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![Mechanism of the transcriptional
regulation of CLDND1 by MZF1. (A) The JASPAR website (https://jaspar.genereg.net/) was used to retrieve the
binding site of the transcription factor MZF1. (B) RT-qPCR and
western blot analysis were performed to detect the expression
levels of CLDND1 in non-small cell lung cancer tissues, using
paracancerous tissues as the control (n=15). (C) RT-qPCR analysis
of CLDND1 mRNA expression in normal bronchial epithelial (BEAS-2B)
and NSCLC cell lines (CAL12T, HCC44, NCIH1993 and A549). (D) After
overexpression of MZF1, RT-qPCR was performed to measure MZF1 and
CLDND1 expression. (E) Dual-luciferase reporter assay examining the
effect of MZF1 on CLDND1 promoter activity. (F) Chromatin
immunoprecipitation assays determining the enrichment of MZF1 in
the CLDND1 promoter region [Chr3:167, 450, 703–167, 450, 714
(hg38)]. All cell experiments were repeated three times. oe,
overexpression; CLDND1, claudin domain-containing 1; MZF1, myeloid
zinc finger 1; RT-qPCR, reverse transcription-quantitative PCR; NC,
negative control; Wt, wild-type; Mut, mutant.](/article_images/mmr/33/1/mmr-33-01-13736-g04.jpg)
