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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-2026 Volume 33 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Review

PDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review)

  • Authors:
    • Chen Zhou
    • Yifei Wang
    • Jie Zhao
    • Yantao Yang
    • Yuhang Yuan
    • Xiaochen Hou
    • Yu Tang
    • Lianhua Ye

  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital Yunan, Kunming, Yunnan 650118, P.R. China, Department of Biomedical Engineering Research, Kunming Medical University, Kunming, Yunnan 650500, P.R. China, Department of Medical Genetics, School of Basic Medical Sciences, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China
  • Article Number: 95
    |
    Published online on: January 22, 2026
       https://doi.org/10.3892/mmr.2026.13806
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Abstract

Pancreatic and duodenal homeobox gene 1 (PDX1) is a critical transcription factor involved in pancreatic development and the functionality of mature β‑cells. PDX1 regulates key genes, including insulin and GLUT2, through its DNA‑binding homologous structural domain. In tumors, PDX1 exhibits complex, context‑dependent functions. In pancreatic ductal adenocarcinoma, it transitions from inhibiting follicular cell transformation to promoting tumor proliferation and preventing apoptosis, ultimately inhibiting epithelial‑mesenchymal transition during metastasis. In gastric cancer, PDX1 acts as a tumor suppressor gene, while in esophageal, colorectal, and prostate cancers, it plays a pro‑oncogenic role. Given the dual role of PDX1 in tumorigenesis, its aberrant expression offers potential applications in tumor diagnosis, treatment, and prognosis. The present review explored the structure, function, and mechanisms of PDX1 in tumors, as well as its clinical translational potential, aiming to provide insights for further basic research and pave the way for clinical drug development.

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Copy and paste a formatted citation
Spandidos Publications style
Zhou C, Wang Y, Zhao J, Yang Y, Yuan Y, Hou X, Tang Y and Ye L: <p>PDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review)</p>. Mol Med Rep 33: 95, 2026.
APA
Zhou, C., Wang, Y., Zhao, J., Yang, Y., Yuan, Y., Hou, X. ... Ye, L. (2026). <p>PDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review)</p>. Molecular Medicine Reports, 33, 95. https://doi.org/10.3892/mmr.2026.13806
MLA
Zhou, C., Wang, Y., Zhao, J., Yang, Y., Yuan, Y., Hou, X., Tang, Y., Ye, L."<p>PDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review)</p>". Molecular Medicine Reports 33.3 (2026): 95.
Chicago
Zhou, C., Wang, Y., Zhao, J., Yang, Y., Yuan, Y., Hou, X., Tang, Y., Ye, L."<p>PDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review)</p>". Molecular Medicine Reports 33, no. 3 (2026): 95. https://doi.org/10.3892/mmr.2026.13806
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou C, Wang Y, Zhao J, Yang Y, Yuan Y, Hou X, Tang Y and Ye L: <p>PDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review)</p>. Mol Med Rep 33: 95, 2026.
APA
Zhou, C., Wang, Y., Zhao, J., Yang, Y., Yuan, Y., Hou, X. ... Ye, L. (2026). <p>PDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review)</p>. Molecular Medicine Reports, 33, 95. https://doi.org/10.3892/mmr.2026.13806
MLA
Zhou, C., Wang, Y., Zhao, J., Yang, Y., Yuan, Y., Hou, X., Tang, Y., Ye, L."<p>PDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review)</p>". Molecular Medicine Reports 33.3 (2026): 95.
Chicago
Zhou, C., Wang, Y., Zhao, J., Yang, Y., Yuan, Y., Hou, X., Tang, Y., Ye, L."<p>PDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review)</p>". Molecular Medicine Reports 33, no. 3 (2026): 95. https://doi.org/10.3892/mmr.2026.13806
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