|
1
|
Knopman DS, Amieva H, Petersen RC, Chételat G, Holtzman DM, Hyman BT, Nixon RA and Jones DT: Alzheimer disease. Nat Rev Dis Primers. 7:332021. View Article : Google Scholar
|
|
2
|
Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chételat G, Teunissen CE, Cummings J and van der Flier WM: Alzheimer's disease. Lancet. 397:1577–1590. 2021. View Article : Google Scholar
|
|
3
|
Rajasekhar K and Govindaraju T: Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease. RSC Adv. 8:23780–23804. 2018. View Article : Google Scholar
|
|
4
|
Zhang F, Zhong RJ, Cheng C, Li S and Le WD: New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer's disease. Acta Pharmacol Sin. 42:1382–1389. 2021. View Article : Google Scholar
|
|
5
|
Chen YG: Research progress in the pathogenesis of Alzheimer's disease. Chin Med J (Engl). 131:1618–1624. 2018. View Article : Google Scholar
|
|
6
|
Wightman EL: Potential benefits of phytochemicals against Alzheimer's disease. Proc Nutr Soc. 76:106–112. 2017. View Article : Google Scholar
|
|
7
|
Tuli HS, Sak K, Gupta DS, Kaur G, Aggarwal D, Parashar NC, Choudhary R, Yerer MB, Kaur J, Kumar M, et al: Anti-inflammatory and anticancer properties of birch bark-derived betulin: Recent developments. Plants (Basel). 10:26632021.
|
|
8
|
Buko V, Kuzmitskaya I, Kirko S, Belonovskaya E, Naruta E, Lukivskaya O, Shlyahtun A, Ilyich T, Zakreska A and Zavodnik I: Betulin attenuated liver damage by prevention of hepatic mitochondrial dysfunction in rats with alcoholic steatohepatitis. Physiol Int. 106:323–334. 2019. View Article : Google Scholar
|
|
9
|
Cho N, Kim HW, Lee HK, Jeon BJ and Sung SH: Ameliorative effect of betulin from Betula platyphylla bark on scopolamine-induced amnesic mice. Biosci Biotechnol Biochem. 80:166–171. 2016. View Article : Google Scholar
|
|
10
|
Farzan M, Farzan M, Shahrani M, Navabi SP, Vardanjani HR, Amini-Khoei H and Shabani S: Neuroprotective properties of Betulin, Betulinic acid, and Ursolic acid as triterpenoids derivatives: A comprehensive review of mechanistic studies. Nutr Neurosci. 27:223–240. 2024. View Article : Google Scholar
|
|
11
|
Tsai CW, Tsai RT, Liu SP, Chen CS, Tsai MC, Chien SH, Hung HS, Lin SZ, Shyu WC and Fu RH: Neuroprotective effects of betulin in pharmacological and transgenic caenorhabditis elegans models of parkinson's disease. Cell Transplant. 26:1903–1918. 2017. View Article : Google Scholar
|
|
12
|
Ma C and Long H: Protective effect of betulin on cognitive decline in streptozotocin (STZ)-induced diabetic rats. Neurotoxicology. 57:104–111. 2016. View Article : Google Scholar
|
|
13
|
Liu Q, Liu JP, Mei JH, Li SJ, Shi LQ, Lin ZH, Xie BY, Sun WG, Wang ZY, Yang XL, et al: Betulin isolated from Pyrola incarnata Fisch. inhibited lipopolysaccharide (LPS)-induced neuroinflammation with the guidance of computer-aided drug design. Bioorg Med Chem Lett. 30:1271932020. View Article : Google Scholar
|
|
14
|
Nogales C, Mamdouh ZM, List M, Kiel C, Casas AI and Schmidt H: Network pharmacology: Curing causal mechanisms instead of treating symptoms. Trends Pharmacol Sci. 43:136–150. 2022. View Article : Google Scholar
|
|
15
|
Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, Li Q, Shoemaker BA, Thiessen PA, Yu B, et al: PubChem 2023 update. Nucleic Acids Res. 51:D1373–D1380. 2023. View Article : Google Scholar
|
|
16
|
Wang X, Shen Y, Wang S, Li S, Zhang W, Liu X, Lai L, Pei J and Li H: PharmMapper 2017 update: A web server for potential drug target identification with a comprehensive target pharmacophore database. Nucleic Acids Res. 45:W356–W360. 2017. View Article : Google Scholar
|
|
17
|
UniProt Consortium: UniProt: The universal protein knowledgebase in 2023. Nucleic Acids Res. 51:D523–D531. 2023. View Article : Google Scholar
|
|
18
|
Stelzer G, Rosen N, Plaschkes I, Zimmerman S, Twik M, Fishilevich S, Stein TI, Nudel R, Lieder I, Mazor Y, et al: The genecards suite: From gene data mining to disease genome sequence analyses. Curr Protoc Bioinformatics. 54:1.30.31–31.30.33. 2016. View Article : Google Scholar
|
|
19
|
Pinero J, Ramirez-Anguita JM, Sauch-Pitarch J, Ronzano F, Centeno E, Sanz F and Furlong LI: The DisGeNET knowledge platform for disease genomics: 2019 update. Nucleic Acids Res. 48:D845–D855. 2020.
|
|
20
|
Davis AP, Wiegers TC, Wiegers J, Wyatt B, Johnson RJ, Sciaky D, Barkalow F, Strong M, Planchart A and Mattingly CJ: CTD tetramers: A new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental health. Toxicol Sci. 195:155–168. 2023. View Article : Google Scholar
|
|
21
|
Amberger JS and Hamosh A: Searching online mendelian inheritance in man (OMIM): A knowledgebase of human genes and genetic phenotypes. Curr Protoc Bioinformatics. 58:1.2.1–1.2.12. 2017. View Article : Google Scholar
|
|
22
|
Bardou P, Mariette J, Escudié F, Djemiel C and Klopp C: Jvenn: An interactive Venn diagram viewer. BMC Bioinformatics. 15:2932014. View Article : Google Scholar
|
|
23
|
Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, Gable AL, Fang T, Doncheva NT, Pyysalo S, et al: The STRING database in 2023: Protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 51:D638–D646. 2023. View Article : Google Scholar
|
|
24
|
Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar
|
|
25
|
Chin CH, Chen SH, Wu HH, Ho CW, Ko MT and Lin CY: cytoHubba: Identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 4:S112014. View Article : Google Scholar
|
|
26
|
Sherman BT, Hao M, Qiu J, Jiao X, Baseler MW, Lane HC, Imamichi T and Chang W: DAVID: A web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res. 50:W216–W221. 2022. View Article : Google Scholar
|
|
27
|
Shen W, Song Z, Zhong X, Huang M, Shen D, Gao P, Qian X, Wang M, He X, Wang T, et al: Sangerbox: A comprehensive, interaction-friendly clinical bioinformatics analysis platform. Imeta. 1:e362022. View Article : Google Scholar
|
|
28
|
Berman HM, Battistuz T, Bhat TN, Bluhm WF, Bourne PE, Burkhardt K, Feng Z, Gilliland GL, Iype L, Jain S, et al: The protein data bank. Acta Crystallogr D Biol Crystallogr. 28:235–242. 2000.
|
|
29
|
Ru J, Li P, Wang J, Zhou W, Li B, Huang C, Li P, Guo Z, Tao W, Yang Y, et al: TCMSP: A database of systems pharmacology for drug discovery from herbal medicines. J Cheminform. 6:132014. View Article : Google Scholar
|
|
30
|
Seeliger D and de Groot BL: Ligand docking and binding site analysis with PyMOL and Autodock/Vina. J Comput Aided Mol Des. 24:417–422. 2010. View Article : Google Scholar
|
|
31
|
Goodsell DS and Olson AJ: Automated docking of substrates to proteins by simulated annealing. Proteins. 8:195–202. 1990. View Article : Google Scholar
|
|
32
|
Wang Z, Sun H, Yao X, Li D, Xu L, Li Y, Tian S and Hou T: Comprehensive evaluation of ten docking programs on a diverse set of protein-ligand complexes: The prediction accuracy of sampling power and scoring power. Phys Chem Chem Phys. 18:12964–12975. 2016. View Article : Google Scholar
|
|
33
|
Chen F, Wang N, Tian X, Su J, Qin Y, He R and He X: The protective effect of mangiferin on formaldehyde-induced HT22 cell damage and cognitive impairment. Pharmaceutics. 15:15682023. View Article : Google Scholar
|
|
34
|
Buttrick GJ and Wakefield JG: PI3-K and GSK-3: Akt-ing together with microtubules. Cell Cycle. 7:2621–2625. 2008. View Article : Google Scholar
|
|
35
|
Pinzi L and Rastelli G: Molecular docking: Shifting paradigms in drug discovery. Int J Mol Sci. 20:43312019. View Article : Google Scholar
|
|
36
|
Liu Y, Shi C, He Z, Zhu F, Wang M, He R, Zhao C, Shi X, Zhou M, Pan S, et al: Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells. Int J Biol Sci. 17:589–602. 2021. View Article : Google Scholar
|
|
37
|
Li H, Deng W, Yang J, Lin Y, Zhang S, Liang Z, Chen J, Hu M, Liu T, Mo G, et al: Corylifol A suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss via attenuating ROS production and impairing mitochondrial function. Biomed Pharmacother. 171:1161662024. View Article : Google Scholar
|
|
38
|
Zang G, Fang L, Chen L and Wang C: Ameliorative effect of nicergoline on cognitive function through the PI3K/AKT signaling pathway in mouse models of Alzheimer's disease. Mol Med Rep. 17:7293–7300. 2018.
|
|
39
|
Rates SM: Plants as source of drugs. Toxicon. 39:603–613. 2001. View Article : Google Scholar
|
|
40
|
Raskin I, Ribnicky DM, Komarnytsky S, Ilic N, Poulev A, Borisjuk N, Brinker A, Moreno DA, Ripoll C, Yakoby N, et al: Plants and human health in the twenty-first century. Trends Biotechnol. 20:522–531. 2002. View Article : Google Scholar
|
|
41
|
Matsuda H, Ishikado A, Nishida N, Ninomiya K, Fujiwara H, Kobayashi Y and Yoshikawa M: Hepatoprotective, superoxide scavenging, and antioxidative activities of aromatic constituents from the bark of Betula platyphylla var. japonica. Bioorg Med Chem Lett. 8:2939–2944. 1998. View Article : Google Scholar
|
|
42
|
Huh JE, Hong JM, Baek YH, Lee JD, Choi DY and Park DS: Anti-inflammatory and anti-nociceptive effect of Betula platyphylla var. japonica in human interleukin-1β-stimulated fibroblast-like synoviocytes and in experimental animal models. J Ethnopharmacol. 135:126–134. 2011. View Article : Google Scholar
|
|
43
|
Hopkins AL: Network pharmacology: The next paradigm in drug discovery. Nat Chem Biol. 4:682–690. 2008. View Article : Google Scholar
|
|
44
|
Sayas CL and Avila J: GSK-3 and tau: A key duet in Alzheimer's disease. Cells. 10:7212021. View Article : Google Scholar
|
|
45
|
He X, Li Z, Rizak JD, Wu S, Wang Z, He R, Su M, Qin D, Wang J and Hu X: Resveratrol attenuates formaldehyde induced hyperphosphorylation of tau protein and cytotoxicity in N2a cells. Front Neurosci. 10:5982016.
|
|
46
|
Long HZ, Cheng Y, Zhou ZW, Luo HY, Wen DD and Gao LC: PI3K/AKT signal pathway: A target of natural products in the prevention and treatment of Alzheimer's disease and parkinson's disease. Front Pharmacol. 12:6486362021. View Article : Google Scholar
|
|
47
|
Beurel E, Grieco SF and Jope RS: Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases. Pharmacol Ther. 148:114–131. 2015. View Article : Google Scholar
|
|
48
|
Plattner F, Angelo M and Giese KP: The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation. J Biol Chem. 281:25457–25465. 2006. View Article : Google Scholar
|
|
49
|
Qu ZS, Li L, Sun XJ, Zhao YW, Zhang J, Geng Z, Fu JL and Ren QG: Glycogen synthase kinase-3 regulates production of amyloid-β peptides and tau phosphorylation in diabetic rat brain. ScientificWorldJournal. 2014:8781232014. View Article : Google Scholar
|
|
50
|
Gabbouj S, Ryhänen S, Marttinen M, Wittrahm R, Takalo M, Kemppainen S, Martiskainen H, Tanila H, Haapasalo A, Hiltunen M and Natunen T: Altered insulin signaling in alzheimer's disease brain-special emphasis on PI3K-Akt pathway. Front Neurosci. 13:6292019. View Article : Google Scholar
|
|
51
|
Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, Xu XJ, Wands JR and de la Monte SM: Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease-is this type 3 diabetes? J Alzheimers Dis. 7:63–80. 2005. View Article : Google Scholar
|
|
52
|
Tulpule K and Dringen R: Formaldehyde in brain: An overlooked player in neurodegeneration? J Neurochem. 127:7–21. 2013. View Article : Google Scholar
|
|
53
|
Liu X, Zhang Y, Wu R, Ye M, Zhao Y, Kang J, Ma P, Li J and Yang X: Acute formaldehyde exposure induced early Alzheimer-like changes in mouse brain. Toxicol Mech Methods. 28:95–104. 2018. View Article : Google Scholar
|
|
54
|
de Souza MT, de Campos Buzzi F, Filho VC, Hess S, Monache FD and Niero R: Phytochemical and antinociceptive properties of Matayba elaeagnoides Radlk. barks. Z Naturforsch C J Biosci. 62:550–554. 2007. View Article : Google Scholar
|
|
55
|
Offen D, Elkon H and Melamed E: Apoptosis as a general cell death pathway in neurodegenerative diseases. J Neural Transm Suppl. 2000:153–166. 2000.
|
|
56
|
Gyparaki MT, Arab A, Sorokina EM, Santiago-Ruiz AN, Bohrer CH, Xiao J and Lakadamyali M: Tau forms oligomeric complexes on microtubules that are distinct from tau aggregates. Proc Natl Acad Sci USA. 118:e20214611182021. View Article : Google Scholar
|
|
57
|
Karikari TK, Pascoal TA, Ashton NJ, Janelidze S, Benedet AL, Rodriguez JL, Chamoun M, Savard M, Kang MS, Therriault J, et al: Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: A diagnostic performance and prediction modelling study using data from four prospective cohorts. Lancet Neurol. 19:422–433. 2020. View Article : Google Scholar
|
|
58
|
Ci X, Zhou J, Lv H, Yu Q, Peng L and Hua S: Betulin exhibits anti-inflammatory activity in LPS-stimulated macrophages and endotoxin-shocked mice through an AMPK/AKT/Nrf2-dependent mechanism. Cell Death Dis. 8:e27982017. View Article : Google Scholar
|
|
59
|
Yang Q, Fei Z and Huang C: Betulin terpenoid targets OVCAR-3 human ovarian carcinoma cells by inducing mitochondrial mediated apoptosis, G2/M phase cell cycle arrest, inhibition of cell migration and invasion and modulating mTOR/PI3K/AKT signalling pathway. Cell Mol Biol (Noisy-le-grand). 67:14–19. 2021. View Article : Google Scholar
|
|
60
|
Han YH, Mun JG, Jeon HD, Kee JY and Hong SH: Betulin inhibits lung metastasis by inducing cell cycle arrest, autophagy, and apoptosis of metastatic colorectal cancer cells. Nutrients. 12:662019. View Article : Google Scholar
|
|
61
|
Jin H, Wang M, Wang J, Cao H, Niu W and Du L: Paeonol attenuates isoflurane anesthesia-induced hippocampal neurotoxicity via modulation of JNK/ERK/P38MAPK pathway and regulates histone acetylation in neonatal rat. J Matern Fetal Neonatal Med. 33:81–91. 2020. View Article : Google Scholar
|
|
62
|
Korsmeyer SJ, Shutter JR, Veis DJ, Merry DE and Oltvai ZN: Bcl-2/Bax: A rheostat that regulates an anti-oxidant pathway and cell death. Semin Cancer Biol. 4:327–332. 1993.
|
|
63
|
Chen KY, Hsu WL, Hsu SW, Chen CH, Hong KT, Tsai CW, Chang WS, Chen CC, Pei JS, Lee HT and Bau DT: Involvement of mitochondrial damage and oxidative stress in apoptosis induced by betulin plus arsenic trioxide in neuroblastoma cells. Anticancer Res. 43:2467–2476. 2023. View Article : Google Scholar
|
|
64
|
Yang K, Chen Z, Gao J, Shi W, Li L, Jiang S, Hu H, Liu Z, Xu D and Wu L: The key roles of GSK-3β in regulating mitochondrial activity. Cell Physiol Biochem. 44:1445–1459. 2017. View Article : Google Scholar
|
|
65
|
Chen K, Xue R, Geng Y and Zhang S: Galangin inhibited ferroptosis through activation of the PI3K/AKT pathway in vitro and in vivo. FASEB J. 36:e225692022. View Article : Google Scholar
|
|
66
|
Dong L, Du H, Zhang M, Xu H, Pu X, Chen Q, Luo R, Hu Y, Wang Y, Tu H, et al: Anti-inflammatory effect of Rhein on ulcerative colitis via inhibiting PI3K/Akt/mTOR signaling pathway and regulating gut microbiota. Phytother Res. 36:2081–2094. 2022. View Article : Google Scholar
|
|
67
|
Yang S, Xie Z, Pei T, Zeng Y, Xiong Q, Wei H, Wang Y and Cheng W: Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1 signaling pathway in Aβ(1–42)-induced Alzheimer's disease mice and glutamate-injured HT22 cells. Chin Med. 17:822022. View Article : Google Scholar
|
|
68
|
Xiong Y, Ruan YT, Zhao J, Yang YW, Chen LP, Mai YR, Yu Q, Cao ZY, Liu FF, Liao W and Liu J: Magnesium-L-threonate exhibited a neuroprotective effect against oxidative stress damage in HT22 cells and Alzheimer's disease mouse model. World J Psychiatry. 12:410–424. 2022. View Article : Google Scholar
|
