3892/mmr.2024.13282
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team