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Current progress of anti‑PD‑1/PDL1 immunotherapy for glioblastoma (Review)

  • Authors:
    • Jianheng Wu
    • Nannan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Gaozhou People's Hospital, Gaozhou, Guangdong 525200, P.R. China, Department of Gastroenterology, Gaozhou People's Hospital, Gaozhou, Guangdong 525200, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 221
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    Published online on: September 30, 2024
       https://doi.org/10.3892/mmr.2024.13344
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Abstract

Glioblastoma (GBM) is the most common central nervous system malignancy in adults. GBM may be classified as grade IV diffuse astrocytoma according to the 2021 World Health Organization revised classification of central nervous system tumors, which means it is the most aggressive, invasive, undifferentiated type of tumor. Immune checkpoint blockade (ICB), particularly anti‑programmed cell death protein‑1 (PD‑1)/PD‑1 ligand‑1 immunotherapy, has been confirmed to be successful across several tumor types. However, in GBM, this treatment is still uncommon and the efficacy is unpredictable, and <10% of patients show long‑term responses. Recently, numerous studies have been conducted to explore what factors may indicate or affect the ICB response rate in GBM, including molecular alterations, immune expression signatures and immune infiltration. The present review aimed to summarize the current progress to improve the understanding of immunotherapy for GBM.
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Copy and paste a formatted citation
Spandidos Publications style
Wu J and Wang N: Current progress of anti‑PD‑1/PDL1 immunotherapy for glioblastoma (Review). Mol Med Rep 30: 221, 2024.
APA
Wu, J., & Wang, N. (2024). Current progress of anti‑PD‑1/PDL1 immunotherapy for glioblastoma (Review). Molecular Medicine Reports, 30, 221. https://doi.org/10.3892/mmr.2024.13344
MLA
Wu, J., Wang, N."Current progress of anti‑PD‑1/PDL1 immunotherapy for glioblastoma (Review)". Molecular Medicine Reports 30.6 (2024): 221.
Chicago
Wu, J., Wang, N."Current progress of anti‑PD‑1/PDL1 immunotherapy for glioblastoma (Review)". Molecular Medicine Reports 30, no. 6 (2024): 221. https://doi.org/10.3892/mmr.2024.13344
Copy and paste a formatted citation
x
Spandidos Publications style
Wu J and Wang N: Current progress of anti‑PD‑1/PDL1 immunotherapy for glioblastoma (Review). Mol Med Rep 30: 221, 2024.
APA
Wu, J., & Wang, N. (2024). Current progress of anti‑PD‑1/PDL1 immunotherapy for glioblastoma (Review). Molecular Medicine Reports, 30, 221. https://doi.org/10.3892/mmr.2024.13344
MLA
Wu, J., Wang, N."Current progress of anti‑PD‑1/PDL1 immunotherapy for glioblastoma (Review)". Molecular Medicine Reports 30.6 (2024): 221.
Chicago
Wu, J., Wang, N."Current progress of anti‑PD‑1/PDL1 immunotherapy for glioblastoma (Review)". Molecular Medicine Reports 30, no. 6 (2024): 221. https://doi.org/10.3892/mmr.2024.13344
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