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New developments in the role of ferroptosis in sepsis‑induced cardiomyopathy (Review)

  • Authors:
    • Dingdeng Wang
    • Xinguang Qu
    • Zhaohui Zhang
    • Gaosheng Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Critical Care Medicine, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang, Hubei 443003, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 118
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    Published online on: March 4, 2025
       https://doi.org/10.3892/mmr.2025.13483
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Abstract

Sepsis is a life‑threatening organ dysfunction disorder caused by dysfunctional host response to infection. Sepsis‑induced cardiomyopathy (SIC) is a common and serious complication of sepsis, and it is associated with increased mortality rates; however, its specific pathogenesis is still unclear. Ferroptosis, which is an iron‑dependent form of programmed cell death, is involved in the pathophysiology of SIC. Further study on the mechanism and therapeutic targets of ferroptosis in SIC may provide new strategies for clinical diagnosis and treatment of this condition. The present article reviews the mechanisms between SIC and ferroptosis, summarizes the progress in research of the involvement of ferroptosis in SIC and provides new potential strategies for further research and treatment in the future.
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Spandidos Publications style
Wang D, Qu X, Zhang Z and Zhou G: New developments in the role of ferroptosis in sepsis‑induced cardiomyopathy (Review). Mol Med Rep 31: 118, 2025.
APA
Wang, D., Qu, X., Zhang, Z., & Zhou, G. (2025). New developments in the role of ferroptosis in sepsis‑induced cardiomyopathy (Review). Molecular Medicine Reports, 31, 118. https://doi.org/10.3892/mmr.2025.13483
MLA
Wang, D., Qu, X., Zhang, Z., Zhou, G."New developments in the role of ferroptosis in sepsis‑induced cardiomyopathy (Review)". Molecular Medicine Reports 31.5 (2025): 118.
Chicago
Wang, D., Qu, X., Zhang, Z., Zhou, G."New developments in the role of ferroptosis in sepsis‑induced cardiomyopathy (Review)". Molecular Medicine Reports 31, no. 5 (2025): 118. https://doi.org/10.3892/mmr.2025.13483
Copy and paste a formatted citation
x
Spandidos Publications style
Wang D, Qu X, Zhang Z and Zhou G: New developments in the role of ferroptosis in sepsis‑induced cardiomyopathy (Review). Mol Med Rep 31: 118, 2025.
APA
Wang, D., Qu, X., Zhang, Z., & Zhou, G. (2025). New developments in the role of ferroptosis in sepsis‑induced cardiomyopathy (Review). Molecular Medicine Reports, 31, 118. https://doi.org/10.3892/mmr.2025.13483
MLA
Wang, D., Qu, X., Zhang, Z., Zhou, G."New developments in the role of ferroptosis in sepsis‑induced cardiomyopathy (Review)". Molecular Medicine Reports 31.5 (2025): 118.
Chicago
Wang, D., Qu, X., Zhang, Z., Zhou, G."New developments in the role of ferroptosis in sepsis‑induced cardiomyopathy (Review)". Molecular Medicine Reports 31, no. 5 (2025): 118. https://doi.org/10.3892/mmr.2025.13483
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