Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
January-2025 Volume 31 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2025 Volume 31 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

PLOD2 exacerbates cervical squamous cell carcinoma by suppressing p53 by binding to YAP1

  • Authors:
    • Meilin Yin
    • Yanhua Weng
    • Tianshu Qi
  • View Affiliations / Copyright

    Affiliations: Clinical Laboratory Department, Beijing Chaoyang District Maternal and Child Health Care Hospital, Beijing 100021, P.R. China, Clinical Laboratory Department, Beijing Da Wang Lu Emergency Hospital, Beijing 100021, P.R. China
    Copyright: © Yin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 23
    |
    Published online on: November 7, 2024
       https://doi.org/10.3892/mmr.2024.13388
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Procollagen‑lysine, 2‑oxoglutarate 5‑dioxygenase 2 (PLOD2) has been identified as an oncogene involved in the progression of several human cancers. However, its role in cervical squamous cell carcinoma (CESC) and its underlying mechanisms are not well understood. In the present study, several public databases, RT‑qPCR and western blotting were employed to detect the expression of PLOD2 and the prognosis in CESC. Cell counting kit‑8 assay, wound healing assay, Transwell assay, western blotting and flow cytometry were utilized to assess the proliferation, migration and cell apoptosis of CESC cells. Cellular senescence was examined by RT‑qPCR and β‑galactosidase staining. Prediction of PLOD2 binding to Yes‑associated protein 1 (YAP1) was assessed using BioGrid, HDock and co‑immunoprecipitation, and p53 and p21 signaling were assessed using immunofluorescence staining. The findings indicated that the expression of PLOD2 was elevated in CESC tissues and cell lines, and PLOD2 silencing caused the inhibition of CESC cell proliferation, migration and the promotion of apoptosis and senescence of CESC cells. PLOD2 was predicted to be bound to YAP1 and YAP1 overexpression reversed the effects of PLOD2 silencing on CESC cell proliferation, cell migration, apoptosis and senescence. In addition, PLOD2 facilitated CESC progression by regulating the P53 pathway through YAP1. PLOD2 exerted pro‑oncogenic effects on CESC through the p53 pathway by binding to YAP1. These findings provide new perspectives for the future study of PLOD2‑targeted therapy for CESC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Chatterjee K, Mukherjee S, Vanmanen J, Banerjee P and Fata JE: Dietary polyphenols, resveratrol and pterostilbene exhibit antitumor activity on an HPV E6-positive cervical cancer model: An in vitro and in vivo analysis. Front Oncol. 9:3522019. View Article : Google Scholar : PubMed/NCBI

2 

Romli R, Mohd Hashim S, Abd Rahman R, Chew KT, Mohamad EMW and Mohammed Nawi A: Understanding cervical cancer screening motivations from women and health practitioners' perspectives: A qualitative exploration. Gynecol Oncol Rep. 52:1013492024. View Article : Google Scholar : PubMed/NCBI

3 

Alqarni SS, Alshehri SM, Alkhateeb MA and Alsudias LS: Assessing Saudi women's awareness about human papillomavirus (HPV) and their susceptibility to receive the vaccine. Hum Vaccin Immunother. 20:23950862024. View Article : Google Scholar : PubMed/NCBI

4 

Singh D, Vignat J, Lorenzoni V, Eslahi M, Ginsburg O, Lauby-Secretan B, Arbyn M, Basu P, Bray F and Vaccarella S: Global estimates of incidence and mortality of cervical cancer in 2020: A baseline analysis of the WHO global cervical cancer elimination initiative. Lancet Glob Health. 11:e197–e206. 2023. View Article : Google Scholar : PubMed/NCBI

5 

Jensen JE, Becker GL, Jackson JB and Rysavy MB: Human papillomavirus and associated cancers: A review. Viruses. 16:6802024. View Article : Google Scholar : PubMed/NCBI

6 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

7 

US Preventive Services Task Force, . Curry SJ, Krist AH, Owens DK, Barry MJ, Caughey AB, Davidson KW, Doubeni CA, Epling JW Jr, Kemper AR, et al: Screening for cervical cancer: US preventive services task force recommendation statement. JAMA. 320:674–686. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Meng Y, Chu T, Lin S and Wu P, Zhi W, Peng T, Ding W, Luo D and Wu P: Clinicopathological characteristics and prognosis of cervical cancer with different histological types: A population-based cohort study. Gynecol Oncol. 163:545–551. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Mayadev JS, Ke G, Mahantshetty U, Pereira MD, Tarnawski R and Toita T: Global challenges of radiotherapy for the treatment of locally advanced cervical cancer. Int J Gynecol Cancer. 32:436–445. 2022. View Article : Google Scholar : PubMed/NCBI

10 

Ran Z, Wu S, Ma Z, Chen X, Liu J and Yang J: Advances in exosome biomarkers for cervical cancer. Cancer Med. 11:4966–4978. 2022. View Article : Google Scholar : PubMed/NCBI

11 

Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, Snijders PJ, Peto J, Meijer CJ and Muñoz N: Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 189:12–19. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Pimple SA and Mishra GA: Global strategies for cervical cancer prevention and screening. Minerva Ginecol. 71:313–320. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Rerucha CM, Caro RJ and Wheeler VL: Cervical cancer screening. Am Fam Physician. 97:441–448. 2018.PubMed/NCBI

14 

Zhou Y, Wang W, Tang J, Hu K and Zhang F: Comparison of outcomes between early-stage cervical cancer patients without high-risk factors undergoing adjuvant concurrent chemoradiotherapy and radiotherapy alone after radical surgery. BMC Cancer. 24:5482024. View Article : Google Scholar : PubMed/NCBI

15 

Nuchpramool P and Hanprasertpong J: Preoperative neutrophil-lymphocyte ratio and platelet-lymphocyte ratio are not clinically useful in predicting prognosis in early stage cervical cancer. Surg Res Pract. 2018:91629212018.PubMed/NCBI

16 

Shi R, Zhang Z, Zhu A, Xiong X, Zhang J, Xu J, Sy MS and Li C: Targeting type I collagen for cancer treatment. Int J Cancer. 151:665–683. 2022. View Article : Google Scholar : PubMed/NCBI

17 

Terajima M, Taga Y, Chen Y, Cabral WA, Hou-Fu G, Srisawasdi S, Nagasawa M, Sumida N, Hattori S, Kurie JM, et al: Cyclophilin-B modulates collagen cross-linking by differentially affecting lysine hydroxylation in the helical and telopeptidyl domains of tendon type I collagen. J Biol Chem. 291:9501–9512. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Piersma B and Bank RA: Collagen cross-linking mediated by lysyl hydroxylase 2: An enzymatic battlefield to combat fibrosis. Essays Biochem. 63:377–387. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Sato K, Parag-Sharma K, Terajima M, Musicant AM, Murphy RM, Ramsey MR, Hibi H, Yamauchi M and Amelio AL: Lysyl hydroxylase 2-induced collagen cross-link switching promotes metastasis in head and neck squamous cell carcinomas. Neoplasia. 23:594–606. 2021. View Article : Google Scholar : PubMed/NCBI

20 

Gong S, Wu C, Duan Y, Fu J, Wang Y, Wu H, Zhang B, Tang J and Wu P: PLODs: Novel prognostic biomarkers and potential immunotherapy targets for head and neck squamous cell carcinoma. Heliyon. 9:e134792023. View Article : Google Scholar : PubMed/NCBI

21 

Sekaran K, Varghese RP, Krishnan S, Zayed H, El Allali A and Doss GPC: Dissecting crucial gene markers involved in HPV-associated oropharyngeal squamous cell carcinoma from RNA-sequencing data through explainable artificial intelligence. Front Biosci (Landmark Ed). 29:2202024. View Article : Google Scholar : PubMed/NCBI

22 

Li G, Wang X and Liu G: PLOD2 is a potent prognostic marker and associates with immune infiltration in cervical cancer. Biomed Res Int. 2021:55123402021.PubMed/NCBI

23 

Liu R, He X, Bao W and Li Z: Enhancement of HPV therapeutic peptide-based vaccine efficacy through combination therapies and improved delivery strategies: A review. Hum Vaccin Immunother. 20:23967102024. View Article : Google Scholar : PubMed/NCBI

24 

Suhaila K, Mukherjee A, Maharjan B, Dhakal A, Lama M, Junkins A, Khakurel U, Jha AN, Jolly PE, Lhaki P and Shrestha S: Human papillomavirus, related diseases, and vaccination: Knowledge and awareness among health care students and professionals in Nepal. J Cancer Educ. 37:1727–1735. 2022. View Article : Google Scholar : PubMed/NCBI

25 

Sada M, Ohuchida K, Horioka K, Okumura T, Moriyama T, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y and Nakamura M: Hypoxic stellate cells of pancreatic cancer stroma regulate extracellular matrix fiber organization and cancer cell motility. Cancer Lett. 372:210–218. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Wu B and Xi S: Bioinformatics analysis of differentially expressed genes and pathways in the development of cervical cancer. BMC Cancer. 21:7332021. View Article : Google Scholar : PubMed/NCBI

27 

S S Shukla V, Khan GN, Eswaran S, Adiga D and Kabekkodu SP: Integrated bioinformatic analysis of miR-15a/16-1 cluster network in cervical cancer. Reprod Biol. 21:1004822021. View Article : Google Scholar : PubMed/NCBI

28 

Li CJ, Chiu YH, Chang C, Chang YCI, Sheu JJ and Chiang AJ: Acetyl coenzyme A synthase 2 acts as a prognostic biomarker associated with immune infiltration in cervical squamous cell carcinoma. Cancers (Basel). 13:31252021. View Article : Google Scholar : PubMed/NCBI

29 

Oughtred R, Rust J, Chang C, Breitkreutz BJ, Stark C, Willems A, Boucher L, Leung G, Kolas N, Zhang F, et al: The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions. Protein sci. 30:187–200. 2021. View Article : Google Scholar : PubMed/NCBI

30 

Dalby B, Cates S, Harris A, Ohki EC, Tilkins ML, Price PJ and Ciccarone VC: Advanced transfection with Lipofectamine 2000 reagent: Primary neurons, siRNA, and high-throughput applications. Methods. 33:95–103. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Li Z, He H, Ren X, Chen Y, Liu W, Pu R, Fang L, Shi Y, Liu D, Zhao J, et al: APOBEC3A suppresses cervical cancer via apoptosis. J Cancer. 14:3429–3443. 2023. View Article : Google Scholar : PubMed/NCBI

32 

Chen Q, Sun X, Luo X, Wang J, Hu J and Feng Y: PIK3R3 inhibits cell senescence through p53/p21 signaling. Cell Death Dis. 11:7982020. View Article : Google Scholar : PubMed/NCBI

33 

Lv S, Wang Y, Xu W and Dong X: Serum exosomal miR-17-5p as a promising biomarker diagnostic biomarker for breast cancer. Clin Lab. 66:2020. View Article : Google Scholar

34 

Zhong C, Ju G, Yang S, Zhao X, Chen J and Li N: Total flavonoids of polygala fallax hemsl induce apoptosis of human ectopic endometrial stromal cells through PI3K/AKT/Bcl-2 signaling pathway. Gynecol Obstet Invest. 88:197–213. 2023. View Article : Google Scholar : PubMed/NCBI

35 

Childs BG, Baker DJ, Kirkland JL, Campisi J and van Deursen JM: Senescence and apoptosis: Dueling or complementary cell fates? EMBO Rep. 15:1139–1153. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Ou HL, Hoffmann R, González-López C, Doherty GJ, Korkola JE and Muñoz-Espín D: Cellular senescence in cancer: From mechanisms to detection. Mol Oncol. 15:2634–2671. 2021. View Article : Google Scholar : PubMed/NCBI

37 

Tzoneva R: Special issue ‘role of apoptosis and cellular senescence in cancer and aging’. Int J Mol Sci. 25:21032024. View Article : Google Scholar : PubMed/NCBI

38 

Goodwin EC, Yang E, Lee CJ, Lee HW, DiMaio D and Hwang ES: Rapid induction of senescence in human cervical carcinoma cells. Proc Natl Acad Sci U S A. 97:10978–10983. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Lan J, Zhang S, Zheng L, Long X, Chen J, Liu X, Zhou M and Zhou J: PLOD2 promotes colorectal cancer progression by stabilizing USP15 to activate the AKT/mTOR signaling pathway. Cancer Sci. 114:3190–3202. 2023. View Article : Google Scholar : PubMed/NCBI

40 

Xu Q, Kong N, Zhao Y, Wu Q, Wang X, Xun X and Gao P: Pan-cancer analyses reveal oncogenic and immunological role of PLOD2. Front Genet. 13:8646552022. View Article : Google Scholar : PubMed/NCBI

41 

Li K, Niu Y, Li K, Zhong C, Qiu Z, Yuan Y, Shi Y, Lin Z, Huang Z, Zuo D, et al: Dysregulation of PLOD2 promotes tumor metastasis and invasion in hepatocellular carcinoma. J Clin Transl Hepatol. 11:1094–1105. 2023.PubMed/NCBI

42 

Yang YS, Jin X, Li Q, Chen YY, Chen F, Zhang H, Su Y, Xiao Y, Di GH, Jiang YZ, et al: Superenhancer drives a tumor-specific splicing variant of MARCO to promote triple-negative breast cancer progression. Proc Natl Acad Sci USA. 119:e22072011192022. View Article : Google Scholar : PubMed/NCBI

43 

Zheng L, Qian B, Tian D, Tang T, Wan S, Wang L, Zhu L and Geng X: FOXA1 positively regulates gene expression by changing gene methylation status in human breast cancer MCF-7 cells. Int J Clin Exp Pathol. 8:96–106. 2015.PubMed/NCBI

44 

Liu T, Liu Y, Gao H, Meng F, Yang S and Lou G: Clinical significance of yes-associated protein overexpression in cervical carcinoma: The differential effects based on histotypes. Int J Gynecol Cancer. 23:735–742. 2013. View Article : Google Scholar : PubMed/NCBI

45 

He C, Mao D, Hua G, Lv X, Chen X, Angeletti PC, Dong J, Remmenga SW, Rodabaugh KJ, Zhou J, et al: The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression. EMBO Mol Med. 7:1426–1449. 2015. View Article : Google Scholar : PubMed/NCBI

46 

He C, Lv X, Huang C, Angeletti PC, Hua G, Dong J, Zhou J, Wang Z, Ma B, Chen X, et al: A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis. Cell Rep. 26:2636–2650. 2019. View Article : Google Scholar : PubMed/NCBI

47 

Deng J, Zhang W, Liu S, An H, Tan L and Ma L: LATS1 suppresses proliferation and invasion of cervical cancer. Mol Med Rep. 15:1654–1660. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Sheekey E and Narita M: p53 in senescence-it's a marathon, not a sprint. FEBS J. 290:1212–1220. 2023. View Article : Google Scholar : PubMed/NCBI

49 

DeFilippis RA, Goodwin EC, Wu L and DiMaio D: Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cells. J Virol. 77:1551–1563. 2003. View Article : Google Scholar : PubMed/NCBI

50 

Zhang Y, Na R and Wang X: LncRNA WT1-AS up-regulates p53 to inhibit the proliferation of cervical squamous carcinoma cells. BMC Cancer. 19:10522019. View Article : Google Scholar : PubMed/NCBI

51 

Lu Y, Mu Y, Chen J, Guan X, Guo L and Wu C: CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1. Theranostics. 12:5051–5068. 2022. View Article : Google Scholar : PubMed/NCBI

52 

Xu X, Shen X, Wang J, Feng W, Wang M, Miao X, Wu Q, Wu L, Wang X Ma Y, et al: YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling. Aging Cell. 20:e134652021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yin M, Weng Y and Qi T: PLOD2 exacerbates cervical squamous cell carcinoma by suppressing p53 by binding to YAP1. Mol Med Rep 31: 23, 2025.
APA
Yin, M., Weng, Y., & Qi, T. (2025). PLOD2 exacerbates cervical squamous cell carcinoma by suppressing p53 by binding to YAP1. Molecular Medicine Reports, 31, 23. https://doi.org/10.3892/mmr.2024.13388
MLA
Yin, M., Weng, Y., Qi, T."PLOD2 exacerbates cervical squamous cell carcinoma by suppressing p53 by binding to YAP1". Molecular Medicine Reports 31.1 (2025): 23.
Chicago
Yin, M., Weng, Y., Qi, T."PLOD2 exacerbates cervical squamous cell carcinoma by suppressing p53 by binding to YAP1". Molecular Medicine Reports 31, no. 1 (2025): 23. https://doi.org/10.3892/mmr.2024.13388
Copy and paste a formatted citation
x
Spandidos Publications style
Yin M, Weng Y and Qi T: PLOD2 exacerbates cervical squamous cell carcinoma by suppressing p53 by binding to YAP1. Mol Med Rep 31: 23, 2025.
APA
Yin, M., Weng, Y., & Qi, T. (2025). PLOD2 exacerbates cervical squamous cell carcinoma by suppressing p53 by binding to YAP1. Molecular Medicine Reports, 31, 23. https://doi.org/10.3892/mmr.2024.13388
MLA
Yin, M., Weng, Y., Qi, T."PLOD2 exacerbates cervical squamous cell carcinoma by suppressing p53 by binding to YAP1". Molecular Medicine Reports 31.1 (2025): 23.
Chicago
Yin, M., Weng, Y., Qi, T."PLOD2 exacerbates cervical squamous cell carcinoma by suppressing p53 by binding to YAP1". Molecular Medicine Reports 31, no. 1 (2025): 23. https://doi.org/10.3892/mmr.2024.13388
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team