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Review Open Access

Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review)

  • Authors:
    • Pingping Tang
    • Jiale Wang
    • Xiaohan Tang
    • Yichun Li
    • Suyun Li
  • View Affiliations / Copyright

    Affiliations: Clinical Anatomy and Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, P.R. China, Department of Obstetrics and Gynecology, The Second Affiliated Hospital University of South China, Hengyang, Hunan 421001, P.R. China
    Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 129
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    Published online on: March 18, 2025
       https://doi.org/10.3892/mmr.2025.13494
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Abstract

Spermatogenesis dysfunction is characterized by abnormal morphology, destruction, atrophy of seminiferous tubules, blocked differentiation of spermatogenic cells, decreased sperm count and increased sperm abnormalities. Inflammation, oxidative stress, endoplasmic reticulum stress and obesity are important factors leading to spermatogenesis dysfunction. It has been demonstrated that insulin‑like growth factor 2 (IGF2) is closely related to the aforementioned factors. In the present review, the relationship between IGF2 and inflammation, oxidative stress, ER stress and obesity was investigated, providing theoretical and experimental evidence on the role of IGF2 in the prevention and treatment of spermatogenesis dysfunction of male infertility.
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Spandidos Publications style
Tang P, Wang J, Tang X, Li Y and Li S: Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review). Mol Med Rep 31: 129, 2025.
APA
Tang, P., Wang, J., Tang, X., Li, Y., & Li, S. (2025). Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review). Molecular Medicine Reports, 31, 129. https://doi.org/10.3892/mmr.2025.13494
MLA
Tang, P., Wang, J., Tang, X., Li, Y., Li, S."Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review)". Molecular Medicine Reports 31.5 (2025): 129.
Chicago
Tang, P., Wang, J., Tang, X., Li, Y., Li, S."Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review)". Molecular Medicine Reports 31, no. 5 (2025): 129. https://doi.org/10.3892/mmr.2025.13494
Copy and paste a formatted citation
x
Spandidos Publications style
Tang P, Wang J, Tang X, Li Y and Li S: Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review). Mol Med Rep 31: 129, 2025.
APA
Tang, P., Wang, J., Tang, X., Li, Y., & Li, S. (2025). Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review). Molecular Medicine Reports, 31, 129. https://doi.org/10.3892/mmr.2025.13494
MLA
Tang, P., Wang, J., Tang, X., Li, Y., Li, S."Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review)". Molecular Medicine Reports 31.5 (2025): 129.
Chicago
Tang, P., Wang, J., Tang, X., Li, Y., Li, S."Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review)". Molecular Medicine Reports 31, no. 5 (2025): 129. https://doi.org/10.3892/mmr.2025.13494
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