Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2024 Volume 30 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2024 Volume 30 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Oroxylin A, a broad‑spectrum anticancer agent, relieves monocrotaline‑induced pulmonary arterial hypertension by inhibiting the Warburg effect in rats

  • Authors:
    • Yan Wang
    • Yamin Fan
    • Yanzi Zhou
    • Tianwang Chen
    • Shangfu Xu
    • Juan Liu
    • Lisheng Li
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China, Key Laboratory of Cell Engineering of Guizhou Province, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 195
    |
    Published online on: August 30, 2024
       https://doi.org/10.3892/mmr.2024.13319
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Pulmonary arterial hypertension (PAH) is a chronic and fatal disease characterized by pulmonary vascular remodeling, similar to the ‘Warburg effect’ observed in cancer, which is caused by reprogramming of glucose metabolism. Oroxylin A (OA), an active compound derived from Scutellaria baicalensis, which can inhibit glycolytic enzymes [hexokinase 2 (HK2), Lactate dehydrogenase (LDH), and pyruvate dehydrogenase kinase 1 (PDK1) by downregulating aerobic glycolysis to achieve the treatment of liver cancer. To the best of our knowledge, however, the impact of OA on PAH has not been addressed. Consequently, the present study aimed to evaluate the potential protective role and mechanism of OA against PAH induced by monocrotaline (MCT; 55 mg/kg). The mean pulmonary artery pressure (mPAP) was measured using the central venous catheter method; HE and Masson staining were used to observe pulmonary artery remodeling. Non‑targeted metabolomics was used to analyze the metabolic pathways and pathway metabolites in MCT‑PAH rats. Western Blot analysis was employed to assess the levels of glucose transporter 1 (Glut1), HK2), pyruvate kinase (PK), isocitrate dehydrogenase 2 (IDH2), pyruvate dehydrogenase kinase 1(PDK1), and lactate dehydrogenase (LDH) protein expression in both lung tissue samples from MCT‑PAH rats. The results demonstrated that intragastric administration of OA (40 and 80 mg/kg) significantly decreased mPAP from 43.61±1.88 mmHg in PAH model rats to 26.51±1.53 mmHg and relieve pulmonary artery remodeling. Untargeted metabolomic analysis and multivariate analysis indicated abnormal glucose metabolic pattern in PAH model rats, consistent with the Warburg effect. OA administration decreased this effect on the abnormal glucose metabolism. The protein levels of key enzymes involved in glucose metabolism were evaluated by western blotting, which demonstrated that OA could improve aerobic glycolysis and inhibit PAH by decreasing the protein levels of Glut1, HK2, LDH, PDK1 and increasing the protein levels of PK and IDH2. In conclusion, OA decreased MCT‑induced PAH in rats by reducing the Warburg effect.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, Carlsen J, Coats AJS, Escribano-Subias P, Ferrari P, et al: 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 43:3618–3731. 2022. View Article : Google Scholar : PubMed/NCBI

2 

Culley MK and Chan SY: Mitochondrial metabolism in pulmonary hypertension: Beyond mountains there are mountains. J Clin Invest. 128:3704–3715. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Sakao S and Tatsumi K: Vascular remodeling in pulmonary arterial hypertension: Multiple cancer-like pathways and possible treatment modalities. Int J Cardiol. 147:4–12. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Spiekerkoetter E, Goncharova EA, Guignabert C, Stenmark K, Kwapiszewska G, Rabinovitch M, Voelkel N, Bogaard HJ, Graham B, Pullamsetti SS and Kuebler WM: Hot topics in the mechanisms of pulmonary arterial hypertension disease: Cancer-like pathobiology, the role of the adventitia, systemic involvement and right ventricular failure. Pulm Circ. 9:20458940198897752019. View Article : Google Scholar : PubMed/NCBI

5 

Han S and Chandel NS: Lessons from cancer metabolism for pulmonary arterial hypertension and fibrosis. Am J Respir Cell Mol Biol. 65:134–145. 2021. View Article : Google Scholar : PubMed/NCBI

6 

Liu X, Zhang L and Zhang W: Metabolic reprogramming: A novel metabolic model for pulmonary hypertension. Front Cardiovasc Med. 9:9575242022. View Article : Google Scholar : PubMed/NCBI

7 

Arai MA, Sakuraba K, Makita Y, Hara Y and Ishibashi M: Evaluation of naturally occurring HIF-1 inhibitors for pulmonary arterial hypertension. Chembiochem. 22:2799–2804. 2021. View Article : Google Scholar : PubMed/NCBI

8 

Reiter RJ, Sharma R and Rosales-Corral S: Anti-warburg effect of melatonin: A proposed mechanism to explain its inhibition of multiple diseases. Int J Mol Sci. 22:7642021. View Article : Google Scholar : PubMed/NCBI

9 

Dewachter L, Dewachter C and Naeije R: New therapies for pulmonary arterial hypertension: An update on current bench to bedside translation. Expert Opin Investig Drugs. 19:469–488. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Peng H, Xiao Y, Deng X, Luo J, Hong C and Qin X: The warburg effect: A new story in pulmonary arterial hypertension. Clin Chim Acta. 461:53–58. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Luo L, Wu J, Lin T, Lian G, Wang H, Gao G and Xie L: Influence of atorvastatin on metabolic pattern of rats with pulmonary hypertension. Aging (Albany NY). 13:11954–11968. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Sajeev A, Hegde M, Girisa S, Devanarayanan TN, Alqahtani MS, Abbas M, Sil SK, Sethi G, Chen JT and Kunnumakkara AB: Oroxylin A: A promising flavonoid for prevention and treatment of chronic diseases. Biomolecules. 12:11852022. View Article : Google Scholar : PubMed/NCBI

13 

Wei L, Zhou Y, Dai Q, Qiao C, Zhao L, Hui H, Lu N and Guo QL: Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma. Cell Death Dis. 4:e6012013. View Article : Google Scholar : PubMed/NCBI

14 

Wei L, Zhou Y, Qiao C, Ni T, Li Z, You Q, Guo Q and Lu N: Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. Cell Death Dis. 6:e17142015. View Article : Google Scholar : PubMed/NCBI

15 

Dai Q, Yin Q, Wei L, Zhou Y, Qiao C, Guo Y, Wang X, Ma S and Lu N: Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of hypoxia-inducible factor-1 in human hepatoma HepG2 cells. Mol Carcinog. 55:1275–1289. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Feng W, Hu Y, An N, Feng Z, Liu J, Mou J, Hu T, Guan H, Zhang D and Mao Y: Alginate oligosaccharide alleviates monocrotaline-induced pulmonary hypertension via anti-oxidant and anti-inflammation pathways in rats. Int Heart J. 61:160–168. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Wang J, Tian C, Zhang J, Zhang J and Wu Z: Oroxylin A ameliorates isoproterenol-induced heart failure model in rats through promoting myocardial autophagy. J China Pharm Univ. 49:731–738. 2018.(In Chinese).

18 

Zhang WB, Zheng YF and Wu YG: Protective effects of oroxylin A against doxorubicin-induced cardiotoxicity via the activation of Sirt1 in mice. Oxid Med Cell Longev. 2021:66105432021. View Article : Google Scholar : PubMed/NCBI

19 

Li LS, Luo YM, Liu J, Zhang Y, Fu XX and Yang DL: Icariin inhibits pulmonary hypertension induced by monocrotaline through enhancement of NO/cGMP signaling pathway in rats. Evid Based Complement Alternat Med. 2016:79154152016. View Article : Google Scholar : PubMed/NCBI

20 

Chambers MC, Maclean B, Burke R, Amodei D, Ruderman DL, Neumann S, Gatto L, Fischer B, Pratt B, Egertson J, et al: A cross-platform toolkit for mass spectrometry and proteomics. Nat Biotechnol. 30:918–920. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Nenni M, Çelebier M, Maçin S, Örsten S, Yabanoğlu-Çiftçi S and Baysal İ: Untargeted metabolomics to discriminate liver and lung hydatid cysts: Importance of metabolites involved in the immune response. Vet Parasitol. 328:1101802024. View Article : Google Scholar : PubMed/NCBI

22 

Kanehisa M, Sato Y, Kawashima M, Furumichi M and Tanabe M: KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. 44:D457–D462. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Dong L, Chen P and Cheng J: Experimental study on different doses of monocrotaline-induced pulmonary hypertension in rats. Chin J Integr Med Cardio-Cerebrovasc Dis. 13:1172–1175. 2015.(In Chinese).

24 

Sajeev A, Hegde M, Daimary UD, Kumar A, Girisa S, Sethi G and Kunnumakkara AB: Modulation of diverse oncogenic signaling pathways by oroxylin A: An important strategy for both cancer prevention and treatment. Phytomedicine. 105:1543692022. View Article : Google Scholar : PubMed/NCBI

25 

Huo TX, Wang XP, Yu Z, Kong B, He Y, Guo QL, Zhang XB and Qiang L: Oroxylin A inhibits the migration of hepatocellular carcinoma cells by inducing NAG-1 expression. Acta Pharmacol Sin. 43:724–734. 2022. View Article : Google Scholar : PubMed/NCBI

26 

Boucherat O, Vitry G, Trinh I, Paulin R, Provencher S and Bonnet S: The cancer theory of pulmonary arterial hypertension. Pulm Circ. 7:285–299. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Naeije R, Richter MJ and Rubin LJ: The physiological basis of pulmonary arterial hypertension. Eur Respir J. 59:21023342022. View Article : Google Scholar : PubMed/NCBI

28 

Bueno-Beti C, Sassi Y, Hajjar RJ and Hadri L: Pulmonary artery hypertension model in rats by monocrotaline administration. Methods Mol Biol. 1816:233–241. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Hu R, Chen N, Yao J, Zhao Q, Zhang F, Li ZY, You QD and Guo QL: The role of Nrf2 and apoptotic signaling pathways in oroxylin A-mediated responses in HCT-116 colorectal adenocarcinoma cells and xenograft tumors. Anticancer Drugs. 23:651–658. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Ni T, He Z, Dai Y, Yao J, Guo Q and Wei L: Oroxylin A suppresses the development and growth of colorectal cancer through reprogram of HIF1α-modulated fatty acid metabolism. Cell Death Dis. 8:e28652017. View Article : Google Scholar : PubMed/NCBI

31 

Muthubharathi BC, Gowripriya T and Balamurugan K: Metabolomics: Small molecules that matter more. Mol Omics. 17:210–229. 2021. View Article : Google Scholar : PubMed/NCBI

32 

Xu W, Comhair S, Chen R, Hu B, Hou Y, Zhou Y, Mavrakis LA, Janocha AJ, Li L, Zhang D, et al: Integrative proteomics and phosphoproteomics in pulmonary arterial hypertension. Sci Rep. 9:186232019. View Article : Google Scholar : PubMed/NCBI

33 

Kao CC, Wedes SH, Hsu JW, Bohren KM, Comhair SA, Jahoor F and Erzurum SC: Arginine metabolic endotypes in pulmonary arterial hypertension. Pulm Circ. 5:124–134. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Li X, Yang Y, Zhang B, Lin X, Fu X, An Y, Zou Y, Wang JX, Wang Z and Yu T: Lactate metabolism in human health and disease. Signal Transduct Target Ther. 7:3052022. View Article : Google Scholar : PubMed/NCBI

35 

Breault NM, Wu D, Dasgupta A, Chen KH and Archer SL: Acquired disorders of mitochondrial metabolism and dynamics in pulmonary arterial hypertension. Front Cell Dev Biol. 11:11055652023. View Article : Google Scholar : PubMed/NCBI

36 

Rafikova O, Meadows ML, Kinchen JM, Mohney RP, Maltepe E, Desai AA, Yuan JX, Garcia JG, Fineman JR, Rafikov R and Black SM: Metabolic changes precede the development of pulmonary hypertension in the monocrotaline exposed rat lung. PLoS One. 11:e1504802016. View Article : Google Scholar

37 

Liang S, Yegambaram M, Wang T, Wang J, Black SM and Tang H: Mitochondrial metabolism, redox and calcium homeostasis in pulmonary arterial hypertension. Biomedicines. 10:3412022. View Article : Google Scholar : PubMed/NCBI

38 

Li T, Li S, Feng Y, Zeng X, Dong S, Li J, Zha L, Luoh, Zhao L, Liu B, et al: Combination of dichloroacetate and atorvastatin regulates excessive proliferation and oxidative stress in pulmonary arterial hypertension development via p38 signaling. Oxid Med Cell Longev. 2020:69736362020.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Fan Y, Zhou Y, Chen T, Xu S, Liu J and Li L: Oroxylin A, a broad‑spectrum anticancer agent, relieves monocrotaline‑induced pulmonary arterial hypertension by inhibiting the Warburg effect in rats. Mol Med Rep 30: 195, 2024.
APA
Wang, Y., Fan, Y., Zhou, Y., Chen, T., Xu, S., Liu, J., & Li, L. (2024). Oroxylin A, a broad‑spectrum anticancer agent, relieves monocrotaline‑induced pulmonary arterial hypertension by inhibiting the Warburg effect in rats. Molecular Medicine Reports, 30, 195. https://doi.org/10.3892/mmr.2024.13319
MLA
Wang, Y., Fan, Y., Zhou, Y., Chen, T., Xu, S., Liu, J., Li, L."Oroxylin A, a broad‑spectrum anticancer agent, relieves monocrotaline‑induced pulmonary arterial hypertension by inhibiting the Warburg effect in rats". Molecular Medicine Reports 30.5 (2024): 195.
Chicago
Wang, Y., Fan, Y., Zhou, Y., Chen, T., Xu, S., Liu, J., Li, L."Oroxylin A, a broad‑spectrum anticancer agent, relieves monocrotaline‑induced pulmonary arterial hypertension by inhibiting the Warburg effect in rats". Molecular Medicine Reports 30, no. 5 (2024): 195. https://doi.org/10.3892/mmr.2024.13319
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Fan Y, Zhou Y, Chen T, Xu S, Liu J and Li L: Oroxylin A, a broad‑spectrum anticancer agent, relieves monocrotaline‑induced pulmonary arterial hypertension by inhibiting the Warburg effect in rats. Mol Med Rep 30: 195, 2024.
APA
Wang, Y., Fan, Y., Zhou, Y., Chen, T., Xu, S., Liu, J., & Li, L. (2024). Oroxylin A, a broad‑spectrum anticancer agent, relieves monocrotaline‑induced pulmonary arterial hypertension by inhibiting the Warburg effect in rats. Molecular Medicine Reports, 30, 195. https://doi.org/10.3892/mmr.2024.13319
MLA
Wang, Y., Fan, Y., Zhou, Y., Chen, T., Xu, S., Liu, J., Li, L."Oroxylin A, a broad‑spectrum anticancer agent, relieves monocrotaline‑induced pulmonary arterial hypertension by inhibiting the Warburg effect in rats". Molecular Medicine Reports 30.5 (2024): 195.
Chicago
Wang, Y., Fan, Y., Zhou, Y., Chen, T., Xu, S., Liu, J., Li, L."Oroxylin A, a broad‑spectrum anticancer agent, relieves monocrotaline‑induced pulmonary arterial hypertension by inhibiting the Warburg effect in rats". Molecular Medicine Reports 30, no. 5 (2024): 195. https://doi.org/10.3892/mmr.2024.13319
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team