Open Access

Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review)

  • Authors:
    • Jincun Li
    • Wenyu Ma
    • Zilei Tang
    • Yingming Li
    • Ruiyu Zheng
    • Yuhuan Xie
    • Gang Li
  • View Affiliations

  • Published online on: November 4, 2024     https://doi.org/10.3892/mmr.2024.13381
  • Article Number: 16
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is a common respiratory disease characterized by hypoxemia and respiratory distress. It is associated with high morbidity and mortality. Due to the complex pathogenesis of ALI, the clinical management of patients with ALI/ARDS is challenging, resulting in numerous post‑treatment sequelae and compromising the quality of life of patients. Macrophages, as a class of innate immune cells, play an important role in ALI/ARDS. In recent years, the functions and phenotypes of macrophages have been better understood due to the development of flow cytometry, immunofluorescence, single‑cell sequencing and spatial genomics. However, no macrophage‑targeted drugs for the treatment of ALI/ARDS currently exist in clinical practice. Natural products are important for drug development, and it has been shown that numerous natural compounds from herbal medicine can alleviate ALI/ARDS caused by various factors by modulating macrophage abnormalities. In the present review, the natural products from herbal medicine that can modulate macrophage abnormalities in ALI/ARDS to treat ALI/ARDS are introduced, and their mechanisms of action, discovered in the previous five years (2019‑2024), are presented. This will provide novel ideas and directions for further research, to develop new drugs for the treatment of ALI/ARDS.
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January-2025
Volume 31 Issue 1

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Spandidos Publications style
Li J, Ma W, Tang Z, Li Y, Zheng R, Xie Y and Li G: Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review). Mol Med Rep 31: 16, 2025.
APA
Li, J., Ma, W., Tang, Z., Li, Y., Zheng, R., Xie, Y., & Li, G. (2025). Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review). Molecular Medicine Reports, 31, 16. https://doi.org/10.3892/mmr.2024.13381
MLA
Li, J., Ma, W., Tang, Z., Li, Y., Zheng, R., Xie, Y., Li, G."Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review)". Molecular Medicine Reports 31.1 (2025): 16.
Chicago
Li, J., Ma, W., Tang, Z., Li, Y., Zheng, R., Xie, Y., Li, G."Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review)". Molecular Medicine Reports 31, no. 1 (2025): 16. https://doi.org/10.3892/mmr.2024.13381