Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
January-2025 Volume 31 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2025 Volume 31 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

Long non‑coding RNA SNHG1 promotes autophagy in vascular smooth muscle cells induced by facilitating CLEC7A 

  • Authors:
    • Hao-Wei Deng
    • Wen-Bin Teng
    • Shao-Dan Zhou
    • Zi-Ming Ye
    • Zi-Mei Dong
    • Rui-Ting Hu
    • Chao Qin
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Neurology, Minzu Hospital of Guangxi Medical University, Nanning, Guangxi 530001, P.R. China
    Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 20
    |
    Published online on: November 5, 2024
       https://doi.org/10.3892/mmr.2024.13385
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Long non‑coding RNAs serve a crucial role in autophagy of vascular smooth muscle cells (VSMCs). The present study aimed to investigate the effect of small nucleolar RNA host gene 1 (SNHG1) on autophagy in VSMCs and the associated underlying mechanisms. Rapamycin was used to induce autophagy in VSMCs and the effects of SNHG1 on the proliferation and migration of VSMCs and the change in phenotype were tested following overexpression and silencing of SNHG1. The target gene of SNHG1 was predicted and validated. SNHG1‑regulated autophagy of VSMCs via C‑type lectin domain family 7 member A (CLEC7A) was determined by combined silencing of SNHG1 and overexpression of CLEC7A. Rapamycin‑induced autophagy in VSMCs changed the cell phenotype from contractile to synthetic, with decreased expression of α‑smooth muscle actin and smooth muscle protein 22a and increased expression of osteopontin. Overexpression of SNHG1 caused the same change in phenotype while the opposite change was observed following SNHG1 silencing. Overexpression of SNHG1 promoted the proliferation and migration of VSMCs. CLEC7A was identified as a target gene of SNHG1 and a direct binding relationship between them was confirmed by RNA immunoprecipitation and RNA pull‑down assays. Overexpression of SNHG1 increased the expression of CLEC7A. The expression of both SNHG1 and CLEC7A was increased during autophagy of VSMCs. Overexpression of SNHG1 promoted autophagy of VSMCs and silencing of CLEC7A reduced this effect of SNHG1. In conclusion, SNHG1 and CLEC7A were increased in VSMCs following autophagy. SNHG1 promotes the conversion of VSMCs from a contractile phenotype to a synthetic phenotype by facilitating CLEC7A expression.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Penn DL, Witte SR, Komotar RJ and Connolly E Jr: The role of vascular remodeling and inflammation in the pathogenesis of intracranial aneurysms. J Clin Neurosci. 21:28–32. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Liao XH, Wang N, Zhao DW, Zheng DL, Zheng L, Xing WJ, Ma WJ, Bao LY, Dong J and Zhang TC: STAT3 protein regulates vascular smooth muscle cell phenotypic switch by interaction with myocardin. J Biol Chem. 290:19641–19652. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Cao T, Zhang L, Yao LL, Zheng F, Wang L, Yang JY, Guo LY, Li XY, Yan YW, Pan YM, et al: S100B promotes injury-induced vascular remodeling through modulating smooth muscle phenotype. Biochim Biophys Acta Mol Basis Dis. 1863:2772–2782. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Zhu LH, Huang L, Zhang X, Zhang P, Zhang SM, Guan H, Zhang Y, Zhu XY, Tian S, Deng K and Li H: Mindin regulates vascular smooth muscle cell phenotype and prevents neointima formation. Clin Sci (Lond). 129:129–145. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Bennett MR, Sinha S and Owens GK: Vascular smooth muscle cells in atherosclerosis. Circ Res. 118:692–702. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Zhen Y and Stenmark H: Autophagosome biogenesis. Cells. 12:6682023. View Article : Google Scholar : PubMed/NCBI

7 

Tai S, Hu XQ, Peng DQ, Zhou SH and Zheng XL: The roles of autophagy in vascular smooth muscle cells. Int J Cardiol. 211:1–6. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Grootaert MOJ, Moulis M, Roth L, Martinet W, Vindis C, Bennett MR and De Meyer GRY: Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis. Cardiovasc Res. 114:622–634. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Cheng CI, Lee YH, Chen PH, Lin YC, Chou MH and Kao YH: Free fatty acids induce autophagy and LOX-1 upregulation in cultured aortic vascular smooth muscle cells. J Cell Biochem. 118:1249–1261. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Li T, Tan X, Zhu S, Zhong W, Huang B, Sun J, Li F and Wang Y: SPARC induces phenotypic modulation of human brain vascular smooth muscle cells via AMPK/mTOR-mediated autophagy. Neurosci Lett. 712:1344852019. View Article : Google Scholar : PubMed/NCBI

11 

Sabeena S: Role of noncoding RNAs with emphasis on long noncoding RNAs as cervical cancer biomarkers. J Med Virol. 95:e285252023. View Article : Google Scholar : PubMed/NCBI

12 

Wang PS, Wang Z and Yang C: Dysregulations of long non-coding RNAs-The emerging ‘lnc’ in environmental carcinogenesis. Semin Cancer Biol. 76:163–172. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Meybodi SM, Soleimani N, Yari A, Javadifar A, Tollabi M, Karimi B, Meybodi ME, Seyedhossaini S, Milan PB and Firoozabadi AD: Circulatory long noncoding RNAs (circulatory-LNC-RNAs) as novel biomarkers and therapeutic targets in cardiovascular diseases: Implications for cardiovascular diseases complications. Int J Biol Macromol. 225:1049–1071. 2023. View Article : Google Scholar : PubMed/NCBI

14 

Cui Y, Zhang F, Zhu C, Geng L, Tian T and Liu H: Upregulated lncRNA SNHG1 contributes to progression of non-small cell lung cancer through inhibition of miR-101-3p and activation of Wnt/β-catenin signaling pathway. Oncotarget. 8:17785–17794. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Li J, Zhang Z, Xiong L, Guo C, Jiang T, Zeng L, Li G and Wang J: SNHG1 lncRNA negatively regulates miR-199a-3p to enhance CDK7 expression and promote cell proliferation in prostate cancer. Biochem Biophys Res Commun. 487:146–152. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Lu Y, Xi J, Zhang Y, Chen W, Zhang F, Li C and Wang Z: SNHG1 inhibits ox-LDL-induced inflammatory response and apoptosis of HUVECs via up-regulating GNAI2 and PCBP1. Front Pharmacol. 11:7032020. View Article : Google Scholar : PubMed/NCBI

17 

Li W, Dong X, He C, Tan G, Li Z, Zhai B, Feng J, Jiang X, Liu C, Jiang H and Sun X: Correction to: LncRNA SNHG1 contributes to sorafenib resistance by activating the Akt pathway and is positively regulated by miR-21 in hepatocellular carcinoma cells. J Exp Clin Cancer Res. 40:3772021. View Article : Google Scholar : PubMed/NCBI

18 

Xu J, Yang R, Hua X, Huang M, Tian Z, Li J, Lam HY, Jiang G, Cohen M and Huang C: lncRNA SNHG1 promotes basal bladder cancer invasion via interaction with PP2A catalytic subunit and induction of autophagy. Mol Ther Nucleic Acids. 21:354–366. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Zhao J, Geng L, Chen Y and Wu C: SNHG1 promotes MPP+-induced cytotoxicity by regulating PTEN/AKT/mTOR signaling pathway in SH-SY5Y cells via sponging miR-153-3p. Biol Res. 53:12020. View Article : Google Scholar : PubMed/NCBI

20 

Wu Y, Zhu B, Yan Y, Bai S, Kang H, Zhang J, Ma W, Gao Y, Hui B, Li R, et al: Long non-coding RNA SNHG1 stimulates ovarian cancer progression by modulating expression of miR-454 and ZEB1. Mol Oncol. 15:1584–1596. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Rizzetto L, De Filippo C, Rivero D, Riccadonna S, Beltrame L and Cavalieri D: Systems biology of host-mycobiota interactions: Dissecting Dectin-1 and Dectin-2 signalling in immune cells with DC-ATLAS. Immunobiology. 218:1428–1437. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Wang Y, Spatz M, Da Costa G, Michaudel C, Lapiere A, Danne C, Agus A, Michel ML, Netea MG, Langella P, et al: Deletion of both Dectin-1 and Dectin-2 affects the bacterial but not fungal gut microbiota and susceptibility to colitis in mice. Microbiome. 10:912022. View Article : Google Scholar : PubMed/NCBI

23 

Al Madhoun A, Kochumon S, Al-Rashed F, Sindhu S, Thomas R, Miranda L, Al-Mulla F and Ahmad R: Dectin-1 as a potential inflammatory biomarker for metabolic inflammation in adipose tissue of individuals with obesity. Cells. 11:28792022. View Article : Google Scholar : PubMed/NCBI

24 

Choraghe RP, Kolodziej T, Buser A, Rajfur Z and Neumann AK: RHOA-mediated mechanical force generation through Dectin-1. J Cell Sci. 133:jcs2361662020. View Article : Google Scholar : PubMed/NCBI

25 

Rouchaud A, Johnson C, Thielen E, Schroeder D, Ding YH, Dai D, Brinjikji W, Cebral J, Kallmes DF and Kadirvel R: Differential gene expression in coiled versus flow-diverter-treated aneurysms: RNA sequencing analysis in a rabbit aneurysm model. AJNR Am J Neuroradiol. 37:1114–1121. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Turhon M, Maimaiti A, Gheyret D, Axier A, Rexiati N, Kadeer K, Su R, Wang Z, Chen X, Cheng X, et al: An immunogenic cell death-related regulators classification patterns and immune microenvironment infiltration characterization in intracranial aneurysm based on machine learning. Front Immunol. 13:10013202022. View Article : Google Scholar : PubMed/NCBI

27 

Hu R, Huang L, Zhou M, Zhou S and Hu R: Expression and clinical significance of CLEC7A in intracranial aneurysm tissues and serum. J Minim Invasive Surg. 16:453–456. 2021.(In Chinese).

28 

Su S, Shi YT, Chu Y, Jiang MZ, Wu N, Xu B, Zhou H, Lin JC, Jin YR, Li XF and Liang J: Sec62 promotes gastric cancer metastasis through mediating UPR-induced autophagy activation. Cell Mol Life Sci. 79:1332022. View Article : Google Scholar : PubMed/NCBI

29 

Qiu WL, Zhang YW, Feng Y, Li LC, Yang L and Xu CR: Deciphering pancreatic islet β cell and α cell maturation pathways and characteristic features at the single-cell level. Cell Metab. 25:1194–1205. e11942017. View Article : Google Scholar : PubMed/NCBI

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Yue Y, Xu J, Li Y, Cheng K, Feng Q, Ma X, Ma N, Zhang T, Wang X, Zhao X and Nie G: Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria. Nat Biomed Eng. 6:898–909. 2022. View Article : Google Scholar : PubMed/NCBI

32 

Gomez-Sanchez R, Yakhine-Diop SM, Rodriguez-Arribas M, Bravo-San Pedro JM, Martínez-Chacón G, Uribe-Carretero E, Pinheiro de Castro DC, Pizarro-Estrella E, Fuentes JM and González-Polo RA: MRNA and protein dataset of autophagy markers (LC3 and p62) in several cell lines. Data Brief. 7:641–647. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Ailawadi G, Moehle CW, Pei H, Walton SP, Yang Z, Kron IL, Lau CL and Owens GK: Smooth muscle phenotypic modulation is an early event in aortic aneurysms. J Thorac Cardiovasc Surg. 138:1392–1399. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Ding Y, Zhang M, Zhang W, Lu Q, Cai Z, Song P, Okon IS, Xiao L and Zou MH: AMP-activated protein kinase alpha 2 deletion induces VSMC phenotypic switching and reduces features of atherosclerotic plaque stability. Circ Res. 119:718–730. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Horita H, Wysoczynski CL, Walker LA, Moulton KS, Li M, Ostriker A, Tucker R, McKinsey TA, Churchill ME, Nemenoff RA and Weiser-Evans MC: Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation. Nat Commun. 7:108302016. View Article : Google Scholar : PubMed/NCBI

36 

Owens GK, Kumar MS and Wamhoff BR: Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev. 84:767–801. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Thyberg J: Phenotypic modulation of smooth muscle cells during formation of neointimal thickenings following vascular injury. Histol Histopathol. 13:871–891. 1998.PubMed/NCBI

38 

Sawyer DM, Pace LA, Pascale CL, Kutchin AC, O'Neill BE, Starke RM and Dumont AS: Lymphocytes influence intracranial aneurysm formation and rupture: Role of extracellular matrix remodeling and phenotypic modulation of vascular smooth muscle cells. J Neuroinflammation. 13:1852016. View Article : Google Scholar : PubMed/NCBI

39 

Jiang B, Li X, Wang M, Li GX, Ren PW, Wang YQ, Xin SJ and Qin LF: Trehalose attenuates abdominal aortic aneurysm formation by inducing autophagy in smooth muscle cells. J Geriatr Cardiol. 20:214–222. 2023. View Article : Google Scholar : PubMed/NCBI

40 

Fang ZM, Feng X, Chen Y, Luo H, Jiang DS and Yi X: Targeting autophagy in aortic aneurysm and dissection. Biomed Pharmacother. 153:1135472022. View Article : Google Scholar : PubMed/NCBI

41 

Zhang L, Luo X, Chen F, Yuan W, Xiao X, Zhang X, Dong Y, Zhang Y and Liu Y: LncRNA SNHG1 regulates cerebrovascular pathologies as a competing endogenous RNA through HIF-1alpha/VEGF signaling in ischemic stroke. J Cell Biochem. 119:5460–5472. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Wang Z, Wang R, Wang K and Liu X: Upregulated long noncoding RNA Snhg1 promotes the angiogenesis of brain microvascular endothelial cells after oxygen-glucose deprivation treatment by targeting miR-199a. Can J Physiol Pharmacol. 96:909–915. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Zhang L, Zhang Q, Lv L, Jianhua Z, Ting C and Wu Y: LncRNA SNHG1 regulates vascular endothelial cell proliferation and angiogenesis via miR-196a. J Mol Histol. 51:117–124. 2020. View Article : Google Scholar : PubMed/NCBI

44 

He FT, Fu XL, Li MH, Fu CY and Chen JZ: LncRNA SNHG1 targets miR-340-5p/PIK3CA axis to regulate microvascular endothelial cell proliferation, migration, and angiogenesis in DR. Kaohsiung J Med Sci. 39:16–25. 2023. View Article : Google Scholar : PubMed/NCBI

45 

Li S, Ni Y, Li C, Xiang Q, Zhao Y, Xu H, Huang W, Wang Y, Wang Y, Zhan J and Liu Y: Long noncoding RNA SNHG1 alleviates high glucose-induced vascular smooth muscle cells calcification/senescence by post-transcriptionally regulating Bhlhe40 and autophagy via Atg10. J Physiol Biochem. 79:83–105. 2023. View Article : Google Scholar : PubMed/NCBI

46 

Legaki E, Koutouratsas T, Theocharopoulos C, Lagkada V and Gazouli M: Polymorphisms in CLEC5A and CLEC7A genes modify risk for inflammatory bowel disease. Ann Gastroenterol. 37:64–70. 2024.PubMed/NCBI

47 

Basson A, Trotter A, Rodriguez-Palacios A and Cominelli F: Mucosal interactions between genetics, diet, and microbiome in inflammatory bowel disease. Front Immunol. 7:2902016. View Article : Google Scholar : PubMed/NCBI

48 

Iliev ID, Funari VA, Taylor KD, Nguyen Q, Reyes CN, Strom SP, Brown J, Becker CA, Fleshner PR, Dubinsky M, et al: Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science. 336:1314–1317. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Turnbull C, Bones J, Stanley M, Medhavy A, Wang H, Lorenzo AMD, Cappello J, Shanmuganandam S, Pandey A, Seneviratne S, et al: DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency. Sci Adv. 9:eadi95662023. View Article : Google Scholar : PubMed/NCBI

50 

Ma J, Zhou M, Song Z, Deng Y, Xia S, Li Y, Huang X, Xiao D, Yin Y and Yin J: Clec7a drives gut fungus-mediated host lipid deposition. Microbiome. 11:2642023. View Article : Google Scholar : PubMed/NCBI

51 

Yang N, Wang M, Lin K, Wang M, Xu D, Han X, Zhao X, Wang Y, Wu G, Luo W, et al: Dectin-1 deficiency alleviates diabetic cardiomyopathy by attenuating macrophage-mediated inflammatory response. Biochim Biophys Acta Mol Basis Dis. 1869:1667102023. View Article : Google Scholar : PubMed/NCBI

52 

Zhao X, Sun J, Xiong L, She L, Li L, Tang H, Zeng Y, Chen F, Han X, Ye S, et al: β-amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of Alzheimer's disease. Int J Biol Sci. 19:3249–3265. 2023. View Article : Google Scholar : PubMed/NCBI

53 

Öhman T, Teirila L, Lahesmaa-Korpinen AM, Cypryk W, Veckman V, Saijo S, Wolff H, Hautaniemi S, Nyman TA and Matikainen S: Dectin-1 pathway activates robust autophagy-dependent unconventional protein secretion in human macrophages. J Immunol. 192:5952–5962. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Deng J, Xu W, Jie Y and Chong Y: Subcellular localization and relevant mechanisms of human cancer-related micropeptides. FASEB J. 37:e232702023. View Article : Google Scholar : PubMed/NCBI

55 

Wei C, Xu Y, Shen Q, Li R, Xiao X, Saw PE and Xu X: Role of long non-coding RNAs in cancer: From subcellular localization to nanoparticle-mediated targeted regulation. Mol Ther Nucleic Acids. 33:774–793. 2023. View Article : Google Scholar : PubMed/NCBI

56 

Cai H, Xu H, Lu H, Xu W, Liu H, Wang X, Zhou G and Yang X: LncRNA SNHG1 facilitates tumor proliferation and represses apoptosis by regulating PPARgamma ubiquitination in bladder cancer. Cancers (Basel). 14:47402022. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Deng H, Teng W, Zhou S, Ye Z, Dong Z, Hu R and Qin C: Long non‑coding RNA SNHG1 promotes autophagy in vascular smooth muscle cells induced by facilitating CLEC7A . Mol Med Rep 31: 20, 2025.
APA
Deng, H., Teng, W., Zhou, S., Ye, Z., Dong, Z., Hu, R., & Qin, C. (2025). Long non‑coding RNA SNHG1 promotes autophagy in vascular smooth muscle cells induced by facilitating CLEC7A . Molecular Medicine Reports, 31, 20. https://doi.org/10.3892/mmr.2024.13385
MLA
Deng, H., Teng, W., Zhou, S., Ye, Z., Dong, Z., Hu, R., Qin, C."Long non‑coding RNA SNHG1 promotes autophagy in vascular smooth muscle cells induced by facilitating CLEC7A ". Molecular Medicine Reports 31.1 (2025): 20.
Chicago
Deng, H., Teng, W., Zhou, S., Ye, Z., Dong, Z., Hu, R., Qin, C."Long non‑coding RNA SNHG1 promotes autophagy in vascular smooth muscle cells induced by facilitating CLEC7A ". Molecular Medicine Reports 31, no. 1 (2025): 20. https://doi.org/10.3892/mmr.2024.13385
Copy and paste a formatted citation
x
Spandidos Publications style
Deng H, Teng W, Zhou S, Ye Z, Dong Z, Hu R and Qin C: Long non‑coding RNA SNHG1 promotes autophagy in vascular smooth muscle cells induced by facilitating CLEC7A . Mol Med Rep 31: 20, 2025.
APA
Deng, H., Teng, W., Zhou, S., Ye, Z., Dong, Z., Hu, R., & Qin, C. (2025). Long non‑coding RNA SNHG1 promotes autophagy in vascular smooth muscle cells induced by facilitating CLEC7A . Molecular Medicine Reports, 31, 20. https://doi.org/10.3892/mmr.2024.13385
MLA
Deng, H., Teng, W., Zhou, S., Ye, Z., Dong, Z., Hu, R., Qin, C."Long non‑coding RNA SNHG1 promotes autophagy in vascular smooth muscle cells induced by facilitating CLEC7A ". Molecular Medicine Reports 31.1 (2025): 20.
Chicago
Deng, H., Teng, W., Zhou, S., Ye, Z., Dong, Z., Hu, R., Qin, C."Long non‑coding RNA SNHG1 promotes autophagy in vascular smooth muscle cells induced by facilitating CLEC7A ". Molecular Medicine Reports 31, no. 1 (2025): 20. https://doi.org/10.3892/mmr.2024.13385
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team