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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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June-2026 Volume 33 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Review Open Access

Oncogene c‑Myc: From molecular mechanism to targeted therapy (Review)

  • Authors:
    • Jianjun Lu
    • Jing Zhu
    • Liqiong Zhang
    • Xiang Zheng
    • Shan Yang
    • Yatong Sang
    • Mingli Yang
    • Yu Tang

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Suzhou Ninth People's Hospital, Suzhou, Jiangsu 215200, P.R. China, Yunnan Key Laboratory of Breast Cancer Precision Medicine, Academy of Biomedical Engineering, Kunming Medical University, Kunming, Yunnan 650000, P.R. China, Department of Genetics, School of Basic Medicine, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 182
    |
    Published online on: April 28, 2026
       https://doi.org/10.3892/mmr.2026.13892
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Abstract

c‑Myc, a member of the MYC family, is an extensively studied proto‑oncogenic transcription factor that plays crucial roles in various biological processes of tumor cells, including proliferation, cell cycle regulation, DNA damage repair, metabolic reprogramming, differentiation and genomic maintenance. Furthermore, in cancer therapeutics, c‑Myc may serve as a key factor influencing targeted drug efficacy and tumor drug resistance. This review comprehensively summarizes the structural characteristics of c‑Myc and its roles and key molecular mechanisms across various malignancies, as well as current strategies for c‑Myc‑targeted therapies and related clinical trials. Additionally, the existing challenges in c‑Myc research are discussed and future research directions are being outlined. The synthesis aims to provide novel insights for fundamental research, offer new perspectives for precision cancer therapy in clinical practice and ultimately bring renewed hope for cancer treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Lu J, Zhu J, Zhang L, Zheng X, Yang S, Sang Y, Yang M and Tang Y: Oncogene c‑Myc: From molecular mechanism to targeted therapy (Review). Mol Med Rep 33: 182, 2026.
APA
Lu, J., Zhu, J., Zhang, L., Zheng, X., Yang, S., Sang, Y. ... Tang, Y. (2026). Oncogene c‑Myc: From molecular mechanism to targeted therapy (Review). Molecular Medicine Reports, 33, 182. https://doi.org/10.3892/mmr.2026.13892
MLA
Lu, J., Zhu, J., Zhang, L., Zheng, X., Yang, S., Sang, Y., Yang, M., Tang, Y."Oncogene c‑Myc: From molecular mechanism to targeted therapy (Review)". Molecular Medicine Reports 33.6 (2026): 182.
Chicago
Lu, J., Zhu, J., Zhang, L., Zheng, X., Yang, S., Sang, Y., Yang, M., Tang, Y."Oncogene c‑Myc: From molecular mechanism to targeted therapy (Review)". Molecular Medicine Reports 33, no. 6 (2026): 182. https://doi.org/10.3892/mmr.2026.13892
Copy and paste a formatted citation
x
Spandidos Publications style
Lu J, Zhu J, Zhang L, Zheng X, Yang S, Sang Y, Yang M and Tang Y: Oncogene c‑Myc: From molecular mechanism to targeted therapy (Review). Mol Med Rep 33: 182, 2026.
APA
Lu, J., Zhu, J., Zhang, L., Zheng, X., Yang, S., Sang, Y. ... Tang, Y. (2026). Oncogene c‑Myc: From molecular mechanism to targeted therapy (Review). Molecular Medicine Reports, 33, 182. https://doi.org/10.3892/mmr.2026.13892
MLA
Lu, J., Zhu, J., Zhang, L., Zheng, X., Yang, S., Sang, Y., Yang, M., Tang, Y."Oncogene c‑Myc: From molecular mechanism to targeted therapy (Review)". Molecular Medicine Reports 33.6 (2026): 182.
Chicago
Lu, J., Zhu, J., Zhang, L., Zheng, X., Yang, S., Sang, Y., Yang, M., Tang, Y."Oncogene c‑Myc: From molecular mechanism to targeted therapy (Review)". Molecular Medicine Reports 33, no. 6 (2026): 182. https://doi.org/10.3892/mmr.2026.13892
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