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Review Open Access

Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)

  • Authors:
    • Ruxia Han
    • Xueying Li
    • Xinfu Gao
    • Guangyao Lv
  • View Affiliations / Copyright

    Affiliations: School of Pharmacy, Binzhou Medical University, Yantai, Shandong 264003, P.R. China, School of Health, Binzhou Polytechnic, Binzhou, Shandong 256600, P.R. China, Department of Pharmacy, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 163
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    Published online on: July 8, 2024
       https://doi.org/10.3892/mmr.2024.13287
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Abstract

Cancer incidence is increasing globally, presenting a growing public health challenge. While anticancer drugs are crucial in treatment, their limitations, including poor targeting ability and high toxicity, hinder effectiveness and patient safety, requiring relentless scientific research and technological advancements to develop safer and more effective therapeutics. Cinnamaldehyde (CA), an active compound derived from the natural plant cinnamon, has garnered attention in pharmacological research due to its diverse therapeutic applications. CA has potential in treating a wide array of conditions, including cardiovascular diseases, diabetes, inflammatory disorders and various forms of cancer. The present review comprehensively summarizes the physicochemical and pharmacokinetic profiles of CA, and delves into the latest advancements in elucidating its potential mechanisms and targets across various cancer types. CA and its derivatives have antitumor effects, which encompass inhibiting cell proliferation, arresting the cell cycle, inducing apoptosis, limiting cell migration and invasion, and suppressing angiogenesis. Additionally, the present review explores targeted formulations of CA, laying a scientific foundation for further exploration of its implications in cancer prevention and treatment strategies.
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Copy and paste a formatted citation
Spandidos Publications style
Han R, Li X, Gao X and Lv G: Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review). Mol Med Rep 30: 163, 2024.
APA
Han, R., Li, X., Gao, X., & Lv, G. (2024). Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review). Molecular Medicine Reports, 30, 163. https://doi.org/10.3892/mmr.2024.13287
MLA
Han, R., Li, X., Gao, X., Lv, G."Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)". Molecular Medicine Reports 30.3 (2024): 163.
Chicago
Han, R., Li, X., Gao, X., Lv, G."Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)". Molecular Medicine Reports 30, no. 3 (2024): 163. https://doi.org/10.3892/mmr.2024.13287
Copy and paste a formatted citation
x
Spandidos Publications style
Han R, Li X, Gao X and Lv G: Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review). Mol Med Rep 30: 163, 2024.
APA
Han, R., Li, X., Gao, X., & Lv, G. (2024). Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review). Molecular Medicine Reports, 30, 163. https://doi.org/10.3892/mmr.2024.13287
MLA
Han, R., Li, X., Gao, X., Lv, G."Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)". Molecular Medicine Reports 30.3 (2024): 163.
Chicago
Han, R., Li, X., Gao, X., Lv, G."Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)". Molecular Medicine Reports 30, no. 3 (2024): 163. https://doi.org/10.3892/mmr.2024.13287
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