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Advances in research on the relationship between the LMNA gene and human diseases (Review)

  • Authors:
    • Jiumei Zhao
    • Huijuan Zhang
    • Chenglong Pan
    • Qian He
    • Kepu Zheng
    • Yu Tang
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory, Chongqing Nanchuan District People's Hospital, Chongqing Medical University, Chongqing 408400, P.R. China, Forensic Science Centre, Kunming Medical University, Kunming, Yunnan 650500, P.R. China, Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, Yunnan 650500, P.R. China, School of Biomedical Engineering, Kunming Medical University, Kunming, Yunnan 650500, P.R. China, Department of Pathology, The Third Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, Yunnan 650500, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 236
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    Published online on: October 14, 2024
       https://doi.org/10.3892/mmr.2024.13358
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Abstract

The LMNA gene, which is responsible for encoding lamin A/C proteins, is recognized as a primary constituent of the nuclear lamina. This protein serves crucial roles in various cellular physiological activities, including the maintenance of cellular structural stability, regulation of gene expression, mechanosensing and cellular motility. A significant association has been established between the LMNA gene and several major human diseases. Mutations, dysregulated expression of the LMNA gene, and improper processing of its encoded protein can result in a spectrum of pathological conditions. These diseases, collectively termed laminopathies, are directly attributed to LMNA gene dysfunction. The present review examines the recent advancements in research concerning the LMNA gene and its association with human diseases, while exploring its pathological roles. Particular emphasis is placed on the current status of LMNA gene research in the context of tumors. This includes an analysis of the abundance of LMNA alterations in cancer and its interplay with various signaling pathways. The aim of the present review was to provide novel perspectives for studying the development of LMNA‑related diseases and additional theoretical insights for basic and clinical translational research in this field.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao J, Zhang H, Pan C, He Q, Zheng K and Tang Y: Advances in research on the relationship between the LMNA gene and human diseases (Review). Mol Med Rep 30: 236, 2024.
APA
Zhao, J., Zhang, H., Pan, C., He, Q., Zheng, K., & Tang, Y. (2024). Advances in research on the relationship between the LMNA gene and human diseases (Review). Molecular Medicine Reports, 30, 236. https://doi.org/10.3892/mmr.2024.13358
MLA
Zhao, J., Zhang, H., Pan, C., He, Q., Zheng, K., Tang, Y."Advances in research on the relationship between the LMNA gene and human diseases (Review)". Molecular Medicine Reports 30.6 (2024): 236.
Chicago
Zhao, J., Zhang, H., Pan, C., He, Q., Zheng, K., Tang, Y."Advances in research on the relationship between the LMNA gene and human diseases (Review)". Molecular Medicine Reports 30, no. 6 (2024): 236. https://doi.org/10.3892/mmr.2024.13358
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao J, Zhang H, Pan C, He Q, Zheng K and Tang Y: Advances in research on the relationship between the LMNA gene and human diseases (Review). Mol Med Rep 30: 236, 2024.
APA
Zhao, J., Zhang, H., Pan, C., He, Q., Zheng, K., & Tang, Y. (2024). Advances in research on the relationship between the LMNA gene and human diseases (Review). Molecular Medicine Reports, 30, 236. https://doi.org/10.3892/mmr.2024.13358
MLA
Zhao, J., Zhang, H., Pan, C., He, Q., Zheng, K., Tang, Y."Advances in research on the relationship between the LMNA gene and human diseases (Review)". Molecular Medicine Reports 30.6 (2024): 236.
Chicago
Zhao, J., Zhang, H., Pan, C., He, Q., Zheng, K., Tang, Y."Advances in research on the relationship between the LMNA gene and human diseases (Review)". Molecular Medicine Reports 30, no. 6 (2024): 236. https://doi.org/10.3892/mmr.2024.13358
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