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Review Open Access

Hyperbaric oxygen therapy for sudden sensorineural hearing loss (Review)

  • Authors:
    • Yuting Sun
    • Shangyuan Wang
    • Huimin Fu
    • Xiaoli Ge
    • Shuming Pan
  • View Affiliations / Copyright

    Affiliations: Emergency Department, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, P.R. China, Emergency Department, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 202150, P.R. China, Emergency Department, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 307
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    Published online on: September 2, 2025
       https://doi.org/10.3892/mmr.2025.13672
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Abstract

Sudden sensorineural hearing loss (SSNHL) is an acute hearing disorder that develops rapidly and is an otolaryngology emergency. Hyperbaric oxygen therapy (HBOT), a non‑pharmacological treatment, has gained increasing attention for SSNHL management. HBOT exerts therapeutic effects by increasing inner ear oxygen partial pressure, improving the microcirculation and reducing inflammation, as its main mechanisms. When combined with glucocorticoids, HBOT can significantly improve treatment outcomes, particularly when initiated as an early intervention. However, its optimal clinical application has not yet been determined, mainly due to the lack of standardized treatment parameters, such as pressure settings, the duration of treatment and the therapeutic time window. In addition, clinical studies have yielded inconsistent results. The purpose of the present review is to explore the biological mechanisms, clinical efficacy and existing controversies of HBOT in the treatment of SSNHL, review and summarize the latest research progress, and discuss potential directions for future development.
View Figures

Figure 1

Mechanism of hyperbaric oxygen
therapy in the treatment of SSNHL. SSNHL, sudden sensorineural
hearing loss; TLR4, Toll-like receptor 4; ROS, reactive oxygen
species; IGF-1, insulin-like growth factor-1; HSP70, heat shock
protein 70; NLR, neutrophil/leukocyte ratio; PLR,
platelet/leukocyte ratio.
View References

1 

Ying YM, Tseng CC, Shin J and Rauch S: Natural history of untreated idiopathic sudden sensorineural hearing loss. Laryngoscope. 134 (Suppl 9):S1–S15. 2024. View Article : Google Scholar : PubMed/NCBI

2 

Xie S, Qiang Q, Mei L, He C, Feng Y, Sun H and Wu X: Multivariate analysis of prognostic factors for idiopathic sudden sensorineural hearing loss treated with adjuvant hyperbaric oxygen therapy. Eur Arch Otorhinolaryngol. 275:47–51. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Feng T, Zhang Q, Wei J, Wang X and Geng Y: Effects of alprostadil combined with hyperbaric oxygen on hearing recovery and hemorheology in patients with sudden sensorineural hearing loss and analysis of related influencing factors. Exp Ther Med. 23:2422022. View Article : Google Scholar : PubMed/NCBI

4 

Çiçek T, Özbilen Acar G and Özdamar Oİ: Evaluation of neutrophil/lymphocyte and platelet/lymphocyte ratios in sudden sensorineural hearing loss and relationship with hyperbaric oxygen therapy. J Int Adv Otol. 17:96–102. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Li H, Zhao D, Diao M, Yang C, Zhang Y, Lv Y, Zhao J and Pan S: Hyperbaric oxygen treatments attenuate the neutrophil-to-lymphocyte ratio in patients with idiopathic sudden sensorineural hearing loss. Otolaryngol Head Neck Surg. 153:606–612. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Chandrasekhar SS, Tsai Do BS, Schwartz SR, Bontempo LJ, Faucett EA, Finestone SA, Hollingsworth DB, Kelley DM, Kmucha ST, Moonis G, et al: Clinical practice guideline: Sudden hearing loss (update). Otolaryngol Head Neck Surg. 161 (1_suppl):S1–S45. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Frosolini A, Franz L, Daloiso A, Lovato A, de Filippis C and Marioni G: Digging into the role of inflammatory biomarkers in sudden sensorineural hearing loss diagnosis and prognosis: A systematic review and meta-analysis. Medicina (Kaunas). 58:9632022. View Article : Google Scholar : PubMed/NCBI

8 

Tsuzuki N and Wasano K: Idiopathic sudden sensorineural hearing loss: A review focused on the contribution of vascular pathologies. Auris Nasus Larynx. 51:747–754. 2024. View Article : Google Scholar : PubMed/NCBI

9 

Mei X, Atturo F, Wadin K, Larsson S, Agrawal S, Ladak HM, Li H and Rask-Andersen H: Human inner ear blood supply revisited: The uppsala collection of temporal bone-an international resource of education and collaboration. Ups J Med Sci. 123:131–142. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Xie W, Dai Q, Liu J, Liu Y, Hellström S and Duan M: Analysis of clinical and laboratory findings of idiopathic sudden sensorineural hearing loss. Sci Rep. 10:60572020. View Article : Google Scholar : PubMed/NCBI

11 

Wang S, Ye Q and Pan Y: Serum non-high-density lipoprotein cholesterol is associated with the risk of sudden sensorineural hearing loss. Medicine (Baltimore). 99:e191752020. View Article : Google Scholar : PubMed/NCBI

12 

Fasano T, Pilia A, Vecchia L, Pertinhez TA, Lasagni D, Baricchi R, Tribi L and Bianchin G: In response to laboratory assessment of sudden sensorineural hearing loss: A case-control study. Laryngoscope. 127:E4212017. View Article : Google Scholar : PubMed/NCBI

13 

Ulu Ş, Kınar A, Bucak A and Özdemir M: Systemic immune inflammatory index of patients with idiopathic sudden sensorineural hearing loss: Comparison of NLR and PRL values. Ear Nose Throat J. 100:726–730. 2021. View Article : Google Scholar : PubMed/NCBI

14 

Qiao XF, Li X, Wang GP, Bai YH, Zheng W and Li TL: Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with sudden sensorineural hearing loss. Med Princ Pract. 28:23–27. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Pawlak-Osinska K, Golda R, Osinski S, Kazmierczak H, Krumrych W, Marzec M and Przybylski G: Circulating immune complexes and heat shock protein 70 in the sera of patients with sudden sensorineural hearing loss. J Int Adv Otol. 14:426–431. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Zhang Y, Jia X, Liu X, Zhao L, Zhou Y, Liang F, Gao Y and Yang J: Hyperbaric oxygen therapy promotes hearing gain with increases in serum IGF-1 and HSP70 in patients with idiopathic sudden sensorineural hearing loss. Evid Based Complement Alternat Med. 2022:13687832022. View Article : Google Scholar : PubMed/NCBI

17 

Baradaranfar M, Dadgarnia M, Zand V, Vaziribozorg S, Mirzade FS and Mirzade M: The role of immunological factors on sudden sensoryneural hearing loss. Iran J Otorhinolaryngol. 30:219–223. 2018.PubMed/NCBI

18 

Plontke SK, Meisner C, Agrawal S, Cayé-Thomasen P, Galbraith K, Mikulec AA, Parnes L, Premakumar Y, Reiber J, Schilder AG and Liebau A: Intratympanic corticosteroids for sudden sensorineural hearing loss. Cochrane Database Syst Rev. 7:CD0080802022.PubMed/NCBI

19 

Kilic O, Kalcioglu MT, Cag Y, Tuysuz O, Pektas E, Caskurlu H and Cetın F: Could sudden sensorineural hearing loss be the sole manifestation of covid-19? An investigation into SARS-cov-2 in the etiology of sudden sensorineural hearing loss. Int J Infect Dis. 97:208–211. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Zhuang W, Wang C, Shi X, Qiu S, Zhang S, Xu B, Chen M, Jiang W, Dong H and Qiao Y: MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss. Int J Mol Med. 41:3448–3456. 2018.PubMed/NCBI

21 

Ortega MA, Fraile-Martinez O, García-Montero C, Callejón-Peláez E, Sáez MA, Álvarez-Mon MA, García-Honduvilla N, Monserrat J, Álvarez-Mon M, Bujan J and Canals ML: A general overview on the hyperbaric oxygen therapy: Applications, mechanisms and translational opportunities. Medicina (Kaunas). 57:8642021. View Article : Google Scholar : PubMed/NCBI

22 

Almutairi N, Alnofal E, Algouhi A, Bamajboor AS and Alzaher N: The effectiveness of hyperbaric oxygen therapy as salvage treatment for sudden sensorineural hearing loss: A retrospective study. Cureus. 12:e108192020.PubMed/NCBI

23 

Bayoumy AB and de Ru JA: The use of hyperbaric oxygen therapy in acute hearing loss: A narrative review. Eur Arch Otorhinolaryngol. 276:1859–1880. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Olex-Zarychta D: Hyperbaric oxygenation as adjunctive therapy in the treatment of sudden sensorineural hearing loss. Int J Mol Sci. 21:85882020. View Article : Google Scholar : PubMed/NCBI

25 

Dünnwald T, Held J, Balan P, Pecher O, Zeiger T, Hartig F, Mur E, Weiss G and Schobersberger W: Combined hyperbaric oxygen partial pressure at 1.4 bar with infrared radiation: A useful tool to improve tissue hypoxemia? Med Sci Monit. 24:4009–4019. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Yamamoto N, Takada R, Maeda T, Yoshii T, Okawa A and Yagishita K: Microcirculation and tissue oxygenation in the head and limbs during hyperbaric oxygen treatment. Diving Hyperb Med. 51:338–344. 2021. View Article : Google Scholar : PubMed/NCBI

27 

Tian G, Zhang S and Yang J: Coexistence of IL-6 −572C/G and ICAM-1 K469E polymorphisms among patients with sudden sensorineural hearing loss. Tohoku J Exp Med. 245:7–12. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Yoon SH, Kim ME, Kim HY, Lee JS and Jang CH: Inflammatory cytokines and mononuclear cells in sudden sensorineural hearing loss. J Laryngol Otol. 133:95–101. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Liu XH, Liang F, Jia XY, Zhao L, Zhou Y and Yang J: Hyperbaric oxygen treatment improves hearing level via attenuating TLR4/NF-κB mediated inflammation in sudden sensorineural hearing loss patients. Biomed Environ Sci. 33:331–337. 2020.PubMed/NCBI

30 

Zhao T, Zhu Y, Yao L, Liu L and Li N: IGF-1 alleviates CCl4-induced hepatic cirrhosis and dysfunction of intestinal barrier through inhibition TLR4/NF-κB signaling mediated by down-regulation HMGB1. Ann Hepatol. 26:1005602021. View Article : Google Scholar : PubMed/NCBI

31 

Rogers SC, Ge X, Brummet M, Lin X, Timm DD, D'Avignon A, Garbow JR, Kao J, Prakash J, Issaian A, et al: Quantifying dynamic range in red blood cell energetics: Evidence of progressive energy failure during storage. Transfusion. 61:1586–1599. 2021. View Article : Google Scholar : PubMed/NCBI

32 

Bai X, Chen S, Xu K, Jin Y, Niu X, Xie L, Qiu Y, Liu XZ and Sun Y: N-acetylcysteine combined with dexamethasone treatment improves sudden sensorineural hearing loss and attenuates hair cell death caused by ros stress. Front Cell Dev Biol. 9:6594862021. View Article : Google Scholar : PubMed/NCBI

33 

Wang S, Hou K, Gui S, Ma Y, Wang S, Zhao S and Zhu X: Insulin-like growth factor 1 in heat stress-induced neuroinflammation: Novel perspective about the neuroprotective role of chromium. Stress Biol. 3:232023. View Article : Google Scholar : PubMed/NCBI

34 

Choi Y, Han SJ, Kim SK and Hong SM: The therapeutic effect of hyperbaric oxygen therapy in patients with severe to profound idiopathic sudden sensorineural hearing loss. Sci Rep. 14:33212024. View Article : Google Scholar : PubMed/NCBI

35 

Zahorec R: Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 102:5–14. 2001.(In English, Slovak). PubMed/NCBI

36 

Xi J, Liu H and Wang X: Prostaglandin E1 effects on CD62p and PAC-1 in patients with sudden sensorineural hearing loss. Thromb Res. 188:31–38. 2020. View Article : Google Scholar : PubMed/NCBI

37 

Gupta M and Somasundaram I: Hyperbaric chambers: Design and function. Hyperbaric Oxygen Therapy: Principles and Applications. Springer Nature Singapore; Singapore: pp. 31–36. 2023, View Article : Google Scholar

38 

Hu Y, Ye Y, Ji X and Wu J: The role of hyperbaric oxygen in idiopathic sudden sensorineural hearing loss. Med Gas Res. 14:180–185. 2024. View Article : Google Scholar : PubMed/NCBI

39 

Mathieu D, Marroni A and Kot J: Tenth european consensus conference on hyperbaric medicine: Preliminary report. Diving Hyperb Med. 46:122–123. 2016.PubMed/NCBI

40 

Kim H, Kong SK, Kim J, Lee HM, Choi SW, Lee IW and Oh SJ: The optimized protocol of hyperbaric oxygen therapy for sudden sensorineural hearing loss. Laryngoscope. 133:383–388. 2023. View Article : Google Scholar : PubMed/NCBI

41 

Chen C, Hu H and Chen RY: Varied effects exerted on sudden sensorineural hearing loss through HBO2 therapeutic pressure. Undersea Hyperb Med Fourth Quarter. 48:417–423. 2021. View Article : Google Scholar : PubMed/NCBI

42 

Umesawa M, Kobashi G, Kitoh R, Nishio SY, Ogawa K, Hato N, Sone M, Fukuda S, Hara A, Ikezono T, et al: Relationships among drinking and smoking habits, history of diseases, body mass index and idiopathic sudden sensorineural hearing loss in Japanese patients. Acta Otolaryngol. 137 (sup565):S17–S23. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Lam M, Bao Y, Hua GB and Sommer DD: Sudden sensorineural hearing loss and metabolic syndrome: A systematic review and meta-analysis. Otol Neurotol. 42:1308–1313. 2021. View Article : Google Scholar : PubMed/NCBI

44 

Holy R, Navara M, Dosel P, Fundova P, Prazenica P and Hahn A: Hyperbaric oxygen therapy in idiopathic sudden sensorineural hearing loss (ISSNHL) in association with combined treatment. Undersea Hyperb Med. 38:137–142. 2011.PubMed/NCBI

45 

Yıldırım E, Murat Özcan K, Palalı M, Cetin MA, Ensari S and Dere H: Prognostic effect of hyperbaric oxygen therapy starting time for sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol. 272:23–28. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Wang HH, Chen YT, Chou SF, Lee LC, Wang JH, Lai YH and Chang HT: Effect of the timing of hyperbaric oxygen therapy on the prognosis of patients with idiopathic sudden sensorineural hearing loss. Biomedicines. 11:26702023. View Article : Google Scholar : PubMed/NCBI

47 

Choi Y, Choi HL, Jeong AY, Kang WS, Park HJ, Chung JW and Ahn JH: Hyperbaric oxygen (HBO) therapy as an effective approach to the treatment of patients with severe idiopathic sudden sensorineural hearing loss. Acta Otolaryngol. 140:383–386. 2020. View Article : Google Scholar : PubMed/NCBI

48 

Zhu Y, He S, Liao K, Li M, Zhao Z and Jiang H: Clinical profiles and prognoses of adult patients with full-frequency sudden sensorineural hearing loss in combination therapy. J Clin Med. 12:14782023. View Article : Google Scholar : PubMed/NCBI

49 

Fu Q, Duan R, Sun Y and Li Q: Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics. Redox Biol. 53:1023522022. View Article : Google Scholar : PubMed/NCBI

50 

Zhang Y, Zhou Y, Jia Y, Wang T and Meng D: Adverse effects of hyperbaric oxygen therapy: A systematic review and meta-analysis. Front Med (Lausanne). 10:11607742023. View Article : Google Scholar : PubMed/NCBI

51 

Wilson WR, Byl FM and Laird N: The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-blind clinical study. Arch Otolaryngol. 106:772–776. 1980. View Article : Google Scholar : PubMed/NCBI

52 

Wei BP, Stathopoulos D and O'Leary S: Steroids for idiopathic sudden sensorineural hearing loss. Cochrane Database Syst Rev. 2013:CD0039982013.PubMed/NCBI

53 

Akuter idiopathischer sensorineuraler hörverlust-steroidpulstherapie oder traditionelle orale prednisolon-therapie? Laryngorhinootologie. 95:748–749. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Huang J, Yang L, Cao X and Wang W: Differences in hearing recovery following intratympanic alone or intravenous dexamethasone with rescue intratympanic steroids for sudden sensorineural hearing loss: A randomised trial. Clin Otolaryngol. 46:546–551. 2021. View Article : Google Scholar : PubMed/NCBI

55 

Skarżyńska MB, Kołodziejak A, Gos E, Sanfis MD and Skarżyński PH: Effectiveness of various treatments for sudden sensorineural hearing loss-a retrospective study. Life (Basel). 12:962022.PubMed/NCBI

56 

Chin CS, Lee TY, Chen YW and Wu MF: Idiopathic sudden sensorineural hearing loss: Is hyperbaric oxygen treatment the sooner and longer, the better? J Pers Med. 12:16522022. View Article : Google Scholar : PubMed/NCBI

57 

Si X, Yu Z, Ren X, Huang L and Feng Y: Efficacy and safety of standardized ginkgo biloba L. Leaves extract as an adjuvant therapy for sudden sensorineural hearing loss: A systematic review and meta-analysis. J Ethnopharmacol. 282:1145872022. View Article : Google Scholar : PubMed/NCBI

58 

Agarwal L and Pothier DD: Vasodilators and vasoactive substances for idiopathic sudden sensorineural hearing loss. Cochrane Database Syst Rev. 2009:CD0034222009.PubMed/NCBI

59 

Caragli V, Franz L, Incognito A, Bitonti S, Guarnaccia M, Cenedese R, Cocimano D, Romano A, Canova G, Zanatta P, et al: Prognostic factors in idiopathic sudden sensorineural hearing loss: The experience of two audiology tertiary referral centres. Medicina (Kaunas). 60:11302024. View Article : Google Scholar : PubMed/NCBI

60 

Sanda N, Sawabe M, Kabaya K, Kawaguchi M, Fukushima A, Nakamura Y, Maseki S, Niwa M, Mori H, Hyodo Y, et al: Clinical impact of hyperbaric oxygen therapy combined with steroid treatment for sudden sensorineural hearing loss: A case-control study. Laryngoscope Investig Otolaryngol. 9:e12972024. View Article : Google Scholar : PubMed/NCBI

61 

Lee JW, Kim H, Kong SK, Kim J, Choi SW and Oh SJ: The effectiveness of salvage hyperbaric oxygen therapy following combined steroid therapy for refractory sudden sensorineural hearing loss. Ann Otol Rhinol Laryngol. 133:400–405. 2024. View Article : Google Scholar : PubMed/NCBI

62 

Skarzynski PH, Kolodziejak A, Gos E, Skarzynska MB, Czajka N and Skarzynski H: Hyperbaric oxygen therapy as an adjunct to corticosteroid treatment in sudden sensorineural hearing loss: A retrospective study. Front Neurol. 14:12251352023. View Article : Google Scholar : PubMed/NCBI

63 

Kayalı Dinç AS, Çayönü M, Boynueğri S, Ünsal Tuna E and Eryılmaz A: Is salvage hyperbaric oxygen therapy effective for sudden sensorineural hearing loss in patients with non-response to corticostreoid treatment? Cureus. 12:e65602020.PubMed/NCBI

64 

Almosnino G, Holm JR, Schwartz SR and Zeitler DM: The role of hyperbaric oxygen as salvage therapy for sudden sensorineural hearing loss. Ann Otol Rhinol Laryngol. 127:672–676. 2018. View Article : Google Scholar : PubMed/NCBI

65 

Suzuki H, Kawaguchi R, Wakasugi T, Do BH, Kitamura T and Ohbuchi T: Efficacy of intratympanic steroid on idiopathic sudden sensorineural hearing loss: An analysis of cases with negative prognostic factors. Am J Audiol. 28:308–314. 2019. View Article : Google Scholar : PubMed/NCBI

66 

Yang CH, Wu RW and Hwang CF: Comparison of intratympanic steroid injection, hyperbaric oxygen and combination therapy in refractory sudden sensorineural hearing loss. Otol Neurotol. 34:1411–1416. 2013. View Article : Google Scholar : PubMed/NCBI

67 

Sun H, Qiu X, Hu J and Ma Z: Comparison of intratympanic dexamethasone therapy and hyperbaric oxygen therapy for the salvage treatment of refractory high-frequency sudden sensorineural hearing loss. Am J Otolaryngol. 39:531–535. 2018. View Article : Google Scholar : PubMed/NCBI

68 

Cavaliere M, De Luca P, Scarpa A, Strzalkowski AM, Ralli M, Calvanese M, Savignano L, Viola P, Cassandro C, Chiarella G and Di Stadio A: Combination of hyperbaric oxygen therapy and oral steroids for the treatment of sudden sensorineural hearing loss: Early or late? Medicina (Kaunas). 58:14212022. View Article : Google Scholar : PubMed/NCBI

69 

Oya R, Horii A, Akazawa H, Osaki Y and Inohara H: Prognostic predictors of sudden sensorineural hearing loss in defibrinogenation therapy. Acta Otolaryngol. 136:271–276. 2016. View Article : Google Scholar : PubMed/NCBI

70 

Celik A and Akil F: Treatment effectiveness according to frequencies in patients with sudden sensorineural hearing loss. Cir Cir. 92:795–803. 2024.PubMed/NCBI

71 

Mariani C, Carta F, Catani G, Lobina S, Marrosu V, Corrias S, Tatti M and Puxeddu R: Idiopathic sudden sensorineural hearing loss: effectiveness of salvage treatment with intratympanic dexamethasone or hyperbaric oxygen therapy in addition to systemic steroids. Front Neurol. 14:12252062023. View Article : Google Scholar : PubMed/NCBI

72 

Včeva A, Zubčić Ž, Mihalj H, Maleš J, Mendeš T and Šestak A: Pretreatment hearing grades and hearing recovery outcomes after primary hyperbaric oxygen treatment in patients with idiopathic sudden sensorineural hearing loss. Diving Hyperb Med. 52:191–196. 2022. View Article : Google Scholar : PubMed/NCBI

73 

Dova S, Psillas G, Tsaligopoulos M, Nikolaidis V, Stefanidou S, Karagiannis G, Kotsiou M, Kaltzidis T and Markou K: The effectiveness of hyperbaric oxygen therapy on the final outcome of patients with sudden sensorineural hearing loss. Am J Otolaryngol. 43:1035642022. View Article : Google Scholar : PubMed/NCBI

74 

Huo Z, Cheng X, Gu J, Hong Y, Wang Z and Zhang Z: Prognostic factors for hearing outcomes in patients that undergo adjuvant hyperbaric oxygen therapy for sudden sensorineural hearing loss. Laryngoscope Investig Otolaryngol. 7:592–598. 2022. View Article : Google Scholar : PubMed/NCBI

75 

Huang C, Tan G, Xiao J and Wang G: Efficacy of hyperbaric oxygen on idiopathic sudden sensorineural hearing loss and its correlation with treatment course: Prospective clinical research. Audiol Neurootol. 26:479–486. 2021. View Article : Google Scholar : PubMed/NCBI

76 

Keseroğlu K, Toptaş G, Uluat A, Bayir Ö, Çadalli Tatar E, Saylam G, Korkmaz MH and Özdek A: Addition of intratympanic steroid or hyperbaric oxygen treatment to systemic steroid treatment in sudden idiopathic sensorineural hearing loss treatment, and long-term results of salvage treatment. Turk J Med Sci. 50:177–183. 2020.PubMed/NCBI

77 

Cho I, Lee HM, Choi SW, Kong SK, Lee IW, Goh EK and Oh SJ: Comparison of two different treatment protocols using systemic and intratympanic steroids with and without hyperbaric oxygen therapy in patients with severe to profound idiopathic sudden sensorineural hearing loss: A randomized controlled trial. Audiol Neurootol. 23:199–207. 2018. View Article : Google Scholar : PubMed/NCBI

78 

Hosokawa S, Hosokawa K, Takahashi G, Sugiyama KI, Nakanishi H, Takebayashi S and Mineta H: Hyperbaric oxygen therapy as concurrent treatment with systemic steroids for idiopathic sudden sensorineural hearing loss: A comparison of three different steroid treatments. Audiol Neurootol. 23:145–151. 2018. View Article : Google Scholar : PubMed/NCBI

79 

Krajcovicova Z, Melus V, Zigo R, Matisáková I, Vecera J and Kaslíková K: Efficacy of hyperbaric oxygen therapy as a supplementary therapy of sudden sensorineural hearing loss in the Slovak republic. Undersea Hyperb Med. 45:363–370. 2018. View Article : Google Scholar : PubMed/NCBI

80 

Khater A, El-Anwar MW, Nofal AA and Elbahrawy AT: Sudden sensorineural hearing loss: Comparative study of different treatment modalities. Int Arch Otorhinolaryngol. 22:245–249. 2018. View Article : Google Scholar : PubMed/NCBI

81 

Chi TH, Chiang MC, Chen RF and Yuan CH: Does the addition of hyperbaric oxygen therapy to conventional treatment modalities influence the outcome of soldiers with idiopathic sudden sensorineural hearing loss? J R Army Med Corps. 164:69–71. 2018. View Article : Google Scholar : PubMed/NCBI

82 

Ajduk J, Ries M, Trotic R, Marinac I, Vlatka K and Bedekovic V: Hyperbaric oxygen therapy as salvage therapy for sudden sensorineural hearing loss. J Int Adv Otol. 13:61–64. 2017. View Article : Google Scholar : PubMed/NCBI

83 

Hosokawa S, Sugiyama KI, Takahashi G, Hashimoto YI, Hosokawa K, Takebayashi S and Mineta H: Hyperbaric oxygen therapy as adjuvant treatment for idiopathic sudden sensorineural hearing loss after failure of systemic steroids. Audiol Neurootol. 22:9–14. 2017. View Article : Google Scholar : PubMed/NCBI

84 

Gülüstan F, Yazıcı ZM, Alakhras WME, Erdur O, Acipayam H, Kufeciler L and Kayhan FT: Intratympanic steroid injection and hyperbaric oxygen therapy for the treatment of refractory sudden hearing loss. Braz J Otorhinolaryngol. 84:28–33. 2016. View Article : Google Scholar : PubMed/NCBI

85 

Ersoy Callioglu E, Tuzuner A, Demirci S, Cengiz C and Caylan R: Comparison of simultaneous systemic steroid and hyperbaric oxygen treatment versus only steroid in idiopathic sudden sensorineural hearing loss. Int J Clin Exp Med. 8:9876–9882. 2015.PubMed/NCBI

86 

Capuano L, Cavaliere M, Parente G, Damiano A, Pezzuti G, Lopardo D and Iemma M: Hyperbaric oxygen for idiopathic sudden hearing loss: Is the routine application helpful? Acta Otolaryngol. 135:692–697. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun Y, Wang S, Fu H, Ge X and Pan S: Hyperbaric oxygen therapy for sudden sensorineural hearing loss (Review). Mol Med Rep 32: 307, 2025.
APA
Sun, Y., Wang, S., Fu, H., Ge, X., & Pan, S. (2025). Hyperbaric oxygen therapy for sudden sensorineural hearing loss (Review). Molecular Medicine Reports, 32, 307. https://doi.org/10.3892/mmr.2025.13672
MLA
Sun, Y., Wang, S., Fu, H., Ge, X., Pan, S."Hyperbaric oxygen therapy for sudden sensorineural hearing loss (Review)". Molecular Medicine Reports 32.5 (2025): 307.
Chicago
Sun, Y., Wang, S., Fu, H., Ge, X., Pan, S."Hyperbaric oxygen therapy for sudden sensorineural hearing loss (Review)". Molecular Medicine Reports 32, no. 5 (2025): 307. https://doi.org/10.3892/mmr.2025.13672
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Wang S, Fu H, Ge X and Pan S: Hyperbaric oxygen therapy for sudden sensorineural hearing loss (Review). Mol Med Rep 32: 307, 2025.
APA
Sun, Y., Wang, S., Fu, H., Ge, X., & Pan, S. (2025). Hyperbaric oxygen therapy for sudden sensorineural hearing loss (Review). Molecular Medicine Reports, 32, 307. https://doi.org/10.3892/mmr.2025.13672
MLA
Sun, Y., Wang, S., Fu, H., Ge, X., Pan, S."Hyperbaric oxygen therapy for sudden sensorineural hearing loss (Review)". Molecular Medicine Reports 32.5 (2025): 307.
Chicago
Sun, Y., Wang, S., Fu, H., Ge, X., Pan, S."Hyperbaric oxygen therapy for sudden sensorineural hearing loss (Review)". Molecular Medicine Reports 32, no. 5 (2025): 307. https://doi.org/10.3892/mmr.2025.13672
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