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Role and clinical value of serum hsa_tsr011468 in lung adenocarcinoma

  • Authors:
    • Ping Zhao
    • Kui Zhu
    • Cuihua Xie
    • Sinan Liu
    • Xiang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Nantong First People's Hospital and The Second Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Laboratory Medicine, Rugao Hospital of Traditional Chinese Medicine, Nantong, Jiangsu 226001, P.R. China, Department of Laboratory Medicine, Nantong First People's Hospital and The Second Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu 226001, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 226
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    Published online on: October 4, 2024
       https://doi.org/10.3892/mmr.2024.13350
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Abstract

Transfer RNA‑derived small RNAs (tsRNAs) are novel non‑coding RNAs that are associated with the pathogenesis of various diseases. However, their association with lung adenocarcinoma (LUAD) has not been studied comprehensively. Therefore, the present study aimed to explore the diagnostic value of a tsRNA, hsa_tsr011468, in LUAD. The OncotRF database was used to screen tsRNAs and reverse transcription‑quantitative PCR (RT‑qPCR) was performed to detect the expression levels of hsa_tsr011468 in various samples. Subsequently, the diagnostic and prognostic values of hsa_tsr011468 for LUAD were determined via receiver operating characteristic (ROC) curve and survival curve analyses, and by assessing clinicopathological parameters. In addition, both nuclear and cytoplasmic RNA were extracted to assess the location of hsa_tsr011468. The OncotRF database identified high expression of hsa_tsr011468 in LUAD. In addition, the results of RT‑qPCR showed that the relative expression levels of hsa_tsr011468 in the serum and tissues of patients with LUAD were higher than those in normal controls. Furthermore, its expression was lower in postoperative serum samples than in preoperative serum samples from patients with LUAD. ROC and survival curves indicated that hsa_tsr011468 had good diagnostic and prognostic value. Furthermore, the clinicopathological analysis revealed that hsa_tsr011468 was associated with tumor size. In addition, hsa_tsr011468 was mainly localized in the cytoplasm of LUAD cells. The present study indicated that hsa_tsr011468 has good diagnostic value and, therefore, could be employed as a serum marker for LUAD.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao P, Zhu K, Xie C, Liu S and Chen X: Role and clinical value of serum hsa_tsr011468 in lung adenocarcinoma. Mol Med Rep 30: 226, 2024.
APA
Zhao, P., Zhu, K., Xie, C., Liu, S., & Chen, X. (2024). Role and clinical value of serum hsa_tsr011468 in lung adenocarcinoma. Molecular Medicine Reports, 30, 226. https://doi.org/10.3892/mmr.2024.13350
MLA
Zhao, P., Zhu, K., Xie, C., Liu, S., Chen, X."Role and clinical value of serum hsa_tsr011468 in lung adenocarcinoma". Molecular Medicine Reports 30.6 (2024): 226.
Chicago
Zhao, P., Zhu, K., Xie, C., Liu, S., Chen, X."Role and clinical value of serum hsa_tsr011468 in lung adenocarcinoma". Molecular Medicine Reports 30, no. 6 (2024): 226. https://doi.org/10.3892/mmr.2024.13350
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao P, Zhu K, Xie C, Liu S and Chen X: Role and clinical value of serum hsa_tsr011468 in lung adenocarcinoma. Mol Med Rep 30: 226, 2024.
APA
Zhao, P., Zhu, K., Xie, C., Liu, S., & Chen, X. (2024). Role and clinical value of serum hsa_tsr011468 in lung adenocarcinoma. Molecular Medicine Reports, 30, 226. https://doi.org/10.3892/mmr.2024.13350
MLA
Zhao, P., Zhu, K., Xie, C., Liu, S., Chen, X."Role and clinical value of serum hsa_tsr011468 in lung adenocarcinoma". Molecular Medicine Reports 30.6 (2024): 226.
Chicago
Zhao, P., Zhu, K., Xie, C., Liu, S., Chen, X."Role and clinical value of serum hsa_tsr011468 in lung adenocarcinoma". Molecular Medicine Reports 30, no. 6 (2024): 226. https://doi.org/10.3892/mmr.2024.13350
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