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High‑fat diet‑induced LCN2 exacerbates myocardial ischemia‑reperfusion injury by enhancing platelet activation

  • Authors:
    • Peng Li
    • Juhai Chen
    • Mingdong Wang
    • Qi Wang
    • Xingde Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology and Pathophysiology, School of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou 561113, P.R. China, Department of Internal Medicine, Guiyang Public Health Treatment Center, Guiyang, Guizhou 550003, P.R. China, Clinical Laboratory, Guiyang Public Health Treatment Center, Guiyang, Guizhou 550003, P.R. China, Department of Histology and Embryology, School of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou 561113, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 205
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    Published online on: September 12, 2024
       https://doi.org/10.3892/mmr.2024.13329
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Abstract

Following acute myocardial infarction, the recovery of blood flow leads to myocardial ischemia‑reperfusion (MI/R) injury, which is primarily characterized by the activation of inflammatory signals, microvascular obstruction, increased oxidative stress and excessive Ca2+ overload. It has also been demonstrated that platelets can exacerbate MI/R injury by releasing reactive oxygen species, inflammatory factors and chemokines, while also obstructing microvessels through thrombus formation. As a bioactive molecule with proinflammatory and chemotactic properties, lipocalin 2 (LCN2) exhibits a positive correlation with obesity, hyperglycemia, hypertriglyceridemia and insulin resistance index, which are all significant risk factors for ischemic cardiomyopathy. Notably, the potential role of LCN2 in promoting atherosclerosis may be related to its influence on the function of macrophages, smooth muscle cells and endothelial cells, but its effect on platelet function has not yet been reported. In the present study, the effect of a high‑fat diet (HFD) on LCN2 expression was determined by detecting LCN2 expression levels in the liver and serum samples of mice through reverse transcription‑quantitative PCR and enzyme linked immunosorbent assay, respectively. The effect of LCN2 on platelet function was evaluated by examining whether LCN2 affected platelet activation, aggregation, adhesion, clot retraction and P‑selectin expression. To determine whether LCN2 aggravated MI/R injury in HFD‑fed mice by affecting platelet and inflammatory cell recruitment, wild‑type and LCN2 knockout mice fed a HFD were subjected to MI/R injury, then hearts were collected for hematoxylin and eosin staining and 2,3,5‑triphenyltetrazolium chloride staining, and immunohistochemistry was employed to detect the expression of CD42b, Ly6G, CD3 and B220. Based on observing the upregulation of LCN2 expression in mice fed a HFD, the present study further confirmed that LCN2 could accelerate platelet activation, aggregation and adhesion. Moreover, in vivo studies validated that knockout of LCN2 not only mitigated MI/R injury, but also inhibited the recruitment of platelets and inflammatory cells in myocardial tissue following ischemia‑reperfusion. In conclusion, the current findings suggested that the effect of HFD‑induced LCN2 on aggravating MI/R injury may totally or partially dependent on its promotion of platelet function.
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View References

1 

Harrington DH, Stueben F and Lenahan CM: ST-elevation myocardial infarction and non-ST-elevation myocardial infarction: Medical and surgical interventions. Crit Care Nurs Clin North Am. 31:49–64. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Wu MY, Yiang GT, Liao WT, Tsai AP, Cheng YL, Cheng PW, Li CY and Li CJ: Current mechanistic concepts in ischemia and reperfusion injury. Cell Physiol Biochem. 46:1650–1667. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Visseren FLJ, Mach F, Smulders YM, Carballo D, Koskinas KC, Bäck M, Benetos A, Biffi A, Boavida JM, Capodanno D, et al: 2021 ESC guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 42:3227–3337. 2021. View Article : Google Scholar : PubMed/NCBI

4 

Algoet M, Janssens S, Himmelreich U, Gsell W, Pusovnik M, Van den Eynde J and Oosterlinck W: Myocardial ischemia-reperfusion injury and the influence of inflammation. Trends Cardiovasc Med. 33:357–366. 2023. View Article : Google Scholar : PubMed/NCBI

5 

Wei Y, Xing J, Su X, Li X, Yan X, Zhao J and Tao H: IL-38 attenuates myocardial ischemia-reperfusion injury by inhibiting macrophage inflammation. Immun Inflamm Dis. 11:e8982023. View Article : Google Scholar : PubMed/NCBI

6 

Zhang J, Hu S, Gao Y, Wei X, Qu Y, Gao R, Lv Y, Wang J, Wang Y, Yang J, et al: Galangin alleviated myocardial ischemia-reperfusion injury by enhancing autophagic flux and inhibiting inflammation. Eur J Pharmacol. 945:1756212023. View Article : Google Scholar : PubMed/NCBI

7 

Chen LQ, Wang WS, Li SQ and Liu JH: Minocycline relieves myocardial ischemia-reperfusion injury in rats by inhibiting inflammation, oxidative stress and apoptosis. Eur Rev Med Pharmacol Sci. 26:3001–3009. 2022.PubMed/NCBI

8 

Seeger JP, Benda NM, Riksen NP, van Dijk AP, Bellersen L, Hopman MT, Cable NT and Thijssen DH: Heart failure is associated with exaggerated endothelial ischaemia-reperfusion injury and attenuated effect of ischaemic preconditioning. Eur J Prev Cardiol. 23:33–40. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Wereski R, Kimenai DM, Bularga A, Taggart C, Lowe DJ, Mills NL and Chapman AR: Risk factors for type 1 and type 2 myocardial infarction. Eur Heart J. 43:127–135. 2022. View Article : Google Scholar : PubMed/NCBI

10 

Cameron SJ, Ture SK, Mickelsen D, Chakrabarti E, Modjeski KL, McNitt S, Seaberry M, Field DJ, Le NT, Abe J and Morrell CN: Platelet extracellular regulated protein kinase 5 is a redox switch and triggers maladaptive platelet responses and myocardial infarct expansion. Circulation. 132:47–58. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Schanze N, Bode C and Duerschmied D: Platelet contributions to myocardial ischemia/reperfusion injury. Front Immunol. 10:12602019. View Article : Google Scholar : PubMed/NCBI

12 

van der Meijden PEJ and Heemskerk JWM: Platelet biology and functions: New concepts and clinical perspectives. Nat Rev Cardiol y. 16:166–179. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Jaberi SA, Cohen A, D'Souza C, Abdulrazzaq YM, Ojha S, Bastaki S and Adeghate EA: Lipocalin-2: Structure, function, distribution and role in metabolic disorders. Biomed Pharmacother. 142:1120022021. View Article : Google Scholar : PubMed/NCBI

14 

Ghosh S, Stepicheva N, Yazdankhah M, Shang P, Watson AM, Hose S, Liu H, Weiss J, Zigler JS Jr, Valapala M, et al: The role of lipocalin-2 in age-related macular degeneration (AMD). Cell Mol Life Sci. 77:835–851. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Eilenberg W, Stojkovic S, Piechota-Polanczyk A, Kaun C, Rauscher S, Gröger M, Klinger M, Wojta J, Neumayer C, Huk I and Demyanets S: Neutrophil gelatinase-associated lipocalin (NGAL) is associated with symptomatic carotid atherosclerosis and drives pro-inflammatory state in vitro. Eur J Vasc Endovasc Surg. 51:623–631. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Mosialou I, Shikhel S, Luo N, Petropoulou PI, Panitsas K, Bisikirska B, Rothman NJ, Tenta R, Cariou B, Wargny M, et al: Lipocalin-2 counteracts metabolic dysregulation in obesity and diabetes. J Exp Med. 217:e201912612020. View Article : Google Scholar : PubMed/NCBI

17 

Catalán V, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Silva C, Rotellar F, Gil MJ, Cienfuegos JA, Salvador J and Frühbeck G: Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans. J Mol Med (Berl). 87:803–813. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S and Aderem A: Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature. 432:917–921. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Wang Y, Lam KS, Kraegen EW, Sweeney G, Zhang J, Tso AW, Chow WS, Wat NM, Xu JY, Hoo RL and Xu A: Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. Clin Chem. 53:34–41. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Jang Y, Lee JH, Wang Y and Sweeney G: Emerging clinical and experimental evidence for the role of lipocalin-2 in metabolic syndrome. Clin Exp Pharmacol Physiol. 39:194–199. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Wu G, Li H, Zhou M, Fang Q, Bao Y, Xu A and Jia W: Mechanism and clinical evidence of lipocalin-2 and adipocyte fatty acid-binding protein linking obesity and atherosclerosis. Diabetes Metab Res Rev. 30:447–456. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Abella V, Scotece M, Conde J, Gómez R, Lois A, Pino J, Gómez-Reino JJ, Lago F, Mobasheri A and Gualillo O: The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases. Biomarkers. 20:565–571. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Schanze N, Hamad MA, Nührenberg TG, Bode C and Duerschmied D: Platelets in myocardial ischemia/reperfusion injury. Hamostaseologie. 43:110–121. 2023. View Article : Google Scholar : PubMed/NCBI

25 

Chen Y, Fu W, Zheng Y, Yang J, Liu Y, Qi Z, Wu M, Fan Z, Yin K, Chen Y, et al: Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activation: A translational study. Eur Heart J. 43:3556–3574. 2022. View Article : Google Scholar : PubMed/NCBI

26 

Chen J, Liu G, Hong Y, Han J, Yang Z, Yang Y, Li H, Wang S, Jue L and Wang Q: Regulation of atherosclerosis by toll-like receptor 4 induced by serum amyloid 1: A systematic in vitro study. Biomed Res Int. 2022:48875932022. View Article : Google Scholar : PubMed/NCBI

27 

Anfossi G, Russo I and Trovati M: Platelet dysfunction in central obesity. Nutr Metab Cardiovasc Dis. 19:440–449. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Santilli F, Vazzana N, Liani R, Guagnano MT and Davì G: Platelet activation in obesity and metabolic syndrome. Obes Rev. 13:27–42. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Barale C and Russo I: Influence of cardiometabolic risk factors on platelet function. Int J Mol Sci. 21:6232020. View Article : Google Scholar : PubMed/NCBI

30 

Mauler M, Herr N, Schoenichen C, Witsch T, Marchini T, Härdtner C, Koentges C, Kienle K, Ollivier V, Schell M, et al: Platelet serotonin aggravates myocardial ischemia/reperfusion injury via neutrophil degranulation. Circulation. 139:918–931. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Davidson SM, Andreadou I, Barile L, Birnbaum Y, Cabrera-Fuentes HA, Cohen MV, Downey JM, Girao H, Pagliaro P, Penna C, et al: Circulating blood cells and extracellular vesicles in acute cardioprotection. Cardiovasc Res. 115:1156–1166. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Gumiężna K, Baruś P, Sygitowicz G, Wiśniewska A, Ochijewicz D, Pasierb K, Klimczak-Tomaniak D, Kuca-Warnawin E, Kochman J, Grabowski M, et al: Immature platelet fraction in cardiovascular diagnostics and antiplatelet therapy monitoring. Cardiol J. 30:817–824. 2023. View Article : Google Scholar : PubMed/NCBI

33 

Margraf A and Zarbock A: Platelets in inflammation and resolution. J Immunol. 203:2357–2367. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Huilcaman R, Venturini W, Fuenzalida L, Cayo A, Segovia R, Valenzuela C, Brown N and Moore-Carrasco R: Platelets, a key cell in inflammation and atherosclerosis progression. Cells. 11:10142022. View Article : Google Scholar : PubMed/NCBI

35 

Shao S, Cao T, Jin L, Li B, Fang H, Zhang J, Zhang Y, Hu J and Wang G: Increased lipocalin-2 contributes to the pathogenesis of psoriasis by modulating neutrophil chemotaxis and cytokine secretion. J Invest Dermatol. 136:1418–1428. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Jang HM, Lee JY, An HS, Ahn YJ, Jeong EA, Shin HJ, Kim KE, Lee J, Koh JS and Roh GS: LCN2 deficiency ameliorates doxorubicin-induced cardiomyopathy in mice. Biochem Biophys Res Commun. 588:8–14. 2022. View Article : Google Scholar : PubMed/NCBI

37 

Li D, Yang Z, Gao S, Zhang H and Fan G: Tanshinone IIA ameliorates myocardial ischemia/reperfusion injury in rats by regulation of NLRP3 inflammasome activation and Th17 cells differentiation. Acta Cir Bras. 37:e3707012022. View Article : Google Scholar : PubMed/NCBI

38 

Hau CS, Kanda N, Tada Y, Shibata S, Uozaki H, Fukusato T, Sato S and Watanabe S: Lipocalin-2 exacerbates psoriasiform skin inflammation by augmenting T-helper 17 response. J Dermatol. 43:785–794. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Chen PC, Ho CH, Fan CK, Liu SP and Cheng PC: Antimicrobial peptide LCN2 inhibited uropathogenic escherichia coli infection in bladder cells in a high-glucose environment through JAK/STAT signaling pathway. Int J Mol Sci. 23:157632022. View Article : Google Scholar : PubMed/NCBI

40 

Kim SL, Shin MW, Seo SY and Kim SW: Lipocalin 2 potentially contributes to tumorigenesis from colitis via IL-6/STAT3/NF-κB signaling pathway. Biosci Rep. 42:BSR202124182022. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li P, Chen J, Wang M, Wang Q and Liu X: High‑fat diet‑induced LCN2 exacerbates myocardial ischemia‑reperfusion injury by enhancing platelet activation. Mol Med Rep 30: 205, 2024.
APA
Li, P., Chen, J., Wang, M., Wang, Q., & Liu, X. (2024). High‑fat diet‑induced LCN2 exacerbates myocardial ischemia‑reperfusion injury by enhancing platelet activation. Molecular Medicine Reports, 30, 205. https://doi.org/10.3892/mmr.2024.13329
MLA
Li, P., Chen, J., Wang, M., Wang, Q., Liu, X."High‑fat diet‑induced LCN2 exacerbates myocardial ischemia‑reperfusion injury by enhancing platelet activation". Molecular Medicine Reports 30.5 (2024): 205.
Chicago
Li, P., Chen, J., Wang, M., Wang, Q., Liu, X."High‑fat diet‑induced LCN2 exacerbates myocardial ischemia‑reperfusion injury by enhancing platelet activation". Molecular Medicine Reports 30, no. 5 (2024): 205. https://doi.org/10.3892/mmr.2024.13329
Copy and paste a formatted citation
x
Spandidos Publications style
Li P, Chen J, Wang M, Wang Q and Liu X: High‑fat diet‑induced LCN2 exacerbates myocardial ischemia‑reperfusion injury by enhancing platelet activation. Mol Med Rep 30: 205, 2024.
APA
Li, P., Chen, J., Wang, M., Wang, Q., & Liu, X. (2024). High‑fat diet‑induced LCN2 exacerbates myocardial ischemia‑reperfusion injury by enhancing platelet activation. Molecular Medicine Reports, 30, 205. https://doi.org/10.3892/mmr.2024.13329
MLA
Li, P., Chen, J., Wang, M., Wang, Q., Liu, X."High‑fat diet‑induced LCN2 exacerbates myocardial ischemia‑reperfusion injury by enhancing platelet activation". Molecular Medicine Reports 30.5 (2024): 205.
Chicago
Li, P., Chen, J., Wang, M., Wang, Q., Liu, X."High‑fat diet‑induced LCN2 exacerbates myocardial ischemia‑reperfusion injury by enhancing platelet activation". Molecular Medicine Reports 30, no. 5 (2024): 205. https://doi.org/10.3892/mmr.2024.13329
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