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ETV4‑mediated transcriptional activation of SLC12A5 exacerbates ferroptosis resistance and glucose metabolism reprogramming in breast cancer cells

  • Authors:
    • Huan Wang
    • Yanyan Dai
    • Fengxiang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Wenzhou Central Hospital, Wenzhou, Zhejiang 325000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 217
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    Published online on: September 26, 2024
       https://doi.org/10.3892/mmr.2024.13341
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Abstract

Solute carrier family 12 member 5 (SLC12A5) is an oncogene in numerous types of cancer, however its function in breast cancer (BC) remains elusive. ETS translocation variant 4 (ETV4) promotes BC. Therefore, the present study aimed to elucidate the role of SLC12A5 in ferroptosis and glucose metabolism in BC cells as well as to understand the underlying mechanism. Analysis of data from the UALCAN database demonstrated expression levels of SLC12A5 in BC and its association with prognosis. Reverse transcription‑quantitative PCR and western blotting were conducted to evaluate the expression levels of SLC12A5 and ETV4 in BC cells. The abilities of BC cells to proliferate, migrate and invade were assessed using Cell Counting Kit‑8, colony formation, wound healing and Transwell assays. Thiobarbituric acid reactive substances assay and a C11 BODIPY 581/591 probe were used to evaluate lipid peroxidation. Ferroptosis resistance was evaluated by the measurement of Fe2+ and ferroptosis‑related solute carrier family 7a member 11 (SLC7A11), glutathione peroxidase 4 (GPX4), acyl‑CoA synthetase long‑chain family member 4 (ACSL4) and transferrin receptor 1 (TFR1) protein levels. Glycolysis was assessed via evaluation of extracellular acidification rate, oxygen consumption rate, lactate production and glucose consumption. Finally, luciferase reporter and chromatin immunoprecipitation assay were used to verify the interaction between ETV4 and the SLC12A5 promoter. UALCAN database analysis indicated that SLC12A5 was upregulated in BC tissues and cells and that SLC12A5 elevation indicated a poor prognosis of patients with BC. SLC12A5 knockdown suppressed the BC cell proliferative, migratory and invasive capabilities. Moreover, SLC12A5 knockdown decreased BC cell ferroptosis resistance and glucose metabolism reprogramming. The transcription factor ETV4 was demonstrated to bind to the SLC12A5 promoter and upregulate its transcription. Furthermore, ETV4 overexpression counteracted the suppressive effect of SLC12A5 knockdown on the BC cell proliferative, migratory and invasive abilities, as well as on ferroptosis resistance and glucose metabolism reprogramming. Transcriptional activation of SLC12A5 by ETV4 modulated the migration, invasion, ferroptosis resistance and glucose metabolism reprogramming of BC cells.
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1 

Zannetti A: Breast cancer: From pathophysiology to novel therapeutic Approaches 2.0. Int J Mol Sci. 24:25422023. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Giaquinto AN and Jemal A: Cancer statistics, 2024. CA Cancer J Clin. 74:12–49. 2024. View Article : Google Scholar : PubMed/NCBI

3 

Houghton SC and Hankinson SE: Cancer progress and priorities: Breast cancer. Cancer Epidemiol Biomarkers Prev. 30:822–844. 2021. View Article : Google Scholar : PubMed/NCBI

4 

De Rose F, Meduri B, De Santis MC, Ferro A, Marino L, Colciago RR, Gregucci F, Vanoni V, Apolone G, Di Cosimo S, et al: Rethinking breast cancer follow-up based on individual risk and recurrence management. Cancer Treat Rev. 109:1024342022. View Article : Google Scholar : PubMed/NCBI

5 

Parisi S, Gambardella C, Conzo G, Ruggiero R, Tolone S, Lucido FS, Iovino F, Fisone F, Brusciano L, Parmeggiani D and Docimo L: Advanced localization technique for non-palpable breast cancer: Radiofrequency alone VS combined technique with ultrasound. J Clin Med. 12:50762023. View Article : Google Scholar : PubMed/NCBI

6 

Parisi S, Ruggiero R, Gualtieri G, Volpe ML, Rinaldi S, Nesta G, Bogdanovich L, Lucido FS, Tolone S, Parmeggiani D, et al: Combined LOCalizer™ and intraoperative ultrasound localization: First experience in localization of non-palpable breast cancer. In Vivo. 35:1669–1676. 2021. View Article : Google Scholar : PubMed/NCBI

7 

Kawiak A: Molecular research and treatment of breast cancer. Int J Mol Sci. 23:96172022. View Article : Google Scholar : PubMed/NCBI

8 

Jiang X, Stockwell BR and Conrad M: Ferroptosis: Mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 22:266–282, 2021.9. View Article : Google Scholar : PubMed/NCBI

9 

Chen X, Kang R, Kroemer G and Tang D: Broadening horizons: The role of ferroptosis in cancer. Nat Rev Clin Oncol. 18:280–296. 2021. View Article : Google Scholar : PubMed/NCBI

10 

Liu J, Kang R and Tang D: Signaling pathways and defense mechanisms of ferroptosis. Febs J. 289:7038–7050. 2022. View Article : Google Scholar : PubMed/NCBI

11 

Sun S, Shen J, Jiang J, Wang F and Min J: Targeting ferroptosis opens new avenues for the development of novel therapeutics. Signal Transduct Target Ther. 8:3722023. View Article : Google Scholar : PubMed/NCBI

12 

Li Z, Chen L, Chen C, Zhou Y, Hu D, Yang J, Chen Y, Zhuo W, Mao M, Zhang X, et al: Targeting ferroptosis in breast cancer. Biomark Res. 8:582020. View Article : Google Scholar : PubMed/NCBI

13 

Fukuda A and Watanabe M: Pathogenic potential of human SLC12A5 variants causing KCC2 dysfunction. Brain Res. 1710:1–7. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Damanskienė E, Balnytė I, Valančiūtė A, Alonso MM and Stakišaitis D: Different effects of valproic acid on SLC12A2, SLC12A5 and SLC5A8 gene expression in pediatric glioblastoma cells as an approach to personalised therapy. Biomedicines. 10:9682022. View Article : Google Scholar : PubMed/NCBI

15 

Jiang Y, Liao HL and Chen LY: A pan-cancer analysis of SLC12A5 reveals its correlations with tumor immunity. Dis Markers. 2021:30626062021. View Article : Google Scholar : PubMed/NCBI

16 

Yuan S, He SH, Li LY, Xi S, Weng H, Zhang JH, Wang DQ, Guo MM, Zhang H, Wang S, et al: A potassium-chloride co-transporter promotes tumor progression and castration resistance of prostate cancer through m(6)A reader YTHDC1. Cell Death Dis. 14:72023. View Article : Google Scholar : PubMed/NCBI

17 

Peng L, Cao Z, Wang Q, Fang L, Yan S, Xia D, Wang J and Bi L: Screening of possible biomarkers and therapeutic targets in kidney renal clear cell carcinoma: Evidence from bioinformatic analysis. Front Oncol. 12:9634832022. View Article : Google Scholar : PubMed/NCBI

18 

Tong Q, Qin W, Li ZH, Liu C, Wang ZC, Chu Y and Xu XD: SLC12A5 promotes hepatocellular carcinoma growth and ferroptosis resistance by inducing ER stress and cystine transport changes. Cancer Med. 12:8526–8541. 2023. View Article : Google Scholar : PubMed/NCBI

19 

Wang L, Zhang Q, Wu P, Xiang W, Xie D, Wang N, Deng M, Cao K, Zeng H, Xu Z, et al: SLC12A5 interacts and enhances SOX18 activity to promote bladder urothelial carcinoma progression via upregulating MMP7. Cancer Sci. 111:2349–2360. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Singh R, Dagar P, Pal S, Basu B and Shankar BS: Significant alterations of the novel 15 gene signature identified from macrophage-tumor interactions in breast cancer. Biochim Biophys Acta Gen Subj. 1862:669–683. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Neri P, Barwick BG, Jung D, Patton JC, Maity R, Tagoug I, Stein CK, Tilmont R, Leblay N, Ahn S, et al: ETV4-dependent transcriptional plasticity maintains MYC expression and results in IMiD resistance in multiple myeloma. Blood Cancer Discov. 5:56–73. 2024. View Article : Google Scholar : PubMed/NCBI

22 

Qi D, Lu M, Xu P, Yao X, Chen Y, Gan L, Li Y, Cui Y, Tong X, Liu S, et al: Transcription factor ETV4 promotes the development of hepatocellular carcinoma by driving hepatic TNF-α signaling. Cancer Commun (Lond). 43:1354–1372. 2023. View Article : Google Scholar : PubMed/NCBI

23 

Cosi I, Moccia A, Pescucci C, Munagala U, Di Giorgio S, Sineo I, Conticello SG, Notaro R and De Angioletti M: Identification and characterization of novel ETV4 splice variants in prostate cancer. Sci Rep. 13:52672023. View Article : Google Scholar : PubMed/NCBI

24 

Zhu T, Zheng J, Zhuo W, Pan P, Li M, Zhang W, Zhou H, Gao Y, Li X and Liu Z: ETV4 promotes breast cancer cell stemness by activating glycolysis and CXCR4-mediated sonic Hedgehog signaling. Cell Death Discov. 7:1262021. View Article : Google Scholar : PubMed/NCBI

25 

Liu B, Zhang J, Meng X, Xie SM, Liu F, Chen H, Yao D, Li M, Guo M, Shen H, et al: HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer. Oncogene. 42:1181–1195. 2023. View Article : Google Scholar : PubMed/NCBI

26 

Chandrashekar DS, Bashel B, Balasubramanya SA, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK and Varambally S: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 19:649–658, 2017.27. View Article : Google Scholar : PubMed/NCBI

27 

Hu H, Miao YR, Jia LH, Yu QY, Zhang Q and Guo AY: AnimalTFDB 3.0: A comprehensive resource for annotation and prediction of animal transcription factors. Nucleic Acids Res. 47:D33–D38, 2019.28. View Article : Google Scholar : PubMed/NCBI

28 

Nusinow DP, Szpyt J, Ghandi M, Rose CM, McDonald ER III, Kalocsay M, Jané-Valbuena J, Gelfand E, Schweppe DK, Jedrychowski M, et al: Quantitative proteomics of the cancer cell line encyclopedia. Cell. 180:387–402e16. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Trayes KP and Cokenakes SEH: Breast cancer treatment. Am Fam Physician. 104:171–178. 2021.PubMed/NCBI

31 

Zhang YN, Xia KR, Li CY, Wei BL and Zhang B: Review of breast cancer pathologigcal image processing. Biomed Res Int. 2021:19947642021.PubMed/NCBI

32 

Criscitiello C and Corti C: Breast cancer genetics: Diagnostics and treatment. Genes (Basel). 13:15932022. View Article : Google Scholar : PubMed/NCBI

33 

Kontou G, Josephine Ng SF, Cardarelli RA, Howden JH, Choi C, Ren Q, Rodriguez Santos MA, Bope CE, Dengler JS, Kelley MR, et al: KCC2 is required for the survival of mature neurons but not for their development. J Biol Chem. 296:1003642021. View Article : Google Scholar : PubMed/NCBI

34 

Tang Y, Qing C, Wang J and Zeng Z: DNA methylation-based diagnostic and prognostic biomarkers for glioblastoma. Cell Transplant. 29:9636897209332412020. View Article : Google Scholar : PubMed/NCBI

35 

Gao JL, Peng K, Shen MW, Hou YH, Qian XB, Meng XW, Ji FH, Wang LN and Yang JP: Suppression of WNK1-SPAK/OSR1 attenuates bone cancer pain by regulating NKCC1 and KCC2. J Pain. 20:1416–1428. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Yang X, Qu Y and Zhang J: Up-regulated LncRNA FEZF1-AS1 promotes the progression of cervical carcinoma cells via MiR-367-3p/SLC12A5 signal axis. Arch Med Res. 53:9–19. 2022. View Article : Google Scholar : PubMed/NCBI

37 

Yang GP, He WP, Tan JF, Yang ZX, Fan RR, Ma NF, Wang FW, Chen L, Li Y, Li Y, et al: Overexpression of SLC12A5 is associated with tumor progression and poor survival in ovarian carcinoma. Int J Gynecol Cancer. 29:1280–1284. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Wang L, Zhang Y, Yang J, Liu L, Yao B, Tian Z and He J: The knockdown of ETV4 inhibits the papillary thyroid cancer development by promoting ferroptosis upon SLC7A11 downregulation. DNA Cell Biol. 40:1211–1221. 2021. View Article : Google Scholar : PubMed/NCBI

39 

Yuan ZY, Dai T, Wang SS, Peng RJ, Li XH, Qin T, Song LB and Wang X: Overexpression of ETV4 protein in triple-negative breast cancer is associated with a higher risk of distant metastasis. Onco Targets Ther. 7:1733–1742. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Dumortier M, Ladam F, Damour I, Vacher S, Bièche I, Marchand N, de Launoit Y, Tulasne D and Chotteau-Lelièvre A: ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis. Breast Cancer Res. 20:732018. View Article : Google Scholar : PubMed/NCBI

41 

Verma S, Shankar E, Chan ER and Gupta S: Metabolic reprogramming and predominance of solute carrier genes during acquired enzalutamide resistance in prostate cancer. Cells. 9:25352020. View Article : Google Scholar : PubMed/NCBI

42 

de Visser KE and Joyce JA: The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth. Cancer Cell. 41:374–403. 2023. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Dai Y and Wang F: ETV4‑mediated transcriptional activation of SLC12A5 exacerbates ferroptosis resistance and glucose metabolism reprogramming in breast cancer cells. Mol Med Rep 30: 217, 2024.
APA
Wang, H., Dai, Y., & Wang, F. (2024). ETV4‑mediated transcriptional activation of SLC12A5 exacerbates ferroptosis resistance and glucose metabolism reprogramming in breast cancer cells. Molecular Medicine Reports, 30, 217. https://doi.org/10.3892/mmr.2024.13341
MLA
Wang, H., Dai, Y., Wang, F."ETV4‑mediated transcriptional activation of SLC12A5 exacerbates ferroptosis resistance and glucose metabolism reprogramming in breast cancer cells". Molecular Medicine Reports 30.6 (2024): 217.
Chicago
Wang, H., Dai, Y., Wang, F."ETV4‑mediated transcriptional activation of SLC12A5 exacerbates ferroptosis resistance and glucose metabolism reprogramming in breast cancer cells". Molecular Medicine Reports 30, no. 6 (2024): 217. https://doi.org/10.3892/mmr.2024.13341
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Dai Y and Wang F: ETV4‑mediated transcriptional activation of SLC12A5 exacerbates ferroptosis resistance and glucose metabolism reprogramming in breast cancer cells. Mol Med Rep 30: 217, 2024.
APA
Wang, H., Dai, Y., & Wang, F. (2024). ETV4‑mediated transcriptional activation of SLC12A5 exacerbates ferroptosis resistance and glucose metabolism reprogramming in breast cancer cells. Molecular Medicine Reports, 30, 217. https://doi.org/10.3892/mmr.2024.13341
MLA
Wang, H., Dai, Y., Wang, F."ETV4‑mediated transcriptional activation of SLC12A5 exacerbates ferroptosis resistance and glucose metabolism reprogramming in breast cancer cells". Molecular Medicine Reports 30.6 (2024): 217.
Chicago
Wang, H., Dai, Y., Wang, F."ETV4‑mediated transcriptional activation of SLC12A5 exacerbates ferroptosis resistance and glucose metabolism reprogramming in breast cancer cells". Molecular Medicine Reports 30, no. 6 (2024): 217. https://doi.org/10.3892/mmr.2024.13341
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