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Endoplasmic reticulum stress induces renal fibrosis in high‑fat diet mice via the TGF‑β/SMAD pathway

  • Authors:
    • Zhidan Mu
    • Bin Li
    • Mingyang Chen
    • Chen Liang
    • Wei Gu
    • Juan Su
  • View Affiliations / Copyright

    Affiliations: Department of Physiology and Pathophysiology, College of Basic Medicine, Dali University, Dali, Yunnan 671000, P.R. China, Department of Infection Disease, First Affiliated Hospital of Dali University, Dali, Yunnan 671000, P.R. China
    Copyright: © Mu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 235
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    Published online on: October 14, 2024
       https://doi.org/10.3892/mmr.2024.13360
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Abstract

The aim of the present study was to investigate the role and mechanism of endoplasmic reticulum stress (ERS) in kidney injury caused by high‑fat diet (HFD). An obese mouse model was established via HFD feeding and intervention was performed by intraperitoneal injection of the ERS inhibitor salubrinal (Sal). Changes in the body and kidney weight and serum biochemical indices of the mice were determined. Hematoxylin and eosin and Masson staining were used to observe the pathological changes of renal tissues. Reverse transcription‑quantitative PCR and western blotting were used to observe the expression of ERS‑related proteins and TGF‑β/SMAD pathway‑related proteins. Immunohistochemistry was employed to explore the distribution of these proteins. Compared with those in the control group, the weight gain, lipid metabolism disorders and deterioration of renal function in the model group were greater. Malondialdehyde was elevated and superoxide dismutase was decreased in renal tissues. The mRNA and protein levels of TGF‑β1, SMAD2/3, α‑smooth muscle actin, collagen I, glucose‑regulated protein 78 and C/EBP‑homologous protein were markedly elevated, whereas SMAD7 was markedly decreased. Sal markedly inhibited the aforementioned effects. This investigation revealed a link between ERS and renal injury caused by HFD. ERS in HFD‑fed mice triggers renal fibrosis through the TGF‑β/SMAD pathway.
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View References

1 

Jiang Z, Wang Y, Zhao X, Cui H, Han M, Ren X, Gang X and Wang G: Obesity and chronic kidney disease. Am J Physiol Endocrinol Metab. 324:E24–E41. 2023. View Article : Google Scholar : PubMed/NCBI

2 

Stasi A, Cosola C, Caggiano G, Cimmarusti MT, Palieri R, Acquaviva PM, Rana G and Gesualdo L: Obesity-related chronic kidney disease: Principal mechanisms and new approaches in nutritional management. Front Nutr. 9:9256192022. View Article : Google Scholar : PubMed/NCBI

3 

Alizadeh S, Ahmadi M, Ghorbani Nejad B, Djazayeri A and Shab-Bidar S: Metabolic syndrome and its components are associated with increased chronic kidney disease risk: Evidence from a meta-analysis on 11 109 003 participants from 66 studies. Int J Clin Pract. May 23–2018.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

4 

Huang R, Fu P and Ma L: Kidney fibrosis: From mechanisms to therapeutic medicines. Signal Transduct Target Ther. 8:1292023. View Article : Google Scholar : PubMed/NCBI

5 

Liu S, Fu S, Jin Y, Geng R, Li Y, Zhang Y, Liu J and Guo W: Tartary buckwheat flavonoids alleviates high-fat diet induced kidney fibrosis in mice by inhibiting MAPK and TGF-β1/Smad signaling pathway. Chem Biol Interact. 379:1105332023. View Article : Google Scholar : PubMed/NCBI

6 

Zhu X, Si F, Hao R, Zheng J and Zhang C: Nuciferine protects against obesity-induced nephrotoxicity through its hypolipidemic, anti-inflammatory, and antioxidant effects. J Agric Food Chem. 71:18769–18779. 2023. View Article : Google Scholar : PubMed/NCBI

7 

Lee LE, Doke T, Mukhi D and Susztak K: The key role of altered tubule cell lipid metabolism in kidney disease development. Kidney Int. 106:24–34. 2024. View Article : Google Scholar : PubMed/NCBI

8 

Zhang SX, Wang JJ, Starr CR, Lee EJ, Park KS, Zhylkibayev A, Medina A, Lin JH and Gorbatyuk M: The endoplasmic reticulum: Homeostasis and crosstalk in retinal health and disease. Prog Retin Eye Res. 98:1012312024. View Article : Google Scholar : PubMed/NCBI

9 

Chen X and Cubillos-Ruiz JR: Endoplasmic reticulum stress signals in the tumour and its microenvironment. Nat Rev Cancer. 21:71–88. 2021. View Article : Google Scholar : PubMed/NCBI

10 

Metcalf MG, Higuchi-Sanabria R, Garcia G, Tsui CK and Dillin A: Beyond the cell factory: Homeostatic regulation of and by the UPRER. Sci Adv. 6:eabb96142020. View Article : Google Scholar : PubMed/NCBI

11 

Merighi A and Lossi L: Endoplasmic reticulum stress signaling and neuronal cell death. Int J Mol Sci. 23:151862022. View Article : Google Scholar : PubMed/NCBI

12 

Ma K, Zhang Y, Zhao J, Zhou L and Li M: Endoplasmic reticulum stress: Bridging inflammation and obesity-associated adipose tissue. Front Immunol. 15:13812272024. View Article : Google Scholar : PubMed/NCBI

13 

Carnuta MG, Deleanu M, Barbalata T, Toma L, Raileanu M, Sima AV and Stancu CS: Zingiber officinale extract administration diminishes steroyl-CoA desaturase gene expression and activity in hyperlipidemic hamster liver by reducing the oxidative and endoplasmic reticulum stress. Phytomedicine. 48:62–69. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Wu L, Guo T, Deng R, Liu L and Yu Y: Apigenin ameliorates insulin resistance and lipid accumulation by endoplasmic reticulum stress and SREBP-1c/SREBP-2 pathway in palmitate-induced HepG2 cells and high-fat diet-fed mice. J Pharmacol Exp Ther. 377:146–156. 2021. View Article : Google Scholar : PubMed/NCBI

15 

Paik J, Fierce Y, Drivdahl R, Treuting PM, Seamons A, Brabb T and Maggio-Price L: Effects of murine norovirus infection on a mouse model of diet-induced obesity and insulin resistance. Comp Med. 60:189–195. 2010.PubMed/NCBI

16 

Tian RD, Chen YQ, He YH, Tang YJ, Chen GM, Yang FW, Li Y, Huang WG, Chen H, Liu X and Lin SD: Phosphorylation of eIF2α mitigates endoplasmic reticulum stress and hepatocyte necroptosis in acute liver injury. Ann Hepatol. 19:79–87. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Tang WB, Ling GH, Sun L and Liu FY: Smad anchor for receptor activation (SARA) in TGF-beta signaling. Front Biosci (Elite Ed). 2:857–860. 2010.PubMed/NCBI

19 

Hojs R, Ekart R, Bevc S and Vodošek Hojs N: Chronic kidney disease and obesity. Nephron. 147:660–664. 2023. View Article : Google Scholar : PubMed/NCBI

20 

Hsu CY, Mcculloch CE, Iribarren C, Darbinian J and Go AS: Body mass index and risk for end-stage renal disease. Ann Intern Med. 144:21–28. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Iseki K, Ikemiya Y, Kinjo K, Inoue T, Iseki C and Takishita S: Body mass index and the risk of development of end-stage renal disease in a screened cohort. Kidney Int. 65:1870–1876. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Zhou S, Wu Q, Lin X, Ling X, Miao J, Liu X, Hu C, Zhang Y, Jia N, Hou FF, et al: Cannabinoid receptor type 2 promotes kidney fibrosis through orchestrating β-catenin signaling. Kidney Int. 99:364–381. 2021. View Article : Google Scholar : PubMed/NCBI

23 

Kume S, Uzu T, Araki S, Sugimoto T, Isshiki K, Chin-Kanasaki M, Sakaguchi M, Kubota N, Terauchi Y, Kadowaki T, et al: Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet. J Am Soc Nephrol. 18:2715–2723. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Stone RC, Pastar I, Ojeh N, Chen V, Liu S, Garzon KI and Tomic-Canic M: Epithelial-mesenchymal transition in tissue repair and fibrosis. Cell Tissue Res. 365:495–506. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Deng B, Yang W, Wang D, Cheng L, Bu L, Rao J, Zhang J, Xie J and Zhang B: Peptide DR8 suppresses epithelial-to-mesenchymal transition via the TGF-β/MAPK signaling pathway in renal fibrosis. Life Sci. 261:1184652020. View Article : Google Scholar : PubMed/NCBI

26 

Li YE, Sowers JR, Hetz C and Ren J: Cell death regulation by MAMs: From molecular mechanisms to therapeutic implications in cardiovascular diseases. Cell Death Dis. 13:5042022. View Article : Google Scholar : PubMed/NCBI

27 

Sims SG, Cisney RN, Lipscomb MM and Meares GP: The role of endoplasmic reticulum stress in astrocytes. Glia. 70:5–19. 2022. View Article : Google Scholar : PubMed/NCBI

28 

Engin A: The pathogenesis of obesity-associated adipose tissue inflammation. Adv Exp Med Biol. 960:221–245. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Lumeng CN and Saltiel AR: Inflammatory links between obesity and metabolic disease. J Clin Invest. 121:2111–2117. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Olefsky JM and Glass CK: Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 72:219–246. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Sun K, Kusminski CM and Scherer PE: Adipose tissue remodeling and obesity. J Clin Invest. 121:2094–2101. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Contreras C, González-García I, Seoane-Collazo P, Martínez-Sánchez N, Liñares-Pose L, Rial-Pensado E, Fernø J, Tena-Sempere M, Casals N, Diéguez C, et al: Reduction of hypothalamic endoplasmic reticulum stress activates browning of white fat and ameliorates obesity. Diabetes. 66:87–99. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Xie H, Huang L, Li Y, Zhang H and Liu H: Endoplasmic reticulum stress and renal lesion in mice with combination of high-fat diet and streptozotocin-induced diabetes. Acta Cir Bras. 31:150–155. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Wang L, Wang HL, Liu TT and Lan HY: TGF-beta as a master regulator of diabetic nephropathy. Int J Mol Sci. 22:78812021. View Article : Google Scholar : PubMed/NCBI

35 

Ye Z and Hu Y: TGF-β1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (review). Int J Mol Med. 48:1322021. View Article : Google Scholar : PubMed/NCBI

36 

Ahmed H, Umar MI, Imran S, Javaid F, Syed SK, Riaz R and Hassan W: TGF-β1 signaling can worsen NAFLD with liver fibrosis backdrop. Exp Mol Pathol. 124:1047332022. View Article : Google Scholar : PubMed/NCBI

37 

Peng D, Fu M, Wang M, Wei Y and Wei X: Targeting TGF-β signal transduction for fibrosis and cancer therapy. Mol Cancer. 21:1042022. View Article : Google Scholar : PubMed/NCBI

38 

Gifford CC, Tang J, Costello A, Khakoo NS, Nguyen TQ, Goldschmeding R, Higgins PJ and Samarakoon R: Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities. Clin Sci (Lond). 135:275–303. 2021. View Article : Google Scholar : PubMed/NCBI

39 

Antar SA, Ashour NA, Marawan ME and Al-Karmalawy AA: Fibrosis: Types, effects, markers, mechanisms for disease progression, and its relation with oxidative stress, immunity, and inflammation. Int J Mol Sci. 24:40042023. View Article : Google Scholar : PubMed/NCBI

40 

de Ceuninck van Capelle C, Spit M and Ten Dijke P: Current perspectives on inhibitory SMAD7 in health and disease. Crit Rev Biochem Mol Biol. 55:691–715. 2020. View Article : Google Scholar : PubMed/NCBI

41 

Gu YY, Liu XS, Huang XR, Yu XQ and Lan HY: Diverse role of TGF-β in kidney disease. Front Cell Dev Biol. 8:1232020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Mu Z, Li B, Chen M, Liang C, Gu W and Su J: Endoplasmic reticulum stress induces renal fibrosis in high‑fat diet mice via the TGF‑β/SMAD pathway. Mol Med Rep 30: 235, 2024.
APA
Mu, Z., Li, B., Chen, M., Liang, C., Gu, W., & Su, J. (2024). Endoplasmic reticulum stress induces renal fibrosis in high‑fat diet mice via the TGF‑β/SMAD pathway. Molecular Medicine Reports, 30, 235. https://doi.org/10.3892/mmr.2024.13360
MLA
Mu, Z., Li, B., Chen, M., Liang, C., Gu, W., Su, J."Endoplasmic reticulum stress induces renal fibrosis in high‑fat diet mice via the TGF‑β/SMAD pathway". Molecular Medicine Reports 30.6 (2024): 235.
Chicago
Mu, Z., Li, B., Chen, M., Liang, C., Gu, W., Su, J."Endoplasmic reticulum stress induces renal fibrosis in high‑fat diet mice via the TGF‑β/SMAD pathway". Molecular Medicine Reports 30, no. 6 (2024): 235. https://doi.org/10.3892/mmr.2024.13360
Copy and paste a formatted citation
x
Spandidos Publications style
Mu Z, Li B, Chen M, Liang C, Gu W and Su J: Endoplasmic reticulum stress induces renal fibrosis in high‑fat diet mice via the TGF‑β/SMAD pathway. Mol Med Rep 30: 235, 2024.
APA
Mu, Z., Li, B., Chen, M., Liang, C., Gu, W., & Su, J. (2024). Endoplasmic reticulum stress induces renal fibrosis in high‑fat diet mice via the TGF‑β/SMAD pathway. Molecular Medicine Reports, 30, 235. https://doi.org/10.3892/mmr.2024.13360
MLA
Mu, Z., Li, B., Chen, M., Liang, C., Gu, W., Su, J."Endoplasmic reticulum stress induces renal fibrosis in high‑fat diet mice via the TGF‑β/SMAD pathway". Molecular Medicine Reports 30.6 (2024): 235.
Chicago
Mu, Z., Li, B., Chen, M., Liang, C., Gu, W., Su, J."Endoplasmic reticulum stress induces renal fibrosis in high‑fat diet mice via the TGF‑β/SMAD pathway". Molecular Medicine Reports 30, no. 6 (2024): 235. https://doi.org/10.3892/mmr.2024.13360
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