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Therapeutic role of histone deacetylase inhibition in an in vitro model of Graves' orbitopathy

  • Authors:
    • Hyeong Ju Byeon
    • Soo Hyun Choi
    • Don O. Kikkawa
    • Jaesang Ko
    • Jin Sook Yoon
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Republic of Korea, Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul 03722, Republic of Korea, Division of Oculofacial Plastic and Reconstructive Surgery, Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, CA 92037, USA
    Copyright: © Byeon et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 218
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    Published online on: September 26, 2024
       https://doi.org/10.3892/mmr.2024.13342
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Abstract

Graves' orbitopathy (GO), a manifestation of Graves' disease, is characterized by orbital fibroblast‑induced inflammation, leading to fibrosis or adipogenesis. Histone deacetylase (HDAC) serves a central role in autoimmune diseases and fibrosis. The present study investigated HDAC inhibition in orbital fibroblasts from patients with GO to evaluate its potential as a therapeutic agent. Primary cultured orbital fibroblasts were treated with an HDAC inhibitor, panobinostat, under the stimulation of IL‑1β, TGF‑β or adipogenic medium. Inflammatory cytokines, and fibrosis‑ and adipogenesis‑related proteins were analyzed using western blotting. The effects of panobinostat on HDAC mRNA expression were measured in GO orbital fibroblasts, and specific HDACs were inhibited using small interfering RNA transfection. Panobinostat significantly reduced the IL‑1β‑induced production of inflammatory cytokines and TGF‑β‑induced production of fibrosis‑related proteins. It also suppressed adipocyte differentiation and adipogenic transcription factor production. Furthermore, it significantly attenuated HDAC7 mRNA expression in GO orbital fibroblasts. In addition, the silencing of HDAC7 led to anti‑inflammatory and anti‑fibrotic effects. In conclusion, by inhibiting HDAC7 gene expression, panobinostat may suppress the production of inflammatory cytokines, profibrotic proteins and adipogenesis in GO orbital fibroblasts. The present in vitro study suggested that HDAC7 could be a potential therapeutic target for inhibiting the inflammatory, adipogenic and fibrotic mechanisms of GO.
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View References

1 

Lazarus JH: Epidemiology of Graves' orbitopathy (GO) and relationship with thyroid disease. Best Pract Res Clin Endocrinol Metab. 26:273–279. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Bahn RS: Graves' ophthalmopathy. N Engl J Med. 362:726–738. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Bartley GB, Fatourechi V, Kadrmas EF, Jacobsen SJ, Ilstrup DM, Garrity JA and Gorman CA: Clinical features of Graves' ophthalmopathy in an incidence cohort. Am J Ophthalmol. 121:284–290. 1996. View Article : Google Scholar : PubMed/NCBI

4 

Rotondo Dottore G, Torregrossa L, Lanzolla G, Mariotti S, Menconi F, Piaggi P, Cristofani Mencacci L, Posarelli C, Maglionico MN, Dallan I, et al: Role of the mononuclear cell infiltrate in Graves' orbitopathy (GO): Results of a large cohort study. J Endocrinol Invest. 45:563–572. 2022. View Article : Google Scholar : PubMed/NCBI

5 

Huang Y, Fang S, Li D, Zhou H, Li B and Fan X: The involvement of T cell pathogenesis in thyroid-associated ophthalmopathy. Eye (Lond). 33:176–182. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Yin X, Latif R, Bahn R and Davies TF: Genetic profiling in Graves' disease: Further evidence for lack of a distinct genetic contribution to Graves' ophthalmopathy. Thyroid. 22:730–736. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Hadj-Kacem H, Rebuffat S, Mnif-Féki M, Belguith-Maalej S, Ayadi H and Péraldi-Roux S: Autoimmune thyroid diseases: Genetic susceptibility of thyroid-specific genes and thyroid autoantigens contributions. Int J Immunogenet. 36:85–96. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Wang Y, Ma XM, Wang X, Sun X, Wang LJ, Li XQ, Liu XY and Yu HS: Emerging insights into the role of epigenetics and gut microbiome in the pathogenesis of Graves' ophthalmopathy. Front Endocrinol (Lausanne). 12:7885352022. View Article : Google Scholar : PubMed/NCBI

9 

Rotondo Dottore G, Bucci I, Lanzolla G, Lanzolla G, Dallan I, Sframeli A, Torregrossa L, Casini G, Basolo F, Figus M, et al: Genetic profiling of orbital fibroblasts from patients with Graves' orbitopathy. J Clin Endocrinol Metab. 106:e2176–e2190. 2021. View Article : Google Scholar : PubMed/NCBI

10 

Kouzarides T: Chromatin modifications and their function. Cell. 128:693–705. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Shakespear MR, Halili MA, Irvine KM, Fairlie DP and Sweet MJ: Histone deacetylases as regulators of inflammation and immunity. Trends Immunol. 32:335–343. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Narita T, Weinert BT and Choudhary C: Functions and mechanisms of non-histone protein acetylation. Nat Rev Mol Cell Biol. 20:156–174. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Gatla HR, Muniraj N, Thevkar P, Yavvari S, Sukhavasi S and Makena MR: Regulation of chemokines and cytokines by histone deacetylases and an update on histone decetylase inhibitors in human diseases. Int J Mol Sci. 20:11102019. View Article : Google Scholar : PubMed/NCBI

14 

Chen H, Pan J, Wang JD, Liao QM and Xia XR: Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes. Inflammation. 39:39–46. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Bahn RS: Thyrotropin receptor expression in orbital adipose/connective tissues from patients with thyroid-associated ophthalmopathy. Thyroid. 12:193–195. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Zhang Y and Zhang B: Trichostatin A, an inhibitor of histone deacetylase, inhibits the viability and invasiveness of hypoxic rheumatoid arthritis fibroblast-like synoviocytes via PI3K/Akt signaling. J Biochem Mol Toxicol. 30:163–169. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Oh BR, Suh DH, Bae D, Ha N, Choi YI, Yoo HJ, Park JK, Lee EY, Lee EB and Song YW: Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro. Arthritis Res Ther. 19:1542017. View Article : Google Scholar : PubMed/NCBI

18 

de Zoeten EF, Wang L, Butler K, Beier UH, Akimova T, Sai H, Bradner JE, Mazitschek R, Kozikowski AP, Matthias P and Hancock WW: Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol. 31:2066–2078. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Jones DL, Haak AJ, Caporarello N, Choi KM, Ye Z, Yan H, Varelas X, Ordog T, Ligresti G and Tschumperlin DJ: TGFβ-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression. J Cell Sci. 132:jcs2334862019. View Article : Google Scholar : PubMed/NCBI

20 

Korfei M, Stelmaszek D, MacKenzie B, Skwarna S, Chillappagari S, Bach AC, Ruppert C, Saito S, Mahavadi P, Klepetko W, et al: Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis. PLoS One. 13:e02079152018. View Article : Google Scholar : PubMed/NCBI

21 

Sanders YY, Hagood JS, Liu H, Zhang W, Ambalavanan N and Thannickal VJ: Histone deacetylase inhibition promotes fibroblast apoptosis and ameliorates pulmonary fibrosis in mice. Eur Respir J. 43:1448–1458. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Ekronarongchai S, Palaga T, Saonanon P, Pruksakorn V, Hirankarn N, van Hagen PM, Dik WA and Virakul S: Histone deacetylase 4 controls extracellular matrix production in orbital fibroblasts from graves' ophthalmopathy patients. Thyroid. 31:1566–1576. 2021.PubMed/NCBI

23 

Atadja P: Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges. Cancer Lett. 280:233–241. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Shao W, Growney J, Feng Y, Wang P, Yan-Neale Y, O'Connor G, Kwon P, Yao YM, Fawell S and Atadja P: Potent anticancer activity of a pan-deacetylase inhibitor panobinostat (LBH589) as a single agent in in vitro and in vivo tumor models. Cancer Res. 68 (9 Suppl):S7352008.

25 

Mourits MP, Koornneef L, Wiersinga WM, Prummel MF, Berghout A and van der Gaag R: Clinical criteria for the assessment of disease activity in Graves' ophthalmopathy: A novel approach. Br J Ophthalmol. 73:639–644. 1989. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Byeon HJ, Chae MK, Ko J, Lee EJ, Kikkawa DO, Jang SY and Yoon JS: The role of adipsin, complement factor D, in the pathogenesis of Graves' orbitopathy. Invest Ophthalmol Vis Sci. 64:132023. View Article : Google Scholar : PubMed/NCBI

28 

Dokmanovic M, Perez G, Xu W, Ngo L, Clarke C, Parmigiani RB and Marks PA: Histone deacetylase inhibitors selectively suppress expression of HDAC7. Mol Cancer Ther. 6:2525–2534. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W and Verdin E: Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. J Biol Chem. 276:35826–35835. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Yan N, Zhou JZ, Zhang JA, Cai T, Zhang W, Wang Y, Muhali FS, Guan L and Song RH: Histone hypoacetylation and increased histone deacetylases in peripheral blood mononuclear cells from patients with Graves' disease. Mol Cell Endocrinol. 414:143–147. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Tan C, Xuan L, Cao S, Yu G, Hou Q and Wang H: Decreased histone deacetylase 2 (HDAC2) in peripheral blood monocytes (PBMCs) of COPD patients. PLoS One. 11:e01473802016. View Article : Google Scholar : PubMed/NCBI

32 

Li Y, Zhou M, Lv X, Song L, Zhang D, He Y, Wang M, Zhao X, Yuan X, Shi G and Wang D: Reduced activity of HDAC3 and increased acetylation of histones H3 in peripheral blood mononuclear cells of patients with rheumatoid arthritis. J Immunol Res. 2018:73135152018. View Article : Google Scholar : PubMed/NCBI

33 

Xie K: Interleukin-8 and human cancer biology. Cytokine Growth Factor Rev. 12:375–391. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Sampson AP: The role of eosinophils and neutrophils in inflammation. Clin Exp Allergy. 30 (Suppl 1):S22–S27. 2000. View Article : Google Scholar

35 

Gu LQ, Jia HY, Zhao YJ, Liu N, Wang S, Cui B and Ning G: Association studies of interleukin-8 gene in Graves' disease and Graves' ophthalmopathy. Endocrine. 36:452–456. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Antonelli A, Fallahi P, Elia G, Ragusa F, Paparo SR, Ruffilli I, Patrizio A, Gonnella D, Giusti C, Virili C, et al: Graves' disease: Clinical manifestations, immune pathogenesis (cytokines and chemokines) and therapy. Best Pract Res Clin Endocrinol Metab. 34:1013882020. View Article : Google Scholar : PubMed/NCBI

37 

Virakul S, van Steensel L, Dalm VASH, Paridaens D, van Hagen PM and Dik WA: Platelet-derived growth factor: A key factor in the pathogenesis of graves' ophthalmopathy and potential target for treatment. Eur Thyroid J. 3:217–226. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Cheng T, Kiser K, Grasse L, Iles L, Bartholomeusz G, Samaniego F, Orlowski RZ and Chandra J: Expression of histone deacetylase (HDAC) family members in bortezomib-refractory multiple myeloma and modulation by panobinostat. Cancer Drug Resist. 4:888–902. 2021.PubMed/NCBI

39 

Hemmatazad H, Rodrigues HM, Maurer B, Brentano F, Pileckyte M, Distler JH, Gay RE, Michel BA, Gay S, Huber LC, et al: Histone deacetylase 7, a potential target for the antifibrotic treatment of systemic sclerosis. Arthritis Rheum. 60:1519–1529. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Huber LC, Distler JHW, Moritz F, Hemmatazad H, Hauser T, Michel BA, Gay RE, Matucci-Cerinic M, Gay S, Distler O and Jüngel A: Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis. Arthritis Rheum. 56:2755–2764. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Kang DH, Yin GN, Choi MJ, Song KM, Ghatak K, Minh NN, Kwon MH, Seong DH, Ryu JK and Suh JK: Silencing histone deacetylase 7 alleviates transforming growth factor-β1-induced profibrotic responses in fibroblasts derived from peyronie's plaque. World J Mens Health. 36:139–146. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Hua HS, Wen HC, Weng CM, Lee HS, Chen BC and Lin CH: Histone deacetylase 7 mediates endothelin-1-induced connective tissue growth factor expression in human lung fibroblasts through p300 and activator protein-1 activation. J Biomed Sci. 28:382021. View Article : Google Scholar : PubMed/NCBI

43 

Saito S, Zhuang Y, Shan B, Danchuk S, Luo F, Korfei M, Guenther A and Lasky JA: Tubastatin ameliorates pulmonary fibrosis by targeting the TGFβ-PI3K-Akt pathway. PLoS One. 12:e01866152017. View Article : Google Scholar : PubMed/NCBI

44 

Liu Y, Wang R, Han H and Li L: Tubastatin A suppresses the proliferation of fibroblasts in epidural fibrosis through phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling pathway. J Pharm Pharmacol. 74:426–434. 2022. View Article : Google Scholar

45 

Guo W, Shan B, Klingsberg RC, Qin X and Lasky JA: Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition. Am J Physiol Lung Cell Mol Physiol. 297:L864–L870. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Bao Y, Kim D, Cho YH, Ku CR, Yoon JS and Lee EJ: Cre-loxP system-based mouse model for investigating Graves' disease and associated orbitopathy. Thyroid. 33:1358–1367. 2023. View Article : Google Scholar : PubMed/NCBI

47 

Wang Y, Abrol R, Mak JYW, Das Gupta K, Ramnath D, Karunakaran D, Fairlie DP and Sweet MJ: Histone deacetylase 7: A signalling hub controlling development, inflammation, metabolism and disease. FEBS J. 290:2805–2832. 2023. View Article : Google Scholar : PubMed/NCBI

48 

Liu L, Dong L, Bourguet E and Fairlie DP: Targeting class IIa HDACs: Insights from phenotypes and inhibitors. Curr Med Chem. 28:8628–8672. 2021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Byeon H, Choi S, Kikkawa DO, Ko J and Yoon J: Therapeutic role of histone deacetylase inhibition in an <em>in vitro</em> model of Graves' orbitopathy. Mol Med Rep 30: 218, 2024.
APA
Byeon, H., Choi, S., Kikkawa, D.O., Ko, J., & Yoon, J. (2024). Therapeutic role of histone deacetylase inhibition in an <em>in vitro</em> model of Graves' orbitopathy. Molecular Medicine Reports, 30, 218. https://doi.org/10.3892/mmr.2024.13342
MLA
Byeon, H., Choi, S., Kikkawa, D. O., Ko, J., Yoon, J."Therapeutic role of histone deacetylase inhibition in an <em>in vitro</em> model of Graves' orbitopathy". Molecular Medicine Reports 30.6 (2024): 218.
Chicago
Byeon, H., Choi, S., Kikkawa, D. O., Ko, J., Yoon, J."Therapeutic role of histone deacetylase inhibition in an <em>in vitro</em> model of Graves' orbitopathy". Molecular Medicine Reports 30, no. 6 (2024): 218. https://doi.org/10.3892/mmr.2024.13342
Copy and paste a formatted citation
x
Spandidos Publications style
Byeon H, Choi S, Kikkawa DO, Ko J and Yoon J: Therapeutic role of histone deacetylase inhibition in an <em>in vitro</em> model of Graves' orbitopathy. Mol Med Rep 30: 218, 2024.
APA
Byeon, H., Choi, S., Kikkawa, D.O., Ko, J., & Yoon, J. (2024). Therapeutic role of histone deacetylase inhibition in an <em>in vitro</em> model of Graves' orbitopathy. Molecular Medicine Reports, 30, 218. https://doi.org/10.3892/mmr.2024.13342
MLA
Byeon, H., Choi, S., Kikkawa, D. O., Ko, J., Yoon, J."Therapeutic role of histone deacetylase inhibition in an <em>in vitro</em> model of Graves' orbitopathy". Molecular Medicine Reports 30.6 (2024): 218.
Chicago
Byeon, H., Choi, S., Kikkawa, D. O., Ko, J., Yoon, J."Therapeutic role of histone deacetylase inhibition in an <em>in vitro</em> model of Graves' orbitopathy". Molecular Medicine Reports 30, no. 6 (2024): 218. https://doi.org/10.3892/mmr.2024.13342
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