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Study on the molecular mechanisms of rifaximin in the treatment of non‑alcoholic steatohepatitis based on the Helicobacter‑DCA‑Fxr‑Hnf1α signalling pathway

  • Authors:
    • Yi-Peng Wan
    • Shuang Li
    • Dan Li
    • Xiao-Mei Huang
    • Jian-Hua Wu
    • Jie Jian
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Teaching, Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, P.R. China
    Copyright: © Wan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 42
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    Published online on: November 28, 2024
       https://doi.org/10.3892/mmr.2024.13407
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Abstract

Non‑alcoholic steatohepatitis (NASH), the more progressive form of non‑alcoholic fatty liver disease, has become a major cause of cirrhosis and liver cancer. The aim of the present study was to investigate the anti‑NASH effect of the nonabsorbable antibiotic rifaximin and its specific molecular mechanisms. A methionine‑choline deficient (MCD) diet was used to induce NASH formation in mice. The mice with NASH were treated with rifaximin to observe its effects on liver fat deposition, hepatocyte inflammation and liver fibrosis. Furthermore, the intestinal microbiota of mice with NASH was analysed by 16S rRNA sequencing and terminal ileal bile acid levels were assessed using liquid chromatography‑electrospray ionization‑tandem mass spectrometry analysis. Furthermore, the correlation between the intestinal microflora and bile acid levels in the terminal ileum was investigated, and the effects of rifaximin on the intestinal Helicobacter‑deoxycholic acid (DCA)‑farnesoid X receptor (Fxr)‑hepatocyte nuclear factor 1α (Hnf1α) signalling pathway were examined. Moreover, analyses of mice after intestinal decontamination with broad‑spectrum antibiotics and of hepatocyte‑specific Hnf1α knockout (Hnf1αH‑KO) mice were used to elucidate the molecular mechanisms by which rifaximin improves NASH. Notably, treatment with rifaximin markedly ameliorated liver steatosis, hepatocyte inflammation and liver fibrosis in mice with MCD diet‑induced NASH. Rifaximin modulated the gut microbiota, especially Helicobacter hepaticus, in mice with NASH. In addition, rifaximin inhibited the intestinal Helicobacter‑DCA‑Fxr‑Hnf1α signalling pathway in mice with NASH. By contrast, rifaximin did not exert an anti‑NASH effect on decontamination‑treated mice or Hnf1αH‑KO mice. Taken together, these results indicated that rifaximin can ameliorate NASH in mice by modulating the Helicobacter‑DCA‑Fxr‑Hnf1α signalling pathway, providing a theoretical basis for the clinical treatment of patients with NASH with rifaximin.
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View References

1 

Younossi Z, Tacke F, Arrese M, Chander Sharma B, Mostafa I, Bugianesi E, Wai-Sun Wong V, Yilmaz Y, George J, Fan J and Vos MB: Global perspectives on nonalcoholic fatty liver disease and nonalcoholic Steatohepatitis. Hepatology. 69:2672–2682. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Friedman SL, Neuschwander-Tetri BA, Rinella M and Sanyal AJ: Mechanisms of NAFLD development and therapeutic strategies. Nat Med. 24:908–922. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Schuster S, Cabrera D, Arrese M and Feldstein AE: Triggering and resolution of inflammation in NASH. Nat Rev Gastroenterol Hepatol. 15:349–364. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Zhang X, Coker OO, Chu ES, Fu K, Lau HCH, Wang YX, Chan AWH, Wei H, Yang X, Sung JJY and Yu J: Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites. Gut. 70:761–774. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Dr De Sousa SM and Prof Norman RJ : Metabolic syndrome, diet and exercise. Best Pract Res Clin Obstet Gynaecol. 37:140–151. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Kim D, Touros A and Kim WR: Nonalcoholic fatty liver disease and metabolic syndrome. Clin Liver Dis. 22:133–140. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Sharpton SR, Ajmera V and Loomba R: Emerging role of the gut microbiome in nonalcoholic fatty liver disease: From composition to function. Clin Gastroenterol Hepatol. 17:296–306. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Ponziani FR, Bhoori S, Castelli C, Putignani L, Rivoltini L, Del Chierico F, Sanguinetti M, Morelli D, Paroni Sterbini F, Petito V, et al: Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease. Hepatology. 69:107–120. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Grabherr F, Grander C, Effenberger M, Adolph TE and Tilg H: Gut dysfunction and non-alcoholic fatty liver disease. Front Endocrinol (Lausanne). 10:6112019. View Article : Google Scholar : PubMed/NCBI

10 

Sun L, Pang Y, Wang X, Wu Q, Liu H, Liu B, Liu G, Ye M, Kong W and Jiang C: Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters. Acta Pharm Sin B. 9:702–710. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Jasirwan COM, Lesmana CRA, Hasan I, Sulaiman AS and Gani RA: The role of gut microbiota in non-alcoholic fatty liver disease: pathways of mechanisms. Biosci Microbiota Food Health. 38:81–88. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Chávez-Talavera O, Tailleux A, Lefebvre P and Staels B: Bile acid control of metabolism and inflammation in obesity, type 2 diabetes, dyslipidemia, and nonalcoholic fatty liver disease. Gastroenterology. 152:1679–1694.e3. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Corbin KD and Zeisel SH: Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr Opin Gastroenterol. 28:159–165. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Liu HY, Walden TB, Cai D, Ahl D, Bertilsson S, Phillipson M, Nyman M and Holm L: Dietary fiber in bilberry ameliorates pre-obesity events in rats by regulating lipid depot, cecal short-chain fatty acid formation and microbiota composition. Nutrients. 11:13502019. View Article : Google Scholar : PubMed/NCBI

15 

Zhu L, Baker SS, Gill C, Liu W, Alkhouri R, Baker RD and Gill SR: Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH. Hepatology. 57:601–609. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Coronel-Castillo CE, Contreras-Carmona J, Frati-Munari AC, Uribe M and Méndez-Sánchez N: Efficacy of rifaximin in the different clinical scenarios of hepatic encephalopathy. Rev Gastroenterol Mex (Engl Ed). 85:56–68. 2020.(In English, Spanish). PubMed/NCBI

17 

Chautant F, Guillaume M, Robic MA, Cadranel JF, Peron JM, Lison H, Cool C, Bureau C and Duhalde V: Lessons from ‘real life experience’ of rifaximin use in the management of recurrent hepatic encephalopathy. World J Hepatol. 12:10–20. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Fodor AA, Pimentel M, Chey WD, Lembo A, Golden PL, Israel RJ and Carroll IM: Rifaximin is associated with modest, transient decreases in multiple taxa in the gut microbiota of patients with diarrhoea-predominant irritable bowel syndrome. Gut Microbes. 10:22–33. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Shah ED, Saini SD and Chey WD: Value-based pricing for rifaximin increases access of patients with irritable bowel syndrome with diarrhea to therapy. Clin Gastroenterol Hepatol. 17:2687–2695.e11. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Abdel-Razik A, Mousa N, Shabana W, Refaey M, Elzehery R, Elhelaly R, Zalata K, Abdelsalam M, Eldeeb AA, Awad M, et al: Rifaximin in nonalcoholic fatty liver disease: Hit multiple targets with a single shot. Eur J Gastroenterol Hepatol. 30:1237–1246. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Gangarapu V, Ince AT, Baysal B, Kayar Y, Kılıç U, Gök Ö, Uysal Ö and Şenturk H: Efficacy of rifaximin on circulating endotoxins and cytokines in patients with nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol. 27:840–845. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Yang L, Liu B, Zheng J, Huang J, Zhao Q, Liu J, Su Z, Wang M, Cui Z, Wang T, et al: Rifaximin alters intestinal microbiota and prevents progression of ankylosing spondylitis in mice. Front Cell Infect Microbiol. 9:442019. View Article : Google Scholar : PubMed/NCBI

23 

Zhu Y, He C, Li X, Cai Y, Hu J, Liao Y, Zhao J, Xia L, He W, Liu L, et al: Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice. J Gastroenterol. 54:347–358. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Ni Q, Ding K, Wang KQ, He J, Yin C, Shi J, Zhang X, Xie WF and Shi YQ: Deletion of HNF1α in hepatocytes results in fatty liver-related hepatocellular carcinoma in mice. FEBS Lett. 591:1947–1957. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu YC, Torbenson MS, Unalp-Arida A, et al: Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 41:1313–1321. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Yue HY, Yin C, Hou JL, Zeng X, Chen YX, Zhong W, Hu PF, Deng X, Tan YX, Zhang JP, et al: Hepatocyte nuclear factor 4alpha attenuates hepatic fibrosis in rats. Gut. 59:236–246. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Nie Y, Liu Q, Zhang W, Wan Y, Huang C and Zhu X: Ursolic acid reverses liver fibrosis by inhibiting NOX4/NLRP3 inflammasome pathways and bacterial dysbiosis. Gut Microbes. 13:19727462021. View Article : Google Scholar : PubMed/NCBI

29 

R Core Team, . R: A language and environment for statistical computing. R Foundation for Statistical Computing; Vienna, Austria: 2021

30 

Quan T, Zhou F, Chen H, Jian L, Yang Y, Xia F, Xiang S, Zhou B and Li S: Ficus hirta Vahl. Ameliorates nonalcoholic fatty liver disease through regulating lipid metabolism and gut microbiota. Oxid Med Cell Longev. 2022:34747232022. View Article : Google Scholar : PubMed/NCBI

31 

Mukherjee S, Zhelnin L, Sanfiz A, Pan J, Li Z, Yarde M, McCarty J and Jarai G: Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype. Am J Transl Res. 11:1531–1540. 2019.PubMed/NCBI

32 

Kumar S, Duan Q, Wu R, Harris EN and Su Q: Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis. Adv Drug Deliv Rev. 176:1138692021. View Article : Google Scholar : PubMed/NCBI

33 

Huang R, Guo F, Li Y, Liang Y, Li G, Fu P and Ma L: Activation of AMPK by triptolide alleviates nonalcoholic fatty liver disease by improving hepatic lipid metabolism, inflammation and fibrosis. Phytomedicine. 92:1537392021. View Article : Google Scholar : PubMed/NCBI

34 

Begley M, Gahan CGM and Hill C: The interaction between bacteria and bile. FEMS Microbiol Rev. 29:625–651. 2005. View Article : Google Scholar : PubMed/NCBI

35 

de Aguiar Vallim TQ, Tarling EJ and Edwards PA: Pleiotropic roles of bile acids in metabolism. Cell Metab. 17:657–669. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Honda T, Ishigami M, Luo F, Lingyun M, Ishizu Y, Kuzuya T, Hayashi K, Nakano I, Ishikawa T, Feng GG, et al: Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice. Metabolism. 69:177–187. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Zhang L, Li HX, Pan WS, Khan FU, Qian C, Qi-Li FR and Xu X: Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signallinging pathway. Biomed Pharmacother. 110:571–581. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Cheng S, Qian K, Wang Y, Wang G, Liu X, Xiao Y and Wang X: PPARγ inhibition regulates the cell cycle, proliferation and motility of bladder cancer cells. J Cell Mol Med. 23:3724–3736. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Voigt RM, Summa KC, Forsyth CB, Green SJ, Engen P, Naqib A, Vitaterna MH, Turek FW and Keshavarzian A: The circadian clock mutation promotes intestinal dysbiosis. Alcohol Clin Exp Res. 40:335–347. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Canfora EE, Meex RCR, Venema K and Blaak EE: Gut microbial metabolites in obesity, NAFLD and T2DM. Nat Rev Endocrinol. 15:261–273. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Swennes AG, Sheh A, Parry NMA, Muthupalani S, Lertpiriyapong K, García A and Fox JG: Helicobacter hepaticus infection promotes hepatitis and preneoplastic foci in farnesoid X receptor (FXR) deficient mice. PLoS One. 9:e1067642014. View Article : Google Scholar : PubMed/NCBI

42 

Qadri I, Hu LJ, Iwahashi M, Al-Zuabi S, Quattrochi LC and Simon FR: Interaction of hepatocyte nuclear factors in transcriptional regulation of tissue specific hormonal expression of human multidrug resistance-associated protein 2 (abcc2). Toxicol Appl Pharmacol. 234:281–292. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Xiong X, Wang X, Lu Y, Wang E, Zhang Z, Yang J, Zhang H and Li X: Hepatic steatosis exacerbated by endoplasmic reticulum stress-mediated downregulation of FXR in aging mice. J Hepatol. 60:847–854. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Purushotham A, Xu Q, Lu J, Foley JF, Yan X, Kim DH, Kemper JK and Li X: Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice. Mol Cell Biol. 32:1226–1236. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wan Y, Li S, Li D, Huang X, Wu J and Jian J: Study on the molecular mechanisms of rifaximin in the treatment of non‑alcoholic steatohepatitis based on the <em>Helicobacter</em>‑DCA‑Fxr‑Hnf1&alpha; signalling pathway. Mol Med Rep 31: 42, 2025.
APA
Wan, Y., Li, S., Li, D., Huang, X., Wu, J., & Jian, J. (2025). Study on the molecular mechanisms of rifaximin in the treatment of non‑alcoholic steatohepatitis based on the <em>Helicobacter</em>‑DCA‑Fxr‑Hnf1&alpha; signalling pathway. Molecular Medicine Reports, 31, 42. https://doi.org/10.3892/mmr.2024.13407
MLA
Wan, Y., Li, S., Li, D., Huang, X., Wu, J., Jian, J."Study on the molecular mechanisms of rifaximin in the treatment of non‑alcoholic steatohepatitis based on the <em>Helicobacter</em>‑DCA‑Fxr‑Hnf1&alpha; signalling pathway". Molecular Medicine Reports 31.2 (2025): 42.
Chicago
Wan, Y., Li, S., Li, D., Huang, X., Wu, J., Jian, J."Study on the molecular mechanisms of rifaximin in the treatment of non‑alcoholic steatohepatitis based on the <em>Helicobacter</em>‑DCA‑Fxr‑Hnf1&alpha; signalling pathway". Molecular Medicine Reports 31, no. 2 (2025): 42. https://doi.org/10.3892/mmr.2024.13407
Copy and paste a formatted citation
x
Spandidos Publications style
Wan Y, Li S, Li D, Huang X, Wu J and Jian J: Study on the molecular mechanisms of rifaximin in the treatment of non‑alcoholic steatohepatitis based on the <em>Helicobacter</em>‑DCA‑Fxr‑Hnf1&alpha; signalling pathway. Mol Med Rep 31: 42, 2025.
APA
Wan, Y., Li, S., Li, D., Huang, X., Wu, J., & Jian, J. (2025). Study on the molecular mechanisms of rifaximin in the treatment of non‑alcoholic steatohepatitis based on the <em>Helicobacter</em>‑DCA‑Fxr‑Hnf1&alpha; signalling pathway. Molecular Medicine Reports, 31, 42. https://doi.org/10.3892/mmr.2024.13407
MLA
Wan, Y., Li, S., Li, D., Huang, X., Wu, J., Jian, J."Study on the molecular mechanisms of rifaximin in the treatment of non‑alcoholic steatohepatitis based on the <em>Helicobacter</em>‑DCA‑Fxr‑Hnf1&alpha; signalling pathway". Molecular Medicine Reports 31.2 (2025): 42.
Chicago
Wan, Y., Li, S., Li, D., Huang, X., Wu, J., Jian, J."Study on the molecular mechanisms of rifaximin in the treatment of non‑alcoholic steatohepatitis based on the <em>Helicobacter</em>‑DCA‑Fxr‑Hnf1&alpha; signalling pathway". Molecular Medicine Reports 31, no. 2 (2025): 42. https://doi.org/10.3892/mmr.2024.13407
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