[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Shi,Yan; Hou,Shu-Ai

doi:10.3892/mmr.2025.13752

January-2026 Volume 33 Issue 1

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Correction Open Access

[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Authors:
- Yan Shi
- Shu-Ai Hou
View Affiliations / Copyright

Affiliations: Department of Critical Care Medicine, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China

Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 42
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Published online on: November 17, 2025

https://doi.org/10.3892/mmr.2025.13752
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Mol Med Rep 24: [Related article:] 712, 2021; DOI: 10.3892/mmr.2021.12351

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that a pair of the p-AMPK western blots shown in Fig. 3B were strikingly similar to AMPK blots shown in Fig. 5A; in addition, the AMPK blots shown in Fig. 4A were similar to the GAPDH blots shown in Fig. 5A, albeit the dimensions and intensities of the bands differed slightly comparing the two figure parts.

Figure 3.

Effect of metformin on the activity of NOX4 and the activation of AMPK. (A) Expression of NOX4 mRNA as determined via reverse transcription-quantitative PCR. (B) Representative protein levels of p-AMPK, AMPK and NOX4 as determined via western blotting. (C) Semi-quantification of NOX4 protein levels. (D) Semi-quantification of the p-AMPK/AMPK ratio. Protein levels were normalized to GAPDH. Data are shown as the mean ± SEM (n=6). #P<0.05, ###P<0.001 vs. Sham; *P<0.05 vs. IR. Sham, sham-operated control; IR, ischemia-reperfusion; met, metformin; NOX, NADPH oxidase; AMPK, adenosine 5’-monophosphate-activated protein kinase; p, phosphorylated.

Figure 4.

AMPK inhibitor upregulates the expression of NOX4 protein in vitro. (A) Representative protein levels of p-AMPK, AMPK and NOX4 as determined via western blotting. (B) Semi-quantification of the p-AMPK/AMPK ratio. (C) Semi-quantification of NOX4 protein levels. Protein levels were normalized to GAPDH. Data are shown as the mean ± SEM (n=6). **P<0.01 vs. HR; #P<0.05 vs. HR + met. CON, control; HR, hypoxia-reoxygenation; met, metformin; comC, compound-C; NOX, NADPH oxidase; AMPK, adenosine 5’-monophosphate-activated protein kinase; p, phosphorylated.

Upon re-examining their original data, the authors realized that inadvertent errors had been made in terms of the assembly of Figs. 3 and 4. The revised versions of Figs. 3 and 4, now showing the correct p-AMPK western blots in Fig. 3B and the AMPK blots in Fig. 4A, are shown on the next page. The authors wish to emphasize that these errors did not affect the results or the main conclusions reported in the study. All the authors approve of the publication of this corrigendum, and the authors are grateful to the Editor of Molecular Medicine Reports for allowing them the opportunity to publish this. The authors regret their oversight in allowing these errors to be included in the paper, and apologize to the readership for any inconvenience caused.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

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