Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2025 Volume 31 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2025 Volume 31 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Glycoprotein 130 improves repressor element‑1 silencing transcription factor‑related axon regenerative capacity in peripheral nerves with aging

  • Authors:
    • So Kawakita
    • Kiyohito Naito
    • Daisuke Kubota
    • Yuji Ueno
    • Takako Negishi‑Koga
    • Yasuhiro Yamamoto
    • Takamaru Suzuki
    • Norizumi Imazu
    • Kenjiro Kawamura
    • Nobutaka Hattori
    • Muneaki Ishijima
  • View Affiliations / Copyright

    Affiliations: Department of Medicine for Orthopedics and Motor Organ, Juntendo University Graduate School of Medicine, Tokyo 113‑8421, Japan, Department of Neurology, Graduate School of Medical Sciences, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan, Department of Orthopedics, Juntendo University Faculty of Medicine, Tokyo 113‑8421, Japan, Department of Neurology, Juntendo University Faculty of Medicine, Tokyo 113‑8421, Japan
    Copyright: © Kawakita et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 121
    |
    Published online on: March 7, 2025
       https://doi.org/10.3892/mmr.2025.13486
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Axon regenerative capacity diminishes with aging and differences in the condition of peripheral nerves between young and elderly individuals have been reported. However, the underlying pathology remains unclear. The expression of repressor element‑1 silencing transcription factor (REST) increases with age and is reported to suppress axon regeneration. The present study investigated the pathology and potential treatment of reduced axon regenerative capacity using REST‑regulated cells and a mouse model. This study examined the molecular expression of the janus kinase 1 (JAK1)/signal transducer and activator of transcription 3 (STAT3) pathway, which is involved in growth‑associated protein 43 (GAP43) expression. In REST‑overexpressed (REST‑OE), glycoprotein 130 (GP130), JAK1 and phosphorylated STAT3 (p‑STAT3) expression was decreased compared with the control (GP130, P=0.004; JAK1, P=0.038; pSTAT3, P=0.015). On the other hand, in REST‑low expressed (siREST), GP130, JAK1 and pSTAT3 expression was increased compared with the control (GP130, P=0.004; JAK1, P=0.003; pSTAT3, P=0.033). It suggested that GP130 plays an important role. Therefore, GP130 agonist was administered to REST‑OE and aged mice and resulted in a significant increase in GAP43 expression (REST‑OE: Protein P=0.018, mRNA P=0.040; aged mice: Protein P=0.016, mRNA P=0.013). The results of this study suggest that the pathology of reduction in peripheral nerve axon regenerative capacity is inhibited by age‑related increase in REST expression, which leads to decreased GP130 expression and inhibition of JAK1/STAT3 pathway activity. These findings suggest that regulating GP130 expression may improve axon regenerative capacity by aging.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Cheng X, Yang Y, Schwebel DC, Liu Z, Li L, Cheng P, Ning P and Hu G: Population ageing and mortality during 1990–2017: A global decomposition analysis. PLoS Med. 17:e10031382020. View Article : Google Scholar : PubMed/NCBI

2 

Tadjerbashi K, Åkesson A and Atroshi I: Incidence of referred carpal tunnel syndrome and carpal tunnel release surgery in the general population: Increase over time and regional variations. J Orthop Surg (Hong Kong). 27:23094990198255722019. View Article : Google Scholar : PubMed/NCBI

3 

Boyd KU, Gan BS, Ross DC, Richards RS, Roth JH and MacDermid JC: Outcomes in carpal tunnel syndrome: Symptom severity, conservative management and progression to surgery. Clin Invest Med. 28:254–260. 2005.PubMed/NCBI

4 

Yamamoto K, Shishido T, Masaoka T, Katori Y and Tanaka S: Postoperative clinical results in cubital tunnel syndrome. Orthopedics. 29:347–353. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Hobby JL, Venkatesh R and Motkur P: The effect of age and gender upon symptoms and surgical outcomes in carpal tunnel syndrome. J Hand Surg Br. 30:599–604. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Wilgis EF, Burke FD, Dubin NH, Sinha S and Bradley MJ: A prospective assessment of carpal tunnel surgery with respect to age. J Hand Surg Br. 31:401–406. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Büttner R, Schulz A, Reuter M, Akula AK, Mindos T, Carlstedt A, Riecken LB, Baader SL, Bauer R and Morrison H: Inflammaging impairs peripheral nerve maintenance and regeneration. Aging Cell. 17:e128332018. View Article : Google Scholar : PubMed/NCBI

8 

Xing Y, Samuvel DJ, Stevens SM, Dubno JR, Schulte BA and Lang H: Age-related changes of myelin basic protein in mouse and human auditory nerve. PLoS One. 7:e345002012. View Article : Google Scholar : PubMed/NCBI

9 

Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS, et al: REST and stress resistance in ageing and Alzheimer's disease. Nature. 507:448–454. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Mampay M and Sheridan GK: REST: An epigenetic regulator of neuronal stress responses in the young and ageing brain. Front Neuroendocrinol. 53:1007442019. View Article : Google Scholar : PubMed/NCBI

11 

Noro T, Shah SH, Yin Y, Kawaguchi R, Yokota S, Chang KC, Madaan A, Sun C, Coppola G, Geschwind D, et al: Elk-1 regulates retinal ganglion cell axon regeneration after injury. Sci Rep. 12:174462022. View Article : Google Scholar : PubMed/NCBI

12 

Jin L, Liu Y, Wu Y, Huang Y and Zhang D: REST is not resting: REST/NRSF in health and disease. Biomolecules. 13:14772023. View Article : Google Scholar : PubMed/NCBI

13 

Kaneko A, Naito K, Nakamura S, Miyahara K, Goto K, Obata H, Nagura N, Sugiyama Y, Kaneko K and Ishijima M: Influence of aging on the peripheral nerve repair process using an artificial nerve conduit. Exp Ther Med. 21:1682021. View Article : Google Scholar : PubMed/NCBI

14 

Goto K, Naito K, Nakamura S, Nagura N, Sugiyama Y, Obata H, Kaneko A and Kaneko K: Protective mechanism against age-associated changes in the peripheral nerves. Life Sci. 253:1177442020. View Article : Google Scholar : PubMed/NCBI

15 

Chung D, Shum A and Caraveo G: GAP-43 and BASP1 in axon regeneration: Implications for the treatment of neurodegenerative diseases. Front Cell Dev Biol. 8:5675372020. View Article : Google Scholar : PubMed/NCBI

16 

Zhang L, Wang Z, Li B, Xia Z, Wang X, Xiu Y, Zhang Z, Chen C, Song H, Li W, et al: The inhibition of miR-17-5p promotes cortical neuron neurite growth via STAT3/GAP-43 pathway. Mol Biol Rep. 47:1795–1802. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Alam MP, Bilousova T, Spilman P, Vadivel K, Bai D, Elias CJ, Evseenko D and John V: A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity. ACS Chem Neurosci. 9:462–468. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Holahan MR: A Shift from a pivotal to supporting role for the growth-associated protein (GAP-43) in the coordination of axonal structural and functional plasticity. Front Cell Neurosci. 11:2662017. View Article : Google Scholar : PubMed/NCBI

19 

Heinrich PC, Behrmann I, Müller-Newen G, Schaper F and Graeve L: Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J. 334:297–314. 1998. View Article : Google Scholar : PubMed/NCBI

20 

McFarlane A, Bellón JS, Meyer T, Pohler E, Piehler J and Moraga I: Differential functional coupling in Gp130-JAK complexes expands the plasticity of the interleukin-6 signaling axis. bioRxiv. doi: 10.1101/2023.05.24.542077. 2023.PubMed/NCBI

21 

Quarta S, Baeumer BE, Scherbakov N, Andratsch M, Rose-John S, Dechant G, Bandtlow CE and Kress M: Peripheral nerve regeneration and NGF-dependent neurite outgrowth of adult sensory neurons converge on STAT3 phosphorylation downstream of neuropoietic cytokine receptor gp130. J Neurosci. 34:13222–13233. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Cafferty WB, Gardiner NJ, Gavazzi I, Powell J, McMahon SB, Heath JK, Munson J, Cohen J and Thompson SW: Leukemia inhibitory factor determines the growth status of injured adult sensory neurons. J Neurosci. 21:7161–7170. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Smith PD, Sun F, Park KK, Cai B, Wang C, Kuwako K, Martinez-Carrasco I, Connolly L and He Z: SOCS3 deletion promotes optic nerve regeneration in vivo. Neuron. 64:617–623. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Shin JE, Geisler S and DiAntonio A: Dynamic regulation of SCG10 in regenerating axons after injury. Exp Neurol. 252:1–11. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Bonilla IE, Tanabe K and Strittmatter SM: Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth. J Neurosci. 22:1303–1315. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Jacobson RD, Virág I and Skene JH: A protein associated with axon growth, GAP-43, is widely distributed and developmentally regulated in rat CNS. J Neurosci. 6:1843–1855. 1986. View Article : Google Scholar : PubMed/NCBI

27 

Grenningloh G, Soehrman S, Bondallaz P, Ruchti E and Cadas H: Role of the microtubule destabilizing proteins SCG10 and stathmin in neuronal growth. J Neurobiol. 58:60–69. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Iino S, Taguchi K, Maekawa S and Nojyo Y: Motor, sensory and autonomic nerve terminals containing NAP-22 immunoreactivity in the rat muscle. Brain Res. 1002:142–150. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Laux T, Fukami K, Thelen M, Golub T, Frey D and Caroni P: GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. J Cell Biol. 149:1455–1472. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Goslin K, Schreyer DJ, Skene JH and Banker G: Changes in the distribution of GAP-43 during the development of neuronal polarity. J Neurosci. 10:588–602. 1990. View Article : Google Scholar : PubMed/NCBI

31 

Schmitt AM, Shi J, Wolf AM, Lu CC, King LA and Zou Y: Wnt-Ryk signalling mediates medial-lateral retinotectal topographic mapping. Nature. 439:31–37. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Christie KJ and Zochodne D: Peripheral axon regrowth: New molecular approaches. Neuroscience. 240:310–324. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Elsaeidi F, Bemben MA, Zhao XF and Goldman D: Jak/Stat signaling stimulates zebrafish optic nerve regeneration and overcomes the inhibitory actions of Socs3 and Sfpq. J Neurosci. 34:2632–2644. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Wood MD and Mackinnon SE: Pathways regulating modality-specific axonal regeneration in peripheral nerve. Exp Neurol. 265:171–175. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Liu RY and Snider WD: Different signaling pathways mediate regenerative versus developmental sensory axon growth. J Neurosci. 21:Rc1642001. View Article : Google Scholar : PubMed/NCBI

36 

Mikulak J, Negrini S, Klajn A, D'Alessandro R, Mavilio D and Meldolesi J: Dual REST-dependence of L1CAM: From gene expression to alternative splicing governed by Nova2 in neural cells. J Neurochem. 120:699–709. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Lietz M, Bach K and Thiel G: Biological activity of RE-1 silencing transcription factor (REST) towards distinct transcriptional activators. Eur J Neurosci. 14:1303–1312. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Gervasi NM, Dimtchev A, Clark DM, Dingle M, Pisarchik AV and Nesti LJ: C-terminal domain small phosphatase 1 (CTDSP1) regulates growth factor expression and axonal regeneration in peripheral nerve tissue. Sci Rep. 11:144622021. View Article : Google Scholar : PubMed/NCBI

39 

Ma CH, Omura T, Cobos EJ, Latrémolière A, Ghasemlou N, Brenner GJ, van Veen E, Barrett L, Sawada T, Gao F, et al: Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice. J Clin Invest. 11:4332–4347. 2011. View Article : Google Scholar

40 

Werner RA, Franzblau A, D'Arcy HJ, Evanoff BA and Tong HC: Differential aging of median and ulnar sensory nerve parameters. Muscle Nerve. 1:60–64. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Koch CM, Andrews RM, Flicek P, Dillon SC, Karaöz U, Clelland GK, Wilcox S, Beare DM, Fowler JC, Couttet P, et al: The landscape of histone modifications across 1% of the human genome in five human cell lines. Genome Res. 17:691–707. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Zhou H, Welcher AA and Shooter EM: BDNF/NT4-5 receptor TrkB and cadherin participate in cell-cell adhesion. J Neurosci Res. 49:281–291. 1997. View Article : Google Scholar : PubMed/NCBI

43 

Mallei A, Rabin SJ and Mocchetti I: Autocrine regulation of nerve growth factor expression by Trk receptors. J Neurochem. 90:1085–1093. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Cao LQ, Chen XL, Wang Q, Huang XH, Zhen MC, Zhang LJ, Li W and Bi J: Upregulation of PTEN involved in rosiglitazone-induced apoptosis in human hepatocellular carcinoma cells. Acta Pharmacol Sin. 28:879–887. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Song JX, Malampati S, Zeng Y, Durairajan SSK, Yang CB, Tong BC, Iyaswamy A, Shang WB, Sreenivasmurthy SG, Zhu Z, et al: A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models. Aging Cell. 19:e130692020. View Article : Google Scholar : PubMed/NCBI

46 

Yu B, Battaglia DM, Foster TP and Nichols CD: Serotonin 5-HT2A receptor activity mediates adipocyte differentiation through control of adipogenic gene expression. Sci Rep. 11:197142021. View Article : Google Scholar : PubMed/NCBI

47 

Wang XD, Wang Q, Chen XL, Huang JF, Yin Y, Da P and Wu H: Trop2 inhibition suppresses the proliferation and invasion of laryngeal carcinoma cells via the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway. Mol Med Rep. 12:865–870. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Tan C, Han LI, Zou L, Luo C, Liu A, Sheng X and Xi D: Expression of P2X7R in breast cancer tissue and the induction of apoptosis by the gene-specific shRNA in MCF-7 cells. Exp Ther Med. 10:1472–1478. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Pola R, Aprahamian TR, Bosch-Marcé M, Curry C, Gaetani E, Flex A, Smith RC, Isner JM and Losordo DW: Age-dependent VEGF expression and intraneural neovascularization during regeneration of peripheral nerves. Neurobiol Aging. 10:1361–1368. 2004. View Article : Google Scholar : PubMed/NCBI

50 

Girouard MP, Bueno M, Julian V, Drake S, Byrne AB and Fournier AE: The molecular interplay between axon degeneration and regeneration. Dev Neurobiol. 78:978–990. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kawakita S, Naito K, Kubota D, Ueno Y, Negishi‑Koga T, Yamamoto Y, Suzuki T, Imazu N, Kawamura K, Hattori N, Hattori N, et al: Glycoprotein 130 improves repressor element‑1 silencing transcription factor‑related axon regenerative capacity in peripheral nerves with aging. Mol Med Rep 31: 121, 2025.
APA
Kawakita, S., Naito, K., Kubota, D., Ueno, Y., Negishi‑Koga, T., Yamamoto, Y. ... Ishijima, M. (2025). Glycoprotein 130 improves repressor element‑1 silencing transcription factor‑related axon regenerative capacity in peripheral nerves with aging. Molecular Medicine Reports, 31, 121. https://doi.org/10.3892/mmr.2025.13486
MLA
Kawakita, S., Naito, K., Kubota, D., Ueno, Y., Negishi‑Koga, T., Yamamoto, Y., Suzuki, T., Imazu, N., Kawamura, K., Hattori, N., Ishijima, M."Glycoprotein 130 improves repressor element‑1 silencing transcription factor‑related axon regenerative capacity in peripheral nerves with aging". Molecular Medicine Reports 31.5 (2025): 121.
Chicago
Kawakita, S., Naito, K., Kubota, D., Ueno, Y., Negishi‑Koga, T., Yamamoto, Y., Suzuki, T., Imazu, N., Kawamura, K., Hattori, N., Ishijima, M."Glycoprotein 130 improves repressor element‑1 silencing transcription factor‑related axon regenerative capacity in peripheral nerves with aging". Molecular Medicine Reports 31, no. 5 (2025): 121. https://doi.org/10.3892/mmr.2025.13486
Copy and paste a formatted citation
x
Spandidos Publications style
Kawakita S, Naito K, Kubota D, Ueno Y, Negishi‑Koga T, Yamamoto Y, Suzuki T, Imazu N, Kawamura K, Hattori N, Hattori N, et al: Glycoprotein 130 improves repressor element‑1 silencing transcription factor‑related axon regenerative capacity in peripheral nerves with aging. Mol Med Rep 31: 121, 2025.
APA
Kawakita, S., Naito, K., Kubota, D., Ueno, Y., Negishi‑Koga, T., Yamamoto, Y. ... Ishijima, M. (2025). Glycoprotein 130 improves repressor element‑1 silencing transcription factor‑related axon regenerative capacity in peripheral nerves with aging. Molecular Medicine Reports, 31, 121. https://doi.org/10.3892/mmr.2025.13486
MLA
Kawakita, S., Naito, K., Kubota, D., Ueno, Y., Negishi‑Koga, T., Yamamoto, Y., Suzuki, T., Imazu, N., Kawamura, K., Hattori, N., Ishijima, M."Glycoprotein 130 improves repressor element‑1 silencing transcription factor‑related axon regenerative capacity in peripheral nerves with aging". Molecular Medicine Reports 31.5 (2025): 121.
Chicago
Kawakita, S., Naito, K., Kubota, D., Ueno, Y., Negishi‑Koga, T., Yamamoto, Y., Suzuki, T., Imazu, N., Kawamura, K., Hattori, N., Ishijima, M."Glycoprotein 130 improves repressor element‑1 silencing transcription factor‑related axon regenerative capacity in peripheral nerves with aging". Molecular Medicine Reports 31, no. 5 (2025): 121. https://doi.org/10.3892/mmr.2025.13486
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team