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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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December-2025 Volume 32 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Correction Open Access

[Corrigendum] Reactive oxygen species‑mediated activation of the Src‑epidermal growth factor receptor‑Akt signaling cascade prevents bortezomib‑induced apoptosis in hepatocellular carcinoma cells

  • Authors:
    • Jinlin Hou
    • Anguo Cui
    • Peiying Song
    • Hui Hua
    • Ting Luo
    • Yangfu Jiang

  • View Affiliations / Copyright

    Affiliations: State Key Labaoratory of Biotherapy, Section of Oncogene, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Laboratory of Stem Cell Biology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 312
    |
    Published online on: September 8, 2025
       https://doi.org/10.3892/mmr.2025.13677
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View Figures

Figure 1

Gefitinib inhibits bortezomib-induced EGFR, Src and Akt phosphorylation. SMMC-7721, Hep3B and HepG2 cells were treated with or without 10 μM gefitinib and 100 nM bortezomib for 24 h, followed by western blot analysis of EGFR, Src and Akt phosphorylation. EGFR, epidermal growth factor receptor; p-, phosphorylated.

Figure 2

Saracatinib decreases bortezomib-induced EGFR, Src and Akt phosphorylation. SMMC-7721, Hep3B and HepG2 cells were treated with or without 1.5 μM saracatinib and 100 nM bortezomib for 24 h, followed by western blot analysis of EGFR, Src and Akt phosphorylation. EGFR, epidermal growth factor receptor; p-, phosphorylated..

Figure 3

ROS mediate the induction of Src, EGFR and Akt phosphorylation by bortezomib. (A) SMMC-7721, Hep3B and HepG2 cells treated with or without 100 nM bortezomib for 24 h, followed by detection of intracellular ROS. The relative levels of ROS were plotted. Values are expressed as the mean ± SD. *P<0.05 vs. control. (B) SMMC-7721 and Hep3B cells treated with or without 5 mM NAC and 100 nM bortezomib for 24 h, followed by detection of intracellular ROS. The relative levels of ROS were plotted. Values are expressed as the mean ± SD. *P<0.05. (C) SMMC-7721, Hep3B and HepG2 cells treated with or without 5 mM NAC and 100 nM bortezomib for 24 h, followed by western blot analysis of EGFR, Src and Akt phosphorylation. ROS, reactive oxygen species; EGFR, epidermal growth factor receptor; p-, phosphorylated; SD, standard deviation; NAC, N-acetyl cysteine..

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Copy and paste a formatted citation
Spandidos Publications style
Hou J, Cui A, Song P, Hua H, Luo T and Jiang Y: [Corrigendum] Reactive oxygen species‑mediated activation of the Src‑epidermal growth factor receptor‑Akt signaling cascade prevents bortezomib‑induced apoptosis in hepatocellular carcinoma cells. Mol Med Rep 32: 312, 2025.
APA
Hou, J., Cui, A., Song, P., Hua, H., Luo, T., & Jiang, Y. (2025). [Corrigendum] Reactive oxygen species‑mediated activation of the Src‑epidermal growth factor receptor‑Akt signaling cascade prevents bortezomib‑induced apoptosis in hepatocellular carcinoma cells. Molecular Medicine Reports, 32, 312. https://doi.org/10.3892/mmr.2025.13677
MLA
Hou, J., Cui, A., Song, P., Hua, H., Luo, T., Jiang, Y."[Corrigendum] Reactive oxygen species‑mediated activation of the Src‑epidermal growth factor receptor‑Akt signaling cascade prevents bortezomib‑induced apoptosis in hepatocellular carcinoma cells". Molecular Medicine Reports 32.6 (2025): 312.
Chicago
Hou, J., Cui, A., Song, P., Hua, H., Luo, T., Jiang, Y."[Corrigendum] Reactive oxygen species‑mediated activation of the Src‑epidermal growth factor receptor‑Akt signaling cascade prevents bortezomib‑induced apoptosis in hepatocellular carcinoma cells". Molecular Medicine Reports 32, no. 6 (2025): 312. https://doi.org/10.3892/mmr.2025.13677
Copy and paste a formatted citation
x
Spandidos Publications style
Hou J, Cui A, Song P, Hua H, Luo T and Jiang Y: [Corrigendum] Reactive oxygen species‑mediated activation of the Src‑epidermal growth factor receptor‑Akt signaling cascade prevents bortezomib‑induced apoptosis in hepatocellular carcinoma cells. Mol Med Rep 32: 312, 2025.
APA
Hou, J., Cui, A., Song, P., Hua, H., Luo, T., & Jiang, Y. (2025). [Corrigendum] Reactive oxygen species‑mediated activation of the Src‑epidermal growth factor receptor‑Akt signaling cascade prevents bortezomib‑induced apoptosis in hepatocellular carcinoma cells. Molecular Medicine Reports, 32, 312. https://doi.org/10.3892/mmr.2025.13677
MLA
Hou, J., Cui, A., Song, P., Hua, H., Luo, T., Jiang, Y."[Corrigendum] Reactive oxygen species‑mediated activation of the Src‑epidermal growth factor receptor‑Akt signaling cascade prevents bortezomib‑induced apoptosis in hepatocellular carcinoma cells". Molecular Medicine Reports 32.6 (2025): 312.
Chicago
Hou, J., Cui, A., Song, P., Hua, H., Luo, T., Jiang, Y."[Corrigendum] Reactive oxygen species‑mediated activation of the Src‑epidermal growth factor receptor‑Akt signaling cascade prevents bortezomib‑induced apoptosis in hepatocellular carcinoma cells". Molecular Medicine Reports 32, no. 6 (2025): 312. https://doi.org/10.3892/mmr.2025.13677
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