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Fibrosis factor CTGF facilitates VCAM‑1‑dependent monocyte adhesion to osteoarthritis synovial fibroblasts via the FAK and JNK pathways

  • Authors:
    • Shan-Chi Liu
    • Yat-Yin Law
    • Yu-Ying Wu
    • Yuan-Li Huang
    • Chun-Hao Tsai
    • Wei-Cheng Chen
    • Chih-Hsin Tang
  • View Affiliations / Copyright

    Affiliations: Institute of Biomedical Sciences, Mackay Medical College, New Taipei City 23245, Taiwan, R.O.C., School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan, R.O.C., Department of Orthopedics, Chung Shan Medical University Hospital, Taichung 40201, Taiwan, R.O.C., Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung 413305, Taiwan, R.O.C., Department of Sports Medicine, College of Health Care, China Medical University, Taichung 40402, Taiwan, R.O.C., Department of Medicine, MacKay Medical College, New Taipei City 23245, Taiwan, R.O.C.
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 124
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    Published online on: March 10, 2025
       https://doi.org/10.3892/mmr.2025.13489
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Abstract

Osteoarthritis (OA) is a long‑term, degenerative joint disease that presents significant clinical challenges and imposes considerable financial burdens. Fibrosis is closely intertwined with the pathogenesis of various degenerative diseases, including OA. Using data from the GDS5401 dataset, the present study determined that expression levels of the fibrosis factor connective tissue growth factor (CTGF) were significantly higher in OA patients than in normal individuals. The present study also identified CTGF elevated expression levels in both OA patients compared with healthy controls and in rats with anterior cruciate ligament transection‑induced OA versus controls. Stimulating OA synovial fibroblasts (OASFs) with CTGF was shown to promote vascular cell adhesion molecule‑1 (VCAM‑1) production, thereby facilitating monocyte adhesion to OASFs. Analysis of a large dataset revealed that monocytes are the only mononuclear cells with significantly elevated levels in OA patients. It also appeared that CTGF‑induced VCAM‑1 production and monocyte adhesion were mediated via the focal adhesion kinase and JNK pathways. These findings suggest that CTGF contributes to OA progression by enhancing monocyte adhesion to the synovial membrane.
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Copy and paste a formatted citation
Spandidos Publications style
Liu S, Law Y, Wu Y, Huang Y, Tsai C, Chen W and Tang C: Fibrosis factor CTGF facilitates VCAM‑1‑dependent monocyte adhesion to osteoarthritis synovial fibroblasts via the FAK and JNK pathways. Mol Med Rep 31: 124, 2025.
APA
Liu, S., Law, Y., Wu, Y., Huang, Y., Tsai, C., Chen, W., & Tang, C. (2025). Fibrosis factor CTGF facilitates VCAM‑1‑dependent monocyte adhesion to osteoarthritis synovial fibroblasts via the FAK and JNK pathways. Molecular Medicine Reports, 31, 124. https://doi.org/10.3892/mmr.2025.13489
MLA
Liu, S., Law, Y., Wu, Y., Huang, Y., Tsai, C., Chen, W., Tang, C."Fibrosis factor CTGF facilitates VCAM‑1‑dependent monocyte adhesion to osteoarthritis synovial fibroblasts via the FAK and JNK pathways". Molecular Medicine Reports 31.5 (2025): 124.
Chicago
Liu, S., Law, Y., Wu, Y., Huang, Y., Tsai, C., Chen, W., Tang, C."Fibrosis factor CTGF facilitates VCAM‑1‑dependent monocyte adhesion to osteoarthritis synovial fibroblasts via the FAK and JNK pathways". Molecular Medicine Reports 31, no. 5 (2025): 124. https://doi.org/10.3892/mmr.2025.13489
Copy and paste a formatted citation
x
Spandidos Publications style
Liu S, Law Y, Wu Y, Huang Y, Tsai C, Chen W and Tang C: Fibrosis factor CTGF facilitates VCAM‑1‑dependent monocyte adhesion to osteoarthritis synovial fibroblasts via the FAK and JNK pathways. Mol Med Rep 31: 124, 2025.
APA
Liu, S., Law, Y., Wu, Y., Huang, Y., Tsai, C., Chen, W., & Tang, C. (2025). Fibrosis factor CTGF facilitates VCAM‑1‑dependent monocyte adhesion to osteoarthritis synovial fibroblasts via the FAK and JNK pathways. Molecular Medicine Reports, 31, 124. https://doi.org/10.3892/mmr.2025.13489
MLA
Liu, S., Law, Y., Wu, Y., Huang, Y., Tsai, C., Chen, W., Tang, C."Fibrosis factor CTGF facilitates VCAM‑1‑dependent monocyte adhesion to osteoarthritis synovial fibroblasts via the FAK and JNK pathways". Molecular Medicine Reports 31.5 (2025): 124.
Chicago
Liu, S., Law, Y., Wu, Y., Huang, Y., Tsai, C., Chen, W., Tang, C."Fibrosis factor CTGF facilitates VCAM‑1‑dependent monocyte adhesion to osteoarthritis synovial fibroblasts via the FAK and JNK pathways". Molecular Medicine Reports 31, no. 5 (2025): 124. https://doi.org/10.3892/mmr.2025.13489
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