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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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June-2026 Volume 33 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Review Open Access

Exercise‑induced extracellular vesicle microRNA regulates physiological function (Review)

  • Authors:
    • Zhonglei Wang
    • Wenjue Guo
    • Haojia He
    • Yi Zhang
    • Na Li
  • View Affiliations / Copyright

    Affiliations: Laboratory of Physiology, School of Basic Medical Sciences, Hebei University, Baoding, Hebei 071000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 161
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    Published online on: April 1, 2026
       https://doi.org/10.3892/mmr.2026.13871
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Abstract

Physical exercise is essential for maintaining health and preventing disease. Various forms of exercise enhance physiological function by regulating multiple body systems, including the metabolic, immune, cardiovascular and nervous systems. Beyond directly improving organ performance, exercise promotes systemic homeostasis through the modulation of extracellular vesicles (EVs), particularly exosomes. Functioning as key mediators of intercellular communication, exosome‑derived microRNAs (miRNAs) exhibit dynamic regulation influenced by exercise type, frequency and intensity. Accumulating evidence suggests that exercise‑induced exosomal miRNAs support organ integrity and play crucial roles in the prevention and treatment of disorders associated with the metabolic, immune, cardiovascular and nervous systems. Elucidating the underlying cellular and molecular mechanisms of these miRNAs may enable their application as diagnostic biomarkers and therapeutic targets for a variety of diseases. The present review summarized advances in the study of exercise‑induced exosomal miRNAs and underscored their potential in promoting health and preventing disease.

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Copy and paste a formatted citation
Spandidos Publications style
Wang Z, Guo W, He H, Zhang Y and Li N: Exercise‑induced extracellular vesicle microRNA regulates physiological function (Review). Mol Med Rep 33: 161, 2026.
APA
Wang, Z., Guo, W., He, H., Zhang, Y., & Li, N. (2026). Exercise‑induced extracellular vesicle microRNA regulates physiological function (Review). Molecular Medicine Reports, 33, 161. https://doi.org/10.3892/mmr.2026.13871
MLA
Wang, Z., Guo, W., He, H., Zhang, Y., Li, N."Exercise‑induced extracellular vesicle microRNA regulates physiological function (Review)". Molecular Medicine Reports 33.6 (2026): 161.
Chicago
Wang, Z., Guo, W., He, H., Zhang, Y., Li, N."Exercise‑induced extracellular vesicle microRNA regulates physiological function (Review)". Molecular Medicine Reports 33, no. 6 (2026): 161. https://doi.org/10.3892/mmr.2026.13871
Copy and paste a formatted citation
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Spandidos Publications style
Wang Z, Guo W, He H, Zhang Y and Li N: Exercise‑induced extracellular vesicle microRNA regulates physiological function (Review). Mol Med Rep 33: 161, 2026.
APA
Wang, Z., Guo, W., He, H., Zhang, Y., & Li, N. (2026). Exercise‑induced extracellular vesicle microRNA regulates physiological function (Review). Molecular Medicine Reports, 33, 161. https://doi.org/10.3892/mmr.2026.13871
MLA
Wang, Z., Guo, W., He, H., Zhang, Y., Li, N."Exercise‑induced extracellular vesicle microRNA regulates physiological function (Review)". Molecular Medicine Reports 33.6 (2026): 161.
Chicago
Wang, Z., Guo, W., He, H., Zhang, Y., Li, N."Exercise‑induced extracellular vesicle microRNA regulates physiological function (Review)". Molecular Medicine Reports 33, no. 6 (2026): 161. https://doi.org/10.3892/mmr.2026.13871
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