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Efficacy of exosomes in acute kidney injury treatment and the associated mechanism (Review)

  • Authors:
    • Zehao Zhang
    • Lecheng She
    • Ming Bai
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 137
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    Published online on: March 26, 2025
       https://doi.org/10.3892/mmr.2025.13503
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Abstract

Acute kidney injury (AKI) is a syndrome characterized by rapid loss of renal function with a high morbidity and mortality. However, due to the complex pathophysiologic mechanisms of AKI, no specific treatment for this disease is currently available. Animal models have demonstrated the protective effects of exosomes on AKI; however, the underlying mechanisms require further investigation. The present review focuses on the efficacy of exosomes derived from different cell sources, including mesenchymal stem cells, endothelial progenitor cells and tubular epithelial cells, in the treatment of AKI and the associated mechanism. Furthermore, the effects of exosomal contents, including microRNAs, circular RNAs, long non‑coding RNAs, messenger RNAs and proteins, on the repair of renal tubules, protection against renal tubular epithelial cell injury, protection against fibrosis, inhibition of early endoplasmic reticulum stress and mediation of inflammation during AKI are also summarized in the present review.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, She L and Bai M: Efficacy of exosomes in acute kidney injury treatment and the associated mechanism (Review). Mol Med Rep 31: 137, 2025.
APA
Zhang, Z., She, L., & Bai, M. (2025). Efficacy of exosomes in acute kidney injury treatment and the associated mechanism (Review). Molecular Medicine Reports, 31, 137. https://doi.org/10.3892/mmr.2025.13503
MLA
Zhang, Z., She, L., Bai, M."Efficacy of exosomes in acute kidney injury treatment and the associated mechanism (Review)". Molecular Medicine Reports 31.5 (2025): 137.
Chicago
Zhang, Z., She, L., Bai, M."Efficacy of exosomes in acute kidney injury treatment and the associated mechanism (Review)". Molecular Medicine Reports 31, no. 5 (2025): 137. https://doi.org/10.3892/mmr.2025.13503
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, She L and Bai M: Efficacy of exosomes in acute kidney injury treatment and the associated mechanism (Review). Mol Med Rep 31: 137, 2025.
APA
Zhang, Z., She, L., & Bai, M. (2025). Efficacy of exosomes in acute kidney injury treatment and the associated mechanism (Review). Molecular Medicine Reports, 31, 137. https://doi.org/10.3892/mmr.2025.13503
MLA
Zhang, Z., She, L., Bai, M."Efficacy of exosomes in acute kidney injury treatment and the associated mechanism (Review)". Molecular Medicine Reports 31.5 (2025): 137.
Chicago
Zhang, Z., She, L., Bai, M."Efficacy of exosomes in acute kidney injury treatment and the associated mechanism (Review)". Molecular Medicine Reports 31, no. 5 (2025): 137. https://doi.org/10.3892/mmr.2025.13503
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