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Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review)

  • Authors:
    • Jincun Li
    • Wenyu Ma
    • Zilei Tang
    • Yingming Li
    • Ruiyu Zheng
    • Yuhuan Xie
    • Gang Li
  • View Affiliations / Copyright

    Affiliations: College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, P.R. China, Yunnan Innovation Team of Application Research on Traditional Chinese Medicine Theory of Disease Prevention, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, P.R. China, Yunnan Provincial University Key Laboratory of Aromatic Chinese Herb Research, Basic Medical School, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 16
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    Published online on: November 4, 2024
       https://doi.org/10.3892/mmr.2024.13381
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Abstract

Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is a common respiratory disease characterized by hypoxemia and respiratory distress. It is associated with high morbidity and mortality. Due to the complex pathogenesis of ALI, the clinical management of patients with ALI/ARDS is challenging, resulting in numerous post‑treatment sequelae and compromising the quality of life of patients. Macrophages, as a class of innate immune cells, play an important role in ALI/ARDS. In recent years, the functions and phenotypes of macrophages have been better understood due to the development of flow cytometry, immunofluorescence, single‑cell sequencing and spatial genomics. However, no macrophage‑targeted drugs for the treatment of ALI/ARDS currently exist in clinical practice. Natural products are important for drug development, and it has been shown that numerous natural compounds from herbal medicine can alleviate ALI/ARDS caused by various factors by modulating macrophage abnormalities. In the present review, the natural products from herbal medicine that can modulate macrophage abnormalities in ALI/ARDS to treat ALI/ARDS are introduced, and their mechanisms of action, discovered in the previous five years (2019‑2024), are presented. This will provide novel ideas and directions for further research, to develop new drugs for the treatment of ALI/ARDS.
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View References

1 

Zhu W, Zhang Y and Wang Y: Immunotherapy strategies and prospects for acute lung injury: Focus on immune cells and cytokines. Front Pharmacol. 13:11033092022. View Article : Google Scholar : PubMed/NCBI

2 

Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, et al: Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 315:788–800. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Hsieh PC, Wu YK, Yang MC, Su WL, Kuo CY and Lan CC: Deciphering the role of damage-associated molecular patterns and inflammatory responses in acute lung injury. Life Sci. 305:1207822022. View Article : Google Scholar : PubMed/NCBI

4 

Mokrá D: Acute lung injury-from pathophysiology to treatment. Physiol Res. 69:S353–S366. 2020.PubMed/NCBI

5 

Mokra D, Mikolka P, Kosutova P and Mokry J: Corticosteroids in acute lung injury: The dilemma continues. Int J Mol Sci. 20:47652019. View Article : Google Scholar : PubMed/NCBI

6 

Wang F, Chen M, Ma J, Wang C, Wang J, Xia H, Zhang D and Yao S: Integrating bulk and single-cell sequencing reveals the phenotype-associated cell subpopulations in sepsis-induced acute lung injury. Front Immunol. 13:9817842022. View Article : Google Scholar : PubMed/NCBI

7 

Lendeckel U, Venz S and Wolke C: Macrophages: Shapes and functions. ChemTexts. 8:122022. View Article : Google Scholar : PubMed/NCBI

8 

Johnston LK, Rims CR, Gill SE, McGuire JK and Manicone AM: Pulmonary macrophage subpopulations in the induction and resolution of acute lung injury. Am J Respir Cell Mol Biol. 47:417–426. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Dang W, Tao Y, Xu X, Zhao H, Zou L and Li Y: The role of lung macrophages in acute respiratory distress syndrome. Inflamm Res. 71:1417–1432. 2022. View Article : Google Scholar : PubMed/NCBI

10 

Wang Z and Wang Z: The role of macrophages polarization in sepsis-induced acute lung injury. Front Immunol. 14:12094382023. View Article : Google Scholar : PubMed/NCBI

11 

Cheng P, Li S and Chen H: Macrophages in lung injury, repair, and fibrosis. Cells. 10:4362021. View Article : Google Scholar : PubMed/NCBI

12 

Aribindi K, Lim M, Lakshminrusimha S and Albertson T: Investigational pharmacological agents for the treatment of ARDS. Expert Opin Investig Drugs. 33:243–277. 2024. View Article : Google Scholar : PubMed/NCBI

13 

Vichare R and Janjic JM: Macrophage-targeted nanomedicines for ARDS/ALI: Promise and potential. Inflammation. 45:2124–2141. 2022. View Article : Google Scholar : PubMed/NCBI

14 

Booz GW, Altara R, Eid AH, Wehbe Z, Fares S, Zaraket H, Habeichi NJ and Zouein FA: Macrophage responses associated with COVID-19: A pharmacological perspective. Eur J. 887:1735472020.PubMed/NCBI

15 

Panahi Y, Gorabi AM, Talaei S, Beiraghdar F, Akbarzadeh A, Tarhriz V and Mellatyar H: An overview on the treatments and prevention against COVID-19. Virol J. 20:232023. View Article : Google Scholar : PubMed/NCBI

16 

Matera MG, Rogliani P, Bianco A and Cazzola M: Pharmacological management of adult patients with acute respiratory distress syndrome. Expert Opin Pharmacother. 21:2169–2183. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Lang FM, Lee KMC, Teijaro JR, Becher B and Hamilton JA: GM-CSF-based treatments in COVID-19: Reconciling opposing therapeutic approaches. Nat Rev Immunol. 20:507–514. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Li S, Feng T, Zhang Y, Shi Q, Wang W, Ren J, Shen G, Gu H, Luo C and Li Y: Lianhua Qingwen protects LPS-induced acute lung injury by promoting M2 macrophage infiltration. J Ethnopharmacol. 320:1174672024. View Article : Google Scholar : PubMed/NCBI

19 

Liang X and Liu JX: Role of macrophage polarization in pulmonary diseases and intervention of traditional Chinese medicines. Zhongguo Zhong Yao Za Zhi. 49:334–343. 2024.(In Chinese). PubMed/NCBI

20 

Dong J, Liu W, Liu W, Wen Y, Liu Q, Wang H, Xiang G, Liu Y and Hao H: Acute lung injury: A view from the perspective of necroptosis. Inflamm Res. 73:997–1018. 2024. View Article : Google Scholar : PubMed/NCBI

21 

Qin Y, Li W, Liu J, Wang F, Zhou W, Xiao L, Zhou P, Wu F, Chen X, Xu S, et al: Andrographolide ameliorates sepsis-induced acute lung injury by promoting autophagy in alveolar macrophages via the RAGE/PI3K/AKT/mTOR pathway. Int Immunopharmacol. 139:1127192024. View Article : Google Scholar : PubMed/NCBI

22 

Ma J, Wang J, Wang J, Zhou J, Jiang C, Chen W, Zhang X, Pan J, Zhu J and Chen M: Araloside A alleviates sepsis-induced acute lung injury via PHD2/HIF-1α in macrophages. Phytomedicine. 135:1560892024. View Article : Google Scholar : PubMed/NCBI

23 

Wang WT, Zhang YY, Li ZR, Li JM, Deng HS, Li YY, Yang HY, Lau CC, Yao YJ, Pan HD, et al: Syringic acid attenuates acute lung injury by modulating macrophage polarization in LPS-induced mice. Phytomedicine. 129:1555912024. View Article : Google Scholar : PubMed/NCBI

24 

Helou DG, Quach C, Hurrell BP, Li X, Li M, Akbari A, Shen S, Shafiei-Jahani P and Akbari O: LAIR-1 limits macrophage activation in acute inflammatory lung injury. Mucosal Immunol. 16:788–800. 2023. View Article : Google Scholar : PubMed/NCBI

25 

Short KR, Kroeze EJBV, Fouchier RAM and Kuiken T: Pathogenesis of influenza-induced acute respiratory distress syndrome. Lancet Infect Dis. 14:57–69. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Luo M, Zhao F, Cheng H, Su M and Wang Y: Macrophage polarization: An important role in inflammatory diseases. Front Immunol. 15:13529462024. View Article : Google Scholar : PubMed/NCBI

27 

Liu C, Xiao K and Xie L: Advances in the regulation of macrophage polarization by mesenchymal stem cells and implications for ALI/ARDS treatment. Front Immunol. 13:9281342022. View Article : Google Scholar : PubMed/NCBI

28 

Chen X, Tang J, Shuai W, Meng J, Feng J and Han Z: Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome. Inflamm Res. 69:883–895. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Wang L, Wang D, Zhang T, Ma Y, Tong X and Fan H: The role of immunometabolism in macrophage polarization and its impact on acute lung injury/acute respiratory distress syndrome. Front Immunol. 14:11175482023. View Article : Google Scholar : PubMed/NCBI

30 

Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, et al: Macrophage activation and polarization: Nomenclature and experimental guidelines. Immunity. 41:14–20. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Aggarwal NR, King LS and D'alessio FR: Diverse macrophage populations mediate acute lung inflammation and resolution. Am J Physiol Lung Cell Mol Physiol. 306:L709–L725. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Fukui S, Iwamoto N, Takatani A, Igawa T, Shimizu T, Umeda M, Nishino A, Horai Y, Hirai Y, Koga T, et al: M1 and M2 monocytes in rheumatoid arthritis: A contribution of imbalance of M1/M2 monocytes to osteoclastogenesis. Front Immunol. 8:19582017. View Article : Google Scholar : PubMed/NCBI

33 

Shi C and Pamer EG: Monocyte recruitment during infection and inflammation. Nat Rev Immunol. 11:762–774. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Wang J, Li Q, Qiu Y and Lu H: COVID-19: Imbalanced cell-mediated immune response drives to immunopathology. Emerg Microbes Infect. 11:2393–2404. 2022. View Article : Google Scholar : PubMed/NCBI

35 

Jiao Y, Zhang T, Zhang C, Ji H, Tong X, Xia R, Wang W, Ma Z and Shi X: Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury. Crit Care. 25:3562021. View Article : Google Scholar : PubMed/NCBI

36 

Li Z, Pan H, Yang J, Chen D, Wang Y, Zhang H and Cheng Y: Xuanfei Baidu formula alleviates impaired mitochondrial dynamics and activated NLRP3 inflammasome by repressing NF-κB and MAPK pathways in LPS-induced ALI and inflammation models. Phytomedicine. 108:1545452023. View Article : Google Scholar : PubMed/NCBI

37 

Liang P, Wang L, Yang S, Pan X, Li J, Zhang Y, Liang Y, Li J and Zhou B: 5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages. J Inflamm (Lond). 19:242022. View Article : Google Scholar : PubMed/NCBI

38 

Bu C, Wang R, Wang Y, Lu B, He S and Zhao X: Taraxasterol inhibits hyperactivation of macrophages to alleviate the sepsis-induced inflammatory response of ARDS rats. Cell Biochem Biophys. 80:763–770. 2022. View Article : Google Scholar : PubMed/NCBI

39 

Fang H, Chen J, Luo J, Hu J, Wang D, Lv L and Zhang W: Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization. Exp Anim. 71:481–490. 2022. View Article : Google Scholar : PubMed/NCBI

40 

Wang L and Zhao M: Suppression of NOD-like receptor protein 3 inflammasome activation and macrophage M1 polarization by hederagenin contributes to attenuation of sepsis-induced acute lung injury in rats. Bioengineered. 13:7262–7276. 2022. View Article : Google Scholar : PubMed/NCBI

41 

Zheng L, Su J, Zhang Z, Jiang L, Wei J, Xu X and Lv S: Salidroside regulates inflammatory pathway of alveolar macrophages by influencing the secretion of miRNA-146a exosomes by lung epithelial cells. Sci Rep. 10:207502020. View Article : Google Scholar : PubMed/NCBI

42 

Cai YC, Huang Q, Wei XL, Mei RH, Sa LN and Hu XL: Effects of salidroside on the secretion of inflammatory mediators induced by lipopolysaccharide in the co-culture of rat alveolar macrophages and type II alveolar epithelial cells. Sheng Li Xue Bao. 71:575–580. 2019.(In Chinese). PubMed/NCBI

43 

Feng H, Zhang D, Yin Y, Kang J and Zheng R: Salidroside ameliorated the pulmonary inflammation induced by cigarette smoke via mitigating M1 macrophage polarization by JNK/c-Jun. Phytother Res. 37:4251–4264. 2023. View Article : Google Scholar : PubMed/NCBI

44 

Li X, Xiao C, Yuan J, Chen X, Li Q and Shen F: Rhein-attenuates LPS-induced acute lung injury via targeting NFATc1/Trem2 axis. Inflamm Res. 72:1237–1255. 2023. View Article : Google Scholar : PubMed/NCBI

45 

Wang W, Wang Z, Yang X, Song W, Chen P, Gao Z, Wu J and Huang F: Rhein ameliorates septic lung injury and intervenes in macrophage metabolic reprogramming in the inflammatory state by sirtuin 1. Life Sci. 310:1211152022. View Article : Google Scholar : PubMed/NCBI

46 

Wu X, Yao J, Hu Q, Kang H, Miao Y, Zhu L, Li C, Zhao X, Li J, Wan M and Tang W: Emodin ameliorates acute pancreatitis-associated lung injury through inhibiting the alveolar macrophages pyroptosis. Front Pharmacol. 13:8730532022. View Article : Google Scholar : PubMed/NCBI

47 

Hu Q, Yao J, Wu X, Li J, Li G, Tang W, Liu J and Wan M: Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation. Acta Pharm Sin B. 12:3986–4003. 2022. View Article : Google Scholar : PubMed/NCBI

48 

Wang S, Liu J, Dong J, Fan Z, Wang F, Wu P, Li X, Kou R and Chen F: Allyl methyl trisulfide protected against LPS-induced acute lung injury in mice via inhibition of the NF-κB and MAPK pathways. Front Pharmacol. 13:9198982022. View Article : Google Scholar : PubMed/NCBI

49 

Zhuo Y, Li D, Cui L, Li C, Zhang S, Zhang Q, Zhang L, Wang X and Yang L: Treatment with 3,4-dihydroxyphenylethyl alcohol glycoside ameliorates sepsis-induced ALI in mice by reducing inflammation and regulating M1 polarization. Biomed Pharmacother. 116:1090122019. View Article : Google Scholar : PubMed/NCBI

50 

Mantovani A, Biswas SK, Galdiero MR, Sica A and Locati M: Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol. 229:176–185. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Yadav S, Priya A, Borade DR and Agrawal-Rajput R: Macrophage subsets and their role: Co-relation with colony-stimulating factor-1 receptor and clinical relevance. Immunol Res. 71:130–152. 2022. View Article : Google Scholar : PubMed/NCBI

52 

Shapouri-Moghaddam A, Mohammadian S, Vazini H, Taghadosi M, Esmaeili SA, Mardani F, Seifi B, Mohammadi A, Afshari JT and Sahebkar A: Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 233:6425–6440. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Liang L, Xu W, Shen A, Fu X, Cen H, Wang S, Lin Z, Zhang L, Lin F and Zhang X: Inhibition of YAP1 activity ameliorates acute lung injury through promotion of M2 macrophage polarization. MedComm (2020). 4:e2932023. View Article : Google Scholar : PubMed/NCBI

54 

Jiang R, Xu J, Zhang Y, Zhu X, Liu J and Tan Y: Ligustrazine alleviate acute lung injury through suppressing pyroptosis and apoptosis of alveolar macrophages. Front Pharmacol. 12:6805122021. View Article : Google Scholar : PubMed/NCBI

55 

Zhou W, Hong J, Liu T, Li M, Jin H and Wang X: Polygonatum polysaccharide regulates macrophage polarization and improves LPS-Induced acute lung injury through TLR4-MAPK/NF-κB pathway. Can Respir J. 2022:1–11. 2022. View Article : Google Scholar

56 

Liu JH, Cao L, Zhang CH, Li C, Zhang ZH and Wu Q: Dihydroquercetin attenuates lipopolysaccharide-induced acute lung injury through modulating FOXO3-mediated NF-κB signaling via miR-132-3p. Pulm Pharmacol Ther. 64:1019342020. View Article : Google Scholar : PubMed/NCBI

57 

Li C, Liu J, Zhang C, Cao L, Zou F and Zhang Z: Dihydroquercetin (DHQ) ameliorates LPS-induced acute lung injury by regulating macrophage M2 polarization through IRF4/miR-132-3p/FBXW7 axis. Pulm Pharmacol Ther. 83:1022492023. View Article : Google Scholar : PubMed/NCBI

58 

Zhang Y, Song D, Peng Z, Wang R, Li K, Ren H, Sun X, Du N and Tang SC: Anisodamine enhances macrophage M2 polarization through suppressing G9a-mediated interferon regulatory factor 4 silencing to alleviate lipopolysaccharide-induced acute lung injury. J Pharmacol Exp Ther. 381:247–256. 2022. View Article : Google Scholar : PubMed/NCBI

59 

Wang Y, Wang X, Zhang L and Zhang R: Alleviation of acute lung injury in rats with sepsis by resveratrol via the phosphatidylinositol 3-Kinase/Nuclear factor-erythroid 2 related factor 2/Heme oxygenase-1 (PI3K/Nrf2/HO-1) pathway. Med Sci Monit. 24:3604–3611. 2018. View Article : Google Scholar : PubMed/NCBI

60 

Zhu X, Liu Q, Wang M, Liang M, Yang X, Xu X, Zou H and Qiu J: Activation of Sirt1 by resveratrol inhibits TNF-α induced inflammation in fibroblasts. PLoS One. 6:e270812011. View Article : Google Scholar : PubMed/NCBI

61 

Misawa T, Saitoh T, Kozaki T, Park S, Takahama M and Akira S: Resveratrol inhibits the acetylated α-tubulin-mediated assembly of the NLRP3-inflammasome. Int Immunol. 27:425–434. 2015. View Article : Google Scholar : PubMed/NCBI

62 

Hu L, Chen Z, Li L, Jiang Z and Zhu L: Resveratrol decreases CD45+CD206− subtype macrophages in LPS-induced murine acute lung injury by SOCS3 signalling pathway. J Cell Mol Med. 23:8101–8113. 2019. View Article : Google Scholar : PubMed/NCBI

63 

Li QR, Tan SR, Yang L, He W, Chen L, Shen FX, Wang Z and Wang HF: Mechanism of chlorogenic acid in alveolar macrophage polarization in Klebsiella pneumoniae-induced pneumonia. J Leukoc Biol. 112:9–21. 2022. View Article : Google Scholar : PubMed/NCBI

64 

Pan MH, Lai CS, Wang YJ and Ho CT: Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice. Biochem Pharmacol. 72:1293–1303. 2006. View Article : Google Scholar : PubMed/NCBI

65 

Chang B, Wang Z, Cheng H, Xu T, Chen J, Wu W, Li Y and Zhang Y: Acacetin protects against sepsis-induced acute lung injury by facilitating M2 macrophage polarization via TRAF6/NF-κB/COX2 axis. Innate Immun. 30:11–20. 2023. View Article : Google Scholar : PubMed/NCBI

66 

Qiao X, Wang H, He Y, Song D, Altawil A, Wang Q and Yin Y: Grape seed proanthocyanidin ameliorates LPS-induced acute lung injury by modulating M2a macrophage polarization via the TREM2/PI3K/Akt pathway. Inflammation. 46:2147–2164. 2023. View Article : Google Scholar : PubMed/NCBI

67 

Wen H, Lu D, Chen H, Zhu Y, Xie Q, Zhang Z and Wu Z: Tetrahydropalmatine induces the polarization of M1 macrophages to M2 to relieve limb ischemia-reperfusion-induced lung injury via inhibiting the TLR4/NF-κB/NLRP3 signaling pathway. Drug Dev Res. 83:1362–1372. 2022. View Article : Google Scholar : PubMed/NCBI

68 

Wu YX, Jiang FJ, Liu G, Wang YY, Gao ZQ, Jin SH, Nie YJ, Chen D, Chen JL and Pang QF: Dehydrocostus lactone attenuates methicillin-resistant staphylococcus aureus-induced inflammation and acute lung injury via modulating macrophage polarization. Int J Mol Sci. 22:97542021. View Article : Google Scholar : PubMed/NCBI

69 

Xie K, Chai YS, Lin SH, Xu F and Wang CJ: Luteolin regulates the differentiation of regulatory T cells and activates IL-10-dependent macrophage polarization against acute lung injury. J Immunol Res. 2021:1–12. 2021. View Article : Google Scholar

70 

Yang L, Zhang YM, Guo MN, Zhang H, Zhu XY, Xu C and Liu YJ: Matrine attenuates lung injury by modulating macrophage polarization and suppressing apoptosis. J Surg Res. 281:264–274. 2023. View Article : Google Scholar : PubMed/NCBI

71 

Ye Z, Wang P, Feng G, Wang Q, Liu C, Lu J, Chen J and Liu P: Cryptotanshinone attenuates LPS-induced acute lung injury by regulating metabolic reprogramming of macrophage. Front Med (Lausanne). 9:10754652022. View Article : Google Scholar : PubMed/NCBI

72 

Zhang J, Wang C, Wang H, Li X, Xu J and Yu K: Loganin alleviates sepsis-induced acute lung injury by regulating macrophage polarization and inhibiting NLRP3 inflammasome activation. Int Immunopharmacol. 95:1075292021. View Article : Google Scholar : PubMed/NCBI

73 

Zhao JY, Pu J, Fan J, Feng XY, Xu JW, Zhang R and Shang Y: Tanshinone IIA prevents acute lung injury by regulating macrophage polarization. J Integr Med. 20:274–280. 2022. View Article : Google Scholar : PubMed/NCBI

74 

Ying ZH, Li HM, Yu WY and Yu CH: Iridin prevented against lipopolysaccharide-induced inflammatory responses of macrophages via inactivation of PKM2-mediated glycolytic pathways. J Inflamm Res. 14:341–354. 2021. View Article : Google Scholar : PubMed/NCBI

75 

Zhao L, Zhang M, Liu YW, Tan Y, Yin J, Chen Y, Chen D and Ni B: Sinomenine alleviates lipopolysaccharide-induced acute lung injury via a PPARβ/δ-dependent mechanism. Eur J Pharmacol. 953:1758382023. View Article : Google Scholar : PubMed/NCBI

76 

Gao WJ, Liu JX, Xie Y, Luo P, Liu ZQ, Liu L and Zhou H: Suppression of macrophage migration by down-regulating Src/FAK/P130Cas activation contributed to the anti-inflammatory activity of sinomenine. Pharmacol Res. 167:1055132021. View Article : Google Scholar : PubMed/NCBI

77 

Yi L, Luo JF, Xie BB, Liu JX, Wang JY, Liu L, Wang PX, Zhou H and Dong Y: α7 nicotinic acetylcholine receptor is a novel mediator of sinomenine anti-inflammation effect in macrophages stimulated by lipopolysaccharide. Shock. 44:188–195. 2015. View Article : Google Scholar : PubMed/NCBI

78 

Zhi YK, Li J, Yi L, Zhu RL, Luo JF, Shi QP, Bai SS, Li YW, Du Q, Cai JZ, et al: Sinomenine inhibits macrophage M1 polarization by downregulating α7nAChR via a feedback pathway of α7nAChR/ERK/Egr-1. Phytomedicine. 100:1540502022. View Article : Google Scholar : PubMed/NCBI

79 

Guo R, Wang H and Cui N: Autophagy regulation on pyroptosis: Mechanism and medical implication in sepsis. Mediators Inflamm. 2021:99250592021. View Article : Google Scholar : PubMed/NCBI

80 

Shi J, Gao W and Shao F: Pyroptosis: Gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci. 42:245–254. 2017. View Article : Google Scholar : PubMed/NCBI

81 

Wei T, Zhang C and Song Y: Molecular mechanisms and roles of pyroptosis in acute lung injury. Chin Med J (Engl). 135:2417–2426. 2022. View Article : Google Scholar : PubMed/NCBI

82 

Tang Y, Yu Y, Li R, Tao Z, Zhang L, Wang X, Qi X, Li Y, Meng T, Qu H, et al: Phenylalanine promotes alveolar macrophage pyroptosis via the activation of CaSR in ARDS. Front Immunol. 14:11141292023. View Article : Google Scholar : PubMed/NCBI

83 

Wu DD, Pan PH, Liu B, Su XL, Zhang LM, Tan HY, Cao Z, Zhou ZR, Li HT, Li HS, et al: Inhibition of alveolar macrophage pyroptosis reduces lipopolysaccharide-induced acute lung injury in mice. Chin Med J (Engl). 128:2638–2645. 2015. View Article : Google Scholar : PubMed/NCBI

84 

Liu Y, Zhang Y, Feng Q, Liu Q, Xie J, Li H, Yang F, Liu X, Gao W, Bai X, et al: GPA peptide attenuates sepsis-induced acute lung injury in mice via inhibiting oxidative stress and pyroptosis of alveolar macrophage. Oxid Med Cell Longev. 2021:1–12. 2021. View Article : Google Scholar : PubMed/NCBI

85 

Li H, Li Y, Song C, Hu Y, Dai M, Liu B and Pan P: Neutrophil extracellular traps augmented alveolar macrophage pyroptosis via AIM2 inflammasome activation in LPS-induced ALI/ARDS. J Inflamm Res. 14:4839–4858. 2021. View Article : Google Scholar : PubMed/NCBI

86 

Hsu CG, Chávez CL, Zhang C, Sowden M, Yan C and Berk BC: The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis. Cell Death Differ. 29:1790–1803. 2022. View Article : Google Scholar : PubMed/NCBI

87 

Liu Y, Zhang Y, You G, Zheng D, He Z, Guo W, Antonina K, Shukhrat Z, Ding B, Zan J and Zhang Z: Tangeretin attenuates acute lung injury in septic mice by inhibiting ROS-mediated NLRP3 inflammasome activation via regulating PLK1/AMPK/DRP1 signaling axis. Inflamm Res. 73:47–63. 2024. View Article : Google Scholar : PubMed/NCBI

88 

Wang X, Wu FP, Huang YR, Li HD, Cao XY, You Y, Meng ZF, Sun KY and Shen XY: Matrine suppresses NLRP3 inflammasome activation via regulating PTPN2/JNK/SREBP2 pathway in sepsis. Phytomedicine. 109:1545742023. View Article : Google Scholar : PubMed/NCBI

89 

Liu Y, Yang H, Zhu F, Ouyang Y and Pan P: Inhibition of STAT3 phosphorylation by colchicine regulates NLRP3 activation to alleviate sepsis-induced acute lung injury. Inflammopharmacology. 31:2007–2021. 2023. View Article : Google Scholar : PubMed/NCBI

90 

Yuan Y, Liao Q, Xue M, Shi Y, Rong L, Song Z, Tong Z, Zheng W, Zhu Q, Cui X and Tao Z: Shufeng jiedu capsules alleviate lipopolysaccharide-induced acute lung inflammatory injury via activation of GPR18 by verbenalin. Cell Physiol Biochem. 50:629–639. 2018. View Article : Google Scholar : PubMed/NCBI

91 

Yang L, Liu T, Zhuo Y, Li D, Li D, Liu J, Gao H, Zhang L, Lin J and Wang X: Verbenalin alleviates acute lung injury induced by sepsis and IgG immune complex through GPR18 receptor. Cell Signal. 109:1107682023. View Article : Google Scholar : PubMed/NCBI

92 

Chen LL, Song C, Zhang Y, Li Y, Zhao YH, Lin FY, Han DD, Dai MH, Li W and Pan PH: Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation. Eur J Pharmacol. 936:1753522022. View Article : Google Scholar : PubMed/NCBI

93 

Zhong C, Yang J, Deng K, Lang X, Zhang J, Li M, Qiu L, Zhong G and Yu J: Tiliroside attenuates NLRP3 inflammasome activation in macrophages and protects against acute lung injury in mice. Molecules. 28:75272023. View Article : Google Scholar : PubMed/NCBI

94 

Xu HW, Li WF, Hong SS, Shao JJ, Chen JH, Chattipakorn N, Wu D, Luo W and Liang G: Tabersonine, a natural NLRP3 inhibitor, suppresses inflammasome activation in macrophages and attenuate NLRP3-driven diseases in mice. Acta Pharmacol Sin. 44:1252–1261. 2023. View Article : Google Scholar : PubMed/NCBI

95 

Shao JJ, Li WF, Sun JF, Zhuang ZS, Min JL, Long XH, Wu GJ, Xu HW and Liang G: Britannin as a novel NLRP3 inhibitor, suppresses inflammasome activation in macrophages and alleviates NLRP3-related diseases in mice. Acta Pharmacol Sin. 45:803–814. 2024. View Article : Google Scholar : PubMed/NCBI

96 

Yang F, Ye XJ, Chen MY, Li HC, Wang YF, Zhong MY, Zhong CS, Zeng B, Xu LH, He XH and Ouyang DY: Inhibition of NLRP3 inflammasome activation and pyroptosis in macrophages by taraxasterol is associated with its regulation on mTOR signaling. Front Immunol. 12:6326062021. View Article : Google Scholar : PubMed/NCBI

97 

Jang WY, Kim MY and Cho JY: Antioxidant, anti-inflammatory, anti-menopausal, and anti-cancer effects of lignans and their metabolites. Int J Mol Sci. 23:154822022. View Article : Google Scholar : PubMed/NCBI

98 

Zhang S, Yang L, Hu D, He S, Cui L, Zhao J, Zhuo Y, Zhang L and Wang X: Syringaresinol alleviates IgG immune complex induced acute lung injury via activating PPARγ and suppressing pyroptosis. Int Immunopharmacol 124(Pt B). 1110712023. View Article : Google Scholar : PubMed/NCBI

99 

Li W, Xu H, Shao J, Chen J, Lin Y, Zheng Z, Wang Y, Luo W and Liang G: Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3-driven inflammatory diseases in mice. Br J Pharmacol. 180:1634–1647. 2023. View Article : Google Scholar : PubMed/NCBI

100 

Liu C, Zhou Y, Tu Q, Yao L, Li J and Yang Z: Alpha-linolenic acid pretreatment alleviates NETs-induced alveolar macrophage pyroptosis by inhibiting pyrin inflammasome activation in a mouse model of sepsis-induced ALI/ARDS. Front Immunol. 14:11466122023. View Article : Google Scholar : PubMed/NCBI

101 

Weavers H, Evans IR, Martin P and Wood W: Corpse engulfment generates a molecular memory that primes the macrophage inflammatory response. Cell. 165:1658–1671. 2016. View Article : Google Scholar : PubMed/NCBI

102 

Sun D, Zhang G, Xie M, Wang Y, Liang X, Tu M, Su Z and Zeng R: Softness enhanced macrophage-mediated therapy of inhaled apoptotic-cell-inspired nanosystems for acute lung injury. J Nanobiotechnology. 21:1722023. View Article : Google Scholar : PubMed/NCBI

103 

Leventis PA and Grinstein S: The distribution and function of phosphatidylserine in cellular membranes. Ann Rev Biophysics. 39:407–427. 2010. View Article : Google Scholar : PubMed/NCBI

104 

Banerjee S, Friggeri A, Liu G and Abraham E: The C-terminal acidic tail is responsible for the inhibitory effects of HMGB1 on efferocytosis. J Leukoc Biol. 88:973–979. 2010. View Article : Google Scholar : PubMed/NCBI

105 

Mahida RY, Scott A, Parekh D, Lugg ST, Hardy RS, Lavery GG, Matthay MA, Naidu B, Perkins GD and Thickett DR: Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis. Eur Respir J. 58:21008292021. View Article : Google Scholar : PubMed/NCBI

106 

Mahida RY, Lax S, Bassford CR, Scott A, Parekh D, Hardy RS, Naidu B, Matthay MA, Stewart PM, Cooper MC, et al: Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS. Front Immunol. 14:11598312023. View Article : Google Scholar : PubMed/NCBI

107 

Martín-Vicente P, López-Martínez C and Albaiceta GM: The last-minute redemption of inflammatory cells in lung repair. Eur Respir J. 59:21030002022. View Article : Google Scholar : PubMed/NCBI

108 

Nepal S, Tiruppathi C, Tsukasaki Y, Farahany J, Mittal M, Rehman J, Prockop DJ and Malik AB: STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation. Proc Natl Acad Sci USA. 116:16513–16518. 2019. View Article : Google Scholar : PubMed/NCBI

109 

Jiang T, Xia Y, Wang W, Zhao J, Liu W, Liu S, Shi S, Li B, He X and Jin Y: Apoptotic bodies inhibit inflammation by PDL1-PD1-mediated macrophage metabolic reprogramming. Cell Prolif. 57:e135312023. View Article : Google Scholar : PubMed/NCBI

110 

Wang Y, Zhang W, Xu Y, Wu D, Gao Z, Zhou J, Qian H, He B and Wang G: Extracellular HMGB1 impairs macrophage-mediated efferocytosis by suppressing the Rab43-controlled cell surface transport of CD91. Front Immunol. 13:7676302022. View Article : Google Scholar : PubMed/NCBI

111 

Aderem A and Underhill DM: Mechanisms of phagocytosis in macrophages. Annu Rev Immunol. 17:593–623. 1999. View Article : Google Scholar : PubMed/NCBI

112 

He F, Gao F, Cai N, Jiang M and Wu C: Chlorogenic acid enhances alveolar macrophages phagocytosis in acute respiratory distress syndrome by activating G protein-coupled receptor 37 (GPR 37). Phytomedicine. 107:1544742022. View Article : Google Scholar : PubMed/NCBI

113 

Aman Y, Schmauck-Medina T, Hansen M, Morimoto RI, Simon AK, Bjedov I, Palikaras K, Simonsen A, Johansen T, Tavernarakis N, et al: Autophagy in healthy aging and disease. Nat Aging. 1:634–650. 2021. View Article : Google Scholar : PubMed/NCBI

114 

Saha S, Panigrahi DP, Patil S and Bhutia SK: Autophagy in health and disease: A comprehensive review. Biomed Pharmacother. 104:485–495. 2018. View Article : Google Scholar : PubMed/NCBI

115 

Wang K, Chen Y, Zhang P, Lin P, Xie N and Wu M: Protective features of autophagy in pulmonary infection and inflammatory diseases. Cells. 8:1232019. View Article : Google Scholar : PubMed/NCBI

116 

Murray PJ: On macrophage diversity and inflammatory metabolic timers. Nat Rev Immunol. 20:89–90. 2020. View Article : Google Scholar : PubMed/NCBI

117 

Liu C, Xiao K and Xie L: Progress in preclinical studies of macrophage autophagy in the regulation of ALI/ARDS. Front Immunol. 13:9227022022. View Article : Google Scholar : PubMed/NCBI

118 

Huang M, Yu Y, Tang X, Dong R, Li X, Li F, Jin Y, Gong S, Wang X, Zeng Z, et al: 3-Hydroxybutyrate ameliorates sepsis-associated acute lung injury by promoting autophagy through the activation of GPR109α in macrophages. Biochem Pharmacol. 213:1156322023. View Article : Google Scholar : PubMed/NCBI

119 

Quach C, Helou DG, Li M, Hurrell BP, Howard E, Shafiei-Jahani P, Soroosh P, Ou JJ, Razani B, Rehan V and Akbari O: Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome. Cell Rep. 42:1129902023. View Article : Google Scholar : PubMed/NCBI

120 

Qiu P, Liu Y, Chen K, Dong Y, Liu S and Zhang J: Hydrogen-rich saline regulates the polarization and apoptosis of alveolar macrophages and attenuates lung injury via suppression of autophagy in septic rats. Ann Transl Med. 9:9742021. View Article : Google Scholar : PubMed/NCBI

121 

Liang J, Liu J, Tang Y, Peng Q, Zhang L, Ma X, Xu N, Wei J and Han H: Sophoridine inhibits endotoxin-induced acute lung injury by enhancing autophagy of macrophage and reducing inflammation. J Leukoc Biol. 112:115–125. 2022. View Article : Google Scholar : PubMed/NCBI

122 

Wen H, Zhang H, Wang W and Li Y: Tetrahydropalmatine protects against acute lung injury induced by limb ischemia/reperfusion through restoring PI3K/AKT/mTOR-mediated autophagy in rats. Pulm Pharmacol Ther. 64:1019472020. View Article : Google Scholar : PubMed/NCBI

123 

Tang D, Cao F, Yan C, Fang K, Ma J, Gao L, Sun B and Wang G: Extracellular Vesicle/Macrophage axis: Potential targets for inflammatory disease intervention. Front Immunol. 13:7054722022. View Article : Google Scholar : PubMed/NCBI

124 

Viola A, Munari F, Sánchez-Rodríguez R, Scolaro T and Castegna A: The metabolic signature of macrophage responses. Front Immunol. 10:14622019. View Article : Google Scholar : PubMed/NCBI

125 

Feng Z, Jing Z, Li Q, Chu L, Jiang Y, Zhang X, Yan L, Liu Y, Jiang J, Xu P, et al: Exosomal STIMATE derived from type II alveolar epithelial cells controls metabolic reprogramming of tissue-resident alveolar macrophages. Theranostics. 13:991–1009. 2023. View Article : Google Scholar : PubMed/NCBI

126 

Zhong WJ, Liu T, Yang HH, Duan JX, Yang JT, Guan XX, Xiong JB, Zhang YF, Zhang CY, Zhou Y and Guan CX: TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury. Int J Biol Sci. 19:242–257. 2023. View Article : Google Scholar : PubMed/NCBI

127 

Breda CN, Davanzo GG, Basso PJ, Câmara NO and Moraes-Vieira PMM: Mitochondria as central hub of the immune system. Redox Biol. 26:1012552019. View Article : Google Scholar : PubMed/NCBI

128 

Rosales C and Uribe-Querol E: Phagocytosis: A fundamental process in immunity. Biomed Res Int. 2017:90428512017. View Article : Google Scholar : PubMed/NCBI

129 

Meidaninikjeh S, Sabouni N, Marzouni HZ, Bengar S, Khalili A and Jafari R: Monocytes and macrophages in COVID-19: Friends and foes. Life Sci. 269:1190102021. View Article : Google Scholar : PubMed/NCBI

130 

Wang Z, Li S and Huang B: Alveolar macrophages: Achilles' heel of SARS-CoV-2 infection. Signal Transduct Target Ther. 7:2422022. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li J, Ma W, Tang Z, Li Y, Zheng R, Xie Y and Li G: Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review). Mol Med Rep 31: 16, 2025.
APA
Li, J., Ma, W., Tang, Z., Li, Y., Zheng, R., Xie, Y., & Li, G. (2025). Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review). Molecular Medicine Reports, 31, 16. https://doi.org/10.3892/mmr.2024.13381
MLA
Li, J., Ma, W., Tang, Z., Li, Y., Zheng, R., Xie, Y., Li, G."Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review)". Molecular Medicine Reports 31.1 (2025): 16.
Chicago
Li, J., Ma, W., Tang, Z., Li, Y., Zheng, R., Xie, Y., Li, G."Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review)". Molecular Medicine Reports 31, no. 1 (2025): 16. https://doi.org/10.3892/mmr.2024.13381
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Ma W, Tang Z, Li Y, Zheng R, Xie Y and Li G: Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review). Mol Med Rep 31: 16, 2025.
APA
Li, J., Ma, W., Tang, Z., Li, Y., Zheng, R., Xie, Y., & Li, G. (2025). Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review). Molecular Medicine Reports, 31, 16. https://doi.org/10.3892/mmr.2024.13381
MLA
Li, J., Ma, W., Tang, Z., Li, Y., Zheng, R., Xie, Y., Li, G."Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review)". Molecular Medicine Reports 31.1 (2025): 16.
Chicago
Li, J., Ma, W., Tang, Z., Li, Y., Zheng, R., Xie, Y., Li, G."Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review)". Molecular Medicine Reports 31, no. 1 (2025): 16. https://doi.org/10.3892/mmr.2024.13381
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